Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill [Biophysics and Computational Biology]

Influenza hemagglutinin (HA) mediates viral entry into host cells through a large-scale conformational rearrangement at low pH that leads to fusion of the viral and endosomal membranes. Crystallographic and biochemical data suggest that a loop-to-coiled-coil transition of the B-loop region of HA is important for driving this structural rearrangement. However,...

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