Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation [Biological Sciences]

Paredes et al. (1) describe polymerase-δ interacting protein 2 (Poldip2) as a novel regulator of mitochondrial lipoylation through stabilization of Ac-CoA synthetase medium-chain family member 1 (ACSM1). We have several concerns with their proposed model based on the following reasons. Prior mammalian and yeast biochemical studies are not consistent with...

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