Zooming in on a small multidrug transporter reveals details of asymmetric protonation [Commentary]

Drug resistance poses a major threat to human health. A principal mechanism of multidrug resistance is the active transport of chemically unrelated compounds out of the cell by integral membrane proteins known as multidrug transporters (1). Multidrug transporters are represented by four superfamilies: ABC (ATP-binding cassette), MFS (major facilitator superfamily),...

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