Fatty Acids in Pregnancy and Risk of Allergic Sensitization and Respiratory Outcomes in Childhood

Some observational studies have suggested associations of higher prenatal fish intake with protection against offspring asthma, attributing associations to greater exposure to marine n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs). Two recent randomized clinical trials have tested that hypothesis. Bisgaard and colleagues1 found that supplementation with n-3 LCPUFAs reduced the risk of persistent wheeze or asthma and lower respiratory tract infections, but not allergic sensitization or eczema, in offspring followed for the first 3 years of life.

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