Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors [Biological Sciences]

Methylation of cytosine residues exerts a critical role in silencing gene transcription. Importantly, DNA methylation patterns are often altered in cancer, with many tumors showing site-specific gain of methylation marks in a background of global hypomethylation (1). In PNAS, Stone et al. (2) show in an ovarian cancer model that...

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