High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing [Pharmacology]

Dysfunctional endothelium causes more disease than any other cell type. Systemically administered RNA delivery to nonliver tissues remains challenging, in large part because there is no high-throughput method to identify nanoparticles that deliver functional mRNA to cells in vivo. Here we report a system capable of simultaneously quantifying how >100...

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