Raf kinase inhibitor protein negatively regulates FcϵRI-mediated mast cell activation and allergic response [Immunology and Inflammation]

The signaling cascades triggered by the cross-linkage of immunoglobulin E (IgE) with its high-affinity receptor (FcεRI) on mast cells contribute to multiple allergic disorders, such as asthma, rhinitis, and atopic dermatitis. Restraint of intracellular signals for mast cell activation is essential to restore homeostasis. In this study, we found that...

https://ift.tt/2J0QKHT