Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria [Applied Biological Sciences]

Malonyl-CoA is an important central metabolite for the production of diverse valuable chemicals including natural products, but its intracellular availability is often limited due to the competition with essential cellular metabolism. Several malonyl-CoA biosensors have been developed for high-throughput screening of targets increasing the malonyl-CoA pool. However, they are limited...

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