Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain [Biophysics and Computational Biology]

The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300. The KIX domain binds regulatory proteins at the distinct MLL and...

https://ift.tt/2IypMHw