Substance P and IL-33 administered together stimulate a marked secretion of IL-1{beta} from human mast cells, inhibited by methoxyluteolin [Immunology and Inflammation]

Mast cells are critical for allergic and inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. SP (0.01–1 μM) administered together with IL-33 (30 ng/mL) to human cultured LAD2 mast cells stimulates a marked increase (P < 0.0001) in secretion of the proinflammatory cytokine...

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