Transcription initiation defines kinetoplast RNA boundaries [Biochemistry]

Mitochondrial genomes are often transcribed into polycistronic RNAs punctuated by tRNAs whose excision defines mature RNA boundaries. Although kinetoplast DNA lacks tRNA genes, it is commonly held that in Trypanosoma brucei the monophosphorylated 5′ ends of functional molecules typify precursor partitioning by an unknown endonuclease. On the contrary, we demonstrate...

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