CFI-400945 is not a selective cellular PLK4 inhibitor [Biological Sciences]

In the PNAS paper "Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers," Kawakami et al. (1) treat lung cancer cell lines and mouse tumor models with the small molecule CFI-400945 and interpret its effects as being solely due to inhibition of Polo-like kinase 4 (PLK4), the...

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