Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection [Immunology and Inflammation]

Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes a range of diseases, including fatal invasive infections. However, the mechanisms by which the innate immune system recognizes GAS are not well understood. We herein report that the C-type lectin receptor macrophage inducible C-type lectin (Mincle) recognizes GAS and...

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