Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin [Biophysics and Computational Biology]

A wide range of mutations in the kinesin motor Kif5A have been linked to a neuronal disorder called hereditary spastic paraplegia (HSP). The position of these mutations can vary, and a range of different motile behaviors have been observed, indicating that the HSP mutants can alter distinct aspects of kinesin...

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