Probing the mechanism of inhibition of amyloid-{beta}(1-42)-induced neurotoxicity by the chaperonin GroEL [Biophysics and Computational Biology]

The human chaperonin Hsp60 is thought to play a role in the progression of Alzheimer's disease by mitigating against intracellular β-amyloid stress. Here, we show that the bacterial homolog GroEL (51% sequence identity) reduces the neurotoxic effects of amyloid-β(1–42) (Aβ42) on human neural stem cell-derived neuronal cultures. To understand the...

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