Spatiotemporal activation of the C/EBP{beta}/{delta}-secretase axis regulates the pathogenesis of Alzheimer’s disease [Neuroscience]

Alzheimer's disease (AD) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (NFT) containing truncated and hyperphosphorylated Tau, extensive neuronal loss, and chronic neuroinflammation. However, the key molecular mechanism that dominates the pathogenesis of AD remains elusive for AD. Here we show that the...

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