Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch [Physiology]

Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of Tmem79, an orphan transmembrane protein linked to AD in both mice and humans....

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