Anaphylaxis to amoxicillin-clavulanate, differenitiating the components

Drug hypersensitivity skin testing (ST) has been standardized only when referring to penicillin. However, this method remains a common practice for other drugs and while being a practical tool, oral provocation tests (OPT) are the gold standard in diagnosis of drug hypersensitivity and should be used when available.1 β-lactams remain the most frequently reported cause of adverse drug reactions.2 Isolated adverse drug reactions to clavulanate, a β-lactamase inhibitor added to amoxicillin to form amoxicillin-clavulanate, remain rarer but have been reported.

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