Ca2+-activated Cl- current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons [Biophysics and Computational Biology]

Activation of most primary sensory neurons results in transduction currents that are carried by cations. One notable exception is the vertebrate olfactory receptor neuron (ORN), where the transduction current is carried largely by the anion Cl−. However, it remains unclear why ORNs use an anionic current for signal amplification. We...

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