Conotoxin {kappa}M-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels [Neuroscience]

The vast complexity of native heteromeric K+ channels is largely unexplored. Defining the composition and subunit arrangement of individual subunits in native heteromeric K+ channels and establishing their physiological roles is experimentally challenging. Here we systematically explored this "zone of ignorance" in molecular neuroscience. Venom components, such as peptide toxins,...

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