Reply to Tobiasson et al.: Zinc depletion is a specific signal for induction of ribosome hibernation in mycobacteria [Biological Sciences]

We previously reported (1) in PNAS that zinc depletion in Mycobacterium smegmatis leads to reprogramming of ribosomes in which five ribosomal proteins (r-proteins) with a conserved zinc-finger CXXC motif (C+) are replaced by their paralogs lacking the motif (C−). Notably, the reprogrammed ribosomes enter into a hibernating state by binding...

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