Background: Smoking remains the leading cause of preventable disease and death in the developed world that kills half of all long-term users. Tobacco use after solid organ transplantation is associated with allograft dysfunction, cancer, and reduced overall survival. Methods: In this single-center, retrospective study, we describe the frequency of tobacco use after lung transplantation (LTx), pre-transplant patient characteristics associated with tobacco use, and the safety, efficacy and outcomes of post-transplant tobacco cessation interventions. Results: Four percent of our LTx cohort resumed tobacco use post-transplant. Chronic obstructive pulmonary disease (COPD) (p= 0.043), the cessation duration prior to LTx (p
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