Regulation of spinogenesis in mature Purkinȷe cells via mGluR/PKC-mediated phosphorylation of CaMKII{beta} [Neuroscience]

Dendritic spines of Purkinje cells form excitatory synapses with parallel fiber terminals, which are the primary sites for cerebellar synaptic plasticity. Nevertheless, how density and morphology of these spines are properly maintained in mature Purkinje cells is not well understood. Here we show an activity-dependent mechanism that represses excessive spine...

http://ift.tt/2sYcmN9