Specific targeting of TGF-{beta} family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease [Physiology]

The transforming growth factor-β (TGF-β) network of ligands and intracellular signaling proteins is a subject of intense interest within the field of skeletal muscle biology. To define the relative contribution of endogenous TGF-β proteins to the negative regulation of muscle mass via their activation of the Smad2/3 signaling axis, we...

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