Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs [Applied Biological Sciences]

Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive findings (i.e., positive results in vitro that are...

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