DNA replication timing alterations identify common markers between distinct progeroid diseases [Medical Sciences]

Progeroid syndromes are rare genetic disorders that phenotypically resemble natural aging. Different causal mutations have been identified, but no molecular alterations have been identified that are in common to these diseases. DNA replication timing (RT) is a robust cell type-specific epigenetic feature highly conserved in the same cell types from...

http://ift.tt/2Bfwpyf