Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II [Biochemistry]

Abasic sites are among the most abundant DNA lesions and interfere with DNA replication and transcription, but the mechanism of their action on transcription remains unknown. Here we applied a combined structural and biochemical approach for a comprehensive investigation of how RNA polymerase II (Pol II) processes an abasic site,...

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