Treg cells limit IFN-{gamma} production to control macrophage accrual and phenotype during skeletal muscle regeneration [Immunology and Inflammation]

Skeletal muscle regeneration is a highly orchestrated process that depends on multiple immune-system cell types, notably macrophages (MFs) and Foxp3+CD4+ regulatory T (Treg) cells. This study addressed how Treg cells rein in MFs during regeneration of murine muscle after acute injury with cardiotoxin. We first delineated and characterized two subsets...

http://ift.tt/2tKoYvj