Innate and adaptive immunity combined for cancer treatment [Immunology and Inflammation]

In PNAS, Kaplanov et al. (1) report on how IL-1β orchestrates recruitment of immunosuppressive monocytes and their polarization in IL-10–producing macrophages during tumor development. This mechanism consequently inhibits and limits CD8+ T cell-driven immune responses and enables tumor outgrowth. Therapeutic blockade of IL-1β and inhibition of monocyte recruitment synergized and...

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