Transnasal endoscopic ultrasound-guided reduction of maxillary sinus wall fracture

Abstract

Surgical morbidity from open reduction and internal fixation (ORIF) of maxillary sinus wall fracture often surpasses the benefits of ORIF. Hence, the authors devised transnasal endoscopic-assisted reduction of maxillary sinus wall fracture (TERM) without internal fixation as a minimally invasive surgery for maxillary sinus wall fracture. The purpose of this study was to investigate the feasibility of TERM in cadavers and patients. Six cadavers were dissected to evaluate the feasibility of TERM. In addition, 20 patients with maxillary sinus wall fractures who underwent TERM in a tertiary hospital from August of 2013 to December of 2015 were enrolled in this study. Demographic factors, type of anesthesia, computed tomography (CT) scans, clinical characteristics of patients, and patient satisfaction with surgery were analyzed. Cadaveric study showed that endoscopic inferior meatus antrostomy is a feasible method of approaching the maxillary sinus wall in cadavers. In addition, counterforce could be applied to the maxillary sinus wall by pushing packed Vaseline-soaked gauze or using a zygomatic process approach via a Gillies incision. Clinical experience revealed that patients experienced good facial contour restoration postoperatively. The extent of fractured bony segments was reduced on postoperative CT without complications. Patient satisfaction with TERM was greater than that with ORIF (p = 0.031). TERM showed its feasibility in both cadaveric study and clinical study. TERM can be a good alternative to ORIF, especially in patients who are reluctant to undergo a facial incision.

http://ift.tt/2rh3DYN

Suboptimal palliative sedation in primary care: an exploration

http://ift.tt/2s1lP62

Perioperative goal-directed therapy with uncalibrated pulse contour methods: impact on fluid management and postoperative outcome

Abstract

Previous meta-analyses suggest that perioperative goal-directed therapy (GDT) is useful to decrease postoperative morbidity. Most GDT studies analysed were done with pulmonary artery catheters, oesophageal Doppler and calibrated pulse contour methods. Uncalibrated pulse contour (uPC) techniques are an appealing alternative but their accuracy has been questioned. The effects of GDT on fluid management (volumes and volume variability) remain unclear. We performed a meta-analysis of randomized controlled trials investigating the effects of GDT with uPC methods on postoperative outcome. The primary endpoint was postoperative morbidity. Fluid volumes and fluid volume variability (standard deviation/mean) over the GDT period were also studied. Nineteen studies met the inclusion criteria (2159 patients). Postoperative morbidity was reduced with GDT (OR 0.46, 95% CI 0.30–0.70, P<0.001). The volume of colloids was higher [weighted mean difference (WMD) +345 ml, 95% CI 148–541 ml, P<0.001] and the volume of crystalloids was lower (WMD –429 ml, 95% CI –634 to –224 ml, P<0.01) in the GDT group than in the control group. However, the total volume of fluid (WMD –220 ml, 95% CI –590 to 150 ml, P=0.25) and the variability of fluid volume (34% vs 33%, P=0.98) were not affected by GDT. The use of GDT with uPC techniques was associated with a decrease in postoperative morbidity. It was not associated with an increase in total fluid volume nor with a decrease in fluid volume variability.

http://ift.tt/2r9IpZ1

Modified Frailty Index Score and Perioperative Risk in Laryngectomy : The 11 Variables Included in Modified Frailty Index Assessment : History of diabetes Functional status (not independent at baseline) History of pneumonia or chronic obstructive pulmonary disease History of congestive cardiac failure History of myocardial infarction History of percutaneous coronary intervention, stent placement, or angina History of hypertension (requiring medical treatment) History of peripheral vascular diseas

http://ift.tt/2sjoYBh

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2rgoOdA

Barking Cough

https://youtu.be/IgZuVo81298?t=33

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2ssxoWz

Modified Frailty Index Score and Perioperative Risk in Laryngectomy : The 11 Variables Included in Modified Frailty Index Assessment : History of diabetes Functional status (not independent at baseline) History of pneumonia or chronic obstructive pulmonary disease History of congestive cardiac failure History of myocardial infarction History of percutaneous coronary intervention, stent placement, or angina History of hypertension (requiring medical treatment) History of peripheral vascular disease or ischemic rest pain History of impaired sensorium History of transient ischemic attack or cerebrovascular accident History of cerebrovascular accident with neurologic deficit

http://orlhealth.blogspot.com/2017/06/modified-frailty-index-score-and.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Bovine cough

http://ift.tt/2rlO1hV

<iframe width="640" height="360" src="https://www.youtube.com/embed/pLzezVufJ1o" frameborder="0" allowfullscreen></iframe>

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2rgJz94

Barking Cough

https://youtu.be/IgZuVo81298?t=33

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Bovine cough

http://orlhealth.blogspot.com/2017/06/hoarse-voice-and-bovine-cough.html

<iframe width="640" height="360" src="https://www.youtube.com/embed/pLzezVufJ1o" frameborder="0" allowfullscreen></iframe>

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Hyperspectral X-ray transmission imaging................................3D chemical imaging

http://ift.tt/2rgMsqu

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2rgPGKz

Persistent lesion hyperintensity on brain diffusion-weighted MRI

http://ift.tt/2ssxsFB

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2s1hGPh

Nausea, vomiting, loss of appetite and oliguria : haemoglobin =12.7 g/dL, indirect bilirubin =2.0 mg/dL, haptoglobin ≤6 mg/dL, platelet count =121 000/μL and schistocytes on peripheral smear.

http://ift.tt/2r91Wss

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

http://ift.tt/2rg9CgN

Hyperspectral X-ray transmission imaging................................3D chemical imaging

http://orlhealth.blogspot.com/2017/06/hyperspectral-x-ray-transmission.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Persistent lesion hyperintensity on brain diffusion-weighted MRI

http://orlhealth.blogspot.com/2017/06/persistent-lesion-hyperintensity-on.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Nausea, vomiting, loss of appetite and oliguria : haemoglobin =12.7 g/dL, indirect bilirubin =2.0 mg/dL, haptoglobin ≤6 mg/dL, platelet count =121 000/μL and schistocytes on peripheral smear.

http://orlhealth.blogspot.com/2017/06/nausea-vomiting-loss-of-appetite-and.html

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239

Publication date: August 2017
Source:Molecular Immunology, Volume 88
Author(s): Qiqing Shi, Bo Xiong, Jing Zhong, Huihui Wang, Duan Ma, Changhong Miao
TLR4, an important Toll-like receptor in innate immunity, can be activated by LPS and induce proinflammatory cytokines to resist invasion of pathogenic microorganism, but excessive inflammation can trigger tissue injury. Many genes negatively regulate TLR4 signaling pathway. Recent studies found that malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) suppressed the expression of cytokine IL6 in Raw264.7 cells stimulated by LPS, but the mechanisms remained unclear. This study investigated the role of MFHAS1 in TLR4 signaling pathway and the possible mechanisms implicated. The results indicated that the expression of MFHAS1 was significantly increased in cells stimulated with LPS. Up-regulation of MFHAS1 effectively suppressed inflammatory cytokine expression in cells exposed to LPS, whereas down-regulation of MFHAS1 markedly increased inflammatory cytokines expression. Co-immunoprecipitation, pull-down and immunofluorescence tests demonstrated that MFHAS1 combined with the B and C subunits of PP2A and induced cytoplasm translocation of the C subunit, leading to decrease dephosphorylation of c-Jun at Thr239 and increase degradation of c-Jun. Reduction of c-Jun protein results in decreased AP-1 activity, which is independent of inhibition of JNK or p38MAPK phosphorylation. Taken together, these results indicate that MFHAS1 suppresses TLR4 signaling pathway through induction of PP2A C subunit cytoplasm translocation and subsequent c-Jun degradation, leading finally to decrease AP-1 activity and cytokines expression.



http://ift.tt/2s0fKXm

Transoral thyroidectomy and parathyroidectomy – A North American series of robotic and endoscopic transoral approaches to the central neck

Publication date: August 2017
Source:Oral Oncology, Volume 71
Author(s): Jonathon O. Russell, James Clark, Salem I. Noureldine, Angkoon Anuwong, Mai G. Al Khademh, Hoon Yub Kim, Vaninder K. Dhillon, Gianlorenzo Dionigi, Ralph P. Tufano, Jeremy D. Richmon
ObjectiveMost thyroid surgery in North America is completed via a cervical incision, which leaves a permanent scar. Approaches without cutaneous incisions offer aesthetic advantages. This series represents the largest series of transoral vestibular approaches to the central neck in North America, and the first published reports of robotic transoral vestibular thyroidectomy for thyroid carcinoma.Materials and methodsData was prospectively collected for patients that underwent transoral vestibular approach thyroidectomy and/or parathyroidectomy between April 2016 and February 2017.ResultsFifteen patients underwent the procedure for removal of the thyroid (n=12), parathyroid (n=2) or both thyroid and parathyroid glands (n=1). The first case was converted to an open procedure. Fourteen were completed through these remote access incisions, including patients with a body mass index as high as 44. There were no permanent complications. The postoperative median Dermatology Life Quality Index score was 3, which indicates a small effect on quality of life.ConclusionThe transoral vestibular approach to the central neck is a promising technique for patients who desire to optimize aesthetics.



http://ift.tt/2siaZvc

Prognostic value of the eighth edition AJCC TNM classification for differentiated thyroid carcinoma

Publication date: August 2017
Source:Oral Oncology, Volume 71
Author(s): Tae Hyuk Kim, Young Nam Kim, Hye In Kim, So Young Park, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Kyunga Kim, Jong Gill Jeong, Sun Wook Kim, Jae Hoon Chung
BackgroundThe prognostic value of the proposed eighth edition of the American Joint Committee on Cancer (AJCC) tumor, node, and metastasis (TNM) classification is currently unclear. The aim of the study was to evaluate the prognostic value of the eighth edition of the AJCC TNM classification.MethodsWe retrospectively assessed 3176 patients with differentiated thyroid carcinoma (DTC) who underwent thyroidectomy at a tertiary Korean hospital from 1996 to 2005. Cancer-specific survival (CSS) was analyzed using the Kaplan–Meier method and compared using the log-rank test. Performance of the eighth edition TNM with respect to prediction of CSS was assessed against the current seventh edition.ResultsUpon reclassification according to the eighth edition, 37.6% of patients were down-staged. The proportions of stage I and II tumors increased from 61.9% to 81.1% and from 1.7% to 16.0%, respectively, whereas those of stage III and IVB (formerly IVC in the seventh edition) decreased from 27.6% to 2.3% and 0.8% to 0.5%, respectively. The proportions of variance explained (PVEs) for the ability of the eighth and the seventh edition to predict CSS were 3.9% and 2.9%, respectively. The C-index values were 0.765 (95% confidence interval 0.764–0.766) for the eighth edition and 0.736 (0.735–0.737) for the seventh edition.ConclusionOur results demonstrate that the eighth edition TNM more accurately predicts CSS for patients with DTC than does the seventh edition.



http://ift.tt/2sRiaHP

Dose-dependent enhancement of T-lymphocyte priming and CTL lysis following ionizing radiation in an engineered model of oral cancer

Publication date: August 2017
Source:Oral Oncology, Volume 71
Author(s): Megan Morisada, Ellen C. Moore, Rachel Hodge, Jay Friedman, Harrison A. Cash, James W. Hodge, James B. Mitchell, Clint T. Allen
ObjectivesDetermine if direct tumor cell cytotoxicity, antigen release, and susceptibility to T-lymphocyte killing following radiation treatment is dose-dependent.Materials and methodsMouse oral cancer cells were engineered to express full-length ovalbumin as a model antigen. Tumor antigen release with uptake and cross presentation of antigen by antigen presenting cells with subsequent priming and expansion of antigen-specific T-lymphocytes following radiation was modeled in vitro and in vivo. T-lymphocyte mediated killing was measured following radiation treatment using a novel impedance-based cytotoxicity assay.ResultsRadiation treatment induced dose-dependent induction of executioner caspase activity and apoptosis in MOC1 cells. In vitro modeling of antigen release and T-lymphocyte priming demonstrated enhanced proliferation of OT-1 T-lymphocytes with 8Gy treatment of MOC1ova cells compared to 2Gy. This was validated in vivo following treatment of established MOC1ova tumors and adoptive transfer of antigen-specific T-lymphocytes. Using a novel impedance–based cytotoxicity assay, 8Gy enhanced tumor cell susceptibility to T-lymphocyte killing to a greater degree than 2Gy.ConclusionIn the context of using clinically-relevant doses of radiation treatment as an adjuvant for immunotherapy, 8Gy is superior to 2Gy for induction of antigen-specific immune responses and enhancing tumor cell susceptibility to T-lymphocyte killing. These findings have significant implications for the design of trials combining radiation and immunotherapy.



http://ift.tt/2shFJfP

The impact of a head and neck microvascular fellowship program on otolaryngology resident training

Objective

To assess the impact of a microvascular head and neck (H&N) fellowship on senior residents' surgical experience.

Study Design

Retrospective review of Accreditation Council for Graduate Medical Education-generated operative case log reports, retrospective chart review, and electronic survey.

Methods

A retrospective review of one institution's residents' H&N operative case logs and free flap operative reports was performed to determine changes in key indicator cases (KICs) after the addition of a H&N fellowship. An electronic survey was distributed to senior residents at all U.S. otolaryngology residency programs to determine residents' perceptions of a H&N fellow's impact on their surgical experience. An electronic survey was distributed to senior medical students applying to surgical residencies to explore the perceived impact that a fellowship has on the desirability of a residency program.

Results

The average number of each postgraduate year (PGY)5's H&N KIC before and after the addition of the fellowship were: parotidectomy, 19 versus 17.8; neck dissection, 33.2 versus 40.6; oral cavity resection, 15.3 versus 12.6; thyroid/parathyroid, 45.5 versus 45.6; and flaps/grafts, 56.7 versus 42. PGY5 participation as first assistant in free flaps dropped from 78% to 17%; however, residents still participated in some aspect of 45% of the cases. Seventy percent of senior residents reported a positive perception of the H&N fellow on their H&N operative experience. Eighty-nine percent of senior medical student respondents reported a nonnegative perception of a fellowship in their applied field.

Conclusion

The addition of a H&N fellowship did not decrease senior residents' H&N KIC, and most senior residents at programs with fellowships report that the fellow has a positive impact on their H&N operative experience.

Level of Evidence

4. Laryngoscope, 2017

http://ift.tt/2rkx2g0

Relationship between Height-Weight Difference Index and Body-Fat Percentage Estimated by Bioelectrical Impedance Analysis in Thai Adults

Introduction. The height-weight difference index (HWDI) is a new indicator for evaluating obesity status. While body-fat percentage (BF%) is considered to be the most accurate obesity evaluation tool, it is a more expensive method and more difficult to measure than the others. Objective. Our objectives were to find the relationship between HWDI and BF% and to find a BF% prediction model from HWDI in relation to age and gender. Method. Bioelectrical impedance analysis was used to measure BF% in 2,771 healthy adult Thais. HWDI was calculated as the difference between height and weight. Pearson's correlation coefficient was used to assess the relationship between HWDI and BF%. Multiple linear and nonlinear regression analysis were used to construct the BF% prediction model. Results. HWDI and BF% were found to be inverse which related to a tendency toward a linear relationship. Results of a multivariate linear regression analysis, which included HWDI and age as variables in the model, predicted BF% to be 34.508 − 0.159 (HWDI) + 0.161 (age) for men and 53.35 − 0.265 (HWDI) + 0.132 (age) for women. Conclusions. The prediction model provides an easy-to-use obesity evaluation tool that should help awareness of underweight and obesity conditions.

http://ift.tt/2sQBXqZ

Biology of Incidental Catch Sea Star Stellaster childreni Gray, 1840 (Echinodermata: Asteroidea), from Malaysian Borneo Exclusive Economic Zone

Sea star (class Asteroidea, phylum Echinodermata) is one of the most successful marine organisms inhabiting a wide range of habitats. As one of the key stone species, sea stars are responsible for maintaining much of the local diversity of species within certain communities. Malaysian Exclusive Economic Zone (EEZ) Resource Survey had been carried out from 16th Aug to 6th Nov 2015 and one of the invertebrate by-catch organisms is sea star Stellaster childreni Gray, 1840. This study documents morphological characters and diet of the sea star, besides providing brief descriptions of the habitats based on particle size analysis and vessel log data sheet. A total of 217 individuals had been examined throughout this study. Fragments of flora and fauna were found in the gut including Mollusca (gastropod, bivalves, and scaphopods), sponge seagrass, and seaweed as well as benthic Foraminifera. Stellaster childreni were found at depth of 45 m to 185 m in the South China Sea off Sarawak Malaysia, with various sea bottom substrata. Approximately 41% of S. childreni were found at a mixture of sandy and muddy substratum, followed by mixture of sandy and coral (19.3%), muddy substratum (17.5%), coral substratum (11.5%), and sandy areas (10.6%). The widely distributed sea star on different types of sea beds suggested healthy deep sea ecosystem; thus Malaysia should explore further potential fisheries resources in the EEZ off Sarawak coast.

http://ift.tt/2sh0RmF

Ischemic stroke complicating thrombolytic therapy with tenecteplase for ST elevation myocardial infarction: two case reports

Hemorrhagic complications are quite common in the rare cases where thrombolysis is performed. Ischemic stroke in the aftermath of thrombolysis for a ST elevation myocardial infarction is a very rare and parado...

http://ift.tt/2reAr4T

25 (OH) D3 levels, incidence and recurrence of different clinical forms of BPPV

Publication date: Available online 11 June 2017
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Sinisa Maslovara, Silva Butkovic Soldo, Anamarija Sestak, Katarina Milinkovic, Jasna Rogic-Namacinski, Anamarija Soldo
IntroductionBenign Paroxysmal Positional Vertigo (BPPV) is the most common cause of dizziness in the general population. It is a condition with potential impact of reduced levels of vitamin D on its recurrent attacks.ObjectivesThe aim of this study was to measure the serum levels of 25-hydroxyvitamin D3 (25-OH D3) in patients with BPPV and determine whether there is a difference in the serum levels of vitamin D3 between patients with and without recurrence, as well as between the different clinical forms of BPPV.MethodsThe study included 40 patients who came to the regular medical examination, diagnosed with PC-BPPV based on the positive Dix-Hallpike's test. All patients underwent Epley manoeuvre after the diagnosis. Patients were classified according to current guidelines for levels of vitamin D3 in the serum in three groups: the deficiency, insufficiency and adequate level.ResultsThe average serum level of 25-OH D3 among respondents was 20.78ng/mL, indicating a lack or insufficiency of the aforementioned 25-OH D3. According to the levels of 25-OH D3, most patients suffer from deficiency (47.5%). 7 (17.5%) respondents had adequate blood level of 25-OH D3, and 14 (35%) respondents suffer from insufficiency. A significant difference was not found in the serum level of 25-OH D3 between patients with and without BPPV recurrence. There was a significant difference in the serum levels of 25-OH D3 in comparison to the clinical form of the disease. Lower 25-OH D3 values were found in patients with canalithiasis compared to those with cupulolithiasis.ConclusionsThere were no significant differences in the vitamin D3 serum level in patients with and without recurrence. The study showed a low level of serum vitamin D3 in most patients, indicating the need for supplemental therapy.



http://ift.tt/2r7JIaw

Students’ knowledge acquisition and ability to apply knowledge into different science contexts in two different independent learning settings

Cukurova, M; Bennett, J; Students' knowledge acquisition and ability to apply knowledge into different science contexts in two different independent learning settings. Research in Science and Technological Education 10.1080/02635143.2017.1336709 .

http://ift.tt/2rYCDdR

Homogeneity of variance of measures associated with objective assessment of esthetic outcome after treatment with radiation therapy in early breast cancer.

Williams, N; (2017) Homogeneity of variance of measures associated with objective assessment of esthetic outcome after treatment with radiation therapy in early breast cancer. Presented at: American Society of Clinical Oncology, Chicago, IL, USA.

http://ift.tt/2refp6w

Heterogeneity of variance in objective measures of aesthetic outcome associated with whole breast external beam radiotherapy compared with intraoperative radiotherapy in early breast cancer.

Williams, N; (2016) Heterogeneity of variance in objective measures of aesthetic outcome associated with whole breast external beam radiotherapy compared with intraoperative radiotherapy in early breast cancer. Presented at: American Society of Clinical Oncology, Chicago, IL, USA.

http://ift.tt/2rYUTUx

Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort.

Baker, E; Iqbal, E; Johnston, C; Broadbent, M; Shetty, H; Stewart, R; Howard, R; Baker, E; Iqbal, E; Johnston, C; Broadbent, M; Shetty, H; Stewart, R; Howard, R; Newhouse, S; Khondoker, M; Dobson, RJB; - view fewer (2017) Trajectories of dementia-related cognitive decline in a large mental health records derived patient cohort. PLoS One , 12 (6) , Article e0178562. 10.1371/journal.pone.0178562 .

http://ift.tt/2remELE

An Optimal Dimensionality Multi-shell Sampling Scheme with Accurate and Efficient Transforms for Diffusion MRI

Bates, AP; Khalid, Z; McEwen, JD; Kennedy, RA; An Optimal Dimensionality Multi-shell Sampling Scheme with Accurate and Efficient Transforms for Diffusion MRI.

http://ift.tt/2rZacMM

Solitary Iris Plasmacytoma With Anterior Chamber Crystalline Deposits.

Stacey, AW; Lavric, A; Thaung, C; Siddiq, S; Sagoo, MS; (2017) Solitary Iris Plasmacytoma With Anterior Chamber Crystalline Deposits. Cornea , 36 (7) pp. 875-877. 10.1097/ICO.0000000000001222 .

http://ift.tt/2rdHjQ5

Polyelectrolyte-Coated Gold Magnetic Nanoparticles for Immunoassay Development: Toward Point of Care Diagnostics for Syphilis Screening

Yang, D; Ma, J; Zhang, Q; Li, N; Yang, J; Raju, PA; Peng, M; Yang, D; Ma, J; Zhang, Q; Li, N; Yang, J; Raju, PA; Peng, M; Luo, Y; Hui, W; Chen, C; Cui, Y; - view fewer (2013) Polyelectrolyte-Coated Gold Magnetic Nanoparticles for Immunoassay Development: Toward Point of Care Diagnostics for Syphilis Screening. Analytical Chemistry , 85 (14) pp. 6688-6695. 10.1021/ac400517e .

http://ift.tt/2rZeBzh

BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas

Gill, S; Broni, J; Jefferies, S; Osin, P; Kovacs, G; Maitland, NJ; Eeles, R; Gill, S; Broni, J; Jefferies, S; Osin, P; Kovacs, G; Maitland, NJ; Eeles, R; Edwards, SM; Dyer, MJS; Willis, TG; Cooper, CS; - view fewer (1999) BCL10 is rarely mutated in human prostate carcinoma, small-cell lung cancer, head and neck tumours, renal carcinoma and sarcomas. BRITISH JOURNAL OF CANCER , 80 (10) pp. 1565-1568. 10.1038/sj.bjc.6990561 .

http://ift.tt/2reujJN

A Metal Mesh Flat Prism For MM-wave Applications

Moseley, P; Savini, G; Pisano, G; Ade, P; Saenz, E; Zhang, J; (2015) A Metal Mesh Flat Prism For MM-wave Applications. In: (Proceedings) 40th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz). IEEE

http://ift.tt/2rYTPjd

A Focusing Metamaterial Based Wollaston Prism

Moseley, P; Savini, G; Saenz, E; Ade, P; Zhang, J; (2014) A Focusing Metamaterial Based Wollaston Prism. In: (Proceedings) 39th International Conference on Infrared, Millimeter, and Terahertz waves (IRMMW-THz). IEEE

http://ift.tt/2reuiWf

eALPS: Estimating abundance levels in pooled sequencing using available genotyping data

Eskin, I; Hormozdiari, F; Conde, L; Riby, J; Skibola, C; Eskin, E; Halperin, E; (2013) eALPS: Estimating abundance levels in pooled sequencing using available genotyping data. In: (pp. pp. 32-44).

http://ift.tt/2rYRtkC

Control of noise for speech intelligibility in open plan classrooms

Greenland, E; Shield, B; Dockrell, J; (2009) Control of noise for speech intelligibility in open plan classrooms. In:

http://ift.tt/2re5uOd

A speech intelligibility test for use with young children in realistic classroom environments

Budd, AL; Shield, BM; Dockrell, J; (2009) A speech intelligibility test for use with young children in realistic classroom environments. In:

http://ift.tt/2rYNhBj

Entropic forces drive self-organization and membrane fusion by SNARE proteins

Mostafavi, H; Thiyagarajan, S; Stratton, BS; Karatekin, E; Warner, JM; Rothman, JE; O'Shaughnessy, B; (2017) Entropic forces drive self-organization and membrane fusion by SNARE proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 114 (21) pp. 5455-5460. 10.1073/pnas.1611506114 .

http://ift.tt/2rdYzUZ

A novel physiological role for ARF1 in the formation of bi-directional tubules from the Golgi.

Bottanelli, F; Kilian, N; Ernst, AM; Rivera-Molina, F; Schroeder, LK; Kromann, EB; Lessard, MD; Bottanelli, F; Kilian, N; Ernst, AM; Rivera-Molina, F; Schroeder, LK; Kromann, EB; Lessard, MD; Erdmann, RS; Schepartz, A; Baddeley, D; Bewersdorf, J; Toomre, D; Rothman, JE; - view fewer (2017) A novel physiological role for ARF1 in the formation of bi-directional tubules from the Golgi. Mol Biol Cell 10.1091/mbc.E16-12-0863 .

http://ift.tt/2rYNg0d

Reindigenización y economía en los Andes, 1820-1870, desde la mirada europea

Pearce, AJ; Reindigenización y economía en los Andes, 1820-1870, desde la mirada europea. Historia Mexicana

http://ift.tt/2reuTqR

Is it safe in numbers?

Christie, N; Pike, I; Is it safe in numbers? Injury Prevention , 21 (276-277)

http://ift.tt/2rYVGop

Editorial: Reading and literacy in developing countries

Paran, A; Williams, E; (2007) Editorial: Reading and literacy in developing countries. Journal of Research in Reading , 30 (1) pp. 1-6. 10.1111/j.1467-9817.2006.00334.x .

http://ift.tt/2rdULTW

Early Cretaceous frog remains from the Okurodani Formation, Tetori Group, Japan

Evans, SE; Manabe, M; (1998) Early Cretaceous frog remains from the Okurodani Formation, Tetori Group, Japan. Paleontological Research , 2 (4) pp. 275-278.

http://ift.tt/2rZfTKQ

Using a P300 brain computer interface for smart home control

Holzner, C; Guger, C; Grönegress, C; Edlinger, G; Slater, M; (2009) Using a P300 brain computer interface for smart home control. In: (pp. pp. 174-177).

http://ift.tt/2rejcQU

Recurrence of melanocytic lesions after laser treatment: benign versus malignant upon dermoscopy

Abstract

The treatment of pigmented lesions includes several approaches depending on the nature of the cutaneous lesion to be treated. When considering melanocytic lesions, a balance between therapeutic aspects and cosmetic concerns for aesthetic sites have to be taken into account, with particular attention for the differential diagnosis between benign and malignant.^1-3 In particular, the increasing awareness for good cosmetic results lead to the development of less invasive techniques, although they hamper the histological assessment, which is the gold standard for the diagnosis of melanocytic lesions.

This article is protected by copyright. All rights reserved.

http://ift.tt/2rOjxZo

Baldness and scalp melanoma

Abstract

Nearly 20% of melanomas occur on the head and neck area¹ but only 2-5% arise on the scalp.² Several studies reported a worse prognosis of scalp melanoma compared to other body sites, being unclear the reason for this phenomenon.³ Melanoma and non-melanoma skin cancer of the scalp are most frequent in bald men older than 65 years.

This article is protected by copyright. All rights reserved.

http://ift.tt/2riP8Po

Secukinumab demonstrates greater sustained improvements in daily activities and personal relationships than ustekinumab in patients with moderate-to-severe plaque psoriasis: 52-week results from the CLEAR study

Abstract

Background

Psoriasis can greatly impact patients' lives by influencing clothing worn as well as by impairing sexual functioning. Secukinumab, a human monoclonal antibody selectively neutralizing interleukin-17A, has demonstrated good efficacy and safety in the treatment of moderate-to-severe psoriasis and psoriatic arthritis with a rapid onset of action and sustained response.

Objective

This analysis using the CLEAR study, a phase 3b double-blind study comparing the efficacy and safety of secukinumab versus ustekinumab in adults with moderate-to-severe plaque psoriasis, evaluated the treatment effects on patient's daily activities and personal relationships.

Methods

Impact on daily activities (interference with home/shopping/garden, and influence on clothes worn) and impact on personal relationships (problems with partner/others, and sexual difficulties) as well as their corresponding subscales were selected from the Dermatology Life Quality Index scale and evaluated for patients treated with secukinumab vs. ustekinumab from the CLEAR study. Treatment differences in mean scores and proportions of responders (score = 0, indicating no impact) were evaluated through 52 weeks. Time to response was evaluated through week 16.

Results

Significant differences between secukinumab and ustekinumab were observed for daily activities and personal relationship at week 16 and sustained through Week 52 (Week 52 response rates for daily activities: 82.9% vs. 73.5%, including interference with home/shopping/garden: 88.5% vs. 78.2%, and influence on clothes worn: 85.6% vs. 74.4%; personal relationship: 86.1% vs. 73.7%, including problems with partner/others: 86.6% vs. 74.8%, and sexual difficulties: 88.5% vs. 74.3%; all P < 0.01). The median time to response was 4 weeks for secukinumab versus 8 weeks for ustekinumab for daily activities and personal relationships (both P < 0.05).

Conclusion

Secukinumab treatment helps patients with moderate-to-severe plaque psoriasis have a more normal life faster when compared to ustekinumab, by providing greater and sustained improvement in clothing choice and sexual functioning.

This article is protected by copyright. All rights reserved.

http://ift.tt/2rOaUOC

Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa

Summary

Background

Hidradenitis suppurativa (HS) is a recalcitrant chronic skin disease with poorly understood immunopathogenic mechanisms. Previous studies reported that the interleukin-36 (IL-36) cytokines (IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist [IL-36RA]) are important players in the pathogenesis of psoriasis (PS).

Objective

We aim to determine whether the IL-36 cytokines are upregulated in HS patients. For this purpose, we analysed local expression and systemic levels of the IL-36 cytokines in HS patients and compared the results to healthy donors and PS patients.

Methods

Skin biopsies from healthy donors and HS and PS patients were analysed for expression of the IL-36 cytokines by immunohistochemistry and semiquantitative real-time PCR. The enzyme-linked immunosorbent assay (ELISA) was used to measure systemic levels of the IL-36 cytokines in the serum of the three donor groups.

Results

The agonists IL-36α, IL-36β, and IL-36γ were found to be upregulated in HS both systemically and lesionally, while the IL-36RA was not differently regulated in comparison to healthy donors.

Conclusion

Our findings suggest that the agonistic IL-36 isoforms are upregulated in HS. The relevance of the enhanced production of IL-36 cytokines in HS pathogenesis remains to be determined.

This article is protected by copyright. All rights reserved.

http://ift.tt/2rO4bE5

Compression therapy for venous leg ulcers: Risk factors for Adverse Events and Complications, Contraindications. A review of present Guidelines

Abstract

Introduction

The adequate use of compression in venous leg ulcer treatment is equally important to patients as well as clinicians. Currently there is a lack of clarity on contra-indications, risk factors, adverse events and complications, when applying compression therapy for venous leg ulcer patients.

Methods

The project aimed to optimize prevention, treatment and maintenance approaches by recognizing contra-indications, risk factors, adverse events and complications, when applying compression therapy for venous leg ulcer patients. A literature review was conducted of current guidelines on venous leg ulcer prevention, management and maintenance.

Results

Searches took place February 29 to April 30, 2016, were prospectively limited to publications in the English and German languages and publication dates were between January 2009 and April 2016. Twenty Guidelines, clinical pathways and consensus papers on compression therapy for venous leg ulcer treatment and for venous disease, were included. Guidelines agreed on the following absolute contraindications: Arterial occlusive disease, heart failure and ankle brachial pressure index (ABPI) < 0.5, but gave conflicting recommendations on relative contraindications, risks and adverse events. Moreover definitions were unclear and not consistent.

Conclusions

Evidence based guidance is needed to inform clinicians on risk factor, adverse effects, complications and contraindications. ABPI values need to be specified and details should be given on the type of compression that is safe to use. Ongoing research challenges the present recommendations, shifting some contraindications into a list of potential indications. Complications of compression can be prevented when adequate assessment is performed and clinicians are skilled in applying compression.

This article is protected by copyright. All rights reserved.

http://ift.tt/2rjdQiH

Self-diagnosed drug allergies: the belief of patients

Abstract

The term of "drug allergy" (DA) may include true hypersensitivity or non-allergic reactions. The rate of self-reporting DA ranges from 4.7% to 11% regardless of age. When patients report a DA, the medical team often decides a full and definitive elimination of the incriminated drug from future therapy, which deeply affects medical care.

This article is protected by copyright. All rights reserved.

http://ift.tt/2rOkCQX