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- CRISPR/Cas9 Editing of the Mouse Thra Gene Produce...
- The Hobnail Variant of Papillary Thyroid Carcinoma...
- Stable Isotope Pharmacokinetic Studies Provide Ins...
- The Burden of Atopic Dermatitis in Adults
- Bibliometric Indicators of the Status of Clinical ...
- Contact Dermatitis to Topical Antiseptics: The Pos...
- Position Statement of the Spanish Academy of Derma...
- Treatment of Malignant Cutaneous Adnexal Neoplasms
- Practical Management of Immunosuppressants in Derm...
- Economic Impact of Atopic Dermatitis in Adults: A ...
- Correlation Between Incisional Biopsy Histological...
- Clinical Research in Dermatology and Venereology i...
- Prospective Single-Center Observational Study of t...
- Intralymphatic Histiocytosis: A Report of 2 Cases
- Large, Long-standing Tumor on the Scalp and Ipsila...
- Pseudoverrucous Lesions of Recent Appearance on th...
- Slow-Growing Pink Papule
- The Good and Bad News About New Drugs for Treating...
- Type I Keystone Island Flap
- A Pink Tumor: Angiolymphoid Hyperplasia With Eosin...
- Male breast cancer mimicking melanoma
- Cutaneous Infiltration due to Waldenström Macroglo...
- Lupus Erythematosus Affecting the Genitalia: An Un...
- Effects of Acoustic Environment on Tinnitus Behavi...
- 5 tips for securing a patient's airway
- Clinical scenario: Patient with facial trauma
- Why Thyroid Health Should Matter to All, Especiall...
- Clinical Thyroidology High-Impact Articles
- Effects of Acoustic Environment on Tinnitus Behavi...
- Erratum to “Experience with a simplified eucapnic ...
- Bleaching and enamel surface interactions resultin...
- For Five Cancers, Screening Skews Risk Factors
- FDA OKs Device for Diabetic Foot Ulcer Treatment
- Running in Cold Weather: Keeping Young Athletes Sa...
- Trends in early hospital readmission after kidney ...
- Abiotic synthesis of purine and pyrimidine ribonuc...
- Fungal-induced protein hyperacetylation in maize i...
- Implantation in eutherians: Which came first, the ...
- Accurate quantification of brown adipose tissue ma...
- Reply to Liu: Inflammation before implantation bot...
- Correction for Larsen and Noack, Identifying the l...
- Phosphorus redox reactions as pinch hitters in mic...
- Bifidobacterium can mitigate intestinal immunopath...
- Nuclear option prevents hyperinfection in the Stro...
- Differential regulation of striatal motor behavior...
- State-space multitaper time-frequency analysis [Ap...
- College completion predicts lower depression but h...
- Initial elevation bias in subjective reports [Soci...
- Effect of oil palm sustainability certification on...
- Functions of maize genes encoding pyruvate phospha...
- SIMS analyses of the oldest known assemblage of mi...
- Artificial antibody created by conformational reco...
- Conserved epitope on influenza-virus hemagglutinin...
- Structure of the chlorovirus PBCV-1 major capsid g...
- Direct electrical stimulation of the amygdala enha...
- Comparison of DNA Damage and Oxidative Stress in P...
- Dexmedetomidine for Improved Quality of Emergence ...
- Characteristics of Desaturation and Respiratory Ra...
- American Society for Enhanced Recovery and Periope...
- Adductor Canal Block With Continuous Infusion Vers...
- Airway Management by Laryngeal Mask Airways for Ce...
- American Society for Enhanced Recovery and Periope...
- Anesthesia for Cesarean Delivery: A Cross-Sectiona...
- Prophylactic Platelet Transfusions for Critically ...
- Heating and Cooling Rates With an Esophageal Heat ...
- Axillary Temperature, as Recorded by the iThermoni...
- Alopecia Areata: Who Gets Screened for Thyroid Dis...
- Predictors for Gingival Index in Middle-Aged Asian...
- Erratum to “Experience with a simplified eucapnic ...
- Study of Anlotinib Plus Irinotecan in Patients Wit...
- Feasibility of Multi-Spectral Endoscopic Imaging f...
- PLD Combined With Cisplatin in the Treatment of Ad...
- Safety and Efficacy of Ulinastatin for Reducing Ra...
- Development of phospho-specific Rab protein antibo...
- The GP Tests of Competence assessment: which part ...
- The Semiotics of Medical Image Segmentation
- X-ray physico-chemical imaging during activation o...
- Brexit, Archaeology and Heritage: Reflections and ...
- Can surgical simulation be used to train detection...
- The British Society for Rheumatology guideline for...
- Post-LASIK exacerbation of granular corneal dystro...
- Engineered method for directional growth of muscle...
- Which patients benefit specifically from short-ter...
- Individual psychological therapy in an acute inpat...
- Frontispiece: Aerosols: A Sustainable Route to Fun...
- Knowledge graph prediction of unknown adverse drug...
- Pigmented epithelioid melanocytoma with nodal mela...
- Diabetic Blindness Caused and Reversed “Trapped” I...
- New Cholesterol Calculation May Avoid Need to Fast...
- Phototherapie der entzündlichen Akne
- Nachtdienst in der Hautklinik
- 308 nm-Excimerlaser
- European guidelines on perioperative venous thromb...
- European guidelines on perioperative venous thromb...
- European Guidelines on perioperative venous thromb...
- European guidelines on perioperative venous thromb...
- European guidelines on perioperative venous thromb...
- European guidelines on perioperative venous thromb...
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Ετικέτες
Τρίτη 2 Ιανουαρίου 2018
CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone
http://ift.tt/2DTxgkN
The Hobnail Variant of Papillary Thyroid Carcinoma: Clinical/Molecular Characteristics of a Large Monocentric Series and Comparison with Conventional Histotypes
Thyroid , Vol. 0, No. 0.
http://ift.tt/2EFuAbR
Stable Isotope Pharmacokinetic Studies Provide Insight into Effects of Age, Sex, and Weight on Levothyroxine Metabolism
Thyroid , Vol. 0, No. 0.
http://ift.tt/2DWwmEq
Position Statement of the Spanish Academy of Dermatology and Venereology on Teledermatology
D. Moreno-Ramírez, G. Romero-Aguilera, P. Pasquali, S. Vaño, L. Ríos-Buceta, J. Malvehy, R. Taberner, L. Ferrándiz
Actas Dermosifiliogr.2018;109:4-5
Full text - PDF
http://ift.tt/2EHxXyM
Treatment of Malignant Cutaneous Adnexal Neoplasms
C. Bernárdez, L. Requena
Actas Dermosifiliogr.2018;109:6-23
Abstract - Full text - PDF
http://ift.tt/2EK2In2
Practical Management of Immunosuppressants in Dermatology
V.M. Leis-Dosil, I. Prats-Caelles
Actas Dermosifiliogr.2018;109:24-34
Abstract - Full text - PDF
http://ift.tt/2DU6yZi
Economic Impact of Atopic Dermatitis in Adults: A Population-Based Study (IDEA Study)
A. Sicras-Mainar, R. Navarro-Artieda, J.M. Carrascosa Carrillo
Actas Dermosifiliogr.2018;109:35-46
Abstract - Full text - PDF
http://ift.tt/2EJlryL
Correlation Between Incisional Biopsy Histological Subtype and a Mohs Surgery Specimen for Nonmelanoma Skin Cancer
E.C. Cortés-Peralta, J. Ocampo-Candiani, O.T. Vázquez-Martínez, I.M. Gutiérrez-Villarreal, I. Miranda-Maldonado, V. Garza-Rodríguez
Actas Dermosifiliogr.2018;109:47-51
Abstract - Full text - PDF
http://ift.tt/2DW67hl
Clinical Research in Dermatology and Venereology in Spanish Research Centers in 2005 Through 2014: Results of the MaIND Study
A. Molina-Leyva, M.A. Descalzo, I. García-Doval
Actas Dermosifiliogr.2018;109:52-7
Abstract - Full text - PDF
http://ift.tt/2ED91sh
Prospective Single-Center Observational Study of the Allergenic Potential of Mercromina Film and Other Common Antiseptics in Patients With Contact Dermatitis
S. Baltà Cruz, N. Moreno Ribera, M.T. Estrach Panella
Actas Dermosifiliogr.2018;109:58-62
Abstract - Full text - PDF
http://ift.tt/2DW5HYj
Intralymphatic Histiocytosis: A Report of 2 Cases
M.E. Gómez-Sánchez, J.M. Azaña-Defez, M.L. Martínez-Martínez, M.T. López-Villaescusa
Actas Dermosifiliogr.2018;109:e1-5
Abstract - Full text - PDF
http://ift.tt/2EFbwdJ
Large, Long-standing Tumor on the Scalp and Ipsilateral Lymphadenopathy
A. Hermosa-Gelbard, C. Moreno García del Real, S. Vañó-Galván
Actas Dermosifiliogr.2018;109:63-4
Full text - PDF
http://ift.tt/2DUEUeL
Pseudoverrucous Lesions of Recent Appearance on the Vulva
L. Padilla-España, J. Bosco Repiso-Jiménez, C. Abitei
Actas Dermosifiliogr.2018;109:65-6
Full text - PDF
http://ift.tt/2DWja1Y
Slow-Growing Pink Papule
J.L. Ramírez-Bellver, S. Saenz Guirado
Actas Dermosifiliogr.2018;109:67-8
Full text - PDF
http://ift.tt/2DVojHM
The Good and Bad News About New Drugs for Treating Alopecia Areata
D. Morgado-Carrasco, E. Rodríguez-Lobato, J. Riera-Monroig, J. Ferrando
Actas Dermosifiliogr.2018;109:69-70
Full text - PDF
http://ift.tt/2DUE55F
Type I Keystone Island Flap
H.A. Cocunubo-Blanco, A. Pérez-Bustillo, E. Manrrique, M.Á. Rodríguez-Prieto
Actas Dermosifiliogr.2018;109:71-2
Full text - PDF
http://ift.tt/2DVnDCr
A Pink Tumor: Angiolymphoid Hyperplasia With Eosinophilia
I. Pérez-López, A. Martínez-López, P. Aguayo-Carreras, M.J. Naranjo-Díaz
Actas Dermosifiliogr.2018;109:73
Full text - PDF
http://ift.tt/2DUN1YU
Male breast cancer mimicking melanoma
T. Kueder Pajares, A.J. García Malinis, P. Manchado López
Actas Dermosifiliogr.2018;109:74
Full text - PDF
http://ift.tt/2DTtN5L
Cutaneous Infiltration due to Waldenström Macroglobulinemia
S. Oscoz-Jaime, A.D. Agulló-Pérez, C. Llanos-Chavarri, J.I. Yanguas-Bayona
Actas Dermosifiliogr.2018;109:75-8
Full text - PDF
http://ift.tt/2DTFUQn
Lupus Erythematosus Affecting the Genitalia: An Unusual Site
E. del Alcázar-Viladomiu, A. López-Pestaña, A. Tuneu-Valls
Actas Dermosifiliogr.2018;109:78-80
Full text - PDF
http://ift.tt/2DWkH8f
Effects of Acoustic Environment on Tinnitus Behavior in Sound-Exposed Rats
Abstract
Laboratory studies often rely on a damaging sound exposure to induce tinnitus in animal models. Because the time course and ultimate success of the induction process is not known in advance, it is not unusual to maintain sound-exposed animals for months while they are periodically assessed for behavioral indications of the disorder. To demonstrate the importance of acoustic environment during this period of behavioral screening, sound-exposed rats were tested for tinnitus while housed under quiet or constant noise conditions. More than half of the quiet-housed rats developed behavioral indications of the disorder. None of the noise-housed rats exhibited tinnitus behavior during 2 months of behavioral screening. It is widely assumed that the "phantom sound" of tinnitus reflects abnormal levels of spontaneous activity in the central auditory pathways that are triggered by cochlear injury. Our results suggest that sustained patterns of noise-driven activity may prevent the injury-induced changes in central auditory processing that lead to this hyperactive state. From the perspective of laboratory studies of tinnitus, housing sound-exposed animals in uncontrolled noise levels may significantly reduce the success of induction procedures. From a broader clinical perspective, an early intervention with sound therapy may reduce the risk of tinnitus in individuals who have experienced an acute cochlear injury.
http://ift.tt/2CsiDca
5 tips for securing a patient's airway
One of the first concerns an EMS provider should have about a patient with significant facial trauma is whether the patient has a patent airway and will be able to maintain that airway. Bleeding, soft tissue swelling, broken teeth and other fractures can all create partial or complete obstruction to the patient's airway. Care must be paid to how the airway is managed in these patients to strike ...
http://ift.tt/2DVgVvR
Clinical scenario: Patient with facial trauma
Rescue 7, Engine 2, respond Code 3 to the intersection of Maple and Division. Multiple callers are reporting a cyclist struck by a vehicle at that location. You arrive on scene where law enforcement is already maintaining manual stabilization of the patient's head and neck. According to the first arriving officer, witnesses state that the patient was riding his bicycle through the intersection ...
http://ift.tt/2EEhueV
Why Thyroid Health Should Matter to All, Especially Women
Hypothyroidism is the most common form of thyroid malfunctions, affecting up to 15 percent of Americans in cases ranging from mild to those requiring medication, according to the American Thyroid Association (ATA). The diagnoses have been climbing because technology has enabled lab tests to recognize milder conditions that weren't recognized previously, says Dr. Elizabeth Pearce, associate professor of medicine at the Boston University School of Medicine and the president-elect of the ATA. January has been designated thyroid awareness month by the ATA.
The post Why Thyroid Health Should Matter to All, Especially Women appeared first on American Thyroid Association.
http://ift.tt/2DRDhi3
Clinical Thyroidology High-Impact Articles
FREE ACCESS through January 12, 2018
Read Now:
Does Having Exophthalmic Graves' Disease Increase a Patient's Risk of Suicide?
Stephen W. Spaulding
Higher Serum FT4 Level Within the Reference Range, but Not Serum TSH, Is Associated With the Development of Atrial Fibrillation
Angela M. Leung
Shear-Wave Elastography in Thyroid Nodules Fails to Discriminate Between Benign and Malignant Tumors
Stephanie A. Fish
FDG-Avid Thyroid Incidentalomas on PET-CT Ordered for Other Malignancies Have No Prognostic Significance in a Large Retrospective Cohort
Martin Biermann
The post Clinical Thyroidology High-Impact Articles appeared first on American Thyroid Association.
http://ift.tt/2EFOdAG
Effects of Acoustic Environment on Tinnitus Behavior in Sound-Exposed Rats
Abstract
Laboratory studies often rely on a damaging sound exposure to induce tinnitus in animal models. Because the time course and ultimate success of the induction process is not known in advance, it is not unusual to maintain sound-exposed animals for months while they are periodically assessed for behavioral indications of the disorder. To demonstrate the importance of acoustic environment during this period of behavioral screening, sound-exposed rats were tested for tinnitus while housed under quiet or constant noise conditions. More than half of the quiet-housed rats developed behavioral indications of the disorder. None of the noise-housed rats exhibited tinnitus behavior during 2 months of behavioral screening. It is widely assumed that the "phantom sound" of tinnitus reflects abnormal levels of spontaneous activity in the central auditory pathways that are triggered by cochlear injury. Our results suggest that sustained patterns of noise-driven activity may prevent the injury-induced changes in central auditory processing that lead to this hyperactive state. From the perspective of laboratory studies of tinnitus, housing sound-exposed animals in uncontrolled noise levels may significantly reduce the success of induction procedures. From a broader clinical perspective, an early intervention with sound therapy may reduce the risk of tinnitus in individuals who have experienced an acute cochlear injury.
http://ift.tt/2CsiDca
Erratum to “Experience with a simplified eucapnic voluntary hyperventilation (EVH) device for diagnosis of exercise-induced bronchospasm”
In the abstract P205, "Experience with a simplified eucapnic voluntary hyperventilation (EVH) device for diagnosis of exercise-induced bronchospasm" (Ann Allergy Asthma Immunol. 2017;119(Suppl 1):S50-S51), the first author was mistakenly left off the abstract. The author list should read: C. Randolph1, R. Rosenthal*2, 1. Waterbury, CT; 2. Great Falls, VA.
http://ift.tt/2qe1MUz
Bleaching and enamel surface interactions resulting from the use of highly-concentrated bleaching gels
Publication date: March 2018
Source:Archives of Oral Biology, Volume 87
Author(s): Guillermo Grazioli, Lisia Lorea Valente, Cristina Pereira Isolan, Helena Alves Pinheiro, Camila Gonçalves Duarte, Eliseu Aldrighi Münchow
Tooth bleaching is considered a non-invasive treatment, although the use of highly-concentrated products may provoke increased surface roughness and enamel demineralization, as well as postoperative sensitivity. Thus, the aim of this study was to investigate whether hydrogen peroxide (H2O2) concentration would affect tooth bleaching effectiveness and the enamel surface properties. Enamel/dentin bovine specimens (6 × 4 mm) were immersed in coffee solution for 7 days and evaluated with a spectrophotometer (Easyshade; baseline), using the CIEL*a*b* color parameters. Hardness was measured using a hardness tester. The specimens were randomly assigned into four groups: one negative control, in which the specimens were not bleached, but they were irradiated with a laser-light source (Whitening Lase II, DMC Equipments); and three groups using distinct H2O2 concentration, namely LP15% (15% Lase Peroxide Lite), LP25% (25% Lase Peroxide Sensy), and LP35% (35% Lase Peroxide Sensy), all products from DMC. The bleached specimens were also irradiated with the laser-light source. After bleaching, all specimens were evaluated using scanning electron microscopy (SEM). pH kinetics and rate was monitored during bleaching. The data were analyzed using ANOVA and Tukey's test (p < 0.05). All bleaching gels produced similar color change (p > 0.05). Concerning hardness, only the LP25% and LP35% significantly reduced hardness after bleaching; also, there was a progressive tendency for a greater percentage reduction in hardness with increased H2O2 concentration of the gel (R2 = 0.9973, p < 0.001). SEM showed that LP25% and LP35% produced an etching pattern on enamel with prism rods exposure. In conclusion, H2O2 concentration above the 15% level does not increase bleaching effectiveness, and may increase the possibility for alteration of enamel hardness, surface morphology, and acidity of the medium. When using H2O2-based bleaching agents, dental practitioners should choose for less concentrated gels, e.g., around the 15% level.
http://ift.tt/2CvO5Fj
For Five Cancers, Screening Skews Risk Factors
Cancer risk factors are typically based on characteristics at the time of diagnosis. In a new essay, a pair of major figures on the US cancer scene explain why that is a problem when cancers are detected by testing.
Medscape Medical News
http://ift.tt/2CyjAPr
FDA OKs Device for Diabetic Foot Ulcer Treatment
Sanuwave's dermaPACE system uses extracorporeal shock waves to mechanically stimulate and heal wounds.
FDA Approvals
http://ift.tt/2lexHPU
Running in Cold Weather: Keeping Young Athletes Safe and Warm
Just because the temperatures are dropping doesn't mean outdoor running and exercising has to drop as well. Runners and other athletes will often continue to train outside through the cold winter months. It can be tempting to either stop running or switch to indoor activities instead of dealing with the cold. Athletes planning to run a race or participate in track and field in the spring should continue to run outside if possible. It is good to maintain the body's endurance.
Here are some tips and tricks to help your dedicated young athlete:
- Choose appropriate clothing
- Footwear is super important! You need to keep good traction on what could be some slippery terrain. You also need to keep your feet warm. Avoid shoes that have mesh as the outer layer (this is super common in most every day running shoes). This will allow snow, ice, and cold in! Try to find shoes with minimal mesh and possibly a more resistant Goretex. It is also helpful to look for moisture wicking socks.
- Pick your clothes wisely. You want clothes that will keep you warm but won't make you overly sweaty. At the start of a run you should aim to be slightly cool because you are only going to get warmer as you start to exert energy.
- Always wear a hat and gloves. Below 30-40 degrees this should always happen!
- Warm up before the run.
- Do a quick warm-up without breaking a sweat so you don't get cold. Go up and down stairs, jump rope, etc. This will help get your muscles going before you start.
- Don't worry about pace and speed
- There are a number of reasons why you can't run as fast when it is cold. Wind, snow/ice, oxygen usage, just to name a few. Focus should be on maintaining endurance rather than going faster.
- Adjust your routes and be safe
- Running into the wind is hard! Try doing a few minutes into the wind and then a few minutes with the wind.
- Stay close to home. It is risky getting farther away – in case you slip and fall.
- Be aware of it getting dark! It gets dark earlier and more quickly. Consider having a flashlight or headlamp in the case it gets dark earlier than expected . Reflective clothing is also helpful. Better yet, plan your runs during the day before it gets dark.
Continuing to run into the winter can be a rewarding experience and following these rules can help keep your young athlete safe. Have a happy, healthy and safe new year!
The post Running in Cold Weather: Keeping Young Athletes Safe and Warm appeared first on ChildrensMD.
http://ift.tt/2qfc6vB
Trends in early hospital readmission after kidney transplantation, 2002 to 2014: a population-based multi-center cohort study
http://ift.tt/2qcPDiT
Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets [Evolution]
Aqueous microdroplets (<1.3 µm in diameter on average) containing 15 mM d-ribose, 15 mM phosphoric acid, and 5 mM of a nucleobase (uracil, adenine, cytosine, or hypoxanthine) are electrosprayed from a capillary at +5 kV into a mass spectrometer at room temperature and 1 atm pressure with 3 mM divalent...
http://ift.tt/2DTQRBr
Fungal-induced protein hyperacetylation in maize identified by acetylome profiling [Plant Biology]
Lysine acetylation is a key posttranslational modification that regulates diverse proteins involved in a range of biological processes. The role of histone acetylation in plant defense is well established, and it is known that pathogen effector proteins encoding acetyltransferases can directly acetylate host proteins to alter immunity. However, it is...
http://ift.tt/2lIFlRT
Implantation in eutherians: Which came first, the inflammatory reaction or attachment? [Biological Sciences]
In PNAS, Griffith et al. (1) examine the transcriptome changes in the opossum uterus during pregnancy. The authors find that term pregnancy, which is correlated with the loss of the eggshell in the opossum, is characterized by an inflammatory response consistent with implantation in humans and mice. They suggest that...
http://ift.tt/2EFJajA
Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography [Medical Sciences]
Detection and quantification of brown adipose tissue (BAT) mass remains a major challenge, as current tomographic imaging techniques are either nonspecific or lack the necessary resolution to quantify BAT mass, especially in obese phenotypes, in which this tissue may be present but inactive. Here, we report quantification of BAT mass...
http://ift.tt/2lHaiGS
Reply to Liu: Inflammation before implantation both in evolution and development [Biological Sciences]
In a paper in PNAS (1) we show that, in opossums, endometrial inflammation follows attachment of the embryo to the uterine wall. We argue that this is similar to what occurred in the first live-bearing mammals, and that inflammatory signaling seen at implantation in eutherians evolved from this attachment-induced inflammation....
http://ift.tt/2DSA1TH
Correction for Larsen and Noack, Identifying the landscape drivers of agricultural insecticide use leveraging evidence from 100,000 fields [Correction]
ENVIRONMENTAL SCIENCES, SUSTAINABILITY SCIENCE Correction for "Identifying the landscape drivers of agricultural insecticide use leveraging evidence from 100,000 fields," by Ashley E. Larsen and Frederik Noack, which was first published May 8, 2017; 10.1073/pnas.1620674114 (Proc Natl Acad Sci USA 114:5473–5478). The authors note that on page 5477, right column, second...
http://ift.tt/2lLnpGy
Phosphorus redox reactions as pinch hitters in microbial metabolism [Microbiology]
Phosphorus (P) is required by all living organisms for the synthesis of genetic and cellular components, metabolism, and energy transfer. The phosphate ion (PO43-, P valence +5), also referred to as inorganic phosphate (Pi), is typically the most easily assimilated P species but is also a limiting nutrient in many...
http://ift.tt/2DTg0fA
Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade [Immunology and Inflammation]
Antibodies that attenuate immune tolerance have been used to effectively treat cancer, but they can also trigger severe autoimmunity. To investigate this, we combined anti–CTLA-4 treatment with a standard colitis model to give mice a more severe form of the disease. Pretreatment with an antibiotic, vancomycin, provoked an even more...
http://ift.tt/2lGTDn8
Nuclear option prevents hyperinfection in the Strongyloides worm war [Pharmacology]
Humans are fighting a grinding war against parasitic nematodes. More than 100 species of nematode parasites are known to infect humans. Additionally, 1.5 billion people are infected by soil-transmitted helminths worldwide that cause an annual disease burden of 5 million years lost due to disability (YLD) (1). This disease burden...
http://ift.tt/2EDaxKV
Differential regulation of striatal motor behavior and related cellular responses by dopamine D2L and D2S isoforms [Neuroscience]
The dopamine D2 receptor (D2R) is a major component of the dopamine system. D2R-mediated signaling in dopamine neurons is involved in the presynaptic regulation of dopamine levels. Postsynaptically, i.e., in striatal neurons, D2R signaling controls complex functions such as motor activity through regulation of cell firing and heterologous neurotransmitter release....
http://ift.tt/2lFvwoM
State-space multitaper time-frequency analysis [Applied Mathematics]
Time series are an important data class that includes recordings ranging from radio emissions, seismic activity, global positioning data, and stock prices to EEG measurements, vital signs, and voice recordings. Rapid growth in sensor and recording technologies is increasing the production of time series data and the importance of rapid,...
http://ift.tt/2DTSLC5
College completion predicts lower depression but higher metabolic syndrome among disadvantaged minorities in young adulthood [Social Sciences]
Individuals with higher educational attainment live healthier and longer lives. However, not everyone benefits equally from higher education. In particular, the black–white gap in life expectancy is greater at higher levels of educational attainment. Furthermore, recent research suggests that disadvantaged African Americans in the rural Southeast who attend college have...
http://ift.tt/2Cv1kpT
Initial elevation bias in subjective reports [Social Sciences]
People's reports of their thoughts, feelings, and behaviors are used in many fields of biomedical and social science. When these states have been studied over time, researchers have often observed an unpredicted and puzzling decrease with repeated assessment. When noted, this pattern has been called an "attenuation effect," suggesting that...
http://ift.tt/2EAdL1U
Effect of oil palm sustainability certification on deforestation and fire in Indonesia [Environmental Sciences]
Many major corporations and countries have made commitments to purchase or produce only "sustainable" palm oil, a commodity responsible for substantial tropical forest loss. Sustainability certification is the tool most used to fulfill these procurement policies, and around 20% of global palm oil production was certified by the Roundtable on...
http://ift.tt/2DU8mkX
Functions of maize genes encoding pyruvate phosphate dikinase in developing endosperm [Agricultural Sciences]
Maize opaque2 (o2) mutations are beneficial for endosperm nutritional quality but cause negative pleiotropic effects for reasons that are not fully understood. Direct targets of the bZIP transcriptional regulator encoded by o2 include pdk1 and pdk2 that specify pyruvate phosphate dikinase (PPDK). This enzyme reversibly converts AMP, pyrophosphate, and phosphoenolpyruvate...
http://ift.tt/2DRM9Eg
SIMS analyses of the oldest known assemblage of microfossils document their taxon-correlated carbon isotope compositions [Evolution]
Analyses by secondary ion mass spectroscopy (SIMS) of 11 specimens of five taxa of prokaryotic filamentous kerogenous cellular microfossils permineralized in a petrographic thin section of the ∼3,465 Ma Apex chert of northwestern Western Australia, prepared from the same rock sample from which this earliest known assemblage of cellular fossils...
http://ift.tt/2DR0p0c
Artificial antibody created by conformational reconstruction of the complementary-determining region on gold nanoparticles [Biophysics and Computational Biology]
To impart biomedical functions to nanoparticles (NPs), the common approach is to conjugate functional groups onto NPs by dint of the functions of those groups per se. It is still beyond current reach to create protein-like specific interactions and functions on NPs by conformational engineering of nonfunctional groups on NPs....
http://ift.tt/2ECRKQ7
Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody [Immunology and Inflammation]
Circulating influenza viruses evade neutralization in their human hosts by acquiring escape mutations at epitopes of prevalent antibodies. A goal for next-generation influenza vaccines is to reduce escape likelihood by selectively eliciting antibodies recognizing conserved surfaces on the viral hemagglutinin (HA). The receptor-binding site (RBS) on the HA "head" and...
http://ift.tt/2lGVkA7
Structure of the chlorovirus PBCV-1 major capsid glycoprotein determined by combining crystallographic and carbohydrate molecular modeling approaches [Biophysics and Computational Biology]
The glycans of the major capsid protein (Vp54) of Paramecium bursaria chlorella virus (PBCV-1) were recently described and found to be unusual. This prompted a reexamination of the previously reported Vp54 X-ray structure. A detailed description of the complete glycoprotein was achieved by combining crystallographic data with molecular modeling. The...
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Direct electrical stimulation of the amygdala enhances declarative memory in humans [Neuroscience]
Emotional events are often remembered better than neutral events, a benefit that many studies have hypothesized to depend on the amygdala's interactions with memory systems. These studies have indicated that the amygdala can modulate memory-consolidation processes in other brain regions such as the hippocampus and perirhinal cortex. Indeed, rodent studies...
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Comparison of DNA Damage and Oxidative Stress in Patients Anesthetized With Desflurane Associated or Not With Nitrous Oxide: A Prospective Randomized Clinical Trial
http://ift.tt/2DTjnmB
Dexmedetomidine for Improved Quality of Emergence From General Anesthesia: A Dose-Finding Study
http://ift.tt/2CEDYM3
Characteristics of Desaturation and Respiratory Rate in Postoperative Patients Breathing Room Air Versus Supplemental Oxygen: Are They Different?
http://ift.tt/2DTaPw2
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Patient-Reported Outcomes in an Enhanced Recovery Pathway
http://ift.tt/2CFknLV
Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial
http://ift.tt/2DSU1We
Airway Management by Laryngeal Mask Airways for Cervical Tracheal Resection and Reconstruction: A Single-Center Retrospective Analysis
http://ift.tt/2CEL0R3
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Gastrointestinal Dysfunction Within an Enhanced Recovery Pathway for Elective Colorectal Surgery
http://ift.tt/2DTcXUT
Anesthesia for Cesarean Delivery: A Cross-Sectional Survey of Provincial, District, and Mission Hospitals in Zimbabwe
http://ift.tt/2CEKS41
Prophylactic Platelet Transfusions for Critically Ill Patients With Thrombocytopenia: A Single-Institution Propensity-Matched Cohort Study
http://ift.tt/2DTcXnR
Heating and Cooling Rates With an Esophageal Heat Exchange System
http://ift.tt/2CIwp7m
Axillary Temperature, as Recorded by the iThermonitor WT701, Well Represents Core Temperature in Adults Having Noncardiac Surgery
http://ift.tt/2CFkkjd
Alopecia Areata: Who Gets Screened for Thyroid Disease?
Many children with alopecia areata get screened for thyroid disease. But do they all need to be?
CHOP Expert Commentary
http://ift.tt/2Cspgu9
Predictors for Gingival Index in Middle-Aged Asian Indians with Type 2 Diabetes from South India: A Cross-Sectional Observational Study
Asian Indians develop type 2 diabetes mellitus (T2DM) much earlier as compared to White Caucasians, due to unique phenotypic and genetic architecture. Periodontitis in T2DM patients is often a neglected clinical feature. This study was conducted to derive predictor variables for gingival index in middle-aged Asian Indians with T2DM in a semiurban population of Dravidian ethnicity from Tamil Nadu, India. T2DM patients (, mean age: years) with periodontitis (, mean age: years) and without periodontitis (, mean age: years) were recruited between 2014 and 2016 by purposive sampling method. Dental examinations for pocket depth (PD) and clinical attachment level (CAL) were performed and gingival index was calculated. Fasting venous blood samples were analysed for measures of glycaemia and cholesterol. Significant positive correlation () was observed for gingival index with glycosylated haemoglobin (HbA1c), pocket depth, presence of T2DM, and clinical attachment level. Stepwise multiple linear regression analysis derived increased pocket depth (), elevated HbA1c (), clinical attachment level (), and presence of diabetes () as significant predictors ( value = 0.67) for increased gingival index in middle aged patients with T2DM. These variables significantly () predispose middle-aged T2DM patients to increased gingival index, thus warranting appropriate intervention.
http://ift.tt/2A6zg7b
Erratum to “Experience with a simplified eucapnic voluntary hyperventilation (EVH) device for diagnosis of exercise-induced bronchospasm”
Source:Annals of Allergy, Asthma & Immunology
http://ift.tt/2lExyFG
Study of Anlotinib Plus Irinotecan in Patients With Esophageal Squamous Cell Carcinoma
Interventions: Drug: Anlotinib Plus Irinotecan; Drug: Irinotecan
Sponsor: The First Affiliated Hospital of Zhengzhou University
Not yet recruiting
http://ift.tt/2Cued4c
Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett's Oesophagus
Intervention: Device: Endoscopy with Polyscope (Polydiagnost TM) coupled with Multi-Spectral Imaging light-source
Sponsor: University of Cambridge
Not yet recruiting
http://ift.tt/2C9PoX7
PLD Combined With Cisplatin in the Treatment of Advanced Poorly Differentiated Thyroid Carcinoma
Interventions: Drug: PLD; Drug: Cisplatin
Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Recruiting
http://ift.tt/2CDr94T
Safety and Efficacy of Ulinastatin for Reducing Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients
Interventions: Drug: Cisplatin; Radiation: Intensity Modulated Radiation Therapy; Drug: Ulinastatin
Sponsors: Sun Yat-sen University; Cancer Hospital of Guangzhou Medical University; First People's Hospital of Foshan; People's Hospital of Zhongshan; Fifth Affiliated Hospital, Sun Yat-Sen University
Not yet recruiting
http://ift.tt/2CctN0k
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Lis, P; Burel, S; Steger, M; Mann, M; Brown, F; Diez, F; Tonelli, F; ... Alessi, DR; + view all Lis, P; Burel, S; Steger, M; Mann, M; Brown, F; Diez, F; Tonelli, F; Holton, JL; Ho, PW; Ho, S-L; Chou, M-Y; Polinski, NK; Martinez, TN; Davies, P; Alessi, DR; - view fewer (2018) Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase. Biochemical Journal , 475 (1) pp. 1-22. 10.1042/BCJ20170802 . Green open access
http://ift.tt/2EBX1HD
The GP Tests of Competence assessment: which part best predicts fitness to practise decisions?
Jayaweera, HK; Potts, H; Keshwani, K; Valerio, C; Baker, M; Mehdizadeh, L; Sturrock, A; (2018) The GP Tests of Competence assessment: which part best predicts fitness to practise decisions? BMC Medical Education (In press).
http://ift.tt/2DRkZgL
The Semiotics of Medical Image Segmentation
Baxter, JSH; Gibson, E; Eagleson, R; Peters, TM; (2018) The Semiotics of Medical Image Segmentation. Medical Image Analysis 10.1016/j.media.2017.11.007 . (In press).
http://ift.tt/2ECn3ub
X-ray physico-chemical imaging during activation of cobalt-based Fischer-Tropsch synthesis catalysts
Beale, AM; Jacques, SDM; Di Michiel, M; Mosselmans, JFW; Price, SWT; Senecal, P; Vamvakeros, A; Beale, AM; Jacques, SDM; Di Michiel, M; Mosselmans, JFW; Price, SWT; Senecal, P; Vamvakeros, A; Paterson, J; - view fewer (2017) X-ray physico-chemical imaging during activation of cobalt-based Fischer-Tropsch synthesis catalysts. Philosophical Transactions of the Royal Society a-mathematical Physical and Engineering Sciences , 376 (2110) 10.1098/rsta.2017.0057 . (In press). Green open access
http://ift.tt/2DPNCuY
Brexit, Archaeology and Heritage: Reflections and Agendas
Gardner, A; Harrison, R; (2017) Brexit, Archaeology and Heritage: Reflections and Agendas. Papers from the Institute of Archaeology , 27 (1) , Article 24. 10.5334/pia-544 . Green open access
http://ift.tt/2ECmyAj
Can surgical simulation be used to train detection and classification of neural networks?
Zisimopoulos, O; Flouty, E; Stacey, M; Muscroft, S; Giataganas, P; Nehme, J; Chow, A; Zisimopoulos, O; Flouty, E; Stacey, M; Muscroft, S; Giataganas, P; Nehme, J; Chow, A; Stoyanov, D; - view fewer (2017) Can surgical simulation be used to train detection and classification of neural networks? Healthcare Technology Letters , 4 (5) pp. 216-222. 10.1049/htl.2017.0064 . Green open access
http://ift.tt/2DPm7BF
The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults: Executive Summary
Gordon, C; Amissah-Arthur, M-B; Gayed, M; Brown, S; Bruce, IN; D'Cruz, D; Empson, B; ... British Society for Rheumatology Standards, Audit and Guidelines, .; + view all Gordon, C; Amissah-Arthur, M-B; Gayed, M; Brown, S; Bruce, IN; D'Cruz, D; Empson, B; Griffiths, B; Jayne, D; Khamashta, M; Lightstone, L; Norton, P; Norton, Y; Schreiber, K; Isenberg, D; British Society for Rheumatology Standards, Audit and Guidelines, .; - view fewer (2018) The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults: Executive Summary. Rheumatology , 57 (1) pp. 14-18. 10.1093/rheumatology/kex291 .
http://ift.tt/2ECthdP
Post-LASIK exacerbation of granular corneal dystrophy type 2 in members of a chinese family
Chao-Shern, C; Me, R; DeDionisio, LA; Ke, BL; Nesbit, MA; Marshall, J; Moore, CBT; (2017) Post-LASIK exacerbation of granular corneal dystrophy type 2 in members of a chinese family. Eye 10.1038/eye.2017.265 . (In press). Green open access
http://ift.tt/2DSHjGV
Engineered method for directional growth of muscle sheets on electrospun fibers
Soliman, E; Bianchi, F; Sleigh, JN; George, JH; Cader, MZ; Cui, Z; Ye, H; (2017) Engineered method for directional growth of muscle sheets on electrospun fibers. Journal of Biomedical Materials Research Part A 10.1002/jbm.a.36312 . (In press).
http://ift.tt/2DPMXK0
Which patients benefit specifically from short-term psychodynamic psychotherapy (STPP) for depression? Study protocol of a systematic review and meta-analysis of individual participant data
Driessen, E; Abbass, AA; Barber, JP; Gibbons, MBC; Dekker, JJM; Fokkema, M; Fonagy, P; ... Cuijpers, P; + view all Driessen, E; Abbass, AA; Barber, JP; Gibbons, MBC; Dekker, JJM; Fokkema, M; Fonagy, P; Hollon, SD; Jansma, EP; de Maat, SCM; Town, JM; Twisk, JWR; Van, HL; Weitz, E; Cuijpers, P; - view fewer (2018) Which patients benefit specifically from short-term psychodynamic psychotherapy (STPP) for depression? Study protocol of a systematic review and meta-analysis of individual participant data. BMJ Open (In press).
http://ift.tt/2ECsXf7
Individual psychological therapy in an acute inpatient setting: service user and psychologist perspectives
Small, C; Pistrang, N; Huddy, V; Williams, C; (2018) Individual psychological therapy in an acute inpatient setting: service user and psychologist perspectives. Psychology and Psychotherapy: Theory, Research and Practice (In press).
http://ift.tt/2DPfUp6
Frontispiece: Aerosols: A Sustainable Route to Functional Materials
Powell, MJ; Carmalt, CJ; (2017) Frontispiece: Aerosols: A Sustainable Route to Functional Materials. Chemistry - A European Journal , 23 (62) pp. 15543-15552. 10.1002/chem.201786261 .
http://ift.tt/2EDsyZy
Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records
Bean, DM; Wu, H; Dzahini, O; Broadbent, M; Stewart, R; Dobson, RJB; (2017) Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records. Scientific Reports , 7 , Article 16416. 10.1038/s41598-017-16674-x . Green open access
http://ift.tt/2DRkwv1
Pigmented epithelioid melanocytoma with nodal melanosis: A rare cause of cystic cervical lymphadenopathy
Abstract
Background
Head and neck malignancies often present as firm, solid nodal masses. However, malignancies arising from Waldeyer's Ring may give rise to cystic lymph nodes.
Methods
A 57-year-old man was referred for left-sided neck swelling of 2 weeks' duration. A CT scan revealed an enlarged cystic cervical node at level 5A/B and he underwent excision biopsy.
Results
Histology reported nodal fibrosis with melanophages. Further examination revealed a black nodule on his back where he had wide excision and the histology confirmed pigmented epithelioid melanocytoma.
Conclusion
Cervical lymphadenopathy can rarely be due to an upper back lesion, such as pigmented epithelioid melanocytoma. Thus, routine clinical examination of the upper back should be performed in patients with cervical lymphadenopathy.
http://ift.tt/2DQbSNq
Diabetic Blindness Caused and Reversed “Trapped” Immune Cells In Rodent Retinas
Johns Hopkins researchers have discovered a cell signaling pathway in mice that triggers vision loss in patients with diabetic retinopathy and retinal vein occlusion – diseases characterized by the closure of blood vessels in the retina, leading to blindness. In experiments that suppressed vascular endothelial growth factor (VEGF) in the eye, researchers were able to re-establish normal blood flow in the retina, offering a potential means of stalling or even reversing diabetes-related blindness.
http://ift.tt/2lHkD51
New Cholesterol Calculation May Avoid Need to Fast Before Testing, Study Suggests
http://ift.tt/2qfz4CI
Phototherapie der entzündlichen Akne
Zusammenfassung
Verfahren der Phototherapie könnten sich als neue Ansätze der Aknebehandlung etablieren, die das Risiko bakterieller Resistenzen nicht steigern und bei günstigem Sicherheitsprofil potenziell wirksam sind. Nach aktuellen Studiendaten bewirkt die photodynamische Therapie eine Verringerung entzündlicher Läsionen und eine deutliche Verbesserung der Akne. Allerdings besteht keine Einigkeit über die optimale Durchführung im Rahmen der Aknebehandlung. Neben der topisch angewendeten photodynamischen Therapie wurden die Intense-pulsed-light-Methode (hochenergetische Lichtblitze), gepulste Farbstofflaser, Kaliumtitanylphosphatlaser, Infrarotdiodenlaser und polychromatische Lichtquellen (Rotlicht, Rot-blau-Licht) als alternative Verfahren eingeführt. Da gut konzipierte Studien zur Wirksamkeitsprüfung im Vergleich zu traditionellen Pharmakotherapien fehlen und die Methoden nicht standardisiert sind, sollten Verfahren wie Laser‑, Intense-pulsed-light- und photodynamische Therapie gegenwärtig nicht als Erstlinienbehandlung der entzündlichen Akne betrachtet werden.
http://ift.tt/2CbO85T
308 nm-Excimerlaser
Zusammenfassung
Die 308 nm-Excimerlasertherapie von Hypopigmentierungen und Vitiligo ist der herkömmlichen UV-Therapie hinsichtlich Ergebnissen und Sicherheit meist überlegen. Sie ist insbesondere vorteilhaft, wenn Herde gezielt behandelt werden können, ohne die übrige Haut zu belasten. Es sind weniger Sitzungen mit geringerer kumulativer Dosierung nötig. Verschiedene Kombinationstherapien können das Resultat verbessern, Auswahlkriterien wie früher Behandlungsbeginn und häufigere Sitzungen mit geringeren Abständen erleichtern die Entscheidung, welche Patienten wie behandelt werden sollen und wie am meisten erreicht wird.
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European guidelines on perioperative venous thromboembolism prophylaxis: Day surgery and fast-track surgery
http://ift.tt/2DNYLfy
European guidelines on perioperative venous thromboembolism prophylaxis: Aspirin
http://ift.tt/2EAAydO
European guidelines on perioperative venous thromboembolism prophylaxis: Cardiovascular and thoracic surgery
http://ift.tt/2DNYEk8
European guidelines on perioperative venous thromboembolism prophylaxis: Intensive care
http://ift.tt/2EBxVZw
European guidelines on perioperative venous thromboembolism prophylaxis: Neurosurgery
http://ift.tt/2EzwD0T
European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly
http://ift.tt/2DQcNxw
European guidelines on perioperative venous thromboembolism prophylaxis: Patients with preexisting coagulation disorders and after severe perioperative bleeding
http://ift.tt/2DMGH5q
European guidelines on perioperative venous thromboembolism prophylaxis: Surgery during pregnancy and the immediate postpartum period
http://ift.tt/2ECDff1
European guidelines on perioperative venous thromboembolism prophylaxis: Inferior vena cava filters
http://ift.tt/2DNYoBG
European guidelines on perioperative venous thromboembolism prophylaxis: Chronic treatments with antiplatelet agents
http://ift.tt/2EBwqKS
European guidelines on perioperative venous thromboembolism prophylaxis: Mechanical prophylaxis
http://ift.tt/2DQbG0J
European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the obese patient
http://ift.tt/2EChRGX
Age and Unplanned Postoperative Visits Predict Outcome after Septoplasty: A National Swedish Register Study
Objective. To study predictors of symptom relief six months after septoplasty using data from the Swedish National Septoplasty Register. Participants. This is a retrospective register study of adult patients undergoing septoplasty in Sweden in 2003–2012. Outcome. Relief of nasal symptoms was analysed in relation to age, gender, size of hospital performing the surgery, addition of turbinoplasty, and unplanned postoperative visits to the hospital due to pain, bleeding, or infection. Results. In all, 76% of the patients () rated their symptoms as "almost gone" or "gone" six months after septoplasty. With every 10-year increase in the age of the patients, the OR was 1.19, 95% CI 1.15–1.23, for a better result and 1.54, 95% CI 1.38–1.71, if the septoplasty was performed at a county hospital versus a university hospital. If there was no unplanned postoperative visit due to pain, bleeding, or infection, the OR for a better result was 1.6, 95% CI 1.39–1.85. Conclusion. In this large national cohort of septoplasties, most of the patients felt that their symptoms had gone or almost gone six months after septoplasty. Higher age, surgery at smaller hospitals, and no unplanned visits to the hospital postoperatively predicted a better outcome.
http://ift.tt/2A3r33y
A novel succinate dehydrogenase subunit B germline variant associated with head and neck paraganglioma in a Dutch kindred: a family based study
Abstract
Objective
In the Netherlands, the majority of hereditary head and neck paragangliomas (HNPGL) are caused by germline variants in the succinate dehydrogenase genes (SDHD, SDHB, SDHAF2). Here, we evaluate a four-generation family linked to a novel SDHB gene variant with the manifestation of a HNPGL.
Design
a family based study.
Setting
The VU University Medical Center (VUmc) Amsterdam, a tertiary clinic for Otolaryngology and Head and Neck Surgery.
Participants and main outcome measures
The index patients presented with an embryonic rhabdomyosarcoma and a non-Hodgkin lymphoma. Array-based comparative genomic hybridization (aCGH) analysis and multiplex ligation-dependent probe amplification (MLPA) revealed a novel deletion of exon 1-3 in the SDHB gene, suspected to predispose to paraganglioma (PGL)/pheochromocytoma (PHEO) syndrome type 4. Subsequently, genetic counseling and DNA testing was offered to all family members at risk. Individuals that tested positive for this novel SDHB gene variant were counseled and additional clinical evaluation was offered for the identification of HNPGL and/or PHEO.
Results
The DNA of 18 family members was tested, resulting in the identification of 10 carriers of the exon 1-3 deletion in the SDHB gene. One carrier was diagnosed with a carotid body PGL and serum catecholamine excess, which was surgically excised. Negative SDHB immunostaining of the carotid body tumour confirmed that it was caused by the SDHB variant. The remaining 9 carriers showed no evidence of PGL/PHEO.
Conclusion
Deletion of exon 1-3 in the SDHB gene is a novel germline variant associated with the formation of hereditary HNPGL.
This article is protected by copyright. All rights reserved.
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Clinical evaluation of a new laser-ablated titanium implant for bone-anchored hearing in 34 patients: 1 year experience
Abstract
In specific patient groups, i.e. children or patients with compromised bone quality, the incidence of implant loss of for bone conduction hearing implants is much higher; further implant optimization is, therefore, needed.
The new laser-ablated titanium implant for bone-anchored hearing implantation has an enlarged contact area for osseointegration compared to the standard implant, aiming to improve implant loss rates.
This retrospective multicenter study is the first to assess the performance of this implant in healthy adults 1 year after surgery.
With excellent survival rates, good soft tissue tolerability, and few complications, the implant is safe to use in healthy adults.
This article is protected by copyright. All rights reserved.
http://ift.tt/2lCekQN