Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer

Thyroid, Ahead of Print.


https://ift.tt/2CIDQNJ

Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study

Thyroid, Ahead of Print.


https://ift.tt/2qd4K95

Progestogen Hypersensitivity: presentation and natural history

To review the published medical literature on the clinical presentation, risk factors, and natural history of hypersensitivity reactions to progestogens.

https://ift.tt/2SjtNnI

Associations of unsafe, unsupportive and underdeveloped neighborhoods with atopic dermatitis in US children

Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 12.97% of US children1 and 7% of US adults.2 Emotional factors, e.g. anxiety and stress, can also exacerbate AD flares and influence the course of disease.3,4 AD also poses a significant financial burden on society and negatively impacts patient and family quality of life.5,6 However, the relationship between childhood AD and neighborhood conditions has yet to be examined.

https://ift.tt/2z7hwKo

Co-existent TBX1 Mutation and Chromosomal 20q13.13-q13.2 Duplication in an Infant with Abnormal TREC Newborn Screening

An eight day old male, term infant of a diabetic mother with patent ductus arteriosus was transferred from an outlying facility for surgical management of truncus arteriosus (TA), coarctation of the aorta, hypoplastic aortic arch, and anomalous origin of the right subclavian artery. The newborn also had absent thymic shadow on chest radiograph, hypocalcemia, and abnormal newborn screening (NBS) for severe combined immunodeficiency (SCID) measuring T cell receptor rearrangement circles (TRECs); threshold cycle (Ct) was 36.86 (Normal <36).

https://ift.tt/2Sl15CU

Markers of systemic involvement and death in hospitalized cancer patients with severe cutaneous adverse reactions

Cancer patients have increased risk of severe cutaneous adverse reactions, without reliable biomarkers to identify predisposition for associated morbidity and mortality. In hospitalized cancer patients with morbilliform rash, elafin, IL-6, TNF-α were associated with mortality. IL-6, IL-10 were associated with drug-related systemic involvement. These biomarkers may guide future therapeutic research.

https://ift.tt/2PZSZhE

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Plaque Psoriasis

Novel topical treatments for psoriasis have not been developed for many years. Tapinarof, a therapeutic AhR modulating agent, is a potential new treatment option for psoriasis patients. Tapinarof, delivered in a 1% cream, achieved ≥75% improvement in Psoriasis Area and Severity Index in 60% of patients treated once daily.

https://ift.tt/2O6XpRT

Histologic predictors of invasion in partially biopsied lentigo maligna melanoma

https://ift.tt/2OUMeBj

A relapsing peeling of oral mucosa

https://ift.tt/2Q5JGfO

Response to “A relapsing peeling of oral mucosa”

https://ift.tt/2OQkeOV

Classic Dermatological Tools: Foreign Body Removal with Punch Biopsy

https://ift.tt/2PWdlIo

Validation of a novel method for localization of parathyroid adenomas using SPECT/CT

Accurate localization of parathyroid adenomas is of critical importance in surgical planning for minimally invasive parathyroidectomy. SPECT/CT is considered the investigation of choice but has limitations reg...

https://ift.tt/2yDknv8

How to Treat Allergic Reactions in Kids

The first time your child has an allergic reaction, it might be hard to recognize. In this episode, our team goes over some of the signs and symptoms of allergic reactions in kids, and we discuss what you can do as a parent if your child has an allergic reaction.

The post How to Treat Allergic Reactions in Kids appeared first on ChildrensMD.

https://ift.tt/2SnwapM

Establishment of Monoclonal Antibody PMab-202 Against Horse Podoplanin

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 233-237, November 2018.


https://ift.tt/2PY8eYa

The Augmenting Effects of the tDNA Insulator on Stable Expression of Monoclonal Antibody in Chinese Hamster Ovary Cells

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 200-206, November 2018.


https://ift.tt/2D3TggJ

Detection of Tiger Podoplanin Using the Anti-Cat Podoplanin Monoclonal Antibody PMab-52

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 224-228, November 2018.


https://ift.tt/2PSRRw2

Novel Monoclonal Antibodies Against Native Human Collectin L1, Using the Heteromeric Complex CL-LK as Immunogen

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 207-211, November 2018.


https://ift.tt/2D5rRed

Generation of a Monoclonal Antibody Against Staphylococcal Superantigen-Like Protein 5 (SSL5) That Discriminates SSL5 from Other SSL Proteins

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 212-217, November 2018.


https://ift.tt/2PXRTCZ

DgMab-6: Antihuman DGKγ Monoclonal Antibody for Immunocytochemistry

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 229-232, November 2018.


https://ift.tt/2D6AUM2

Establishment of P38Bf, a Core-Fucose-Deficient Mouse-Canine Chimeric Antibody Against Dog Podoplanin

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Volume 37, Issue 5, Page 218-223, November 2018.


https://ift.tt/2PSRNfM

Wem gehört mein Implantat?

https://ift.tt/2JjKbAH

Klarstellungen zum Thema Datenschutz

https://ift.tt/2Pm5ozo

Wie würden Sie entscheiden?

https://ift.tt/2JjK8Vx

Keine Angst vor dem „bösen Wolf“

https://ift.tt/2Pq82Eb

Failure to Accurately Disclose Conflicts of Interest in Article Published in JAMA Otolaryngology–Head & Neck Surgery

To the Editor I write to take full responsibility for failing to report appropriate conflict of interest disclosures in articles published in JAMA Otolaryngology–Head & Neck Surgery and the JAMA Network journals between 2015 and 2018, including "Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: A Secondary Analysis of a Randomized Clinical Trial," published online on April 9, 2016, and in the September 2016 issue of JAMA Otolaryngology–Head & Neck Surgery. In that article, I had reported nothing to disclose. In the interest of full disclosure, I now report the following financial interests and activities that I had been involved in from 2013 to the present, regardless of potential relevance:

https://ift.tt/2RbWWQc

Missing Conflict of Interest Disclosure

In the Original Investigation titled "Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: a Secondary Analysis of a Randomized Clinical Trial," published in the September 2016 issue of JAMA Otolaryngology–Head & Neck Surgery, conflict of interest disclosures were not reported accurately by José Baselga, MD, PhD. Dr Baselga has written a Letter to the journal explaining this inconsistent reporting of potential conflict of interest disclosures. This article was corrected online.

https://ift.tt/2ORlMs3

Issue of the Annals of Econometrics on Indirect Estimation Methods in Finance and Economics

Halbleib, R; Kristensen, D; Renault, E; Veredas, D; (2018) Issue of the Annals of Econometrics on Indirect Estimation Methods in Finance and Economics. Journal of Econometrics , 205 (1) pp. 1-5. 10.1016/j.jeconom.2018.03.002 .

https://ift.tt/2Da1gg2

Infrastructure Resilience: A Multi-Disciplinary Perspective

Dolan, T; Jude, S; Varga, L; Quinn, A; Carhart, N; (2018) Infrastructure Resilience: A Multi-Disciplinary Perspective. (ICIF White Paper Collection ). International Centre for Infrastructure Futures (ICIF): London, UK. Green open access

https://ift.tt/2EJHZnj

A systematic review and meta-analysis of adverse outcomes following non-buried versus buried kirschner wires for paediatric lateral condyle elbow fractures

Wormald, JCR; Park, CY; Eastwood, DM; (2017) A systematic review and meta-analysis of adverse outcomes following non-buried versus buried kirschner wires for paediatric lateral condyle elbow fractures. Journal of Children's Orthopaedics , 11 (6) pp. 465-471. 10.1302/1863-2548.11.170119 . Green open access

https://ift.tt/2Da14xk

Does orthopaedic surgery improve quality of life and function in patients with mucopolysaccharidoses?

Williams, N; Challoumas, D; Eastwood, DM; (2017) Does orthopaedic surgery improve quality of life and function in patients with mucopolysaccharidoses? Journal of Children's Orthopaedics , 11 (4) pp. 289-297. 10.1302/1863-2548.11.170042 . Green open access

https://ift.tt/2EVnCU2

The effects of macroprudential policies on managing capital flows

Uz Akdogan, I; (2018) The effects of macroprudential policies on managing capital flows. Empirical Economics 10.1007/s00181-018-1541-5 . (In press).

https://ift.tt/2D7bhKX

Facebook Interactions: An Ethnographic Perspective

Miller, D; Venkatraman, S; (2018) Facebook Interactions: An Ethnographic Perspective. Social Media and Society , 4 (3) 10.1177/2056305118784776 . Green open access

https://ift.tt/2EVnxjc

Posteromedial bowing of the tibia: A benign condition or a case for limb reconstruction?

Wright, J; Hill, RA; Eastwood, DM; Hashemi-Nejad, A; Calder, P; Tennant, S; (2018) Posteromedial bowing of the tibia: A benign condition or a case for limb reconstruction? Journal of Children's Orthopaedics , 12 (2) pp. 187-196. 10.1302/1863-2548.12.170211 . Green open access

https://ift.tt/2D72qc7

Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures

Augustin, K; Williams, S; Cunningham, M; Devlin, AM; Friedrich, M; Jayasekera, A; Hussain, MA; ... Williams, RSB; + view all Augustin, K; Williams, S; Cunningham, M; Devlin, AM; Friedrich, M; Jayasekera, A; Hussain, MA; Holliman, D; Mitchell, P; Jenkins, A; Chen, PE; Walker, MC; Williams, RSB; - view fewer (2018) Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures. Epilepsia 10.1111/epi.14578 . (In press). Green open access

https://ift.tt/2EVnmEy

Rites of Passage: Mortuary Practice, Population Dynamics, and Chronology at the Carrowkeel Passage Tomb Complex, Co. Sligo, Ireland

Kador, T; CASSIDY, LARAM; Geber, J; Hensey, R; Meehan, P; Moore, S; (2018) Rites of Passage: Mortuary Practice, Population Dynamics, and Chronology at the Carrowkeel Passage Tomb Complex, Co. Sligo, Ireland. Proceedings of the Prehistoric Society (In press).

https://ift.tt/2D3J07W

The effect of low resolution and coverage on the accuracy of susceptibility mapping

Karsa, A; Punwani, S; Shmueli, K; (2018) The effect of low resolution and coverage on the accuracy of susceptibility mapping. Magnetic Resonance in Medicine 10.1002/mrm.27542 . (In press). Green open access

https://ift.tt/2EL1AU7

cath-resolve-hits: a new tool that resolves domain matches suspiciously quickly

Lewis, TE; Sillitoe, I; Lees, JG; (2018) cath-resolve-hits: a new tool that resolves domain matches suspiciously quickly. Bioinformatics 10.1093/bioinformatics/bty863 . (In press). Green open access

https://ift.tt/2D8oDH1

A method for the dynamic correction of B0-related distortions in single-echo EPI at 7 T

Dymerska, B; Poser, BA; Barth, M; Trattnig, S; Robinson, SD; (2018) A method for the dynamic correction of B0-related distortions in single-echo EPI at 7 T. NeuroImage , 168 pp. 321-331. 10.1016/j.neuroimage.2016.07.009 . Green open access

https://ift.tt/2EJ2Cjh

Fluid Transport Properties from 3D Tomographic Images of Electrospun Carbon Electrodes for Flow Batteries

Kok, MDR; Jervis, R; Shearing, PR; Gostick, JT; (2017) Fluid Transport Properties from 3D Tomographic Images of Electrospun Carbon Electrodes for Flow Batteries. In: Manivannan, M and Narayan, S and Kostecki, R and Johnson, C and Atanassov, PB, (eds.) ECS Transactions. (pp. pp. 129-143). Electrochemical Society (ECS) Green open access

https://ift.tt/2D77oFW

Comparison of skin autofluorescence, a marker of tissue advanced glycation end-products in peritoneal dialysis patients using standard and biocompatible glucose containing peritoneal dialysates

Vongsanim, S; Fan, S; Davenport, A; (2018) Comparison of skin autofluorescence, a marker of tissue advanced glycation end-products in peritoneal dialysis patients using standard and biocompatible glucose containing peritoneal dialysates. Nephrology 10.1111/nep.13510 . (In press).

https://ift.tt/2EVn0hc

Evaluating combinations of diagnostic tests to discriminate different dementia types

Bruun, M; Rhodius-Meester, HFM; Koikkalainen, J; Baroni, M; Gjerum, L; Lemstra, AW; Barkhof, F; ... van der Flier, WM; + view all Bruun, M; Rhodius-Meester, HFM; Koikkalainen, J; Baroni, M; Gjerum, L; Lemstra, AW; Barkhof, F; Remes, AM; Urhemaa, T; Tolonen, A; Rueckert, D; van Gils, M; Frederiksen, KS; Waldemar, G; Scheltens, P; Mecocci, P; Soininen, H; Lötjönen, J; Hasselbalch, SG; van der Flier, WM; - view fewer (2018) Evaluating combinations of diagnostic tests to discriminate different dementia types. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring , 10 pp. 509-518. 10.1016/j.dadm.2018.07.003 . Green open access

https://ift.tt/2D4OeQR

Key clinical benefits of neuroimaging at 7 T

Trattnig, S; Springer, E; Bogner, W; Hangel, G; Strasser, B; Dymerska, B; Cardoso, PL; Trattnig, S; Springer, E; Bogner, W; Hangel, G; Strasser, B; Dymerska, B; Cardoso, PL; Robinson, SD; - view fewer (2018) Key clinical benefits of neuroimaging at 7 T. NeuroImage , 168 pp. 477-489. 10.1016/j.neuroimage.2016.11.031 . Green open access

https://ift.tt/2EMXlY3

A PMD-adaptive DBP Receiver Based on SNR Optimization

Liga, G; Czegledi, CB; Bayvel, P; (2018) A PMD-adaptive DBP Receiver Based on SNR Optimization. In: Proceedings of the Optical Fiber Communication Conference 2018. (pp. W2A.53). OSA Publishing: San Diego, CA, USA.

https://ift.tt/2D5aydf

Viraemia before, during and after pregnancy in HIV-infected women on antiretroviral therapy in rural KwaZulu-Natal, South Africa, 2010-2015

Chetty, T; Newell, M-L; Thorne, C; Coutsoudis, A; (2018) Viraemia before, during and after pregnancy in HIV-infected women on antiretroviral therapy in rural KwaZulu-Natal, South Africa, 2010-2015. Tropical Medicine & International Health , 23 (1) pp. 79-91. 10.1111/tmi.13001 .

https://ift.tt/2ELdzkp

Who am I? Secure identity registration on distributed ledgers

Azouvi, S; Al-Bassam, M; Meiklejohn, S; (2017) Who am I? Secure identity registration on distributed ledgers. In: Garcia-Alfaro, J and Navarro-Arribas, G and Hartenstein, H and Herrera-Joancomartí, J, (eds.) Data Privacy Management, Cryptocurrencies and Blockchain Technology: ESORICS 2017 International Workshops, DPM 2017 and CBT 2017, Oslo, Norway, September 14-15, 2017, Proceedings. (pp. pp. 373-389). Springer: Cham, Switzerland. Green open access

https://ift.tt/2D5AkxU

On the Design of Coded Modulation for Fiber Optical Communications

Alvarado, A; Liga, G; Fehenberger, T; Schmalen, L; (2017) On the Design of Coded Modulation for Fiber Optical Communications. In: Proceedings of the Signal Processing in Photonic Communications 2017 (SPPCom ). OSA Publishing: New Orleans, Louisiana, USA. Green open access

https://ift.tt/2ENmAJO

A good beginning makes a good ending: association between acute pain trajectory and chronic postsurgical pain

https://ift.tt/2SmnG27

Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease

Publication date: Available online 25 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Andrew R. Patterson, Paige Bolcas, Kristin Lampe, Rachel Cantrell, Brandy Ruff, Ian Lewkowich, Simon P. Hogan, Edith M. Janssen, Jack Bleesing, Gurjit K. Khurana Hershey, Kasper Hoebe

Abstract

Background

The GTPase of immunity-associated protein 5 is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 SNPs have been linked with an increased risk for asthma, while the loss of Gimap5 in mice has been associated with severe CD4⁺ T cell-driven immune pathology.

Objective

To identify the molecular and cellular mechanisms by which Gimap5-deficiency predisposes to allergic airway disease.

Methods

CD4⁺ T cell polarization and the development of pathogenic CD4⁺ T cells were assessed in Gimap5-deficient mice and a human patient with a GIMAP5 loss-of-function (LOF) mutation. House dust mite (HDM)-induced airway inflammation was assessed using a complete Gimap5 LOF (Gimap5^sph/sph) and conditional Gimap5^fl/flCd4^Cre/ert2 mice.

Results

GIMAP5 LOF mutations in both mice and humans are associated with spontaneous polarization towards pathogenic T_H17 and T_H2 cells in vivo. Mechanistic studies in vitro reveal that impairment of Gimap5-deficient T_H cell differentiation is associated with increased DNA damage, particularly during T_H1 polarizing conditions. The DNA damage in Gimap5-deficient CD4⁺ T cells could be controlled by TGFβ, thereby promoting T_H17 polarization. When challenged with HDM in vivo, Gimap5-deficient mice displayed an exacerbated asthma phenotype (inflammation and airway hyperresponsiveness) with increased development of T_H2, T_H17, and pathogenic T_H17/ T_H2 cells.

Conclusion

Activation of Gimap5-deficient CD4⁺ T cells is associated with increased DNA damage and reduced survival that can be overcome by TGFβ. This leads to a selective survival of pathogenic T_H17 cells, but also T_H2 in humans and mice, ultimately promoting allergic airway disease.

https://ift.tt/2PrivPu

Advances in Food Allergy in 2017

Publication date: Available online 25 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Corinne A. Keet, Katrina J. Allen

Abstract

This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance and management of food allergies in schools were published, and development of new guidelines for prevention of food allergy. There were several important epidemiological studies helping us understand the phenotypes of allergic disease, and new hypotheses proposed for how best to prevent food allergy. Finally, there was a welcome increased attention to non-IgE mediated food allergies.

https://ift.tt/2JgDmzx

Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders

Publication date: Available online 25 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Jennie Yoo, Meghan C. Halley, E. Anne Lown, Veronica Yank, Katherine Ort, Morton J. Cowan, Morna J. Dorsey, Heather Smith, Sumathi Iyengar, Christopher Scalchunes, Christina Mangurian

Abstract

Background

Caregivers of children with primary immunodeficiency disorders (PIDs) experience significant psychological distress during their child's hematopoietic cell transplantation (HCT) process.

Objectives

This study aims to understand caregiver challenges and identify areas for healthcare system-level improvements to enhance caregiver well-being.

Methods

In this mixed-methods study, caregivers of children with PIDs were contacted in August to November 2017 via on-line and electronic mailing lists of rare disease consortiums and foundations. Caregivers were invited to participate in an on-line survey assessing sociodemographic variables, child's medical characteristics, psychosocial support use, and WHO-5 Well-Being Index. Open-ended questions about healthcare system improvements were included. Descriptive statistics and linear multivariate regression analyses were conducted. A modified content analysis method was used to code responses and identify emergent themes.

Results

Among the 80 caregiver respondents, caregivers had a median age of 34 years (range 23-62 years), were predominantly female, white, and married with male children diagnosed with SCID. In the adjusted regression model, lower caregiver well-being was significantly associated with lower household income and medical complications. Challenges during HCT include maintaining relationships with partners and the child's healthy sibling(s), managing self-care, and coping with feelings of uncertainty. Caregivers suggested several organizational-level solutions to enhance psychosocial support, including respite services, on-line connections to other PID caregivers, and bedside mental health services.

Conclusions

Certain high-risk sub-populations of caregivers may need more targeted psychosocial support to reduce long-term impact of the HCT experience upon their wellbeing. Caregivers suggested several organizational-level solutions for provision of this support.

https://ift.tt/2PsKYEE

Validation of a novel method for localization of parathyroid adenomas using SPECT/CT

Abstract

Background

Accurate localization of parathyroid adenomas is of critical importance in surgical planning for minimally invasive parathyroidectomy. SPECT/CT is considered the investigation of choice but has limitations regarding localization of superior versus inferior adenomas. We proposed a novel method for localization using SPECT/CT by determining the anterior-posterior relationship of the adenoma to a horizontal line in the coronal plane through the tracheoesophageal groove. Our objective was to determine the accuracy, validity, and inter-rater reliability of this method.

Method

This was a retrospective review of patients who underwent parathyroidectomy for a single adenoma between 2010-2017. SPECT/CT images were reviewed by two staff Otolaryngologists, a Radiologist, an Otolaryngology fellow and Otolaryngology resident. Results were compared using intra-operative report as the gold standard.

Overall accuracy in determining superior/inferior and right/left adenomas was calculated, as well as Cohen's Kappa to determine agreement with operative report and inter-rater reliability. The performance was compared to that of the original radiology report.

Results

One hundred thirty patients met criteria and were included. Our method correctly identified the location of the adenoma in terms of both side and superior/inferior position in 80.4% [76 - 84%] of patients, which considerably outperformed the original radiology report at 48.5% [4-78%] accuracy. The agreement level between our method and operative report was high (Kappa=0.717 [0.691-0.743]), as was the inter-rater reliability (Kappa=0.706 [0.674-0.738]).

Conclusion

We report a novel method for localization of parathyroid adenomas using SPECT/CT which outperforms standard radiology reporting. This tool can be used by surgeons and radiologists to better inform and plan for minimally invasive parathyroidectomy.

https://ift.tt/2PrfwGM

CA209-891: Neoadjuvant and Adjuvant Nivolumab as Immune Checkpoint Inhibition in Oral Cavity Cancer

Condition:   Squamous Cell Carcinoma of the Oral Cavity
Interventions:   Biological: Nivolumab, Surgery, Radiotherapy;   Biological: Nivolumab, Surgery, Chemoradiotherapy
Sponsors:   The Clatterbridge Cancer Centre NHS Foundation Trust;   University of Liverpool;   Bristol-Myers Squibb
Not yet recruiting

https://ift.tt/2PVgTKY

Regorafenib Combined With Irinotecan as Second-line in Patients With Metastatic Gastro-oesophageal Adenocarcinomas

Conditions:   Adenocarcinoma of the Stomach;   Adenocarcinoma of the Gastroesophageal Junction
Interventions:   Combination Product: Regorafenib and Irinotecan;   Drug: Irinotecan
Sponsor:   UNICANCER
Not yet recruiting

https://ift.tt/2AsBt07

Lateral pharyngotomy

Publication date: Available online 25 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): O. Laccourreye, A. Villeneuve, F. Rubin, F.C. Holsinger

Abstract

Based on a review of the medical literature, the authors document the key technical points, variants, technical errors to avoid and main functional results of lateral pharyngotomy for resection of cancers originating from the lateral oro and/or hypopharynx.

https://ift.tt/2At98H6

Assessment of swallowing function after circumferential pharyngolaryngectomy. A multicenter study by the GETTEC group

Publication date: Available online 25 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): S. Morinière, P. Gorphe, F. Espitalier, D. Blanchard, N. Fakhry, N. Saroul, C. Bach, X. Dufour, C. Fuchsmann, S. Vergez, S. Albert

Abstract

Objective

Circumferential pharyngolaryngectomy is performed for advanced pharyngeal tumor or in a context of postradiation recurrence. Several free or pedicle flaps have been described for pharyngeal defect reconstruction, with choice at the surgeon's discretion. The aim of this study was to evaluate long-term swallowing function according to the type of flap used for reconstruction.

Material and method

A multicenter retrospective study was conducted from January to September 2016 within the French GETTEC head and neck tumor study group. All patients in remission after circumferential pharyngolaryngectomy were included and filled out the Deglutition Handicap Index (DHI) questionnaire and underwent swallowing function fiberoptic endoscopy assessment. 46 patients (39 men, 7 women) were included. Reconstruction used a tubularized forearm free flap (FFF group) in 19 cases, pectoralis major myocutaneous flap (PMMF group) in 15 cases and free jejunum flap (FJF group) in 12 cases.

Results

Mean DHI was 24: 20 in the FFF group, 23 in the FJF group and 25 in the PMMF group, without significant differences. 27 patients had normal swallowing, 9 mixed diet, 8 liquid diet and 3 were fed by gastrostomy. On endoscopy, free flaps (FJF and FFF) were associated with significantly greater rates of normal swallowing of saliva and yogurt than in the PMMF group (P = 0.04).

Conclusion

Type of flap reconstruction after circumferential pharyngolaryngectomy had no significant impact on postoperative swallowing function assessed on the self-administered DHI questionnaire.

https://ift.tt/2RfZuwU

Impact of cochlear implantation on peripheral vestibular function in adults

Publication date: Available online 25 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): V. Colin, P. Bertholon, S. Roy, A. Karkas

Abstract

Objective

Cochlear implantation may have a detrimental effect on vestibular function and residual hearing. Our goal was to investigate the impact of cochlear implantation on peripheral vestibular function and the symptomatology that ensues.

Material and methods

A prospective observational study included all adults undergoing cochlear implantation by the same operator between July 2014 and December 2015, with pre- and postoperative (4 months) neurovestibular balance examination comprising a questionnaire and clinical tests [head impulse test (HIT), head-shaking test (HST), skull vibration test (SVT)] and instrumental tests [caloric test of the lateral semicircular canal and cervical vestibular-evoked myogenic potentials (cVEMP)].

Results

Twenty-two patients were included, with a mean age of 62 years and sex-ratio of 1.2. Before implantation, 50% of subjects (n = 11) reported at least one episode of vertigo associated with balance disorder during their life. After implantation, there were 11 cases of vertigo but only one patient described persistent discomfort related to vertigo 4 months after surgery. Patients with impaired vestibular function after 4 months, taking all symptoms together, were all aged more than 75 years. HIT was abnormal in 18% of cases before implantation and in 59% after (P = NS). HST showed nystagmus in one patient both before and after surgery. Only 18% of patients showed nystagmus induced by SVT before surgery, increasing to one-third after surgery (P = NS). Caloric test of the lateral canal showed hypofunction in 50% of cases before surgery, including 10% of cases with areflexia. This rate increased after surgery to 58%, with 18% areflexia (P = NS). cVEMPs were not detected in 68% of cases before implantation and this rate increased to 86% after surgery (P = NS). There were no significant associations (P > 0.05) between test results and symptoms.

Conclusions

In the medium term, although older subjects more frequently presented vestibular disorder, cochlear implantation induced little vertigo or balance disorder, sometimes even improving vestibular function. However, vestibular disorders were frequent preoperatively and increased postoperatively. We tested vestibular function on different stimulation frequencies and yet found no correlation between postoperative test results and postoperative vertigo.

https://ift.tt/2AtsqM9

The ILTS Consensus Conference on NAFLD/NASH and liver transplantation

No abstract available

https://ift.tt/2z5u3hl

Cardiac transplantation across preformed HLA-antibody barriers

No abstract available

https://ift.tt/2SlWPmv

Haploidentical Hematopoietic Stem Cell Transplant complicated by Atypical Hemolytic Uremic Syndrome and Kidney Transplant from the same donor with no Immunosuppression but C5 Inhibition

Background Atypical hemolytic uremic syndrome (aHUS) is life-threatening condition particularly when complicating allograft hematopoietic stem cell transplant (HSCT). In the past, the outcome was very poor with the majority of patients reaching end stage renal disease (ESRD) or dying with little or no chances of kidney transplant (KTx) due to the high risk of relapse. The availability of C5 inhibition has opened up significant therapeutic opportunities and has improved the outcome particularly if complement dysregulation (CD) is the underlying pathogenetic mechanism. Methods: We describe a peculiar case of a girl with aHUS complicating HSCT and her subsequent successful KTx received from the same donor thus performed without immunosuppression but anti C5 inhibition. Results Soon after HSCT performed for acute lymphoblastic leukemia, the patient developed a thrombotic microangiopathy (TA-TMA) due to CD and reached ESRD. After 2 years on dialysis the patient received a KTx from her father who was already the HSCT donor. Given the full chimerism, no immunosuppressive agent was prescribed except a short (2 days) course of steroids and eculizumab to prevent aHUS relapse. Nine months after the KTx the patient is well with normal renal function, no immunosuppression and continues eculizumab prevention of aHUS (1 infusion every 21 days). Conclusions All patients with TA-TMA should be screened for the causes of CD. C5 inhibition with eculizumab is an important therapeutic resource to manage this complication. When KTx is necessary, immunosuppression can be safely withhold in case of same donor for both grafts and documented full chimerism. Correspondence information: Ardissino Gianluigi, Center for HUS Control, Prevention and Management, Fondazione, IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda, 9, 20122 Milan, Italy, e-mail: ardissino@centroseu.org Authorship page Authorship: Ardissino Gianluigi: participated in the writing of the paper Cresseri Donata: participated in the writing of the paper Giglio Fabio: participated in the writing of the paper Onida Francesco.: participated in the writing of the paper Iannuzzella Francesco: participated in the writing of the paper Tel Francesca: participated in the writing of the paper Giussani Antenore: participated in the writing of the paper Messa Piergiorgio: participated in the writing of the paper Longhi Selena: participated in the writing of the paper Vincenti Daniele: participated in the writing of the paper Tedeschi Silvana: participated in the writing of the paper Cugno Massimo: participated in the writing of the paper Ciceri Fabio: participated in the writing of the paper Disclosure: The authors declare no conflicts of interest Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2z56yF3

Preserved Renal-Allograft Function and successful treatment of metastatic Merkel cell cancer post Nivolumab therapy

No abstract available

https://ift.tt/2SlWKiH

Everolimus and Long-term Clinical Outcomes in Kidney Transplant Recipients: A Registry-based 10-year Follow-up of Five Randomized Trials

Background Data regarding the long-term efficacy of everolimus-based immunosuppression for kidney transplantation are lacking. Existing randomised controlled trials are limited by short follow-up duration which limits capacity to assess impact on graft and patient survival. Methods We linked individual trial participants to the Australian and New Zealand Dialysis and Transplant Registry. Using a one-step meta-analysis approach, we investigated the ten-year risk of graft loss, mortality and graft function in 349 participants from five randomised-trials of everolimus-based immunosuppression. Results Two-hundred and forty-two patients randomised to everolimus and 107 control patients were followed for a median of 9-years (IQR 7.1, 9.8 years). There were no significant differences in the risk of all-cause graft loss [adjusted HR (95% confidence interval) 1.16 (0.69-1.94)], mortality [adjusted HR 1.51 (0.78-2.93)] and death-censored graft loss in everolimus versus control [adjusted HR 1.00 (0.50-2.01)). For patients in the early initiation (de novo or

https://ift.tt/2z3c2QD

Evolution of robotic systems for transoral head and neck surgery

Publication date: December 2018

Source: Oral Oncology, Volume 87

Author(s): Howard Poon, Changsheng Li, Wenchao Gao, Hongliang Ren, Chwee Ming Lim

Abstract

Oropharyngeal tumor is traditionally resected from an open approach, often necessitating the need of a midline mandibulotomy in order to remove tumor safely with oncologic margins. The limitations imposed by a transoral route include poor visualization of the inferior extent of the oropharynx, rigid instrumentation, and inability to resect tumor that extends caudally into the supraglottis. While visualization with angled endoscopes, coupled with flexible laser development and microscopic magnification may overcome some of these limitations, this technique suffers from linear trajectory of the instruments which hampers expedient surgical resection in a 3-dimensional fashion. With development of the Da Vinci Surgical System, the safety and oncologic feasibility of removing oropharyngeal tumors are made possible because it provides a 3-dimensional magnification of the surgical field and wristed maneuverability of the surgical instruments which enable surgeons to operate around tight anatomical confines. Nevertheless, this first-generation robot is continually being modified with more flexibility and maneuverability through the development of robots like the FLEX Robotic System and more recently the Da Vinci Single Port System (SP). In this review, we will discuss the historic developments of robots for transoral applications, present the current approved robotic systems, and highlight the upcoming robots for transoral robotic surgery (TORS). Finally, we will also propose an ideal TORS surgical robot by highlighting the engineering technologies to accomplish these challenges.

https://ift.tt/2JilVyG

Prophylactic versus reactive gastrostomy tube placement in advanced head and neck cancer treated with definitive chemoradiotherapy: A systematic review

Publication date: December 2018

Source: Oral Oncology, Volume 87

Author(s): Shearwood McClelland, Janna Z. Andrews, Huma Chaudhry, Sewit Teckie, Anuj Goenka

Abstract

Although chemoradiotherapy (CRT) has improved disease outcomes in advanced head and neck cancer (aHNC), toxicity remains a major concern. Treatment interruptions and decreased quality of life (QOL) can occur due to malnutrition, secondary to mucositis, dysphagia and odynophagia. Gastrostomy tubes are used in many patients to improve nutrition during CRT. The optimal timing of PEG placement in patients with aHNC undergoing CRT remains controversial. Using the PubMed database, we performed a systematic review of published CRT series in aHNC to guide decision-making regarding optimal timing of percutaneous endoscopic gastrostomy (PEG) placement. We aimed to compare outcomes when patients are treated with prophylactic PEG (pPEG) versus reactive PEG (rPEG). Twenty-two studies examining the role of PEG placement in CRT for aHNC were reviewed. pPEG reduces the number of malnourished patients (defined as >10% of body weight), but average weight loss at various time points following treatment appears similar to patients with rPEG. pPEG is also associated with improved QOL at 6 months, and greater long term PEG dependence. Clinical and dosimetric parameters that correlate with malnutrition in patients without pPEG include advanced age, percent weight loss preceding treatment, and radiation dose to the pharyngeal constrictor muscles. Based on this evidence, our institutional strategy is to encourage pPEG in those patients deemed at greatest risk of becoming malnourished during the course of treatment, and to approach the remainder of patients with rPEG.

https://ift.tt/2Pjlqdl

The existence of early stage oral mucosal melanoma: A 10-year retrospective analysis of 170 patients in a single institute

Publication date: December 2018

Source: Oral Oncology, Volume 87

Author(s): Yunteng Wu, Lizheng Wang, Xuhui Ma, Wei Guo, Guoxin Ren

Abstract

Background

Oral mucosal melanoma (OMM) is an aggressive tumor with an extremely low incidence, and the current TNM Staging System has classified all OMMs as high stage. However, controversy remains regarding the existence of early stage OMMs.

Patients and methods

The clinical and pathological features, treatments and outcomes of 170 OMM patients treated in a single institution from January 2007 to July 2017 were retrospectively analyzed. Multivariate analysis was performed to identify significant prognostic factors for overall survival (OS).

Results

Multivariate analysis identified positive cervical lymph nodes (p < 0.0001), nodular OMMs (p < 0.0001), ulceration (p = 0.002), and level III or level IV invasion (p < 0.0001) as independent poor prognostic factors for OS. Nodular OMM patients with a tumor size ≤1 cm had a better outcome than those with a tumor size >1 cm (p < 0.0001). Twenty-two patients with superficial invasion had a favorable survival without the need of adjuvant therapy (postoperative chemotherapy or radiotherapy), and the current TNM Staging System was not suitable for those patients. Patients with deep invasion were more likely to suffer from recurrence and distant metastasis.

Conclusions

Tumor size ≤1 cm and OMM in situ, although extremely rare, do exist. It is advisable for AJCC to consider tumor size ≤1 cm and OMM in situ as the early stage of OMM when updating the new Oral Melanoma Staging System.

https://ift.tt/2JgNOXW

Successful oral desensitization in children with cow's milk anaphylaxis: Clinical and laboratory evaluation up to nine-years follow-up

Publication date: Available online 25 October 2018

Source: Allergologia et Immunopathologia

Author(s): M. Alves-Correia, Â. Gaspar, L.-M. Borrego, J. Azevedo, C. Martins, M. Morais-Almeida

Abstract

Introduction

Cow's milk protein allergy (CMPA) is the most common food allergy in children worldwide. Some children have severe and persistent CMPA, with near-fatal reactions after exposure to trace amounts of cow's milk-proteins (CMP). Strict avoidance diet is difficult, negatively affects quality of life and represents a conservative approach. Therefore, different therapeutic strategies are necessary.

Objective

We aimed to assess long-term efficacy and safety of oral immunotherapy (OIT) in children with severe and long-lasting IgE-mediated CMPA.

Materials and methods

The authors present four case reports of patients with CMPA who underwent CMP-OIT, that have been under long-term follow-up up to nine years. We provide information about the clinical and laboratory evaluation. Skin prick tests (SPT), specific IgE and IgG4 were performed before, during, and after OIT. Immune profile after OIT was assessed by flow cytometry (lymphocyte subsets, regulatory T and B cells).

Results

The success rate was 100%, and all patients currently have a free diet with minimal diary ingestion of 200 mL CMP or equivalent. Specific IgE levels and SPT to CMP have progressively decreased, and specific IgG4 levels have increased. CD4⁺CD25⁺CD127^−/dim regulatory T cells were increased after OIT.

Conclusions

OIT ensured a clinical tolerance state after up to nine years, confirmed by both clinical and immune profile, allowing a diet without restrictions, with high satisfaction from patients and caregivers. We emphasize that OIT should be performed only by allergy experts in the hospital setting, and that only motivated families should be enrolled, since it is essential to ensure CMP daily intake at home.

https://ift.tt/2AstSi7

Exomol Molecular Line Lists XXX: a Complete High-accuracy Line List for Water

Polyansky, OL; Kyuberis, AA; Zobov, NF; Tennyson, J; Yurchenko, SN; Lodi, L; (2018) Exomol Molecular Line Lists XXX: a Complete High-accuracy Line List for Water. Monthly Notices of the Royal Astronomical Society , 480 (2) pp. 2597-2608. 10.1093/mnras/sty1877 . Green open access

https://ift.tt/2ArPaMz

Quantum dot quantum cascade detector on Si Substrate

Huang, J; Guo, D; Deng, Z; Chen, W; Wu, T; Chen, Y; Liu, H; ... Chen, B; + view all Huang, J; Guo, D; Deng, Z; Chen, W; Wu, T; Chen, Y; Liu, H; Wu, J; Chen, B; - view fewer (2018) Quantum dot quantum cascade detector on Si Substrate. In: Proceedings Conference on Lasers and Electro-Optics. The Optical Society of America (OSA)

https://ift.tt/2PWsQjL

K-cut Cosmic Shear: Tunable Power Spectrum Sensitivity to Test Gravity

Taylor, PL; Bernardeau, F; Kitching, TD; (2018) K-cut Cosmic Shear: Tunable Power Spectrum Sensitivity to Test Gravity. Physical Review D , 98 (8) , Article 083514. 10.1103/PhysRevD.98.083514 . Green open access

https://ift.tt/2AsUeQS

Measurements of Higgs Boson Properties in the Diphoton Decay Channel With 36 fb(-1) of pp Collision Data at Root s=13 TeV With the ATLAS Detector

Aaboud, M; Collaboration, ATLAS; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abidi, SH; ... 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Caron, S; Carquin, E; Carra, S; Carrillo-Montoya, GD; Casadei, D; Casado, MP; Casha, AF; Casolino, M; Casper, DW; Castelijn, R; Gimenez, VC; Castro, NF; Catinaccio, A; Catmore, JR; Cattai, A; Caudron, J; Cavaliere, V; Cavallaro, E; Cavalli, D; Cavalli-Sforza, M; Cavasinni, V; Celebi, E; Ceradini, F; Alberich, LC; Cerqueira, AS; Cerri, A; Cerrito, L; Cerutti, F; Cervelli, A; Cetin, SA; Chafaq, A; Chakraborty, D; Chan, SK; Chan, WS; Chan, YL; Chang, P; Chapman, JD; Charlton, DG; Chau, CC; Barajas, CAC; Che, S; Cheatham, S; Chegwidden, A; Chekanov, S; Chekulaev, SV; Chelkov, GA; Chelstowska, MA; Chen, C; Chen, C; Chen, H; Chen, J; Chen, J; Chen, S; Chen, S; Chen, X; Chen, Y; Cheng, HC; Cheng, HJ; Cheplakov, A; Cheremushkina, E; El Moursli, RC; Cheu, E; Cheung, K; Chevalier, L; Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; 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Darbo, G; Darmora, S; Dassoulas, J; Dattagupta, A; Daubney, T; Davey, W; David, C; Davidek, T; Davis, DR; Davison, P; Dawe, E; Dawson, I; De, K; de Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; de Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Debbe, R; Debenedetti, C; Dedovich, DV; Dehghanian, N; Deigaard, I; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Dell'Acqua, A; Dell'Asta, L; Della Pietra, M; della Volpe, D; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Demilly, A; Denisov, SP; Denysiuk, D; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Girolamo, B; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; 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A synaptic threshold mechanism for computing escape decisions

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A New Family of Urea-Based Low Molecular-Weight Organogelators for Environmental Remediation: the Influence of Structure

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An experimental investigation on pressure response and phase transition of supercritical carbon dioxide releases from a small-scale pipeline

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Measuring Accessibility Using Gravity and Radiation Models

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How to share your (FAIR) data

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A capacitance-to-digits readout circuit for integrated humidity sensors for monitoring the in-package humidity of ultra-small medical implants

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Cross-Sectional Analysis of UK Research Studies in 2015: Results From a Scoping Project With the UK Health Research Authority

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Clinical implementations of 4D pencil beam scanned particle therapy: Report on the 4D treatment planning workshop 2016 and 2017

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Modelling the Tucana III Stream - a Close Passage With the LMC

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Effectiveness and Safety of Herbal Medicines for Induction of Labour: a Systematic Review and Meta-analysis

Zamawe, C; King, C; Jennings, HM; Mandiwa, C; Fottrell, E; (2018) Effectiveness and Safety of Herbal Medicines for Induction of Labour: a Systematic Review and Meta-analysis. BMJ Open , 8 (10) , Article e022499. 10.1136/bmjopen-2018-022499 . Green open access

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Rapidly Evolving Transients in the Dark Energy Survey

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Evidence for Z(C)(+/-)(3900) in Semi-inclusive Decays of B-flavored Hadrons

Abazov, VM; Abbott, B; Acharya, BS; Adams, M; Adams, T; Agnew, JP; Alexeev, GD; ... Zivkovic, L; + view all Abazov, VM; Abbott, B; Acharya, BS; Adams, M; Adams, T; Agnew, JP; Alexeev, GD; Alkhazov, G; Alton, A; Askew, A; Atkins, S; Augsten, K; Aushev, V; Aushev, Y; Avila, C; Badaud, F; Bagby, L; Baldin, B; Bandurin, D; Banerjee, S; Barberis, E; Baringer, P; Bartlett, JF; Bassler, U; Bazterra, V; Bean, A; Begalli, M; Bellantoni, L; Beri, SB; Bernardi, G; Bernhard, R; Bertram, I; Besancon, M; Beuselinck, R; Bhat, PC; Bhatia, S; Bhatnagar, V; Blazey, G; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Boos, EE; Borissov, G; Borysova, M; Brandt, A; Brandt, O; Brochmann, M; Brock, R; Bross, A; Brown, D; Bu, XB; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Buszello, CP; Camacho-Perez, E; Casey, BCK; Castilla-Valdez, H; Caughron, S; Chakrabarti, S; Chan, KM; Chandra, A; Chapon, E; Chen, G; Cho, SW; Choi, S; Choudhary, B; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, WE; Corcoran, M; Couderc, F; Cousinou, M-C; Cuth, J; Cutts, D; Das, A; Davies, G; de Jong, SJ; De La Cruz-Burelo, E; Deliot, F; Demina, R; Denisov, D; Denisov, SP; Desai, S; Deterre, C; DeVaughan, K; Diehl, HT; Diesburg, M; Ding, PF; Dominguez, A; Drutskoy, A; Dubey, A; Dudko, L; Duperrin, A; Dutt, S; Eads, M; Edmunds, D; Ellison, J; Elvira, VD; Enari, Y; Evans, H; Evdokimov, A; Evdokimov, VN; Faure, A; Feng, L; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, HE; Fortner, M; Fox, H; Franc, J; Fuess, S; Garbincius, PH; Garcia-Bellido, A; Garcia-Gonzalez, JA; Gavrilov, V; Geng, W; Gerber, CE; Gershtein, Y; Ginther, G; Gogota, O; Golovanov, G; Grannis, PD; Greder, S; Greenlee, H; Grenier, G; Gris, P; Grivaz, J-F; Grohsjean, A; Grunendahl, S; Grunewald, MW; Guillemin, T; Gutierrez, G; Gutierrez, P; Haley, J; Han, L; Harder, K; Harel, A; Hauptman, JM; Hays, J; Head, T; Hebbeker, T; Hedin, D; Hegab, H; Heinson, AP; Heintz, U; Hensel, C; Heredia-De La Cruz, I; Herner, K; Hesketh, G; Hildreth, MD; Hirosky, R; Hoang, T; Hobbs, JD; Hoeneisen, B; Hogan, J; Hohlfeld, M; Holzbauer, JL; Howley, I; Hubacek, Z; Hynek, V; Iashvili, I; Ilchenko, Y; Illingworth, R; Ito, AS; Jabeen, S; Jaffre, M; Jayasinghe, A; Jeong, MS; Jesik, R; Jiang, P; Johns, K; Johnson, E; Johnson, M; Jonckheere, A; Jonsson, P; Joshi, J; Jung, AW; Juste, A; Kajfasz, E; Karmanov, D; Katsanos, I; Kaur, M; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, YN; Kiselevich, I; Kohli, JM; Kozelov, A; Kraus, J; Kumar, A; Kupco, A; Kurca, T; Kuzmin, VA; Lammers, S; Lebrun, P; Lee, HS; Lee, SW; Lee, WM; Lei, X; Lellouch, J; Li, D; Li, H; Li, L; Li, QZ; Lim, JK; Lincoln, D; Linnemann, J; Lipaev, VV; Lipton, R; Liu, H; Liu, Y; Lobodenko, A; Lokajicek, M; de Sa, RL; Luna-Garcia, R; Lyon, AL; Maciel, AKA; Madar, R; Magana-Villalba, R; Malik, S; Malyshev, VL; Mansour, J; Martinez-Ortega, J; McCarthy, R; McGivern, CL; Meijer, MM; Melnitchouk, A; Menezes, D; Mercadante, PG; Merkin, M; Meyer, A; Meyer, J; Miconi, F; Mondal, NK; Mulhearn, M; Nagy, E; Narain, M; Nayyar, R; Neal, HA; Negret, JP; Neustroev, P; Nguyen, HT; Nunnemann, T; Orduna, J; Osman, N; Pal, A; Parashar, N; Parihar, V; Park, SK; Partridge, R; Parua, N; Patwa, A; Penning, B; Perfilov, M; Peters, Y; Petridis, K; Petrillo, G; Petroff, P; Pleier, M-A; Podstavkov, VM; Popov, A; Prewitt, M; Price, D; Prokopenko, N; Qian, J; Quadt, A; Quinn, B; Ratoff, PN; Razumov, I; Ripp-Baudot, I; Rizatdinova, F; Rominsky, M; Ross, A; Royon, C; Rubinov, P; Ruchti, R; Sajot, G; Sanchez-Hernandez, A; Sanders, MP; Santos, AS; Savage, G; Savitskyi, M; Sawyer, L; Scanlon, T; Schamberger, RD; Scheglov, Y; Schellman, H; Schott, M; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shary, V; Shaw, S; Shchukin, AA; Shkola, O; Simak, V; Skubic, P; Slattery, P; Snow, GR; Snow, J; Snyder, S; Soldner-Rembold, S; Sonnenschein, L; Soustruznik, K; Stark, J; Stefaniuk, N; Stoyanova, DA; Strauss, M; Suter, L; Svoisky, P; Titov, M; Tokmenin, VV; Tsai, Y-T; Tsybychev, D; Tuchming, B; Tully, C; Uvarov, L; Uvarov, S; Uzunyan, S; Van Kooten, R; van Leeuwen, WM; Varelas, N; Varnes, EW; Vasilyev, IA; Verkheev, AY; Vertogradov, LS; Verzocchi, M; Vesterinen, M; Vilanova, D; Vokac, P; Wahl, HD; Wang, MHLS; Warchol, J; Watts, G; Wayne, M; Weichert, J; Welty-Rieger, L; Williams, MRJ; Wilson, GW; Wobisch, M; Wood, DR; Wyatt, TR; Xie, Y; Yamada, R; Yang, S; Yasuda, T; Yatsunenko, YA; Ye, W; Ye, Z; Yin, H; Yip, K; Youn, SW; Yu, JM; Zennamo, J; Zhao, TG; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L; - view fewer (2018) Evidence for Z(C)(+/-)(3900) in Semi-inclusive Decays of B-flavored Hadrons. Physical Review D , 98 (5) , Article 052010. 10.1103/PhysRevD.98.052010 . Green open access

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Search for the Higgs Boson Produced in Association With a Vector Boson and Decaying Into Two Spin-zero Particles in the H → Aa → 4b Channel in Pp Collisions at S√=13 Tev With the Atlas Detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Arabidze, G; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Åkesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Alconada Verzini, MJ; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Alvarez Gonzalez, B; Álvarez Piqueras, D; Alviggi, MG; Amadio, BT; Amaral Coutinho, Y; Ambroz, L; Amelung, C; Amidei, D; Amor Dos Santos, SP; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Aparisi Pozo, JA; Aperio Bella, L; Arabidze, G; - view fewer (2018) Search for the Higgs Boson Produced in Association With a Vector Boson and Decaying Into Two Spin-zero Particles in the H → Aa → 4b Channel in Pp Collisions at S√=13 Tev With the Atlas Detector. Journal of High Energy Physics , 2018 , Article 31. 10.1007/JHEP10(2018)031 . Green open access

https://ift.tt/2AtIRZ1

Final Results on82 Se Double Beta Decay to the Ground State of82 Kr From the Nemo-3 Experiment

Arnold, R; Augier, C; Barabash, AS; Basharina-Freshville, A; Blondel, S; Blot, S; Bongrand, M; ... Vilela, C; + view all Arnold, R; Augier, C; Barabash, AS; Basharina-Freshville, A; Blondel, S; Blot, S; Bongrand, M; Boursette, D; Brudanin, V; Busto, J; Caffrey, AJ; Calvez, S; Cascella, M; Cerna, C; Cesar, JP; Chapon, A; Chauveau, E; Chopra, A; Dawson, L; Duchesneau, D; Durand, D; Egorov, V; Eurin, G; Evans, JJ; Fajt, L; Filosofov, D; Flack, R; Garrido, X; Gómez, H; Guillon, B; Guzowski, P; Hodák, R; Huber, A; Hubert, P; Hugon, C; Jullian, S; Klimenko, A; Kochetov, O; Konovalov, SI; Kovalenko, V; Lalanne, D; Lang, K; Lemière, Y; Le Noblet, T; Liptak, Z; Liu, XR; Loaiza, P; Lutter, G; Macolino, C; Mamedov, F; Marquet, C; Mauger, F; Morgan, B; Mott, J; Nemchenok, I; Nomachi, M; Nova, F; Nowacki, F; Ohsumi, H; Pahlka, RB; Patrick, C; Perrot, F; Piquemal, F; Povinec, P; Přidal, P; Ramachers, YA; Remoto, A; Reyss, JL; Riddle, CL; Rukhadze, E; Rukhadze, NI; Saakyan, R; Salazar, R; Sarazin, X; Shitov, Y; Simard, L; Šimkovic, F; Smetana, A; Smolek, K; Smolnikov, A; Söldner-Rembold, S; Soulé, B; Štekl, I; Suhonen, J; Sutton, CS; Szklarz, G; Thomas, J; Timkin, V; Torre, S; Tretyak, VI; Tretyak, VI; Umatov, VI; Vanushin, I; Vilela, C; - view fewer (2018) Final Results on⁸2 Se Double Beta Decay to the Ground State of⁸2 Kr From the Nemo-3 Experiment. The European Physical Journal C , 78 , Article 821. 10.1140/epjc/s10052-018-6295-x . Green open access

https://ift.tt/2PYL9F0

The Strong Lensing Insights Into the Dark Energy Survey (Strides) 2016 Follow-up Campaign – I. Overview and Classification of Candidates Selected by Two Techniques

Treu, T; Agnello, A; Baumer, MA; Birrer, S; Buckley-Geer, EJ; Courbin, F; Kim, YJ; ... Smith, M; + view all Treu, T; Agnello, A; Baumer, MA; Birrer, S; Buckley-Geer, EJ; Courbin, F; Kim, YJ; Lin, H; Marshall, PJ; Nord, B; Schechter, PL; Sivakumar, PR; Abramson, LE; Anguita, T; Apostolovski, Y; Auger, MW; Chan, JHH; Chen, GCF; Collett, TE; Fassnacht, CD; Hsueh, JW; Lemon, C; McMahon, RG; Motta, V; Ostrovski, F; Rojas, K; Rusu, CE; Williams, P; Frieman, J; Meylan, G; Suyu, SH; Abbott, TMC; Abdalla, FB; Allam, S; Annis, J; Avila, S; Banerji, M; Brooks, D; Rosell, AC; Carrasco Kind, M; Carretero, J; Castander, FJ; D'Andrea, CB; da Costa, LN; De Vicente, J; Doel, P; Eifler, TF; Flaugher, B; Fosalba, P; García-Bellido, J; Goldstein, DA; Gruen, D; Gruendl, RA; Gutierrez, G; Hartley, WG; Hollowood, D; Honscheid, K; James, DJ; Kuehn, K; Kuropatkin, N; Lima, M; Maia, MAG; Martini, P; Menanteau, F; Miquel, R; Plazas, AA; Romer, AK; Sanchez, E; Scarpine, V; Schindler, R; Schubnell, M; Sevilla-Noarbe, I; Smith, M; - view fewer (2018) The Strong Lensing Insights Into the Dark Energy Survey (Strides) 2016 Follow-up Campaign – I. Overview and Classification of Candidates Selected by Two Techniques. Monthly Notices of the Royal Astronomical Society , 481 (1) pp. 1041-1054. 10.1093/MNRAS/STY2329 . (In press). Green open access

https://ift.tt/2AsSo2E

Generation of a Cancer Testis Antigen Mcherry Reporter Hct116 Colorectal Carcinoma Cell Line

Chhetri, JB; Drousioti, E; Guerra-Assunção, JA; Herrero, J; Ooi, SKT; (2018) Generation of a Cancer Testis Antigen Mcherry Reporter Hct116 Colorectal Carcinoma Cell Line. Heliyon , 4 (10) , Article e00858. 10.1016/j.heliyon.2018.e00858 . Green open access

https://ift.tt/2PTLE36

Editorial Board

Publication date: November 2018

Source: Autoimmunity Reviews, Volume 17, Issue 11

Author(s):

https://ift.tt/2CD4tUp

CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders

Publication date: Available online 26 October 2018

Source: Clinical Immunology

Author(s): Marta Cuenca, Jordi Sintes, Árpád Lányi, Pablo Engel

Abstract

CD84 (SLAMF5) is a member of the SLAM family of cell-surface immunoreceptors. Broadly expressed on most immune cell subsets, CD84 functions as a homophilic adhesion molecule, whose signaling can activate or inhibit leukocyte function depending on the cell type and its stage of activation or differentiation. CD84-mediated signaling regulates diverse immunological processes, including T cell cytokine secretion, natural killer cell cytotoxicity, monocyte activation, autophagy, cognate T:B interactions, and B cell tolerance at the germinal center checkpoint. Recently, alterations in CD84 have been related to autoimmune and lymphoproliferative disorders. Specific allelic variations in CD84 are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. In chronic lymphocytic leukemia, CD84 mediates intrinsic and stroma-induced survival of malignant cells. In this review, we describe our current understanding of the structure and function of CD84 and its potential role as a therapeutic target and biomarker in inflammatory autoimmune disorders and cancer.

https://ift.tt/2Sicbsx

SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?

Publication date: Available online 25 October 2018

Source: Clinical Immunology

Author(s): Inna Gordiienko, Larysa Shlapatska, Larysa Kovalevska, Svetlana P. Sidorenko

Abstract

SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. It is widely expressed on cells within hematopoietic system. In hematologic malignancies CD150 cell surface expression is restricted to cutaneous T-cell lymphomas, few types of B-cell non-Hodgkin's lymphoma, near half of cases of chronic lymphocytic leukemia, Hodgkin's lymphoma, and multiple myeloma. Differential expression among various types of hematological malignancies allows considering CD150 as diagnostical and potential prognostic marker. Moreover, CD150 may be a target for antibody-based or measles virus oncolytic therapy. Due to CD150 signaling properties it is involved in regulation of malignant cell fate decision and tumor microenvironment in Hodgkin's lymphoma and chronic lymphocytic leukemia. This review summarizes evidence for the important role of CD150 in pathogenesis of hematologic malignancies.

https://ift.tt/2z2V459

Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe

Publication date: Available online 26 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Naboth Matinhira, Nyarai D. Soko, Tsitsi Bandason, Ramon G. Jenson, Titus Dzongodza, Christian von Buchwald, Clemence Chidziva

Abstract

Objective

Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent thrust of the Zimbabwean government to reduce incidence of HPV related cervical cancer in Zimbabwe through vaccination against HPV. We therefore set out to type HPV genotypes causing RRP in Zimbabwe. We also describe for the first time, the demographics of Zimbabwean RRP patients, the characteristics of patients with different HPV types and possible risk factors of HPV infection in our setting.

Methods

We conducted a prospective, hospital based study were patients were recruited from two national otorhinolaryngology hospitals in Zimbabwe. All patients diagnosed with RRP during a twenty four month period were included in the study. A questionnaire was administered per patient to collect both demographic and clinical variables. HPV DNA was extracted from formalin fixed paraffin embedded laryngeal tissue. The extracted HPV DNA was amplified using polymerase chain reaction and next generation sequencing was used to genotype the HPV types.

Results

A total of 52 patients all aged 14 years and under were recruited into the study. Only Juvenile onset RRP cases were observed over the two year period and 64% of the patients were HPV positive. HPV types 6 and 11 were the dominant types observed constituting 85% of all HPV types. The remaining 15% constituted of HPV 16 and HPV 18. 27% of the patients had coinfection with at least two different HPV types. There were no statistically significant differences between the characteristics of HPV positive and HPV negative patients. No statistically significant risk factors were observed.

Conclusion

HPV types 6 and 11 were the predominant genotypes causing RRP in Zimbabwe. Thus the use of quadrivalent or even nonavalent HPV vaccines may play an important role in the prevention and management of RRP in Zimbabwe.

https://ift.tt/2Q2BcXa

Is chemotherapy the best option for chronic lymphocytic leukemia associated Wells’ syndrome? Reply to “Case of Wells’ syndrome: A rare association with the clinical course of chronic lymphocytic leukemia”

The Journal of Dermatology, EarlyView.


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Itching, chloroquine, and malaria: a review of recent molecular and neuroscience advances and their contribution to mechanistic understanding and therapeutics of chronic non‐histaminergic pruritus

International Journal of Dermatology, EarlyView.


https://ift.tt/2PYIM4L

Explaining the modal force of natural laws

Abstract

In this paper, I will defend the thesis that fundamental natural laws are distinguished from accidental empirical generalizations neither by metaphysical necessity (e.g. Ellis 1999, 2001; Bird in Analysis, 65(2), 147–155, 2005, 2007) nor by contingent necessitation (Armstrong 1983). The only sort of modal force that distinguishes natural laws, I will argue, arises from the peculiar physical property of mutual independence of elementary interactions exemplifying the laws. Mutual independence of elementary interactions means that their existence and their nature do not depend in any way on which other interactions presently occur. It is exactly this general physical property of elementary interactions in the actual world that provides natural laws with their specific modal force and grounds the experience of nature's 'recalcitrance'. Thus, the modal force of natural laws is explained by contingent non-modal properties of nature. In the second part of the paper, I deal with some alleged counterexamples to my approach: constraint laws, compositional laws, symmetry principles and conservation laws. These sorts of laws turn out to be compatible with my approach: constraint laws and compositional laws do not represent the dynamics of interaction-types by themselves, but only as constitutive parts of a complete set of equations, whereas symmetry principles and conservation laws do not represent any specific dynamics, but only impose general constraints on possible interactions.

https://ift.tt/2CFeUXA