Primary Osteosarcoma of Sphenoid and Ethmoid Sinus in a 17 Year Female: Case Report

Abstract

Primary osteosarcoma of sphenoid and ethmoid sinus present as a challenge in head neck cancer. A 17 year female presented with left sided hemifacial pain, headache with nasal discharge. Clinico-radiological finding showed mass in sphenoethmoid recess spreading to adjacent structures. Endoscopic resection was done. Histopathological diagnosis was osteosarcoma of sphenoid and ethmoid sinus. Adjuvant chemotherapy administered. Osteosarcomas of sphenoid and ethmoid sinus are aggressive tumors with variable clinical features warranting high clinical suspicion.

http://bit.ly/2ByXs5E

Randomized, single‐blinded, crossover study of a novel wound dressing vs current clinical practice after percutaneous collagen induction therapy

Summary

Introduction

Skin rejuvenation procedures have become common with sophisticated technologies with reduced downtime and related risks. Recently, microneedling has been paired with radiofrequency to create Fractional Radiofrequency Microneedling (FRFM) to induce neocollagenesis. Frequently, topical products are applied immediately after the needling. This procedure is known as percutaneous collagen induction therapy (PCIT). Postoperative topical wound care is critical for prompt rapid and safe healing, with moist wound healing deemed of primary importance for fast and correct scarring process. An ideal dressing enables a moist environment while reducing postprocedural inflammatory responses in the first stages of wound healing.

Objective

To evaluate whether an innovative silicone‐based wound dressing is superior than standard of care therapy in decreasing severity and duration of treatment‐site acute inflammatory reactions post PCIT.

Materials and Methods

Endymed PRO Intensif Handpiece (Endymed, Israel) was used for the full‐face FRFM procedure. Subjects (n = 20) applied treatment (Stratacel^®—Stratpharma SG, Switzerland) and control (Aquaphor^®—Beiersdorf Inc, USA) immediately after the procedure and daily; they were evaluated immediately postprocedure (baseline assessment), at 2, 3 and 7 days postprocedure. Digital and 3D pictures (Antera 3D Camera for Skin Analysis—Miravex, Ireland) were taken at each assessment.

Results

All patients healed properly without reporting adverse reactions to any of the studied products. Erythema at each study visit was significantly reduced with the use of the novel wound dressing (P < 0.001). A statistically significant difference in favor of the innovative wound dressing also emerged with respect to the patient‐rated product properties (P = 0.008), such as feel on skin, drying time and stickiness.

Conclusions

The novel wound dressing reduced signs of acute inflammation following PCIT when compared to standard of care, without reporting adverse events and resulting in a more favorable outcome from a patient perspective.

http://bit.ly/2N28jJS

Primary Tonsillar Epithelioid Follicular Dendritic Cell Sarcoma: Report of a Rare Case Mimicking Undifferentiated Carcinoma and a Brief Review of the Literature

Abstract

We present a 52 years old male with a left tonsillar follicular dendritic cell sarcoma with prominent epithelioid features that on light microscopical examination bore a striking resemblance to a lymphoepithelial or undifferentiated carcinoma. The tumor was immunohistochemically positive for CD21 and CD35 and negative for cytokeratins. Two distinct histopathological features (both present in our case) that may serve as clues to the correct diagnosis on light microscopical examination were formation of ectatic pseudovascular spaces lined by malignant cells and the presence of non-neoplastic multinucleated giant cells. Familiarity with the above-mentioned morphological clues, and awareness that this tumour may occur in anatomical sites outside the lymph node, are essential for accurate diagnosis.

http://bit.ly/2N1Pjeo

Primary Osteosarcoma of Sphenoid and Ethmoid Sinus in a 17 Year Female: Case Report

Abstract

Primary osteosarcoma of sphenoid and ethmoid sinus present as a challenge in head neck cancer. A 17 year female presented with left sided hemifacial pain, headache with nasal discharge. Clinico-radiological finding showed mass in sphenoethmoid recess spreading to adjacent structures. Endoscopic resection was done. Histopathological diagnosis was osteosarcoma of sphenoid and ethmoid sinus. Adjuvant chemotherapy administered. Osteosarcomas of sphenoid and ethmoid sinus are aggressive tumors with variable clinical features warranting high clinical suspicion.

http://bit.ly/2ByXs5E

Contribution of Nitric oxide synthase 3 genetic variants to nasopharyngeal carcinoma risk and progression in a Tunisian population

Abstract

Purpose

We conduct this study to evaluate the clinical and functional impact of Nitric Oxide Synthase 3 (NOS3) T-786C and G894T genetic variants on nasopharyngeal carcinoma (NPC) risk and progression in a Tunisian population.

Methods

259 NPC patients and 169 healthy controls were enrolled into our case–control study. Blood samples were genotyped by the RFLP-PCR analysis. The levels of Nitric oxide (NO) were measured by a colorimetric assay kit in the plasma of NPC patients, healthy controls and according to NOS3 genotypes. The correlation between the NOS3 variants and the clinicopathological parameters was examined.

Results

We found no linkage disequilibrium between NOS3 T-786C and G894T variants. These results showed that NOS3 variants were genetically independent. In contrast to NOS3 T-786C, a significant association was found between NOS3 G894T polymorphism and NPC risk. The 894T allele decreased significantly in NPC patients and appeared as protective factor (OR = 0.65, CI 95%= 0.48–0.88, p = 0.006). NPC patients had significantly higher levels of plasma NO as compared to healthy controls (p = 0.0011). The T-786C mutation reduced the levels of plasma NO and decreased risk of lymph node metastasis in NPC patients (OR = 0.64, 95% CI = 0.43–0.96; p = 0.03). In contrast, NOS3 G894T polymorphism had no effects neither on NO plasma levels nor clinical parameters.

Conclusions

This is the first study to associate NPC with significantly higher levels of plasma NO. NOS3-derived NO could play key roles in NPC pathogenesis. NOS3 variants differently contribute to NPC risk and progression in a Tunisian population. NOS3 G894T was associated with NPC risk. NOS3 T-786C decreased the levels of plasma NO and reduced the development of regional lymph node metastasis.

http://bit.ly/2GnioAv

Botulinumtoxin A für eine schönere Halskurve

Ein verkürzter Hals wird von vielen als unästhetisch angesehen. Er kann unter anderem durch eine Hypertrophie des Trapeziusmuskels entstehen. Die Injektion von Botulinumtoxin A kann das Erscheinungsbild maßgeblich verbessern und die Patientenzufriedenheit erhöhen.

http://bit.ly/2BykrOa

Upload nur mit Einverständniserklärung!

Wenn Patienten die neue E-Gesundheitsakte Vivy mit ihren Daten gefüllt sehen wollen, gibt es einige Aspekte zu beachten. Die Kassenärztliche Bundesvereinigung hat nun Informationen zusammengestellt.

http://bit.ly/2X861O2

Ärztliche Sorgfaltspflicht wahren

Der Deutsche Ärztetag hat das Fernbehandlungsverbot gelockert und damit einen wichtigen Grundstein für die Patientenbehandlung per Video, Telefon oder E-Mail gelegt. Ein Rechtsanwalt erklärt, für welche Patienten eine Fernbehandlung infrage kommt.

http://bit.ly/2TO0qdI

Wenn es beim Einlesen der E-Card hakt

Immer wieder kommt es in Arztpraxen beim Einlesen von Gesundheitskarten zu technischen Problemen. Die Kassenärztliche Vereinigung Nordrhein gibt einen Überblick über die gängigsten Fehlermeldungen und hat Tipps, was dann zu tun ist.

http://bit.ly/2TO0j1M

Strahlende Haut durch Nahrungsergänzungsmittel

http://bit.ly/2Bxepxp

Dauerhafte Hautstraffung bei Cellulite

http://bit.ly/2TO0eLw

Kein automatischer Urlaubsverfall zum Jahreswechsel

Mit zwei Urteilen hat der Europäische Gerichtshof (EuGH) wiederholt die Arbeitnehmerrechte im Hinblick auf Urlaubsansprüche gestärkt. Der EuGH hat mit seinen Entscheidungen den lange geltenden Grundsatz über Bord geworfen, dass Urlaubsansprüche zum Jahresende automatisch verfallen. Dies kann für jeden Praxisinhaber erhebliche Mehrkosten und -belastungen mit sich bringen. Es lohnt also ein Blick auf die Auswirkungen der Urteile für die tägliche Praxis und darauf, wie man sich vor nachteiligen Folgen schützen kann.

http://bit.ly/2BxejG3

Atrophe Aknenarben: gelen statt nadeln?

Der Schweregrad atropher Aknenarben war sechs Monate nach der Behandlung mit topischem Tazaroten-Gel bei guter Verträglichkeit in gleichem Maß verbessert wie nach Microneedling, so eine Studie.

http://bit.ly/2TTETQw

Ein Schritt in die richtige Richtung!

http://bit.ly/2BxegtR

Mit Laserlipolyse Körperfett entfernen und Bindegewebe straffen

http://bit.ly/2RZ6LkC

Methotrexat bei Alopecia areata/totalis?

Die Therapie von Alopecia areata/totalis mit Methotrexat (MTX) ist bisher nur unzureichend untersucht worden. In einer neuen Literatursuche fanden die Autoren Hinweise auf ein erneutes Haarwachstum nach MTX-Therapie.

http://bit.ly/2RYxY6Y

Betriebsausfall durch Unwetter einkalkulieren

Ist die Praxis aufgrund eines Hochwassers nicht zugänglich, drohen massive Betriebsausfälle — selbst im zweiten Stock. Praxen sollten sich deswegen gut gegen die möglichen Folgen versichern.

http://bit.ly/2WZwygf

Neue Befunde bestätigen: Dexpanthenol forciert die Wundheilung

http://bit.ly/2RZ6Dl8

Mit körpereigenen Ressourcen zu einem besseren Hautbild

Viele Patienten finden es besonders verlockend, ihr autologes Regenerationspotenzial zu nutzen. So erfreut sich die Anwendung einer aus dem eigenen Blut gewonnenen Thrombozytenfraktion wachsender Beliebtheit — auch in der ästhetischen Dermatologie.

http://bit.ly/2X1VFin

Wirksamkeit von OTC-Produkten bei Hyperpigmentierungen

Dank Over-the-counter-Produkten benötigen Menschen mit Hyperpigmentierungen nicht unbedingt ein Rezept vom Arzt, wenn sie ihr Hautbild verschönern möchten. Aber welche Cremes sind bei Patienten am beliebtesten, welche wirken am besten, wie lange werden sie eingesetzt — und sind verschreibungspflichtige Produkte vielleicht nicht doch besser? Das wurde jetzt in einer neuen Studie in den USA untersucht.

http://bit.ly/2RZ77Yu

„Ästhetik für Einsteiger“

http://bit.ly/2WWF93f

Hybrid-Plattform zur Körper- und Gesichtskonturierung

http://bit.ly/2RZ72Ea

DSGVO — wann droht eine Abmahnung?

Mit der Datenschutzgrundverordnung (DSGVO) wurden zahlreiche neue Verpflichtungen für die ärztliche Praxis eingeführt, die bereits viel diskutiert und aufbereitet sind. Unbeleuchtet bleibt dabei häufig die Frage, welche Rechtsfolgen ein Verstoß gegen die DSGVO überhaupt nach sich ziehen kann. Gerade die Sorge vor Sanktionen ist aber wesentlicher Anlass, sich mit der DSGVO intensiv zu beschäftigen.

http://bit.ly/2X031TK

Ist Body-Contouring nach bariatrischer Operation absolut notwendig?

http://bit.ly/2RZ6mi6

Medical Needling bei Verbrennungsnarben im Kindesalter

Verbrennungen im Kindesalter gehören zu den psychisch und physisch am stärksten traumatisierenden Verletzungen. Sie können eine lebenslange Stigmatisierung durch Narbenbildung hinterlassen. Die konservative Narbentherapie schließt direkt an die Akutbehandlung an, kann jedoch die Ausbildung von hypertrophen oder kontrakten und damit bewegungseinschränkenden Narben nicht immer verhindern. Besonders am kindlichen wachsenden Organismus müssen die Narben jahrelang behandelt und beobachtet werden, um die Entwicklung des Kindes nicht zu beeinträchtigen.

http://bit.ly/2X02WiU

Outcome of a giant coronary artery mycotic pseudoaneurysm secondary to non-typhoid Salmonella managed without surgical intervention

A 48-year-old woman with a history of AIDS, a recent coronary artery bypass graft operation and prior bacteraemia with non-typhoid Salmonella presented with non-exertional chest pain and elevated troponins. The cardiac catheterisation and coronary CT angiography revealed a 9 cm pseudoaneurysm arising from the proximal left anterior descending artery. The blood cultures confirmed non-typhoid Salmonella. Emergent surgery was initially deferred due to her complex anatomy. Moreover, the hospital course was complicated by Epstein-Barr virus meningitis and an associated decline in the patient's mentation. Consequently, the mycotic pseudoaneurysm was medically managed with antibiotics and strict blood pressure goals. The natural history of giant mycotic coronary artery pseudoaneurysm formation and progression is appreciated through this first reported medically managed case. The follow-up coronary CT angiography at 3 months showed evidence of pseudoaneurysm leakage into surrounding tissue. The patient expired at 5 months from an unknown cause.

http://bit.ly/2N1iNJk

Atypical presentation of IgG4 sclerosing cholangitis

IgG₄ sclerosing cholangitis (ISC) is a rare disease which usually presents in patients in their 60's or above. Patients often present with obstructive jaundice as the first symptom, especially when associated with autoimmune pancreatitis. We report the case of a 20-year-old man who presented with acute abdominal pain, which was subsequently diagnosed as ISC in addition to autoimmune pancreatitis following magnetic resonance cholangiopancreatography (MRCP). The patient was thus treated with steroids.

http://bit.ly/2SNUJ26

Child with unusual combination of sickle cell disease and autosomal recessive agammaglobulinemia associated with a novel CD79a gene mutation

This article describes a novel mutation in CD79a gene identified in a child with sickle cell disease (SCD), who was diagnosed with autosomal recessive agammaglobulinaemia in the context of prolonged febrile syndrome. The association of a primary immunodeficiency with SCD in the same child was unexpected.

http://bit.ly/2N42BHh

Bilateral maxillary palatal talon cusps in deciduous central incisors

'Talon cusp' is a developmental dental disturbance characterised by a cuspal projection in the cingulum area or cementoenamel junction, with normal enamel and dentin containing varying degrees of pulp tissue. The prevalence of talon cusp varies with race, age and the criteria used for diagnosis. It has been reported in the maxillary and mandibular arches of both the deciduous and permanent dentitions. The prevalence of the talon cusp in the deciduous dentition is reported to be 2.1% in Saudi Arabian subjects. The purpose of this paper is to report the rare bilateral presence of talon cusps on the deciduous maxillary central incisors of a 4-year-old female patient with a family history of consanguineous marriage.

http://bit.ly/2SNjoUi

Intermediate uveitis in a child with phosphatase and tensin homolog gene mutation and Bannayan-Riley-Ruvalcaba syndrome

Bannayan-Riley-Ruvalcaba syndrome (BRRS) is a congenital disorder characterised by macrocephaly, multiple hamartomas, lipomas, and pigmented macules of the glans penis. Intermediate uveitis is characterised by chronic inflammatory cells aggregates on the pars plana (snowbanks) and within the vitreous cavity (snowballs). We describe what we believe to be the first case of intermediate uveitis associated with BRRS. Early examination under anaesthesia should be considered in the management of young children diagnosed with this syndrome in order to provide appropriate ocular evaluation, treatment and follow-up. Further research is needed to establish a better understanding of the ophthalmic manifestations of this syndrome.

http://bit.ly/2N20Eew

Cutaneous angiosarcoma with lymphoedema: the Stewart-Treves syndrome

http://bit.ly/2SNUAM6

Isolated superior petrosal sinus dural arteriovenous fistula treated with selective sinus packing using a quadriaxial catheter system

A 67-year-old patient presented with a headache, vertigo and nausea, followed by a disturbance of consciousness. CT and MRI showed venous ectasia at the left cerebellopontine angle and extensive oedema in the left cerebellum. Angiography demonstrated a dural arteriovenous fistula that appeared at the left superior petrosal sinus–cavernous sinus) junction. After the evaluation of the shunt point, occluded areas were recanalised via the femoral vein with a quadriaxial catheter system using a 6-Fr guiding sheath, 6-Fr guiding catheter, 4.2-Fr catheter and microcatheter. Selective coil embolisation was performed, resulting in shunt removal.

http://bit.ly/2SL56Ub

The Devil Is in the Details

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors' commentary follows. Stage. A 75-year-old woman…

http://bit.ly/2Gml3dV

β-Catenin nuclear expression discriminates deep penetrating nevi from other cutaneous melanocytic tumors

Abstract

Recent advances in genomics have improved the molecular classification of cutaneous melanocytic tumors. Among them, deep penetrating nevi (DPN) and plexiform nevi have been linked to joint activation of the MAP kinase and dysregulation of the β-catenin pathways. Immunohistochemical studies have confirmed cytoplasmic and nuclear expression of β-catenin and its downstream effector cyclin D1 in these tumors. We assessed nuclear β-catenin immunohistochemical expression in a large group of DPN as well as in the four most frequent differential diagnoses of DPN: "blue" melanocytic tumors, Spitz tumors, nevoid and SSM melanomas, and pigmented epithelioid melanocytomas (PEM). Nuclear β-catenin expression was positive in 98/100 DPN and 2/16 of melanomas (one SSM and one nevoid melanoma with a plexiform clone) and was negative in all 30 Spitz, 26 blue, and 6 PEM lesions. In 41% DPN, β-catenin expression was positive in more than 30% nuclei. No differences were observed in cytoplasmic and nuclear cyclin D1 expression between these tumor groups, suggesting alternate, β-catenin-independent, activation pathways. We have subsequently studied nuclear β-catenin expression in a set of 13 tumors with an ambiguous diagnosis, for which DPN was part of the differential diagnosis. The three out of four patients showing canonical DPN mutation profiles were the only β-catenin-positive cases. We conclude that nuclear β-catenin expression, independently from CCND1 expression, in a dermal melanocytic tumor is an argument for its classification as DPN. In ambiguous cases and in early combined DPN lesions, this antibody can be helpful as a screening tool. β-Catenin is also potentially expressed in a subset of malignant melanomas with CTNNB1 mutations.

http://bit.ly/2N0SP8M

Recent success and limitations of immune checkpoint inhibitors for cancer: a lesson from melanoma

Abstract

Several researches have been carried over the last few decades to understand of how cancer evades the immune system and thus to identify therapies that could directly act on patient's immune system in the way of restore or induce a response to cancer. As a consequence, "cancer immunotherapy" is conquering predominantly the modern scenario of the fight against cancer. The recent clinical success of immune checkpoint inhibitors (ICIs) has created an entire new class of anti-cancer drugs and restored interest in the field of immuno-oncology, leading to regulatory approvals of several agents for the treatment of a variety of malignancies. The first to be approved in 2011 was the anti-CTLA-4 antibody ipilimumab for the treatment of unresectable or metastatic melanoma. Subsequently, the anti-PD-1s, nivolumab and pembrolizumab, received regulatory approvals for the treatment of melanoma and several other cancers. More recently, three anti-PD-L1 antibodies have received approval: atezolizumab and durvalumab for locally advanced or metastatic urothelial carcinoma and metastatic non-small cell lung cancer (NSCLC) and avelumab for the treatment of locally advanced or metastatic urothelial carcinoma and metastatic Merkel cell carcinoma. This review, starting from the results of melanoma trials, highlights in turn different ICIs and data for different indications in several malignancies are included under each drug class.

http://bit.ly/2SKodO7

Two rare cases of endosalpingiosis in the axillary sentinel lymph nodes: evaluation of immunohistochemical staining and one-step nucleic acid amplification (OSNA) assay in patients with breast cancer

Abstract

Benign inclusions, such as endosalpingiosis, in an axillary sentinel lymph node (SLN) can be misdiagnosed as metastatic breast carcinoma. However, endosalpingiosis is rare in lymph nodes above the diaphragm. Among 792 patients with breast carcinoma who underwent sentinel lymph node biopsy at our center, 2 patients have experienced benign glandular inclusions in 3 SLNs, and all of these glandular inclusions were lined with columnar and ciliated epithelial cells. Immunohistochemistry revealed that the epithelial cells were positive for Müllerian markers (e.g., PAX8 and WT-1) and negative for mammary markers (e.g., mammaglobin, GCDFP-15, and GATA3), which confirm the diagnosis of endosalpingiosis. The epithelial cells were positive for CK19 but the one-step nucleic acid amplification assay revealed negative results for the axillary SLNs. Although endosalpingiosis is rare in axillary SLNs, care is needed to identify these rare cases and avoid unnecessary axillary lymph node dissection, overstaging, and overtreatment.

http://bit.ly/2N3kPbT

Outcome measures to be considered on asthma in elderly

Purpose of review Asthma is a chronic heterogeneous respiratory disease which is characterized by airflow limitation and variable respiratory symptoms. Asthma in patients more than 65 years of age has an important negative impact on quality of life. The pathophysiology and treatment of asthma in older patients are not as well identified as in younger groups of ages. In this review we intend to outline characteristics found in elderly adults which distinguish them from other age groups of patients with asthma. Recent findings With increasing age, there are alterations in the innate and adaptive immune responses, known as 'immunosenescence.' These age-associated modifications include an altered response after a pathogenic exposure or tissue injury, moderately mediated through an irreversible loss of cellular replication and defective tissue repair. Summary Asthma is a consequence of complex gene–environment interactions, with diversity in clinical presentation and the type and intensity of airway inflammation and remodeling. Age-associated changes in lung physiology and morphology may occur and contribute to asthma. Aging is correlated with a notable decrease in elastic recoil, greater chest wall rigidity, and poor respiratory muscle strength. Underreporting of symptoms by elderly patients is common because of multiple underlying causes. Video abstract http://bit.ly/2I7ztAi. Correspondence to Sandra Nora Gonzalez-Diaz, MD, PhD, Monterrey, Nuevo León, Mexico. Tel: +52 (818) 348 2459; e-mail: sgonzalezdiaz@yahoo.com Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-allergy.com). Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

http://bit.ly/2Gl9Qu7

Trends in hospitalizations related to anaphylaxis, angioedema and urticaria in the United States

Allergic disorders are a common clinical disorders with high rates of health care usage.1 Studies from developed countries have suggested an increasing prevalence of allergic diseases. 2–4 However, the data on the epidemiology of anaphylaxis, angioedema and urticaria are limited, with only small cohort studies available. 1,4 Recent studies from the United Kingdom (UK) and Australia have noted marked increase in hospitalizations related to urticaria, angioedema and anaphylaxis.1,4 Epidemiological study and incidence data of these conditions, however, depend on several factors, including diagnostic criteria used, variation in patient surveys, disease incidence in the general population and also diagnostic awareness among physicians.

http://bit.ly/2E6vcc9

Does angioedema influence the quality of life in chronic spontaneous urticaria patients?

Chronic spontaneous urticaria (CSU) symptoms are wheals in a number of cases accompanied by recurrent angioedema. The proportion of CSU patients manifesting both wheals and angioedema and those reporting only one type of symptoms is different - a similar number of patients experience both symptoms or wheals only, whereas 1–13% experience angioedema only1,2. Symptoms of CSU have a detrimental influence on patients' quality of life. Additionally, the coexistence between angioedema symptoms and wheals is related to prolonged disease duration2.

http://bit.ly/2UTwooX

Preventing Carbon Monoxide Poisoning

Once, when working in the ER, I saw a family of four adults and five kids who came in with symptoms of headache and nausea. After getting some more information and doing some additional tests, I confirmed that they were all cases of carbon monoxide poisoning. You can't see or smell carbon monoxide, but at high levels, it can kill a person in minutes.

Carbon monoxide (CO) is produced whenever any fuel such as gas, oil, kerosene, wood or charcoal is burned. If one maintains and uses appliances that burn fuel properly, then the amount of CO produced is usually not hazardous. However, when fuel-burning devices are not properly vented, operated or maintained, CO can build up to dangerous concentrations indoors. According to the Centers for Disease Control and Prevention (CDC), over 400 Americans die every year from accidental CO poisoning that is non-fire related. There are more than 20,000 emergency room visits and over 4,000 hospitalizations related to non-fire related CO poisoning.

Symptoms

It is easy for CO to build up to high levels surreptitiously, especially in the winter months when heaters, furnaces and fireplaces are being used in closed rooms without adequate ventilation. The symptoms at moderate levels of carbon monoxide poisoning include headache, dizziness, confusion, weakness, nausea, vomiting and confusion. High levels can cause unconsciousness and death. Low levels can cause shortness of breath, mild nausea and mild headaches, and may have longer-term effects on your health. When breathed over long periods of time, low concentrations of CO may also contribute to other illnesses. Since many of these symptoms are similar to those of the flu, food poisoning or other illnesses, it's often easy not to think about CO as the cause of these symptoms.

Safety Tips

Fortunately, you can take simple measures to prevent CO problems. One such action is the installation of a CO alarm to detect this potentially deadly gas. Do not consider CO alarms as a replacement to properly working appliances. Also, do not select your CO detectors solely on the basis of cost. Look for Underwriters Laboratories (UL) certification on any detector you purchase. A few additional tips to prevent CO poisoning:

• Have all fuel-burning appliances (furnaces, stoves, space heaters, dryers and water heaters) professionally installed and maintained.
• Never use a portable generator indoors, including in your home, garage, basement, crawlspace, shed or partially-enclosed area – even with ventilation. Opening doors and windows or using fans will not prevent CO buildup in the home.
• Never bring a charcoal grill in an enclosed area – even with ventilation or even in a fireplace.
• Do not use a gas oven to heat your home, even for a short time.
• Do not sleep in any room with an unvented gas or kerosene space heater.
• Install CO alarms near sleeping areas. Alarms can be battery operated, plug-in with battery backup or hardwired with battery backup.
• Have a qualified technician inspect your fuel-burning appliances and chimneys and make sure they are operating correctly and that there is nothing blocking the fumes from being vented out of the house.
• Have a mechanic check the exhaust system of your car or truck every year. A small leak in the exhaust system can lead to a buildup of CO inside the car. Never leave a car running in an attached garage, even with the garage door open.

Helpful Questions To Ask Yourself

Think about these questions with regard to the possibility of CO poisoning in your house:

• Do your symptoms occur only in the house?
• Do they disappear or decrease when you leave home and reappear when you return?
• Is anyone else in your household complaining of similar symptoms? Did everyone's symptoms appear about the same time?
• Are you using any fuel-burning appliances in the home?
• Has anyone inspected your appliances lately? Are you certain they are working properly?

What To Do If You Experience Symptoms

Carbon monoxide is a silent killer. It is colorless, tasteless and odorless. Neither people nor animals can tell when they are breathing it, but it can be fatal. If you experience symptoms that you think could be from CO poisoning, GET FRESH AIR IMMEDIATELY. Open doors and windows, turn off combustion appliances and leave the house. Call 911. Go to the nearest emergency room and tell the physician you suspect CO poisoning.

If CO poisoning has occurred, it can often be diagnosed by a blood test done soon after exposure. When you see the doctor, note that history is more important than symptoms. The most important way to recognize carbon monoxide poisoning is by recognizing the danger signs of behaviors and activities leading up to the moment that symptoms started appearing. In order to determine that your symptoms are related to carbon monoxide poisoning, your doctor may ask you questions about the recent weather, duration of symptoms and activities during that time, such as a family barbecue under the patio. This information can help confirm that your symptoms are truly carbon monoxide poisoning.

The post Preventing Carbon Monoxide Poisoning appeared first on ChildrensMD.

http://bit.ly/2BxWtmh

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds [Biochemistry]

The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein–protein interactions. We have refined crystallization conditions for KRAS169Q61H-yielding crystals suitable for soaking with compounds and exploited this to...

http://bit.ly/2St2yLa

Peptidic degron for IMiD-induced degradation of heterologous proteins [Biochemistry]

Current systems for modulating the abundance of proteins of interest in living cells are powerful tools for studying protein function but differ in terms of their complexity and ease of use. Moreover, no one system is ideal for all applications, and the best system for a given protein of interest...

http://bit.ly/2SRwss5

Mutual interplay between IL-17-producing {gamma}{delta}T cells and microbiota orchestrates oral mucosal homeostasis [Immunology and Inflammation]

γδT cells are a major component of epithelial tissues and play a role in tissue homeostasis and host defense. γδT cells also reside in the gingiva, an oral tissue covered with specialized epithelium that continuously monitors the challenging dental biofilm. Whereas most research on intraepithelial γδT cells focuses on the...

http://bit.ly/2SRwOPr

Zinc depletion does not necessarily induce ribosome hibernation in mycobacteria [Biological Sciences]

In PNAS, Li et al. (1) recently reported analysis of Mycobacterium smegmatis ribosomes formed under zinc-limited conditions. A zinc chelator [N,N,N′,N′-tetrakis(2-pyridylmethyl)-ethylenediamine] was added to growth medium and an extended purification procedure was employed to obtain zinc-depleted (C−) ribosomes for cryo-EM. The structure was solved at 3.5-Å resolution and showed five...

http://bit.ly/2tk0PJa

Transgressive segregation reveals mechanisms of Arabidopsis immunity to Brassica-infecting races of white rust (Albugo candida) [Plant Biology]

Arabidopsis thaliana accessions are universally resistant at the adult leaf stage to white rust (Albugo candida) races that infect the crop species Brassica juncea and Brassica oleracea. We used transgressive segregation in recombinant inbred lines to test if this apparent species-wide (nonhost) resistance in A. thaliana is due to natural...

http://bit.ly/2SRwznv

Reply to Tobiasson et al.: Zinc depletion is a specific signal for induction of ribosome hibernation in mycobacteria [Biological Sciences]

We previously reported (1) in PNAS that zinc depletion in Mycobacterium smegmatis leads to reprogramming of ribosomes in which five ribosomal proteins (r-proteins) with a conserved zinc-finger CXXC motif (C+) are replaced by their paralogs lacking the motif (C−). Notably, the reprogrammed ribosomes enter into a hibernating state by binding...

http://bit.ly/2GCtIbn

Agent-based representations of objects and actions in the monkey pre-supplementary motor area [Neuroscience]

Information about objects around us is essential for planning actions and for predicting those of others. Here, we studied pre-supplementary motor area F6 neurons with a task in which monkeys viewed and grasped (or refrained from grasping) objects, and then observed a human doing the same task. We found "action-related...

http://bit.ly/2UUVBz4

Quantum dots crack the influenza uncoating puzzle [Biophysics and Computational Biology]

One hundred years ago, the devastating 1918–1919 Spanish influenza pandemic took the lives of 50 to 100 million people, or 3 to 5% of the world population (1). Influenza A virus (IAV) pandemics occur when an animal IAV crosses the species barrier, usually by acquiring a new genetic trait by...

http://bit.ly/2SP1uk0

Correction for Su et al., Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria [Corrections]

MICROBIOLOGY Correction for "Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria," by Yu-bin Su, Bo Peng, Hui Li, Zhi-xue Cheng, Tian-tuo Zhang, Jia-xin Zhu, Dan Li, Min-yi Li, Jin-zhou Ye, Chao-chao Du, Song Zhang, Xian-liang Zhao, Man-jun Yang, and Xuan-xian Peng, which was first published January 30,...

http://bit.ly/2Bs5i0T

Species coexistence through competition and rapid evolution [Ecology]

With nature "red in tooth and claw" (1), how do so many species coexist? Why do some species not outcompete the others to extinction? This is a question that has long fascinated ecologists and evolutionary biologists (2), especially given the incredible diversity of seemingly similar species in tropical forests or...

http://bit.ly/2N6yn6I

Ferroptosis as a target for protection against cardiomyopathy [Medical Sciences]

Heart disease is the leading cause of death worldwide. A key pathogenic factor in the development of lethal heart failure is loss of terminally differentiated cardiomyocytes. However, mechanisms of cardiomyocyte death remain unclear. Here, we discovered and demonstrated that ferroptosis, a programmed iron-dependent cell death, as a mechanism in murine...

http://bit.ly/2SRwLDf

Biodiversity conservation of Morlocks in west-central Texas [Evolution]

In PNAS, Devitt et al. (1) present a profoundly interesting and important report of phylogeographic and phylogenetic analyses of a group of salamanders in the genus Eurycea in the Edwards and Trinity aquifers in west-central Texas. These analyses led the authors to extend the scope of their study to analyze...

http://bit.ly/2N4m8Y1

Stimulus complexity shapes response correlations in primary visual cortex [Neuroscience]

Spike count correlations (SCCs) are ubiquitous in sensory cortices, are characterized by rich structure, and arise from structured internal dynamics. However, most theories of visual perception treat contributions of neurons to the representation of stimuli independently and focus on mean responses. Here, we argue that, in a functional model of...

http://bit.ly/2SRwEaN

Magnetic control of graphitic microparticles in aqueous solutions [Applied Physical Sciences]

Graphite is an inexpensive material with useful electrical, magnetic, thermal, and optical properties. It is also biocompatible and used universally as a substrate. Micrometer-sized graphitic particles in solution are therefore ideal candidates for novel lab-on-a-chip and remote manipulation applications in biomedicine, biophysics, chemistry, and condensed-matter physics. However, submerged graphite is...

http://bit.ly/2SRwZu5

Thickness scaling of ferroelectricity in BiFeO3 by tomographic atomic force microscopy [Applied Physical Sciences]

Nanometer-scale 3D imaging of materials properties is critical for understanding equilibrium states in electronic materials, as well as for optimization of device performance and reliability, even though such capabilities remain a substantial experimental challenge. Tomographic atomic force microscopy (TAFM) is presented as a subtractive scanning probe technique for high-resolution, 3D...

http://bit.ly/2SLCY3k

SNARE machinery is optimized for ultrafast fusion [Biophysics and Computational Biology]

SNARE proteins zipper to form complexes (SNAREpins) that power vesicle fusion with target membranes in a variety of biological processes. A single SNAREpin takes about 1 s to fuse two bilayers, yet a handful can ensure release of neurotransmitters from synaptic vesicles much faster: in a 10th of a millisecond....

http://bit.ly/2N6ymzG

Species delimitation in endangered groundwater salamanders: Implications for aquifer management and biodiversity conservation [Evolution]

Groundwater-dependent species are among the least-known components of global biodiversity, as well as some of the most vulnerable because of rapid groundwater depletion at regional and global scales. The karstic Edwards–Trinity aquifer system of west-central Texas is one of the most species-rich groundwater systems in the world, represented by dozens...

http://bit.ly/2N6xvyY

Exploring fast proton transfer events associated with lateral proton diffusion on the surface of membranes [Chemistry]

Proton diffusion (PD) across biological membranes is a fundamental process in many biological systems, and much experimental and theoretical effort has been employed for deciphering it. Here, we report on a spectroscopic probe, which can be tightly tethered to the membrane, for following fast (nanosecond) proton transfer events on the...

http://bit.ly/2SGQa9P

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies [Medical Sciences]

Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can mediate tumor infiltration and confer resistance to antiangiogenic drugs. Unfortunately, this mode of tumor progression is difficult to target...

http://bit.ly/2N6xHhG

Dynamics of frequency-swept nuclear spin optical pumping in powdered diamond at low magnetic fields [Physics]

A broad effort is underway to improve the sensitivity of NMR through the use of dynamic nuclear polarization. Nitrogen vacancy (NV) centers in diamond offer an appealing platform because these paramagnetic defects can be optically polarized efficiently at room temperature. However, work thus far has been mainly limited to single...

http://bit.ly/2N6yijq

Szent-Györgyi Prize to honor NCI’s Steven A. Rosenberg

The 2019 Szent-Györgyi Prize for Progress in Cancer Research will be awarded to NCI's Steven A. Rosenberg, M.D., Ph.D., for his pioneering role in the development of immunotherapy.

http://bit.ly/2TNMHU4

Non Familial Cherubism: A Case Report

Abstract

Cherubism might occur in solitary cases or in several members of the family, often in many generations. Treatment depends on the clinical course of the disease. The reported case is an example of solitary sporadic occurrence within a family, which is a less documented condition in the literature.

http://bit.ly/2N0BFIs

Safety of outpatient admission and comparison of different surgical techniques in adult tonsillectomy

Abstract

Purpose

To investigate the safety of outpatient admission and the effects of surgical technique in tonsillectomy operations of adult patients.

Methods

The digital database was scanned for patients aged ≥ 15 years that underwent tonsillectomy in our institution between years 2014 and 2018. Demographic and clinical characteristics, the surgical technique, length of stay (LOS) in hospital, re-admissions after discharge, complications and interventions performed were recorded.

Results

A total of 276 patients met the inclusion criteria, comprising 139 (50.4%) females and 137 (49.6%) males with a mean age of 27.17 ± 9.41 years. The most common indication was recurrent tonsillitis (n = 223, 80.8%), and surgical techniques used were bipolar scissors (CURIS^®, Sutter Medizintechnik, Germany) (n = 137, 49.6%), cold dissection (n = 75, 27.2%) and/or plasma blade (PEAK Surgical, Medtronic, USA) (n = 64, 23.2%). A total of 43 (15.5%) re-admissions from 37 (13.4%) patients were recorded because of bleeding (n = 33, 70.2%) and/or odynodysphagia (n = 13, 27.7%). Non-surgical interventions were sufficient in 32 (74.4%) cases, while surgical interventions were required in 11 (25.6%) patients. In patients where "hot" techniques (bipolar scissors, plasma blade) were used and in patients with complaints in the first 24 h postoperatively, significantly increased rates of elongated LOS values for more than 1 day were determined (p < 0.01, p < 0.001).

Conclusions

Adult tonsillectomy is a safe surgical procedure with low complication, re-operation and mortality rates. Significantly increased rates of elongated LOS values for more than 1 day and re-admissions after discharge were determined in those patients having complications in the first 24 h postoperatively. Cold dissection seems to be more advisable than hot techniques for outpatient tonsillectomy among adult patients.

http://bit.ly/2BrR687

Non Familial Cherubism: A Case Report

Abstract

Cherubism might occur in solitary cases or in several members of the family, often in many generations. Treatment depends on the clinical course of the disease. The reported case is an example of solitary sporadic occurrence within a family, which is a less documented condition in the literature.

http://bit.ly/2N0BFIs

Development of an Experimental System “Computer-Aided Diagnosis in Neurotology (CADINO)” for Vertigo

Abstract

Computer-based medical diagnosis expert systems, when used by clinicians, familiar with the limitations of the system, were found both accurate and educationally helpful. Vertigo is one of the most common complaints of the patients and the specialists who manage these patients are not easily available. Diagnostic expert system can help clinicians including general practitioners in providing reasonable diagnostic suggestions while dealing with patients with vertigo/dizziness when the specialist doctors are not available. To provide an understanding about the method of making an expert system "Computer-Aided Diagnosis in Neurotology (CADINO)" for dizzy patients and highlight its potential uses. CADINO, developed during this original research project, is an expert computer program which is capable of making diagnoses in patients with vertigo. CADINO includes more than 100 causes of vertigo. It was developed in Microsoft Office using hyperlinks. CADINO has the potential of making diagnoses in patients with vertigo. It differs from most other programs for computer-assisted diagnosis in the generality of its approach and knowledge base. Specific deficiencies of CADINO include its inability to explain its thinking. CADINO can broaden the clinicians' scope and awareness regarding the findings which are important for making the differential diagnoses in patients with vertigo/dizziness. Though the CADINO on its face value seems to improve patient safety and quality of care by enhancing knowledge and cognitive skills of the clinicians, yet it remains a research tool and will need clinical evaluation in terms of diagnostic accuracy.

http://bit.ly/2TKQEsK

Roles of Ki-67 and p16 as biomarkers for unknown primary head and neck squamous cell carcinoma

Abstract

Purpose

Treatment guidelines have not been established for unknown primary head and neck squamous cell carcinoma (SCC). For these patients, chemoradiotherapy (CRT) can provide a better prognosis than that for patients with other head and neck cancers. The presence of HPV in the tumor is associated with a better outcome. However, not all patients with HPV-positive unknown primary head and neck SCC experience good treatment outcomes in actual clinical settings.

Methods

We thus retrospectively determined the Ki-67 proliferation index and p16 expression status to assess the associations of these parameters with treatment outcomes of patients with unknown primary head and neck SCC.

Results

The subjects were 13 patients who underwent CRT after surgery or excision biopsy between 1999 and 2016. The 2- and 5-year overall survival (OS) rate was 76.9% and 68.4%, respectively. The prognostic factor was age. There was no significant difference in survival between patients with a high Ki-67 vs. low Ki-67 or between patients with p16-positive vs. p16-negative metastases OS. However, all p16-positive patients with low Ki-67 showed good locoregional control.

Conclusions

The combination of ki67 expression and p16 expression status may allow prediction of local control more accurately than p16 expression status alone.

http://bit.ly/2TM1Bdl

Effects of azathioprine and its metabolites on inflammatory cytokines in human nasal polyp organ cultures

Background

Oral steroids are recommended for the treatment of nasal polyps (NPs), but prolonged use is avoided because of side effects. Topical steroids can also control NPs without significant complications; however, the response to this is partially successful, and additional therapies are needed to treat glucocorticoid‐resistant NPs. Azathioprine (AZA) and its first metabolite 6‐mercaptopurine (6‐MP) are important immunosuppressants used for the therapy of various diseases. The aim of this study was to investigate the effects of AZA and 6‐MP on inflammatory cytokines in organ‐cultured NPs.

Methods

NP explants were cultured using an air‐liquid interface method. Cultures were maintained in the absence and presence of steroid, AZA, and 6‐MP for 72 hours. Elaboration of cytokines tumor necrosis factor alpha (TNF‐α), interleukin (IL)‐2, IL‐4, IL‐5, and IL‐13 into the supernatant was quantitated using the enzyme‐linked immunosorbent assay (ELISA). The messenger RNA (mRNA) expression levels of TNF‐α, IL‐2, IL‐4, IL‐5, and IL‐13 in cultured mucosa were measured using real‐time polymerase chain reaction. Hematoxylin and eosin staining of cultured mucosa was performed to observe inflammatory cells. Immunohistochemistry was done to evaluate the distribution pattern of inflammatory cytokines in NP explants.

Results

On histologic examination, less inflammatory cell infiltration was found in NPs treated by steroid, AZA, and 6‐MP than in control, but there was no statistical significance (p = 0.218). On immunohistochemistry, IL‐13 showed a steady falling tendency in submucosal glands by steroid, AZA, and 6‐MP. Expression of TNF‐α, IL‐2, IL‐4, IL‐5, and IL‐13 mRNA in the NPs treated by steroid, AZA, and 6‐MP were significantly lower than those of the control (p < 0.001 for all). By ELISA, IL‐2 and IL‐13 were significantly lower with topical steroid, AZA, and 6‐MP treatment (p = 0.012 and p < 0.001).

Conclusion

Topical AZT decreases inflammatory cytokines on human NP explants and this could have future therapeutic implications for NPs.

http://bit.ly/2Gqy99U

Effect of commercial nasal steroid preparation on bacterial growth

Background

Topical budesonide (Pulmicort; AstraZeneca AB, Sodertalje, Sweden) is commonly used in the management of chronic rhinosinusitis (CRS). Although its use is due to its perceived anti‐inflammatory effect, studies have suggested that it may also have antibacterial properties. To make the hydrophobic steroid molecule suitable for topical administration, pharmaceutical excipients are used in commercial steroid formulations. Herein we investigated the antibacterial action of commercial budesonide and its excipients.

Methods

Planktonic and biofilm forms of Staphylococcus aureus and methicillin‐resistant Staphylococcus aureus (MRSA) were treated with Pulmicort or its excipients at clinically relevant concentrations. Bacterial growth was determined by optical density, resazurin assays, colony‐forming unit counts, and Giemsa staining. Minimum inhibitory concentration (MIC) studies assessed excipients' potentiation of antibiotics. Experiments were conducted in triplicate and results analyzed using one‐way analysis of variance.

Results

There was significant reduction in planktonic and biofilm growth of S aureus and MRSA on exposure to budesonide (p < 0.0001) and its excipients (p < 0.0001). Excipient ethylene diamine‐tetraactic acid (EDTA) demonstrated an antibacterial property even at the low concentrations used in topical preparations (p < 0.0001). With amoxicillin, excipients exhibited a potential additive/synergistic effect on MIC, whereas erythromycin and aminoglycosides showed an antagonistic action.

Conclusion

The commercial product Pulmicort has a direct antibacterial effect on the planktonic and biofilm forms of S aureus and MRSA. This effect is at least in part mediated through the excipient EDTA in the product. Excipients also influenced the antimicrobial activity of antibiotics depending on the bacterial strain and antibiotic tested.

http://bit.ly/2Im2jx1

Whole brain g-ratio mapping using myelin water imaging (MWI) and neurite orientation dispersion and density imaging (NODDI)

Jung, W; Lee, J; Shin, H-G; Nam, Y; Zhang, H; Oh, S-H; Lee, J; (2018) Whole brain g-ratio mapping using myelin water imaging (MWI) and neurite orientation dispersion and density imaging (NODDI). NeuroImage , 182 pp. 379-388. 10.1016/j.neuroimage.2017.09.053 . Green open access

http://bit.ly/2GKoquD

New graft manipulation strategies improved outcome of mismatched stem cell transplantation in children with primary immunodeficiencies

Elfeky, R; Shah, RM; Unni, MN; Ottaviano, G; Rao, K; Chiesa, R; Amrolia, P; ... Veys, P; + view all Elfeky, R; Shah, RM; Unni, MN; Ottaviano, G; Rao, K; Chiesa, R; Amrolia, P; Worth, A; Flood, T; Abinun, M; Hambleton, S; Cant, AJ; Gilmour, K; Adams, S; Ahsan, G; Barge, D; Gennery, AR; Qasim, W; Slatter, M; Veys, P; - view fewer (2019) New graft manipulation strategies improved outcome of mismatched stem cell transplantation in children with primary immunodeficiencies. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2019.01.030 . (In press).

http://bit.ly/2trG7qZ

A cancellation theorem for generalized Swan modules

Johnson, FEA; A cancellation theorem for generalized Swan modules. Illinois Journal of Mathematics (In press).

http://bit.ly/2GETwn2

British Thoracic Society Guideline for bronchiectasis in adults

Hill, AT; Sullivan, AL; Chalmers, JD; De Soyza, A; Elborn, JS; Floto, RA; Grillo, L; ... Loebinger, MR; + view all Hill, AT; Sullivan, AL; Chalmers, JD; De Soyza, A; Elborn, JS; Floto, RA; Grillo, L; Gruffydd-Jones, K; Harvey, A; Haworth, CS; Hiscocks, E; Hurst, JR; Johnson, C; Kelleher, WP; Bedi, P; Payne, K; Saleh, H; Screaton, NJ; Smith, M; Tunney, M; Whitters, D; Wilson, R; Loebinger, MR; - view fewer (2019) British Thoracic Society Guideline for bronchiectasis in adults. Thorax , 74 (Suppl 1) pp. 1-69. 10.1136/thoraxjnl-2018-212463 . Green open access

http://bit.ly/2tgnwOr

In memoriam: Professor Philip H. Quanjer

Stocks, J; Steenbruggen, I; (2017) In memoriam: Professor Philip H. Quanjer. European Respiratory Journal , 50 (3) , Article 1701660. 10.1183/13993003.01660-2017 . Green open access

http://bit.ly/2GDPtHR

Biosocial spaces and neurocomputational governance: brain-based and brain-targeted technologies in education

Williamson, B; Pykett, J; Nemorin, S; (2018) Biosocial spaces and neurocomputational governance: brain-based and brain-targeted technologies in education. Discourse: Studies in the Cultural Politics of Education , 39 (2) pp. 258-275. 10.1080/01596306.2018.1394421 .

http://bit.ly/2tjiD7l

Population receptive field tuning properties of visual cortex during childhood

Dekker, T; Schwarzkopf, S; De Haas, B; Nardini, M; Sereno, M; (2019) Population receptive field tuning properties of visual cortex during childhood. Developmental Cognitive Neuroscience 10.1016/j.dcn.2019.01.001 . (In press). Green open access

http://bit.ly/2GDIb6Y

Identifying posture cells in the brain

Chen, G; (2018) Identifying posture cells in the brain. Science , 362 (6414) pp. 520-521. 10.1126/science.aav3819 .

http://bit.ly/2tjIhZy

I paladini di Calvino, Gianini e Luzzati, e Monicelli: memoria del fascismo, storia delle emozioni, parodia

Sica, B; (2019) I paladini di Calvino, Gianini e Luzzati, e Monicelli: memoria del fascismo, storia delle emozioni, parodia. Cahiers d'études romanes (In press).

http://bit.ly/2GEAe1a

Proceedings of the 4th International Genetic Improvement Workshop, , GI@ICSE 2018, Gothenburg, Sweden, June 2, 2018

Petke, J; Stolee, KT; Langdon, WB; Weimer, W; (2018) Proceedings of the 4th International Genetic Improvement Workshop, , GI@ICSE 2018, Gothenburg, Sweden, June 2, 2018. In: Proceedings of the 4th International Workshop on Genetic Improvement Workshop. ACM Green open access

http://bit.ly/2tgm66s

Monogenic mimics of Behçet's disease in the young

Papadopoulou, C; Omoyinmi, E; Standing, A; Pain, CE; Booth, C; D'Arco, F; Gilmour, K; ... Brogan, PA; + view all Papadopoulou, C; Omoyinmi, E; Standing, A; Pain, CE; Booth, C; D'Arco, F; Gilmour, K; Buckland, M; Eleftheriou, D; Brogan, PA; - view fewer (2019) Monogenic mimics of Behçet's disease in the young. Rheumatology , Article key445. 10.1093/rheumatology/key445 . (In press).

http://bit.ly/2GCe3sA

Log-Likelihood Clustering-Enabled Passive RF Sensing for Residential Activity Recognition

Li, W; Tan, B; Xu, Y; Piechocki, RJ; (2018) Log-Likelihood Clustering-Enabled Passive RF Sensing for Residential Activity Recognition. IEEE Sensors Journal , 18 (13) pp. 5413-5421. 10.1109/JSEN.2018.2834739 . Green open access

http://bit.ly/2tjQU6f

Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA

Pinto Pereira, SM; Stein Merkin, S; Seeman, T; Power, C; (2019) Understanding associations of early-life adversities with mid-life inflammatory profiles: Evidence from the UK and USA. Brain, Behavior, and Immunity 10.1016/j.bbi.2019.01.016 . (In press).

http://bit.ly/2GDN93x

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

Renders, M; Dumbre, S; Abramov, M; Kestemont, D; Margamuljana, L; Largy, E; Cozens, C; ... Herdewijn, P; + view all Renders, M; Dumbre, S; Abramov, M; Kestemont, D; Margamuljana, L; Largy, E; Cozens, C; Vandenameele, J; Pinheiro, VB; Toye, D; Frère, J-M; Herdewijn, P; - view fewer (2019) Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases. Nucleic Acids Research 10.1093/nar/gkz008 . (In press). Green open access

http://bit.ly/2tjQPiX

Effectiveness of a volunteer befriending programme for patients with schizophrenia – a randomised controlled trial

Priebe, S; Chevalier, A; Hamborg, T; Golden, E; King, M; Pistrang, N; (2019) Effectiveness of a volunteer befriending programme for patients with schizophrenia – a randomised controlled trial. British Journal of Psychiatry (In press).

http://bit.ly/2GFMC0P

Underestimating the true impact of obesity – Authors' reply

Nyberg, ST; Batty, GD; Kivimaki, M; (2019) Underestimating the true impact of obesity – Authors' reply. Lancet Public Health , 4 (1) e17-e17. 10.1016/S2468-2667(18)30260-3 . Green open access

http://bit.ly/2tjQ9dp

Protect to damage? Institutional work, unintended consequences and institutional dynamics

Song, EY; (2019) Protect to damage? Institutional work, unintended consequences and institutional dynamics. Organization Studies 10.1177/0170840618814564 . (In press). Green open access

http://bit.ly/2GDMUWb

Genetic Improvement of Software (Dagstuhl Seminar 18052)

Petke, J; Le Goues, C; Forrest, S; Langdon, WB; (2018) Genetic Improvement of Software (Dagstuhl Seminar 18052). In: Dagstuhl Reports. (pp. pp. 158-182). Dagstuhl Publishing Green open access

http://bit.ly/2tmawXi

Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial

Anderson, IM; Blamire, A; Branton, T; Clark, R; Downey, D; Dunn, G; Easton, A; ... McAllister-Williams, RH; + view all Anderson, IM; Blamire, A; Branton, T; Clark, R; Downey, D; Dunn, G; Easton, A; Elliott, R; Elwell, C; Hayden, K; Holland, F; Karim, S; Loo, C; Lowe, J; Nair, R; Oakley, T; Prakash, A; Sharma, PK; Williams, SR; McAllister-Williams, RH; - view fewer (2017) Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial. Lancet Psychiatry , 4 (5) pp. 365-377. 10.1016/S2215-0366(17)30077-9 . Green open access

http://bit.ly/2GDMM99

Teaching as a research-engaged profession: Uncovering a blind spot and revealing new possibilities

Lambert, D; (2018) Teaching as a research-engaged profession: Uncovering a blind spot and revealing new possibilities. London Review of Education , 16 (3) pp. 357-370. 10.18546/LRE.16.3.01 . Green open access

http://bit.ly/2tiCX8L

Ein 7‑jähriger Junge mit leicht juckenden, weißlichen, stecknadelkopfgroßen Papeln

http://bit.ly/2IhG5MC

HPV as a marker for molecular characterization in head and neck oncology: Looking for a standardization of clinical use and of detection method(s) in clinical practice

Abstract

Background

A consensus about the most appropriate diagnostic method(s) for head and neck human papillomavirus (HPV)‐induced carcinogenesis is still lacking because most of the commercially available assays have been designed for the cervix.

Methods

This article summarizes current data and trends concerning HPV diagnostic strategies in oropharyngeal squamous cell carcinoma (OPSCC). Six main approaches are described.

Results

The diagnostic gold standard for HPV‐related OPSCC, focusing on E6/E7 mRNA detection, requires fresh samples. Because most frequently available samples are formalin‐fixed paraffin‐embedded (FFPE), the pros and cons of the different approaches were analyzed.

Conclusions

In the FFPE samples, the immunohistochemistry of p16, which is considered appropriate to assess HPV‐driven carcinogenesis in OPSCC according to the 8th American Joint Committee on Cancer TNM classification, may not be specific enough to become the diagnostic standard in the perspective of treatment deintensification. p16 may play a safer role in combination with another highly sensible assay. Other promising approaches are based on DNA detection through real‐time polymerase chain reaction and RNAscope.

http://bit.ly/2GFdCxO

Development of an Experimental System “Computer-Aided Diagnosis in Neurotology (CADINO)” for Vertigo

Abstract

Computer-based medical diagnosis expert systems, when used by clinicians, familiar with the limitations of the system, were found both accurate and educationally helpful. Vertigo is one of the most common complaints of the patients and the specialists who manage these patients are not easily available. Diagnostic expert system can help clinicians including general practitioners in providing reasonable diagnostic suggestions while dealing with patients with vertigo/dizziness when the specialist doctors are not available. To provide an understanding about the method of making an expert system "Computer-Aided Diagnosis in Neurotology (CADINO)" for dizzy patients and highlight its potential uses. CADINO, developed during this original research project, is an expert computer program which is capable of making diagnoses in patients with vertigo. CADINO includes more than 100 causes of vertigo. It was developed in Microsoft Office using hyperlinks. CADINO has the potential of making diagnoses in patients with vertigo. It differs from most other programs for computer-assisted diagnosis in the generality of its approach and knowledge base. Specific deficiencies of CADINO include its inability to explain its thinking. CADINO can broaden the clinicians' scope and awareness regarding the findings which are important for making the differential diagnoses in patients with vertigo/dizziness. Though the CADINO on its face value seems to improve patient safety and quality of care by enhancing knowledge and cognitive skills of the clinicians, yet it remains a research tool and will need clinical evaluation in terms of diagnostic accuracy.

http://bit.ly/2TKQEsK

Radiotherapy Plus Concurrent Nimotuzumab or Cisplatin in Stage II-III Nasopharyngeal Carcinoma

Conditions:   Nasopharyngeal Carcinoma;   Nasopharyngeal Neoplasms;   Nasopharyngeal Diseases;   Head and Neck Neoplasm
Interventions:   Drug: Nimotuzumab;   Drug: Cisplatin
Sponsors:   Sun Yat-sen University;   Affiliated Cancer Hospital & Institute of Guangzhou Medical University;   Guangdong General Hospital;   First Affiliated Hospital, Sun Yat-Sen University
Recruiting

http://bit.ly/2Go1ge2

Ponatinib in Advanced or Metastatic Medullary Thyroid Cancer

Condition:   Medullary Thyroid Cancer
Intervention:   Drug: Ponatinib
Sponsors:   Antonio Fojo;   Millennium Pharmaceuticals, Inc.
Not yet recruiting

http://bit.ly/2Ia7foi

Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer

Condition:   Oropharynx Cancer
Interventions:   Drug: Nivolumab;   Radiation: Chemoradiation
Sponsor:   UNICANCER
Not yet recruiting

http://bit.ly/2Ia764e

Role of Microbiome as a Biomarkers in Locoregionally-Advanced Oropharyngeal Squamous Cell Carcinoma 2

Condition:   Head and Neck Squamous Cell Carcinoma
Intervention:   Drug: MET-4
Sponsors:   University Health Network, Toronto;   NuBiyota
Not yet recruiting

http://bit.ly/2GpiFTq

A Single Dry Needling Session of the Obliquus Capitis Inferior for the Altered Sensorimotor Function in People With Neck Pain

Conditions:   Whiplash Syndrome;   Neck Pain
Interventions:   Other: dry needling;   Other: Sham needling
Sponsor:   University of Valencia
Recruiting

http://bit.ly/2Ia6XxI

Radikale Prostatektomie beim lokal fortgeschrittenen und metastasierten Prostatakarzinom

Zusammenfassung

Hintergrund

Der Anteil der Patienten mit lokal fortgeschrittenem oder (oligo)metastasiertem Prostatakarzinom (PCa) hat in den letzten Jahren zugenommen. Im Vergleich zu Patienten mit lokalisiertem PCa ist ohne eine Lokaltherapie das Risiko lokaler Komplikationen höher und die onkologischen Ergebnisse schlechter.

Ziel

Der Stellenwert der radikalen Prostatektomie (RP) bei klinisch lokal fortgeschrittenem oder metastasiertem Prostatakarzinom wird erörtert.

Material und Methoden

Es erfolgten eine systematische Literaturrecherche und Zusammenstellung relevanter Artikel aus PubMed und Medline.

Ergebnisse

Aktuelle Leitlinien empfehlen die RP als eine der Behandlungsoptionen bei Patienten mit lokal fortgeschrittenem PCa. Die Durchführung einer RP bei Patienten mit metastasiertem PCa hingegen sollte nur innerhalb klinischer Studien durchgeführt werden. Im Vergleich zu Patienten ohne eine lokale Behandlung verringert die RP das Risiko lokaler Komplikationen deutlich. Während beim lokal fortgeschrittenen PCa ein klarer onkologischer Nutzen für die RP gezeigt werden konnte, ist der Nutzen bei Patienten mit metastasierten Erkrankungen immer noch umstritten. Aufgrund schwierigerer Operationsbedingungen und einer erhöhten Wahrscheinlichkeit für ein multimodales Therapiekonzept werden in der Literatur eine höhere perioperative Morbidität und schlechtere funktionelle Ergebnisse im Vergleich zu Patienten mit lokalisiertem PCa berichtet.

Schlussfolgerung

Während die RP für Patienten mit lokal fortgeschrittenem PCa genauso wie im lokalisierten Stadium durchgeführt werden kann, muss der Nutzen bei Vorliegen einer metastasierten Erkrankung weiter geklärt werden. Alle Patienten, die sich einer RP unterziehen, müssen besonders im Hinblick auf das mögliche schlechtere funktionelle Ergebnis beraten werden.

http://bit.ly/2GnCxXh

Gastrointestinal stromal tumor of the lesser omentum: a case report and review of the literature

Abstract

A 72-year-old woman visited our hospital for a routine health examination and underwent abdominal ultrasonography, which revealed an intra-abdominal tumor. Abdominal computed tomography and magnetic resonance imaging showed a well-defined solid mass of ~3 cm in diameter lying adjacent to the stomach. The mass was preoperatively diagnosed as gastrointestinal stromal tumor of the stomach. At laparotomy, a well-encapsulated tumor was found in the lesser omentum. It was slightly adherent to the stomach wall but was removed without difficulty. Therefore, only enucleation of the tumor was performed. The excised tumor, which was 35 × 30 × 25 mm³ in size, had a white cut surface without necrosis or hemorrhage. According to the pathological findings, the tumor was classified as a very low-risk gastrointestinal stromal tumor originating in the lesser omentum. Gastrointestinal stromal tumor of the lesser omentum is very rare, and surgical resection is the only effective treatment modality.

http://bit.ly/2GoeDdY

Perforation of Heterotopic Gastric Mucosa in ileal duplication in an adult: A case report

Abstract

Bowel duplication with heterotopic gastric mucosa (HGM) is a known but uncommon pathology. It usually presents with intussusception or melena in the early years of life. We present a case of ileal duplication with HGM with a rare presentation of bowel perforation and peritonitis in an adult male.

http://bit.ly/2IhvPE6

Massive adult cystic lymphangioma of the breast

Abstract

Adult cystic lymphangiomas are exceedingly rare tumors resulting from malformation of the lymphatic vessels. Like their pediatric counterparts, these lesions almost exclusively involve the head and neck. However, adult cystic lymphangiomas have been reported in several organs. Those involving the breast are exceptionally rare, with only a few reported instances. Here, we present the case of a 27-year-old woman who attended a surgical breast clinic with a 2-year history of a large, disfiguring left breast mass. Pathology was consistent with adult cystic lymphangioma of the breast. Measuring 21.0 × 20.0 × 6.0 cm³, this represents the second largest of its kind and the largest reported case in an African American patient.

http://bit.ly/2GmoZeG

Approach to a large rare diaphragmatic hernia in a patient undergoing cardiac surgery

Abstract

Hernia of Morgagni is an unusual congenital defect of the sternal portion of the diaphragm. Its concurrence with cardiac surgical pathology is rarely described in the literature. Notwithstanding, huge hernia of Morgagni have been noted to cause serious peri-operative impediment and complications. We report the case of a 50-year-old gentleman with a massive Morgagni hernia that threatened strangulation during cardiopulmonary bypass. We describe the combined surgical approach undertaken to repair this hernia, with an accompanying review of the literature relating to misadventure and management of similar large hernia coinciding with cardiac surgery.

http://bit.ly/2I9NSvM

Recurrent acute pancreatitis in a patient with both gallbladder and cystic duct agenesis and polycystic liver disease

Abstract

Agenesis of the gallbladder and cystic duct is a rare congenital anomaly occurring in <0.1% of the population. However, combined gallbladder and cystic duct agenesis (CDA) with polycystic liver disease associated with recurrent acute pancreatitis (RAP) has not been reported earlier. Herein we report a case of a 36-year-old female patient who was admitted to the hospital and successfully treated for acute pancreatitis most probably caused in the background of gallbladder and CDA with polycystic liver disease. In case of non-visualization of gallbladder with the presence of biliary symptoms after repeated ultrasonographic examinations, advanced techniques like MRCP, computed tomography, EUS and even endoscopic retrograde cholangiopancreatography (ERCP) to visualize biliary anatomy must be conducted before any surgical intervention. We present a case of gallbladder and CDA causing RAP by the formation of microlithiasis treated successfully with ERCP and without any unnecessary surgery, its management and review of the literature is assessed.

http://bit.ly/2GkWNsx

Spontaneous regression of a sporadic intra-abdominal located desmoid-type fibromatosis

Abstract

Background

Desmoid-type fibromatosis (DTF) is a rare benign proliferation of myofibroblasts with an unpredictable disease course. Treatment of intra-abdominal located DTF is difficult because of the close relationship with vital organs.

Case presentation

A healthy young male presents with an asymptomatic palpable mass in the lower right abdominal quadrant. A computed tomography shows a 10 × 7 cm² pear-shaped mass, and pathological examination revealed DTF. A watchful waiting approach was initiated, as the patient was asymptomatic and surgery would imply a significant amount of intestinal resection. After a follow-up of 2 years, the tumor has regressed spontaneously and the patient is still without symptoms.

Conclusions

DTF is a difficult to treat condition where individualized management is appropriate. An asymptomatic patient could be treated with a watchful waiting approach, even with intra-abdominal location. Thereby sparing unnecessary morbidity as the tumor can be stable for many years or even regress spontaneously.

http://bit.ly/2I8Ge4M

Madurella mycetomatis infection of the buttock in an Eritrean refugee in Switzerland: a case report

Mycetoma is a neglected infectious disease caused by a fungus (eumycetoma) or bacteria (actinomycetoma); it is characterized by chronic local inflammation with sinus formation and purulent discharge. Its cours...

http://bit.ly/2GEeO4v

Does climate change influence people’s migration decisions in Maldives?

Kelman, I; Orlowska, J; Upadhyay, H; Stojanov, R; Webersik, C; Simonelli, AC; Procházka, D; Kelman, I; Orlowska, J; Upadhyay, H; Stojanov, R; Webersik, C; Simonelli, AC; Procházka, D; Němec, D; - view fewer (2019) Does climate change influence people's migration decisions in Maldives? Climatic Change 10.1007/s10584-019-02376-y . (In press). Green open access

http://bit.ly/2TH3MyN

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)

Strauss, VY; Shaw, R; Virdee, PS; Hurt, CN; Ward, E; Tranter, B; Patel, N; ... Mukherjee, S; + view all Strauss, VY; Shaw, R; Virdee, PS; Hurt, CN; Ward, E; Tranter, B; Patel, N; Bridgewater, J; Parsons, P; Radhakrishna, G; O'Neill, E; Sebag-Montefiore, D; Hawkins, M; Corrie, PG; Maughan, T; Mukherjee, S; - view fewer (2019) Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2). BMC Cancer , 19 , Article 121. 10.1186/s12885-019-5307-z . Green open access

http://bit.ly/2BytLl1

Operando spectroscopy study of the carbon dioxide electro-reduction by iron species on nitrogen-doped carbon

Genovese, C; Schuster, ME; Gibson, E; Gianolio, D; Posligua, V; Grau-Crespo, R; Cibin, G; ... Arrigo, R; + view all Genovese, C; Schuster, ME; Gibson, E; Gianolio, D; Posligua, V; Grau-Crespo, R; Cibin, G; Wells, PP; Garai, D; Solokha, V; Krick Calderon, S; Velasco-Velez, JJ; Ampelli, C; Perathoner, S; Held, G; Centi, G; Arrigo, R; - view fewer (2018) Operando spectroscopy study of the carbon dioxide electro-reduction by iron species on nitrogen-doped carbon. Nature Communications , 9 , Article 935. 10.1038/s41467-018-03138-7 . Green open access

http://bit.ly/2TLRy8f

Cognitive mapping style relates to posterior-anterior hippocampal volume ratio

Brunec, IK; Robin, J; Patai, EZ; Ozubko, JD; Javadi, A-H; Barense, MD; Spiers, HJ; Brunec, IK; Robin, J; Patai, EZ; Ozubko, JD; Javadi, A-H; Barense, MD; Spiers, HJ; Moscovitch, M; - view fewer (2019) Cognitive mapping style relates to posterior-anterior hippocampal volume ratio. Hippocampus 10.1002/hipo.23072 . Green open access

http://bit.ly/2BrpwrB

The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study

Thanapirom, K; Treeprasertsuk, S; Soonthornworasiri, N; Poovorawan, K; Chaiteerakij, R; Komolmit, P; Phaosawasdi, K; Thanapirom, K; Treeprasertsuk, S; Soonthornworasiri, N; Poovorawan, K; Chaiteerakij, R; Komolmit, P; Phaosawasdi, K; Pinzani, M; - view fewer (2019) The incidence, etiologies, outcomes, and predictors of mortality of acute liver failure in Thailand: a population-base study. BMC Gastroenterology , 19 , Article 18. 10.1186/s12876-019-0935-y . Green open access

http://bit.ly/2TLRoOb

Axioms and Actions for Preventing Disasters

Kelman, I; (2019) Axioms and Actions for Preventing Disasters. Progress in Disaster Science (In press).

http://bit.ly/2Bz393t

Annotation of gene product function from high-throughput studies using the Gene Ontology

Attrill, H; Gaudet, P; Huntley, RP; Lovering, RC; Engel, SR; Poux, S; Van Auken, KM; ... Gene Ontology Consortium, ; + view all Attrill, H; Gaudet, P; Huntley, RP; Lovering, RC; Engel, SR; Poux, S; Van Auken, KM; Georghiou, G; Chibucos, MC; Berardini, TZ; Wood, V; Drabkin, H; Fey, P; Garmiri, P; Harris, MA; Sawford, T; Reiser, L; Tauber, R; Toro, S; Gene Ontology Consortium, ; - view fewer (2019) Annotation of gene product function from high-throughput studies using the Gene Ontology. Database , 2019 , Article baz007. 10.1093/database/baz007 . (In press). Green open access

http://bit.ly/2TFFcOZ

SIG on Telepresence Robots

El mimouni, Houda; Fussell, Susan R.; Herring, Susan; Neustaedter, Carman; Rode, Jennifer; (2018) SIG on Telepresence Robots. Presented at: CHI Conference on Human Factors in Computing Systems, Montreal QC, Canada. Green open access

http://bit.ly/2BxdNb3

Editorial

Blakemore, S-J; (2019) Editorial. Developmental Cognitive Neuroscience , Article 100617. 10.1016/j.dcn.2019.100617 . (In press). Green open access

http://bit.ly/2TLR9Th

The Core Techniques of Morenian Psychodrama: A Systematic Review of Literature

Cruz, A; Sales, CMD; Alves, P; Moita, G; (2018) The Core Techniques of Morenian Psychodrama: A Systematic Review of Literature. Frontiers in Psychology , 9 , Article 1263. 10.3389/fpsyg.2018.01263 . Green open access

http://bit.ly/2BwXyuu

Atypical intrinsic neural timescale in autism

Watanabe, T; Rees, G; Masuda, N; (2019) Atypical intrinsic neural timescale in autism. eLife , 8 , Article e42256. 10.7554/eLife.42256 . Green open access

http://bit.ly/2TKTyO1

Parents’ views and experiences of talking about autism with their children

Crane, L; Jones, L; Prosser, R; Taghrizi, M; Pellicano, E; (2019) Parents' views and experiences of talking about autism with their children. Autism (In press).

http://bit.ly/2BvHGbu

First do no harm: the Hippocratic oath as an inspiration for compassionate architecture

Chrysikou, E; First do no harm: the Hippocratic oath as an inspiration for compassionate architecture. In: Neighbourhoods of the future: creating a brighter future for our older selves. (pp. 210-215). Agile Ageing Alliance

http://bit.ly/2TKAWhg

Taking the gilt off the gingerbread: Reverberations of the metrics cult (ure) on the theory of social representations

Tomicic, A; (2018) Taking the gilt off the gingerbread: Reverberations of the metrics cult (ure) on the theory of social representations. Papers on Social Representations , 27 (2) 5.1-5.22. Green open access

http://bit.ly/2BtehPi

The Assessment of Trait Emotional Intelligence: Psychometric Characteristics of the TEIQue-Full Form in a Large Italian Adult Sample

Chirumbolo, A; Picconi, L; Morelli, M; Petrides, KV; (2019) The Assessment of Trait Emotional Intelligence: Psychometric Characteristics of the TEIQue-Full Form in a Large Italian Adult Sample. Frontiers in Psychology , 9 , Article 2786. 10.3389/fpsyg.2018.02786 . Green open access

http://bit.ly/2TLQPnx

Overcoming barriers to using precision teaching with a web-based programme

Hayes, B; Heather, A; Jones, D; Clarke, C; (2018) Overcoming barriers to using precision teaching with a web-based programme. Educational Psychology in Practice , 34 (2) pp. 166-174. 10.1080/02667363.2018.1433129 .

http://bit.ly/2ByG4xN

Mood and Learning in Health Care Settings

Mohamad Nazry, NN; (2017) Mood and Learning in Health Care Settings. Health Care : Current Reviews , 05 (03) 10.4172/2375-4273.1000202 . Green open access

http://bit.ly/2TLQSzJ

Statistics Notes: Percentage differences, symmetry, and natural logarithms

Cole, TJ; Altman, DG; (2017) Statistics Notes: Percentage differences, symmetry, and natural logarithms. BMJ , 358 , Article j3683. 10.1136/bmj.j3683 . Green open access

http://bit.ly/2ByG8O3

How effective are targeted interventions for externalising behaviour when delivered in primary schools?

O'Connor, K; Hayes, BJ; (2018) How effective are targeted interventions for externalising behaviour when delivered in primary schools? International Journal of School & Educational Psychology 10.1080/21683603.2018.1530157 . (In press).

http://bit.ly/2TLQC3J

Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation

Ma, D; Holmes, HE; Cardoso, MJ; Modat, M; Harrison, IF; Powell, NM; O'Callaghan, JM; ... Ourselin, S; + view all Ma, D; Holmes, HE; Cardoso, MJ; Modat, M; Harrison, IF; Powell, NM; O'Callaghan, JM; Ismail, O; Johnson, RA; O'Neill, MJ; Collins, EC; Beg, MF; Popuri, K; Lythgoe, MF; Ourselin, S; - view fewer (2019) Study the Longitudinal in vivo and Cross-Sectional ex vivo Brain Volume Difference for Disease Progression and Treatment Effect on Mouse Model of Tauopathy Using Automated MRI Structural Parcellation. Frontiers in Neuroscience , 13 , Article 11. 10.3389/fnins.2019.00011 . Green open access

http://bit.ly/2Brpos7

Factors of success of low‐dose macrolides in chronic sinusitis: Systematic review and meta‐analysis

Objective

To assess the prognostic factors that predict favorable outcomes of low‐dose macrolides (LDMs) in treating chronic rhinosinusitis (CRS).

Methods

Randomized controlled trials studying the effects of LDMs in treating CRS were included. Data were pooled for meta‐analysis. Primary outcome was Sino‐Nasal Outcome Test (SNOT). Six prognostic factors: CRS subtypes, serum immunoglobulin (Ig)E level, membered lactone ring of macrolides, concurrent endoscopic sinus surgery (ESS), and dosage and duration of the LDMs were assessed by subgroup analyses.

Results

Ten studies (608 patients) met the inclusion criteria. LDMs and placebo were not different in SNOT improvement (standardized mean difference [SMD] = −0.23, 95% confidence interval [CI]: −0.69 to 0.24). Subgroup analyses showed that the effects favored LDMs in the patients with CRS without polyps (SMD = −0.64, 95% CI: −1.01 to −0.27) compared to CRS with polyps, and the patients receiving a half dose (SMD = −0.64, 95% CI: −1.01 to −0.27) compared to a very low dose. There was no difference in SNOT improvement between LDMs plus standard treatment compared to standard treatment (SMD = −0.52, 95% CI: −1.57 to 0.53). Subgroup analyses showed that the effects favored LDMs in the patients receiving LDMs for a duration of 24 weeks (SMD = −1.68, 95% CI: −2.40 to −0.95) compared to 8 and 12 weeks. There was no difference between the 14‐membered and 15‐membered ring LDMs. Assessment of concurrent ESS found mixed results. Serum IgE level could not be assessed.

Conclusions

LDMs provided favorable outcomes in patients with CRS without polyps. A half dose of macrolides should be given for a duration of 24 weeks.

Level of Evidence

1a Laryngoscope, 2019

http://bit.ly/2Sq8YL3

In reference to pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury

http://bit.ly/2DumByC

Therapieoptionen des lokal begrenzten Prostatakarzinoms

Zusammenfassung

Etablierte Therapieoptionen des lokalisierten Prostatakarzinoms (T1–2N0M0 [T: Tumorgrad, N: Lymphknotenstatus, M: Metastasen]), welche aufgrund des üblicherweise langsamen Krankheitsverlaufs bei Patienten mit einer Lebenserwartung von mindestens 10 Jahren empfohlen werden, sind die aktive Überwachung, die radikale Prostatektomie, die Brachytherapie und die perkutane Bestrahlung. Die Wahl der Therapieform orientiert sich am Tumorstadium bzw. der Risikogruppe, den Komorbiditäten sowie der Patientenpräferenz. Neben dem onkologischen Ergebnis sind die potenziellen Nebenwirkungen der jeweiligen Lokaltherapie mit dem Betroffenen zu diskutieren, wobei insbesondere Einschränkungen der Harnkontinenz und Erektionsfähigkeit möglich sind.

http://bit.ly/2RVHQOT

Langzeitlebensqualität bei Patienten mit Kopf-Hals-Tumoren

Zusammenfassung

Hintergrund

Die Diagnose eines Kopf-Hals-Tumors geht zwar nicht mit einer vielversprechenden Langzeitprognose einher, aber je nach Art des Tumors überleben annähernd 50 % der Patienten wenigsten 5 Jahre. Es gibt nur wenige wissenschaftliche Belege für die Lebensqualität dieser Langzeitüberlebenden.

Methoden

In der Datenbank PubMed wurde eine Suche nach Artikeln durchgeführt, die Ergebnisse zur Lebensqualität für Patienten mit einem Kopf-Hals-Tumor und einem Überleben von mindestens 5 Jahren enthalten.

Ergebnisse

Dabei wurden 8 Studien aus verschiedenen Ländern gefunden, in denen 4 verschiedene Messinstrumente verwendet wurden. Die Ergebnisse zeigen, dass die Überlebenden vor allem Schwierigkeiten mit dem Schlafen, Schmerzen, Fatigue, Dyspnoe, Schlucken und Kauen haben; die funktionellen Werte waren manchmal niedriger (schlechter) als die Ergebnisse in der Allgemeinbevölkerung, in einem Fall aber auch gleich.

Schlussfolgerung

Weiterhin fehlt ein klares Bild über die Lebensqualität in dieser speziellen Patientengruppe. Es gibt wissenschaftliche Belege dafür, dass einige Patienten Schwierigkeiten mit dem Schlucken und einen trockenen Mund haben sowie Probleme mit dem Schlafen, Fatigue, Schmerzen und Dyspnoe. Eine Studie mit einer großen Stichprobe aus dieser speziellen Patientengruppe ist erforderlich.

http://bit.ly/2SLo8dd

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2

Abstract

Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion interleukin-2 (IL-2), for which high dose is standard. To assess a modified TIL protocol using lower dose IL-2, we performed a single institution phase II protocol in unresectable, metastatic melanoma. The primary endpoint was response rate. Secondary endpoints were safety and assessment of immune correlates following TIL infusion. Twelve metastatic melanoma patients were treated with non-myeloablative lymphodepleting chemotherapy, TIL, and low-dose subcutaneous IL-2 (125,000 IU/kg/day, maximum 9–10 doses over 2 weeks). All but one patient had previously progressed after treatment with immune checkpoint inhibitors. No unexpected adverse events were observed, and patients received an average of 6.8 doses of IL-2. By RECIST v1.1, two patients experienced a partial response, one patient had an unconfirmed partial response, and six had stable disease. Biomarker assessment confirmed an increase in IL-15 levels following lymphodepleting chemotherapy as expected and a lack of peripheral regulatory T-cell expansion following protocol treatment. Interrogation of the TIL infusion product and monitoring of the peripheral blood following infusion suggested engraftment of TIL. In one responding patient, a population of T cells expressing a T-cell receptor Vβ chain that was dominant in the infusion product was present at a high percentage in peripheral blood more than 2 years after TIL infusion. This study shows that this protocol of low-dose IL-2 following adoptive cell transfer of TIL is feasible and clinically active. (ClinicalTrials.gov identifier NCT01883323.)

http://bit.ly/2RX8p6u

Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus

Abstract

Introduction

Metastatic renal cell cancer (mRCC) patients have a median overall survival (mOS) of approximately 28 months. Until recently, mammalian target of rapamycin (mTOR) inhibition with everolimus was the standard second-line treatment regimen for mRCC patients, improving median progression-free survival (mPFS). Treatment with everolimus supports the expansion of immunosuppressive regulatory T cells (Tregs), which exert a negative effect on antitumor immune responses. In a phase 1 dose-escalation study, we have recently demonstrated that a low dose of 50 mg oral cyclophosphamide once daily can be safely combined with everolimus in mRCC patients and prevents the everolimus-induced increase in Tregs.

Materials and methods

In a multicenter phase 2 study, performed in patients with mRCC not amenable to or progressive on a vascular endothelial growth factor (VEGF)-receptor tyrosine kinase inhibitor (TKI) containing treatment regimen, we assessed whether the addition of this metronomic dosing schedule of cyclophosphamide to therapy with everolimus could result in an improvement of progression-free survival (PFS) after 4 months of treatment.

Results

Though results from this study confirmed that combination treatment effectively lowered circulating levels of Tregs, addition of cyclophosphamide did not improve the PFS rate at 4 months. For this reason, the study was abrogated at the predefined interim analysis.

Conclusion

Although the comprehensive immunomonitoring analysis performed in this study provides relevant information for the design of future immunotherapeutic approaches, the addition of metronomic cyclophosphamide to mRCC patients receiving everolimus cannot be recommended.

http://bit.ly/2WYr7yf

Editorial Board

Publication date: March 2019

Source: Molecular Immunology, Volume 107

Author(s):

http://bit.ly/2IbBzPw

Does angioedema influence the quality of life in chronic spontaneous urticaria patients?

Publication date: Available online 12 February 2019

Source: Annals of Allergy, Asthma & Immunology

Author(s): A. Oles-Krykowska, K. Badura-Brzoza, Z. Brzoza

http://bit.ly/2UW1VGW

Identification of Four Novel Mutations in MYO7A Gene and Their Association with Nonsyndromic Deafness and Usher Syndrome 1B

Publication date: Available online 11 February 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Yunlong Li, Jie Su, Chao Ding, Fangqing Yu, Baosheng Zhu

Abstract

Introduction

MYO7A gene has been shown to be associated with Usher syndrome 1B and nonsyndromic deafness. Although a lot of mutations have been reported in MYO7A gene, novel MYO7A mutations are continuously to be identified.

Methods

Targeted next generation sequencing was performed on the two unrelated patients with Usher syndrome 1B and nonsyndromic deafness respectively. The identified mutations from targeted next generation sequencing were further validated by Sanger sequencing, and analyzed by bioinformatics tools, like SIFT, Polyphen-2, PyMOL, I-Mutant 2.0 and so on.

Results

By analyzing the sequencing data of these two patients, four novel MYO7A mutations were revealed: (i) MYO7A p.Tyr560Ser and p.Ala2039Pro were associated with Usher syndrome 1B. (ii) MYO7A c.2187 +2_+8 delTGAGCAC and p.Leu728Pro were related to nonsyndromic hearing loss. These mutations were further proved to be possibly disease-causing by segregation analysis, conservation analysis and bioinformatics tools.

Conclusions

Four novel MYO7A mutations were identified in the present study. These findings provided new evidence for the genetic counseling of Usher syndrome 1B and nonsyndromic deafness.

http://bit.ly/2UUitia

Comparison of three different surgical techniques for designing pharyngeal flaps according to findings of videonasopharyngoscopy and multiplanar videofluoroscopy

Publication date: Available online 11 February 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Pablo Antonio Ysunza, Kongkrit Chaiyasate, Matthew Rontal, Kenneth Shaheen, Blake Bartholomew

Abstract

Background

Velopharyngeal insufficiency (VPI) occurs when the velopharyngeal sphincter (VPS) is unable to completely seal anatomical closure between the nasal and oral cavities during speech. Palatal repair can restore VPS function but the prevalence of VPI after repair has been reported ranging from 20% to 40%. The combination of flexible videonasopharyngoscopy (FVNP) and multiplanar videofluoroscopy (MPVF) has been reported as the best approach for assessing the VPS mechanism and planning effective surgical procedures aimed to correct VPI.

Objective

To study the outcome of three different techniques for performing pharyngeal flaps with the common denominator of individually designing the flap according to findings of VFNP and MPVF.

Material and Methods

A total of 140 cases of pharyngeal flap surgery were reviewed. Three surgeons performed 3 different surgical techniques. All cases underwent nasometry, VNP and MPVF preoperatively. All surgical procedures were carefully planned and designed according to findings of VNP and MPVF.

Results

Nasal emission was completely eliminated in all cases. One-hundred-thirty-four patients (95%) demonstrated mean nasalance within normal limits after the surgical procedure whereas 6 patients persisted with mean nasalance scores above reference values postoperatively. There were no intraoperative or postoperative complications in any of the cases. No clinical data of sleep disordered breathing was detected in any of the cases after 2 months of postoperative follow-up. However, one case presented with clinical data of sleep disordered breathing 8 months postoperatively.

Conclusions

The results of this study suggest that as long as pharyngeal flaps are being designed according to the findings of imaging procedures, different surgical techniques can provide similar successful outcomes with minimal complications.

http://bit.ly/2E4cxO4

Sialendoscopy plus laser lithotripsy in sialolithiasis of the submandibular gland in 64 patients: A simple and safe procedure

Publication date: Available online 11 February 2019

Source: Auris Nasus Larynx

Author(s): Thomas Guenzel, Stephan Hoch, Niels Heinze, Thomas Wilhelm, Christian Gueldner, Achim Franzen, Annekathrin Coordes, Anja Lieder, Susanne Wiegand

Abstract

Objective

To demonstrate the safety and efficiency of holmium laser-assisted lithotripsy during sialendoscopy of the submandibular gland using a retrospective, interventional consecutive case series.

Methods

We performed 374 sialendoscopies between 2008 and 2015 and evaluated all patients regarding clinical symptoms, clinical findings, therapy and outcome. We performed 109 procedures of holmium laser-assisted lithotripsy in 64 patients whose sialoliths measured 5 mm or more in diameter. In addition to retrospective case note reviews, we performed telephone interviews of all patients in January 2017.

Results

We performed 374 consecutive submandibular gland sialendoscopy procedures in 276 patients between 2008 to 2015. Sialolithiasis had either previously been diagnosed, or symptoms highly suggestive of sialolithiasis of the submandibular gland presented in 197 patients.

Holmium laser-assisted Laser lithotripsy was performed in 109 cases (64.9%). Smaller mobile concrement was removed directly either by forceps or wire basket, or following marsupialisation of the submandibular duct. This was the case in 88 patients (29.1%). Three patients (0.8%) required surgical removal of the submandibular gland due to early abscess. The majority of patients (n = 374 procedures; 90.1%) remained symptom-free after two or more years following intervention. In the remaining procedures (n = 37 procedures; 9.9%), patients reported discreet postprandial problems but did not seek medical attention. In total, we managed to preserve the submandibular gland and avoid open surgery in 99% of patients through endoscopic management of submandibular concrement and duct stenosis.

Conclusion

Holmium laser-assisted lithotripsy is a simple, safe, and effective procedure for treating patients with sialolithiasis of the submandibular gland. Removal of the gland is rarely required, and removing the gland without prior sialendoscopy is no longer recommended. It should be offered to all patients with submandibular gland sialolithiasis, or such patients should be referred to the appropriate centre for sialendoscopy before submandibulectomy is considered.

http://bit.ly/2IaND3t

The anatomical and radiological evaluation of the Vidian canal on cone-beam computed tomography images

Abstract

Introduction

The aim of this study is to explore the anatomy of the Vidian nerve to elucidate the appropriate surgical approach based on preoperative cone-beam computed tomography (CBCT) images.

Materials and methods

The Vidian canal and its surrounding structures were morphometrically evaluated retrospectively in CBCT images of 400 cases by the Planmeca Romexis program. The types of the Vidian canal were determined and seven parameters were measured from the images.

Results

Three types of the Vidian canal according to the relationship with the sphenoid bone were found as follows: the Vidian canal totally protruded into the sphenoid sinus (19.75%), partially protruded into sphenoid sinus (44.37%) and embedded inside bony tissue of the body of sphenoid bone (35.87%). The position of the Vidian canal was medial (34.62%), on the same line (55.12%) and lateral (10.25%) to the medial plate of the pterygoid process. The distance between the Vidian canal and the vomerine crest, the mid-sagittal plane, the round foramen, the palatovaginal canal, and the superior wall of the sphenoid sinus, the length of the Vidian canal and the angle between the Vidian canal and the sagittal plane was found to be 16.69 ± 2.14, 13.80 ± 2.00, 8.88 ± 1.60, 5.83 ± 1.37, 23.98 ± 2.68, 13.29 ± 1.71 mm and 25.78° ± 3.68° in males, 14.62 ± 1.66, 11.43 ± 1.28, 8.51 ± 1.63, 5.78 ± 0.57, 22.37 ± 2.07, 12.91 ± 1.26 mm and 23.43° ± 3.07° in females, respectively.

Conclusions

Our results may assist with proper treatment for surgical procedures around the Vidian canal with a high success rate and minimal complications. Therefore, the results obtained in this study contribute to the literature.

http://bit.ly/2BxwJ9H

Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions

Publication date: Available online 11 February 2019

Source: Auris Nasus Larynx

Author(s): Koji Araki, Masayuki Tomifuji, Kosuke Uno, Hiroshi Suzuki, Yuya Tanaka, Shingo Tanaka, Eiko Kimura, Akihiro Shiotani

Abstract

Objective

The fiber-guided carbon dioxide (CO₂) laser is a useful device for laryngopharyngeal surgery. The flexible CO₂ wave-guide laser has been developed and commercially available for several years. However, the transnasal use of CO₂ flexible wave-guided laser surgery through the instrument channel of a flexible endoscope (CO₂ TNFLS) is not permitted in Japan. This feasibility study aimed to assess the value and the safety of an in-office CO₂ TNFLS procedure.

Methods

Patients with small laryngopharyngeal diseases were enrolled from June 2015. Eligible patients had indications with lesions generally localized superficial lesions such as the benign tumor, leukoplakia, and premalignant lesion-like carcinoma in situ (CIS). Patients were locally well anesthetized using xylocaine. After removing as much of the lesion(s) as possible with flexible forceps, the remainder of the lesions were evaporated using CO₂ TNFLS through the instrument channel of a flexible endoscope under local anesthesia.

Results

Eighteen surgeries involving 13 patients, including 9 papilloma (7 recurrent respiratory papilloma [RRP]), 2 carcinoma in situ, 1 leukoplakia, and 1 large epiglottic cyst), were performed. Four patients with RRP required multiple surgeries. Except for 3 patients with RRP, all patients achieved disease control without additional intervention. All procedures were completed with no severe adverse events.

Conclusion

Office-based CO₂ TNFLS is safe and feasible for patients with laryngopharyngeal pathologies. It is especially valuable for RRP patients with small lesions to avoid surgery under general anesthesia.

http://bit.ly/2BrmpzV

Pratique et enjeux de la simulation en dermatologie

Publication date: Available online 11 February 2019

Source: Annales de Dermatologie et de Vénéréologie

Author(s): L. Martin, J.C. Granry

http://bit.ly/2DzSrtC

Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus

Publication date: Available online 11 February 2019

Source: Autoimmunity Reviews

Author(s): Nancy P. Duarte Delgado, Gloria Vásquez, Blanca L. Ortiz-Reyes

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE.

http://bit.ly/2TGVK97

Conceptual, statistical and clinical interpretation of results from a systematic review and meta-analysis of prevalence of cervical HPV infection in women with SLE

Publication date: Available online 11 February 2019

Source: Autoimmunity Reviews

Author(s): Rama Jayaraj, Chellan Kumarasamy

http://bit.ly/2TGVIhv

Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma

Publication date: Available online 11 February 2019

Source: Allergologia et Immunopathologia

Author(s): M. Demirci, H.B. Tokman, H.K. Uysal, S. Demiryas, A. Karakullukcu, S. Saribas, H. Cokugras, B.S. Kocazeybek

Abstract

Introduction and objectives

The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. prausnitzii amounts using real-time quantitative PCR (qPCR) in the gut microbiota of children with allergic asthma and in healthy controls.

Materials and methods

In total, 92 children between the ages of three and eight who were diagnosed with asthma and 88 healthy children were included in the study and bacterial DNA was isolated from the stool samples using the stool DNA isolation Kit. qPCR assays were studied with the microbial DNA qPCR Kit for A. muciniphila and microbial DNA qPCR Kit for F. prausnitzii.

Results

Both bacterial species showed a reduction in the patient group compared to healthy controls. A. muciniphila and F. prausnitzii were found to be 5.45 ± 0.004, 6.74 ± 0.01 and 5.71 ± 0.002, 7.28 ± 0.009 in the stool samples of the asthma and healthy control groups, respectively.

Conclusions

F. prausnitzii and A. muciniphila may have induced anti-inflammatory cytokine IL-10 and prevented the secretion of pro-inflammatory cytokines like IL-12. These findings suggest that A. muciniphila and F. prausnitzii may suppress inflammation through its secreted metabolites.

http://bit.ly/2Dvcmdj