http://ift.tt/2h4LC8P
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Παρασκευή 3 Νοεμβρίου 2017
Nationwide French Study of RET Variants Detected from 2003 to 2013 Suggests a Possible Influence of Polymorphisms as Modifiers
http://ift.tt/2h4LC8P
Subclinical Sensitization with Diphenylcyclopropenone is Sufficient for the Treatment of Alopecia Areata: Retrospective Analysis of 159 Cases
Conventional diphenylcyclopropenone contact immunotherapy has been used in the treatment of extensive alopecia areata, but can be associated with severe adverse effects (AEs).Even without an eczematous reaction after sensitization, sufficient therapeutic responses were achieved without severe AEs.Sensitization to induce an eczematous reaction may not be required for successful contact immunotherapy.
http://ift.tt/2A68Jah
Preventing and Responding to Teen Dating Violence: A National Study of School Principals' Perspectives and Practices
Violence and Gender , Vol. 0, No. 0.
http://ift.tt/2iYurtD
Founder Effect of the RETC611Y Mutation in Multiple Endocrine Neoplasia 2A in Denmark: A Nationwide Study
http://ift.tt/2Ah81b4
An exotic abscess within the United Kingdom from The Gambia: a case report
Furuncular myiasis is a parasitic infection of a live mammal by fly larvae commonly seen in Africa. However, with an increase in international tourism, there is a significant rise in exotic infection in non-en...
http://ift.tt/2haRHny
Conjugated Bilirubin Upregulates TIM-3 Expression on CD4+CD25+ T Cells: Anti-Inflammatory Implications for Hepatitis A Virus Infection
Viral Immunology , Vol. 0, No. 0.
http://ift.tt/2itscKU
Elastic stains in the evaluation of DCIS with comedo necrosis in breast cancers
Abstract
As concerns the microscopic morphology of ductal carcinoma in situ (DCIS), neoplastic cells are surrounded by both a myoepithelial cell layer and a basement membrane as expected from the outer structure of ducts and lobules. However, in some cases, it is impossible to state whether the structures involved by the disease are ducts or lobules. Altogether 1220 anatomic structures involved by DCIS displaying comedo necrosis from 27 slides of 21 patients (seen on both haematoxylin and eosin-stained and orcein-stained slides) were identified as representing ducts, likely ducts, unclassifiable structures, likely acini or acini on the basis of their distribution and resemblance to normal anatomic structures. All structures were then rated as having a circumferential elastic layer (as normal ducts), a partial elastic layer around more or less than half of the periphery or having no peripheral elastic layer at all (as normal acini). Structures classified as ducts or likely ducts were likely to have an elastic coating, whereas acini and likely acini had no such coating. Unclassifiable structures were generally devoid of an elastic layer. Structures (and cases) that were likely to represent neoductgenesis as proposed by Zhou et al. (Int J Breast Cancer 2014;2014:581706) were generally unclassifiable and devoid of outer elastic layer. Many duct-like structures in DCIS with comedo necrosis are devoid of elastic layer typical of normal ducts, suggesting that these structures are abnormal despite conservation of the myoepithelium and the basement membrane.
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Analgesic Drug Prescription After Carpal Tunnel Surgery: A Pharmacoepidemiological Study Investigating Postoperative Pain.
Background and Objectives: Carpal tunnel syndrome is a frequent cause of neuropathic pain of the upper limb. Surgery is often proposed in second-line treatment, leading to an expected decrease in analgesic drug consumption. The main objective of this study was to investigate the variations in analgesic drug prescriptions, with a special focus on constant or increasing prescription patterns, before and after surgery for carpal tunnel syndrome. Methods: We designed a retrospective cohort study of French beneficiaries from the health insurance system in Midi-Pyrenees area. All patients undergoing carpel tunnel surgery during a specified period were identified and included. Definition of increased or constant prescription of analgesics was based on the comparison of the accumulated defined daily doses received by months and a difference between early preoperative (2 months before) and late postoperative period (2-12 months after surgery) superior to a -3.5 margin. We performed 4 multivariate logistic regression models to identify factors associated with increased or constant analgesic drug prescription patterns (for all analgesics, opioid, antineuropathic, nonopioid drugs). Results: Among the 3665 patients included, 3255 (89%) received at least 1 analgesic drug during the late postoperative period (39% [n = 1426] for opioids and 15% [n = 563] for antineuropathic drugs). Prescription of analgesic, opioid, or antineuropathic drugs was maintained or increased in the late postoperative period in 11%, 5%, and 3% of the population, respectively. High levels of preoperative pain and female sex were associated with an increase in opioid use, whereas inpatient surgery (vs ambulatory surgery), high levels of preoperative pain, and psychiatric disorders were found to be associated with an increase in antineuropathic drug use. Conclusions: This study revealed that approximately 3% to 5% of patients undergoing carpal tunnel surgery had persistent and even increased use of opioid or antineuropathic drugs more than 2 months after surgery, in relation with possible chronic postoperative pain. Considering the incidence of carpal tunnel syndrome, the risks associated with persistent opioid use in this population should be further monitored. Copyright (C) 2017 by American Society of Regional Anesthesia and Pain Medicine.
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http://ift.tt/2lOVj0m
Transversus Abdominis Plane Catheters for Analgesia Following Abdominal Surgery in Adults.
Transversus abdominis plane (TAP) catheters are increasingly being used as an opioid-sparing analgesic technique following abdominal surgery. The aim of this systematic review is to evaluate the efficacy and safety of TAP catheters for postoperative analgesia following abdominal surgery in adults. The authors searched electronic databases and relevant reference lists for randomized controlled trials published between inception and January 2017. Twelve randomized controlled trials were identified, comprising 661 participants, with several trials showing either an equivalence or superiority in analgesia compared with the alternative modality. Because of the extremely heterogeneous nature of the studies, a specific consensus regarding their results, or the ability to construct a meta-analysis, is unviable. Although there are promising indications for the benefit of TAP catheter techniques, extrapolation/comparison of results and application to patient care will be better elucidated when there is more standardization of TAP catheter techniques and the methodology for measuring efficacy. Copyright (C) 2017 by American Society of Regional Anesthesia and Pain Medicine.
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http://ift.tt/2lOV3OW
Multimarker Assessment of Diastolic Dysfunction in Metabolic Syndrome Patients
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0.
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Editorial Board/Aims & Scope
Source:Oral Oncology, Volume 74
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The clinicopathological spectrum of olfactory neuroblastoma and sinonasal neuroendocrine neoplasms: Refinements in diagnostic criteria and impact of multimodal treatments on survival
Source:Oral Oncology, Volume 74
Author(s): Mario Turri-Zanoni, Roberta Maragliano, Paolo Battaglia, Marta Giovannardi, Paolo Antognoni, Davide Lombardi, Maria Laura Morassi, Ernesto Pasquini, Paolo Tarchini, Sofia Asioli, Maria Pia Foschini, Fausto Sessa, Piero Nicolai, Paolo Castelnuovo, Stefano La Rosa
ObjectivesTo provide a comprehensive review of the clinical and histopathological features of olfactory neuroblastoma (ONB) and other sinonasal neuroendocrine neoplasms (NENs), in order to refine diagnostic criteria, analyze treatment outcomes, and identify prognostic factors.MethodsData from an Italian multi-institutional database were analyzed. Patients were treated surgically via a minimally-invasive endoscopic approach followed by adjuvant radiotherapy or radiochemotherapy. Neoadjuvant cisplatin/etoposide chemotherapy was administered in cases of poorly-differentiated tumors. A centralized pathology review was performed in all cases. Patients were prospectively observed for survival. Overall (OS) and Disease-free survival (DFS) estimates were determined from Kaplan-Meier analysis and compared using the log-rank test. Statistically significant variables were entered in a multivariate Cox regression model.Results98 patients with a median follow-up of 53months were included. Morphology review and the incorporation of cytokeratin 8/18 in the immunohistochemical panel modified the final diagnosis in 8/98 (8.2%) cases. The neoplasms were ultimately classified into four groups with different immunohistochemical profiles and clinical behaviors: ONB in 67 cases (5-year-OS, 91.6%); NEC (poorly-differentiated neuroendocrine carcinoma) in 22 cases (5-year-OS, 42.6%); MiNEN (mixed neuroendocrine/non-neuroendocrine neoplasm) in five cases (5-year-OS, 0%,0/5 cases); and NET (well-differentiated neuroendocrine tumor) in four cases (5-year-OS, 50%, 2/4 cases). Hyams grade and Ki67 index were independent prognostic factors for ONB. Neoadjuvant chemotherapy appeared to be associated with improved OS and DFS for NEC, independent of other clinicopathological variables.ConclusionsInduction chemotherapy improves survival outcomes in patients affected by poorly-differentiated tumors. Recent advances in histopathological diagnosis, including CK8/18 staining, allow to plan the most appropriate range of multimodal treatments.
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Chemotherapy regimens containing taxanes or fluorouracil in nasopharyngeal carcinoma: Which better?
Source:Oral Oncology, Volume 74
Author(s): Jing-Lin Mi, Bin Zhang, Yu-Fei Pan, Yi-Xin Su, Jin-Fang Fan, Shu-Fang Liao, Xiao-Li Qin, Da-Cheng Yao, Hua-Ying Tang, Wei Jiang
ObjectivesThe efficacy of various chemotherapy regimens in nasopharyngeal carcinoma (NPC) remains under debate. We compared the efficacy and toxicity of a taxane-based regimen and regimen including fluorouracil in NPC.Materials and methodsEight-hundred and six patients with stage II-IVB NPC from four institutions in China were pair-matched (1:1 ratio) to the cisplatin plus fluorouracil (PF) group or cisplatin plus taxanes (TP) group using eight clinical factors. Overall survival (OS), disease-free survival (DFS), locoregional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS) were assessed using the Kaplan-Meier method and Cox regression model. Toxicities were assessed in all patients.ResultsThree-year DFS was significantly better in the TP group than PF group (82.5% vs. 72.7%, P=0.002), with no significant difference in OS, LRRFS or DMFS. TP led to significantly better DFS compared to PF in the subgroups advanced stage NPC, patients aged ≤45-years-old and female patients. In multivariate analysis, chemotherapy regimen was an independent prognostic factor for DFS [hazard ratio, 0.591, 95% CI 0.444–0.786, P=0.000]. Grade 3–4 leukopenia, neutropenia and anemia were significantly more common in the TP group; grade 3–4 mucositis, vomiting, vasculitis and diarrhea were more common in the PF group.ConclusionTaxane-based regimens have a higher efficacy in NPC than regimens including fluorouracil, especially in patients with advanced stage, patients aged≤45-years-old and female patients.
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Reconstruction Special Edition, Issue 1
Source:Oral Oncology, Volume 74
Author(s): Matthew Old
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Perforator based rectus free tissue transfer for head and neck reconstruction: New reconstructive advantages from an old friend
Source:Oral Oncology, Volume 74
Author(s): Stephen Y. Kang, Matthew E. Spector, Douglas B. Chepeha
ObjectivesTo demonstrate three reconstructive advantages of the perforator based rectus free tissue transfer: long pedicle, customizable adipose tissue, and volume reconstruction without muscle atrophy within a contained space.Materials and methodsThirty patients with defects of the head and neck were reconstructed with the perforator based rectus free tissue transfer.ResultsTransplant success was 93%. Mean pedicle length was 13.4cm. Eleven patients (37%) had vessel-poor necks and the long pedicle provided by this transplant avoided the need for vein grafts in these patients. Adipose tissue was molded in 17 patients (57%). Twenty-five patients (83%) had defects within a contained space, such as the orbit, where it was critical to have a transplant that avoided muscle atrophy.ConclusionsThe perforator based rectus free tissue transfer provides a long pedicle, moldable fat for flap customization, and is useful in reconstruction of defects within a contained space where volume loss due to muscle atrophy is prevented.
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Reflections: Paul Bernard Chretien, MD (1931-2017)
Publication date: November 2017
Source:Oral Oncology, Volume 74
Author(s): Gregory T. Wolf
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Vascular consideration in repair of total scalp avulsion
Jun Karibe<br />Oct 24, 2017; 2017:bcr-2017-220605-bcr-2017-220605<br />Unusual presentation of more common disease/injury
http://ift.tt/2xWkU8R
Use of a dynamic gait trainer for a child with thoracic level spinal cord injury
Wendy Altizer<br />Oct 10, 2017; 2017:bcr-2017-220756-bcr-2017-220756<br />Novel treatment (new drug/intervention; established drug/procedure in new situation)
http://ift.tt/2zaJ8xz
Severe liver injury due to Epsom salt naturopathy
Cyriac Abby Philips<br />Oct 2, 2017; 2017:bcr-2017-221718-bcr-2017-221718<br />Images in...
http://ift.tt/2xYuDf6
Could kinesiology taping help mitigate pain, breathlessness and abdominal-related symptoms in cancer?
Gourav Banerjee<br />Feb 24, 2017; 2017:bcr2016216695-bcr2016216695<br />case-report
http://ift.tt/2zcARcC
Unexpected Cardiac Computed Tomography Findings in Patients With Postoperative Myocardial Injury
BACKGROUND: Postoperative myocardial injury (PMI) is a strong predictor of mortality after noncardiac surgery. PMI is believed to be attributable to coronary artery disease (CAD), yet its etiology is largely unclear. We aimed to quantify the prevalence of significant CAD in patients with and without PMI using coronary computed tomography angiography (CCTA). METHODS: This prospective cohort study included patients of 60 years or older without a history of cardiac disease and with and without PMI after intermediate- to high-risk noncardiac surgery. PMI was defined as any serum troponin I level ≥60 ng/L on the first 3 postoperative days. Main exclusion criteria were known cardiac disease and postoperative ischemic symptoms or electrocardiography abnormalities. Noninvasive imaging consisted of a postoperative CCTA. Main outcome was CAD defined as >50% coronary stenosis on CCTA. RESULTS: The analysis included 66 patients. Median peak troponin levels in the PMI (n = 46) and control group (n = 20) were 150 (interquartile range, 120–298) vs 15 (interquartile range, 10–31) ng/L (P
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http://ift.tt/2xXo1xs
Neuroprotective Effects of Fasudil, a Rho-Kinase Inhibitor, After Spinal Cord Ischemia and Reperfusion in Rats
BACKGROUND: Excessive Rho/Rho-kinase pathway activation occurs subsequent to stroke. We examined the neuroprotective effects of pre- and posttreatment with fasudil (a Rho-kinase inhibitor) in a rat transient spinal cord ischemia-reperfusion model under normothermic conditions. METHODS: After approval by our animal research committee, male Sprague-Dawley rats were assigned to 1 of 6 groups: pre- and postcontrol (C); pre- and postfasudil (F); and pre- and postsham (S). Fasudil (10 mg/kg) or normal saline was administered intravenously over 30 minutes before ischemia in the pre-F or pre-C groups, and over 30 minutes after reperfusion in the post-F or post-C groups. Sham groups were not subjected to ischemia. Ischemia was induced by aortic occlusion using a balloon catheter combined with hypotension for 10 minutes. Neurologic deficit scores (NDS; 0–8 points) were assessed 1, 7, and 14 days after ischemia, and then histopathologic outcomes were assessed. RESULTS: NDS 7 and 14 days after ischemia in the pre-F group (median [range]; 3.5 [2–6] and 2.5 [0–6]) were lower than those in the pre-C group (5.5 [4–7] and 4.5 [4–6]; P = .046 and P = .049), whereas NDS in the post-F group and in the post-C group were not different. The numbers of intact neurons in the gray matter in the pre- and post-F groups (mean ± standard deviation [95% confidence interval]: 25 ± 7 [20–30] and 16 ± 5 [12–19]) were greater than those in the pre- and post-C groups (11 ± 5 [7–14] and 9 ± 3 [7–11]; P
http://ift.tt/2zbPDQI
http://ift.tt/2zbPDQI
The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants
Venous thromboembolism is recognized as a leading cause of maternal death in the United States. Thromboprophylaxis has been highlighted as a key preventive measure to reduce venous thromboembolism–related maternal deaths. However, the expanded use of thromboprophylaxis in obstetrics will have a major impact on the use and timing of neuraxial analgesia and anesthesia for women undergoing vaginal or cesarean delivery and other obstetric surgeries. Experts from the Society of Obstetric Anesthesia and Perinatology, the American Society of Regional Anesthesia, and hematology have collaborated to develop this comprehensive, pregnancy-specific consensus statement on neuraxial procedures in obstetric patients receiving thromboprophylaxis or higher dose anticoagulants. To date, none of the existing anesthesia societies' recommendations have weighed the potential risks of neuraxial procedures in the presence of thromboprophylaxis, with the competing risks of general anesthesia with a potentially difficult airway, or maternal or fetal harm from avoidance or delayed neuraxial anesthesia. Furthermore, existing guidelines have not integrated the pharmacokinetics and pharmacodynamics of anticoagulants in the obstetric population. The goal of this consensus statement is to provide a practical guide of how to appropriately identify, prepare, and manage pregnant women receiving thromboprophylaxis or higher dose anticoagulants during the ante-, intra-, and postpartum periods. The tactics to facilitate multidisciplinary communication, evidence-based pharmacokinetic and spinal epidural hematoma data, and Decision Aids should help inform risk–benefit discussions with patients and facilitate shared decision making. Accepted for publication August 24, 2017. Funding: None. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (http://ift.tt/KegmMq). The Appendix provides the full list of the SOAP VTE Taskforce members, along with their respective affiliations. Reprints will not be available from the authors. Address correspondence to Lisa Leffert, MD, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114. Address e-mail to lleffert@partners.org. © 2017 International Anesthesia Research Society
http://ift.tt/2xY9EsX
http://ift.tt/2xY9EsX
The Anesthesia Records of Harvey Cushing and Ernest Codman
Hundreds of thousands of anesthesia records are created each day. The earliest records were prepared by 2 medical students in late 19th-century Boston. Ernest Codman and Harvey Cushing went on to become prominent surgeons and contributed much to the safety of the surgical patient. Cushing's career is celebrated due to his associations with William Stewart Halsted, Peter Bent Brigham Hospital, Yale University, in New Haven, Connecticut, and his biography of Sir William Osler. Codman is remembered for introducing the morbidity and mortality conference as well as his drive to improve outcomes and patient safety. We analyze every anesthetic record created by Codman and Cushing and provide both a historical context and perspective on many ways in which their doggedness, brilliance, and insight anticipated many advances that enhanced safety for patients undergoing surgical procedures. Accepted for publication September 4, 2017. Funding: This study received intramural support. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (http://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Sukumar P. Desai, MD, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115. Address e-mail to sdesai@partners.org. © 2017 International Anesthesia Research Society
http://ift.tt/2zczydP
http://ift.tt/2zczydP
Colloids and the Microcirculation
Colloid solutions have been advocated for use in treating hypovolemia due to their expected effect on improving intravascular retention compared with crystalloid solutions. Because the ultimate desired effect of fluid resuscitation is the improvement of microcirculatory perfusion and tissue oxygenation, it is of interest to study the effects of colloids and crystalloids at the level of microcirculation under conditions of shock and fluid resuscitation, and to explore the potential benefits of using colloids in terms of recruiting the microcirculation under conditions of hypovolemia. This article reviews the physiochemical properties of the various types of colloid solutions (eg, gelatin, dextrans, hydroxyethyl starches, and albumin) and the effects that they have under various conditions of hypovolemia in experimental and clinical scenarios. Accepted for publication September 27, 2017. Funding: H.H. received funding from the China Scholarship Council (No. 201608110082) and the Organization Department of Beijing Municipal Committee (No. 2015000020124G072). C.I. has received honoraria and independent research grants from Fresenius-Kabi, Bad Homburg, Germany, and Baxter HealthCare, Deerfield, IL. The authors declare no conflicts of interest. Reprints will not be available from the authors. Address correspondence to Can Ince, PhD, Department of Intensive Care, Erasmus Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, the Netherlands. Address e-mail to c.ince@erasmusmc.nl. © 2017 International Anesthesia Research Society
http://ift.tt/2xXXujO
http://ift.tt/2xXXujO
Profil der Kaposi-Sarkom-Patienten im Kompetenznetz HIV/AIDS
Zusammenfassung
Hintergrund
Das Kaposi-Sarkom (KS) stellt die häufigste der Neoplasien dar, die das „acquired immune deficiency syndrome" (AIDS) definieren. Es wurden nur wenige Studien über den Verlauf und die Behandlung des mit dem „human immunodeficiency virus" (HIV) assoziierten KS in Deutschland durchgeführt.
Ziel der Arbeit
Im Rahmen dieser Studie wurde der Verlauf des HIV-assoziierten KS bei Patienten aus der Kohortendatenbank des Kompetenznetz HIV/AIDS beobachtet.
Material und Methoden
Von HIV-positiven Patienten mit KS aus 9 deutschen Schwerpunktzentren wurden Daten des Zeitraum 1987–2011 retrospektiv erhoben. Kaplan-Meier-Kurven für die Rezidiv- und Überlebenswahrscheinlichkeit wurden berechnet.
Ergebnisse
Bei 222 Patienten wurde ein KS im medianen Lebensalter von 38,5 ± 10,1 Jahren diagnostiziert. Es waren nahezu ausschließlich Männer betroffen (97,7 %). Die HI-Viruslast zum Diagnosezeitpunkt lag bei 7,4 % unter 50 Kopien/ml. Es entwickelten 55,5 % der Patienten ein KS bei CD4-Zellzahlen unter 200 Zellen/µl und 9,5 % bei über 500 Zellen/µl. Bei 68 Patienten bestand die KS-Therapie ausschließlich in der Optimierung bzw. der Einleitung der antiretroviralen Therapie (ART). Zusätzlich wurden 71 Patienten mit pegyliertem liposomalem Doxorubicin behandelt. Während der medianen Follow-up-Dauer von 8,9 ± 4,9 Jahren traten bei 80,2 % der Patienten keine KS-Rezidive auf. Die Überlebenswahrscheinlichkeiten nach 5 und 10 Jahren betrugen 96,8 % und 91,3 %.
Schlussfolgerung
Auch bei gutem Immunstatus traten HIV-assoziierte KS auf. Eine effektive ART stellte die wichtigste Therapiesäule dar. Bei angemessener Therapie zeigten HIV-positive Patienten mit KS eine gute Überlebensrate.
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Chyluria: a scourge of our region
Rajan Kumar Sinha<br />Jul 6, 2015; 2015:bcr2014209188-bcr2014209188<br />case-report
http://ift.tt/2j0ZuF1
Vanishing lung syndrome mistaken for bilateral spontaneous pneumothorax
Faisal A Khasawneh<br />Oct 17, 2013; 2013:bcr2013201016-bcr2013201016<br />case-report
http://ift.tt/2Ai3Hs4
Devastating complication of silver nitrate instillation for the treatment of chyluria
Manish Garg<br />Sep 26, 2013; 2013:bcr2013201270-bcr2013201270<br />case-report
http://ift.tt/2j0ZjJR
Tuberculous gumma: a forgotten entity in the UK
Louise Parker<br />Sep 26, 2013; 2013:bcr2013010462-bcr2013010462<br />case-report
http://ift.tt/2AfGKG2
Asymptomatic submitral aneurysm: an uncommon complication of a common disease
G Vivek<br />Jun 24, 2013; 2013:bcr2013200032-bcr2013200032<br />case-report
http://ift.tt/2j0Z8OH
Successful treatment of massive intractable pericardial effusion in a patient with systemic lupus erythematosus with tocilizumab
Yasuyuki Kamata<br />Dec 21, 2012; 2012:bcr2012007834-bcr2012007834<br />case-report
http://ift.tt/2AfGF5c
Biomarkers related to bullous pemphigoid activity and outcome
Abstract
Bullous pemphigoid (BP) is the most common autoimmune sub-epidermal blistering disease of the skin. Investigation of the BP-associated pathophysiological processes during the last decades showed that the generation of auto-antibodies directed against the hemidesmosome proteins BP180 and BP230, a hallmark of the BP-associated autoimmune response, leads to the recruitment of inflammatory immune cells at the dermal-epidermal junction, and subsequently to the release of a large amount of inflammatory molecules involved in blister formation. Analysis in transversal and longitudinal studies of autoantibodies and inflammatory molecules production both at time of diagnosis and under treatment was mainly performed within the serum but also in the blister fluid. Some autoimmune or inflammatory molecules expression was related to the presence of clinical signs, while others were mere bystanders. In this review, we focused on the autoimmune and inflammatory molecules that have been identified as potential biomarkers of BP development and outcome.
This article is protected by copyright. All rights reserved.
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Tanning Salons Often Ignore Laws Restricting Use by Minors
More than one-third of indoor tanning salons don't follow state laws limiting use by children and teens, a U.S. study suggests.
Reuters Health Information
http://ift.tt/2hzLLkZ
Hyalinizing Clear Cell Carcinoma of the Tonsil: A Case Report
Abstract
Hyalinzing clear cell carcinoma is a rare tumor of the oral cavity and is even more rarely located in the tonsil. Here, we present a case report of a pedunculated tonsillar mass in a nearly asymptomatic patient that was present for 2 years prior to removal. Complete surgical excision was achieved and no adjuvant therapy was recommended. We include a discussion of this rare pathology and its typical clinical presentation and course.
http://ift.tt/2lMZgCw
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature
Abstract
Sclerosing mucoepidermoid carcinoma of the salivary gland (SMEC) is a rare subtype of mucoepidermoid carcinoma (MEC), first described in 1987 by Chan and Saw. As far as we are aware, only 30 cases have been published since then. Most cases were located in the parotid gland with some cases described in the submandibular and minor salivary glands. SMEC typically presents as a long-standing mass, with a non-specific enhancing appearance on imaging and is often non-diagnostic on fine needle aspiration, making pre-operative diagnosis very difficult. It is characterised by dense sclerosis within an otherwise typical MEC, frequently with lymphoid proliferation and eosinophils at the periphery. The histological diagnosis of SMEC can be challenging, as the sclerosis may obscure the other morphological features, which can lead to misdiagnosis. Grading can also be difficult, and the prognostic value of grading for SMEC remains unclear. Herein is described a new case of SMEC, presenting clinically as chronic sialadenitis in the left submandibular gland of a 41 year old male. A brief literature review and the issues surrounding diagnosis and grading are also discussed.
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Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity
Abstract
The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted of a proliferation of spindle and epithelioid looking cells. Cells were arranged in loose fascicles and sheets. Rhabdomyoblast-like cells were also seen. No mitotic figures were present. Lesional cells were reactive to cytokeratin AE1/AE3 and CD31. Lesional cell reactivity to S100 protein, HMB 45, SMA, Desmin and CD34 was negative. Following the diagnosis, a wide excision for clear margins was performed. No recurrence has been reported 2 years since the removal. The PMH is a cutaneous tumor that behaves in an indolent fashion. This is the first report of oral involvement by this neoplasm. Recognition of its histopathological features and immunohistochemical reactivity will prevent misadventures in the diagnosis of oral lesions.
http://ift.tt/2yqOSXf
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature
Abstract
Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.
http://ift.tt/2lLv4b1
Hyalinizing Clear Cell Carcinoma of the Bronchus
Abstract
Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative. Mucicarmine stain also was negative in the lesional cells. Fluorescence in situ hybridization using break apart probes revealed rearrangement of the Ewing Sarcoma Breakpoint Region 1 gene locus. The morphologic, immunophenotypic and cytogenetic findings confirmed the diagnosis of HCCC, most likely of bronchial submucosal gland origin. To our knowledge, only two other reports of primary pulmonary HCCC are available in English literature.
http://ift.tt/2yrGer9
Hyalinizing Clear Cell Carcinoma of the Tonsil: A Case Report
Abstract
Hyalinzing clear cell carcinoma is a rare tumor of the oral cavity and is even more rarely located in the tonsil. Here, we present a case report of a pedunculated tonsillar mass in a nearly asymptomatic patient that was present for 2 years prior to removal. Complete surgical excision was achieved and no adjuvant therapy was recommended. We include a discussion of this rare pathology and its typical clinical presentation and course.
http://ift.tt/2lMZgCw
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature
Abstract
Sclerosing mucoepidermoid carcinoma of the salivary gland (SMEC) is a rare subtype of mucoepidermoid carcinoma (MEC), first described in 1987 by Chan and Saw. As far as we are aware, only 30 cases have been published since then. Most cases were located in the parotid gland with some cases described in the submandibular and minor salivary glands. SMEC typically presents as a long-standing mass, with a non-specific enhancing appearance on imaging and is often non-diagnostic on fine needle aspiration, making pre-operative diagnosis very difficult. It is characterised by dense sclerosis within an otherwise typical MEC, frequently with lymphoid proliferation and eosinophils at the periphery. The histological diagnosis of SMEC can be challenging, as the sclerosis may obscure the other morphological features, which can lead to misdiagnosis. Grading can also be difficult, and the prognostic value of grading for SMEC remains unclear. Herein is described a new case of SMEC, presenting clinically as chronic sialadenitis in the left submandibular gland of a 41 year old male. A brief literature review and the issues surrounding diagnosis and grading are also discussed.
http://ift.tt/2yrAvSi
Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity
Abstract
The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted of a proliferation of spindle and epithelioid looking cells. Cells were arranged in loose fascicles and sheets. Rhabdomyoblast-like cells were also seen. No mitotic figures were present. Lesional cells were reactive to cytokeratin AE1/AE3 and CD31. Lesional cell reactivity to S100 protein, HMB 45, SMA, Desmin and CD34 was negative. Following the diagnosis, a wide excision for clear margins was performed. No recurrence has been reported 2 years since the removal. The PMH is a cutaneous tumor that behaves in an indolent fashion. This is the first report of oral involvement by this neoplasm. Recognition of its histopathological features and immunohistochemical reactivity will prevent misadventures in the diagnosis of oral lesions.
http://ift.tt/2yqOSXf
Olfactory Neuroblastoma with Divergent Differentiation: An Unusual Histologic Finding in a Rare Tumor
Abstract
Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract that arises from olfactory epithelium. There have been reports, mainly in tumors treated with chemoradiation or with distant metastases, describing focal histologic changes of divergent cell populations within archetypal ONB. Only three cases have been reported of ONB coexisting with non-neuroendocrine tumors. We describe our experience with a 35-year-old male with a nasal cavity mass extending into the anterior cranial fossa. Pathology revealed this to be a high grade malignant neoplasm with features of olfactory neuroblastoma and a significant divergent population of pancytokeratin and epithelial membrane antigen-reactive cells. The patient underwent combined endoscopic and open craniofacial resection followed by adjuvant chemoradiation. We describe the clinical presentation, treatment, and outcome followed by a review of the literature. Surgical pathology clearly demonstrated two cell populations evenly distributed and displaying classic histologic and immunohistochemical markers of ONB, as well as poorly differentiated cells with an epithelial immunophenotype. The patient is now 16 months status post completion of treatment with no evidence of recurrence. Our patient's presentation is unique and unusual in that the tumor demonstrated a high grade olfactory neuroblastoma and a divergent, epithelial-marker reactive cell population in the same tumor. This combined appearance is unusual and may represent an "olfactory carcinoma". Only one previous case has reported carcinomatous involvement of an ONB. There is insufficient information in the literature to draw conclusions on the impact these divergent cell populations have on prognosis or treatment.
http://ift.tt/2lf2BVI
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature
Abstract
Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.
http://ift.tt/2lLv4b1
Hyalinizing Clear Cell Carcinoma of the Bronchus
Abstract
Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative. Mucicarmine stain also was negative in the lesional cells. Fluorescence in situ hybridization using break apart probes revealed rearrangement of the Ewing Sarcoma Breakpoint Region 1 gene locus. The morphologic, immunophenotypic and cytogenetic findings confirmed the diagnosis of HCCC, most likely of bronchial submucosal gland origin. To our knowledge, only two other reports of primary pulmonary HCCC are available in English literature.
http://ift.tt/2yrGer9
Improving SSVEP-BCI Performance Using Pre-Trial Normalization Methods
James Hanshaw, JH; Wei Liu, WL; Romano, DM; (2017) Improving SSVEP-BCI Performance Using Pre-Trial Normalization Methods. In: Proceedings of 8th IEEE International Conference on Cognitive InfoCommunications. IEEE: Debrecen, Hungary. (In press).
http://ift.tt/2zuJl1A
Control of a Realistic Wave Energy Converter Model Using Least-Squares Policy Iteration
Anderlini, E; Forehand, DIM; Bannon, E; Abusara, M; (2017) Control of a Realistic Wave Energy Converter Model Using Least-Squares Policy Iteration. IEEE Transactions on Sustainable Energy , 8 (4) pp. 1618-1628. 10.1109/TSTE.2017.2696060 . Green open access
http://ift.tt/2zhWeev
Control of a Point Absorber Using Reinforcement Learning
Anderlini, E; Forehand, DIM; Stansell, P; Xiao, Q; Abusara, M; (2016) Control of a Point Absorber Using Reinforcement Learning. IEEE Transactions on Sustainable Energy , 7 (4) pp. 1681-1690. 10.1109/TSTE.2016.2568754 . Green open access
http://ift.tt/2zvptf6
The Apprentice’s Tale: entry to multiple communities of practice for working class boys
Galvani, RG; (2017) The Apprentice's Tale: entry to multiple communities of practice for working class boys. Doctoral thesis , UCL (University College London). Green open access
http://ift.tt/2ziDYlc
Structure and vacancy distribution in copper telluride nanoparticles influence plasmonic activity in the near-infrared
Willhammar, T; Sentosun, K; Mourdikoudis, S; Goris, B; Kurttepeli, M; Bercx, M; Lamoen, D; ... Van Tendeloo, G; + view all Willhammar, T; Sentosun, K; Mourdikoudis, S; Goris, B; Kurttepeli, M; Bercx, M; Lamoen, D; Partoens, B; Pastoriza-Santos, I; Perez-Juste, J; Liz-Marzan, LM; Bals, S; Van Tendeloo, G; - view fewer (2017) Structure and vacancy distribution in copper telluride nanoparticles influence plasmonic activity in the near-infrared. Nature Communications , 8 , Article 14925. 10.1038/ncomms14925 . Green open access
http://ift.tt/2zuJeTI
Designing simple and efficient Markov chain Monte Carlo proposal kernels
Yang, Z; Thawornwattana, Y; Dalquen, D; (2017) Designing simple and efficient Markov chain Monte Carlo proposal kernels. Bayesian Analysis (In press).
http://ift.tt/2ziDUSu
The mirror of knowledge: the mirror as an instrument of revelation in Greco-Roman philosophy and religion
Fernando, RN; (2017) The mirror of knowledge: the mirror as an instrument of revelation in Greco-Roman philosophy and religion. Doctoral thesis , UCL (University College London).
http://ift.tt/2zuJ9PU
Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375
Al-Qathama, A; Gibbons, S; Prieto Garcia, J; (2017) Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375. Oncotarget 10.18632/oncotarget.21625 . (In press). Green open access
http://ift.tt/2zh8E6K
Fractional Brownian motion, the Matern process, and stochastic modeling of turbulent dispersion
Lilly, JM; Sykulski, AM; Early, JJ; Olhede, SC; (2017) Fractional Brownian motion, the Matern process, and stochastic modeling of turbulent dispersion. Nonlinear Processes in Geophysics , 24 (3) pp. 481-514. 10.5194/npg-24-481-2017 . Green open access
http://ift.tt/2zuJ4M6
Molecular genetics and genotype-phenotype correlation of inherited corneal dystrophies
Evans, CJ; (2017) Molecular genetics and genotype-phenotype correlation of inherited corneal dystrophies. Doctoral thesis , UCL (University College London).
http://ift.tt/2zhWdXZ
Using compartment models of diffusion MRI to investigate the preterm brain
Eaton-Rosen, Zachary; (2017) Using compartment models of diffusion MRI to investigate the preterm brain. Doctoral thesis , UCL (University College London). Green open access
http://ift.tt/2ztIWfU
Modeling of Depressurization-Induced Superheating for Compressed Liquefied Gases
Zheng, W; Mahgerefteh, H; Jamois, D; Hebrard, J; Proust, C; (2017) Modeling of Depressurization-Induced Superheating for Compressed Liquefied Gases. Industrial & Engineering Chemistry Research , 56 (18) pp. 5432-5442. 10.1021/acs.iecr.7b00105 .
http://ift.tt/2zgmqq5
The characterisation of NK cells generated in vitro from cord blood haematopoietic stem cells
Domogala, AJ; (2017) The characterisation of NK cells generated in vitro from cord blood haematopoietic stem cells. Doctoral thesis , UCL (University College London). Green open access
http://ift.tt/2ztIQF4
Advancing trial design in progressive multiple sclerosis.
Miller, DH; Thompson, AJ; (2017) Advancing trial design in progressive multiple sclerosis. Multiple Sclerosis Journal , 23 (12) pp. 1571-1572. 10.1177/1352458517729767 .
http://ift.tt/2zgmgyZ
Housing as Urbanism: The role of Housing Policies in Reducing Urban Inequalities. A study of post 2006 Housing Programmes in Puente Alto, Chile
Cocina Varas, Camila Loreto; (2017) Housing as Urbanism: The role of Housing Policies in Reducing Urban Inequalities. A study of post 2006 Housing Programmes in Puente Alto, Chile. Doctoral thesis , UCL (University College London).
http://ift.tt/2ztII8y
Descendants of the Jurassic turiasaurs from Iberia found refuge in the Early Cretaceous of western USA
Royo-Torres, R; Upchurch, P; Kirkland, JI; DeBlieux, D; Foster, JR; Cobos, A; Alcalá, L; (2017) Descendants of the Jurassic turiasaurs from Iberia found refuge in the Early Cretaceous of western USA. Scientific Reports , 7 , Article 14311. 10.1038/s41598-017-14677-2 . Green open access
http://ift.tt/2zgm96x
Structural investigation of the folding of an immunoglobulin domain during biosynthesis on the ribosome
Cassaignau, AME; (2017) Structural investigation of the folding of an immunoglobulin domain during biosynthesis on the ribosome. Doctoral thesis , UCL (University College London).
http://ift.tt/2ztIvCi
The association between dog walking, physical activity and owner's perceptions of safety: cross-sectional evidence from the US and Australia
Christian, H; Wood, L; Nathan, A; Kawachi, I; Houghton, S; Martin, K; McCune, S; (2016) The association between dog walking, physical activity and owner's perceptions of safety: cross-sectional evidence from the US and Australia. BMC Public Health , 16 , Article 1010. 10.1186/s12889-016-3659-8 . Green open access
http://ift.tt/2zglVfH
Neural encoding of the vertical plane in freely-moving rats
Casali, Giulio; (2017) Neural encoding of the vertical plane in freely-moving rats. Doctoral thesis , UCL (University College London);. Green open access
http://ift.tt/2zu5oG1
Optimisation Approaches for Energy Supply Chains
Calderón Vergara, Andrés Joaquín; (2017) Optimisation Approaches for Energy Supply Chains. Doctoral thesis , UCL (University College London).
http://ift.tt/2zglMJb
Hyalinizing Clear Cell Carcinoma of the Tonsil: A Case Report
Abstract
Hyalinzing clear cell carcinoma is a rare tumor of the oral cavity and is even more rarely located in the tonsil. Here, we present a case report of a pedunculated tonsillar mass in a nearly asymptomatic patient that was present for 2 years prior to removal. Complete surgical excision was achieved and no adjuvant therapy was recommended. We include a discussion of this rare pathology and its typical clinical presentation and course.
http://ift.tt/2lMZgCw
Sclerosing Mucoepidermoid Carcinoma of the Submandibular Gland Presenting as Chronic Sialadenitis: A Case Report and Review of Literature
Abstract
Sclerosing mucoepidermoid carcinoma of the salivary gland (SMEC) is a rare subtype of mucoepidermoid carcinoma (MEC), first described in 1987 by Chan and Saw. As far as we are aware, only 30 cases have been published since then. Most cases were located in the parotid gland with some cases described in the submandibular and minor salivary glands. SMEC typically presents as a long-standing mass, with a non-specific enhancing appearance on imaging and is often non-diagnostic on fine needle aspiration, making pre-operative diagnosis very difficult. It is characterised by dense sclerosis within an otherwise typical MEC, frequently with lymphoid proliferation and eosinophils at the periphery. The histological diagnosis of SMEC can be challenging, as the sclerosis may obscure the other morphological features, which can lead to misdiagnosis. Grading can also be difficult, and the prognostic value of grading for SMEC remains unclear. Herein is described a new case of SMEC, presenting clinically as chronic sialadenitis in the left submandibular gland of a 41 year old male. A brief literature review and the issues surrounding diagnosis and grading are also discussed.
http://ift.tt/2yrAvSi
Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity
Abstract
The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted of a proliferation of spindle and epithelioid looking cells. Cells were arranged in loose fascicles and sheets. Rhabdomyoblast-like cells were also seen. No mitotic figures were present. Lesional cells were reactive to cytokeratin AE1/AE3 and CD31. Lesional cell reactivity to S100 protein, HMB 45, SMA, Desmin and CD34 was negative. Following the diagnosis, a wide excision for clear margins was performed. No recurrence has been reported 2 years since the removal. The PMH is a cutaneous tumor that behaves in an indolent fashion. This is the first report of oral involvement by this neoplasm. Recognition of its histopathological features and immunohistochemical reactivity will prevent misadventures in the diagnosis of oral lesions.
http://ift.tt/2yqOSXf
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature
Abstract
Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.
http://ift.tt/2lLv4b1
Hyalinizing Clear Cell Carcinoma of the Bronchus
Abstract
Hyalinizing clear cell carcinoma (HCCC) is an uncommon low-grade minor salivary gland neoplasm that usually arises in the head and neck region. We report a 55-year-old man who presented with a 2.5 cm lung mass that was partially obstructing the right bronchus intermedius. The tumor consisted of cords and nests of clear and eosinophilic cells in a hyalinized stromal background. The neoplastic cells expressed cytokeratin (CK) 7, CK 5/6, high-molecular weight cytokeratin (34BE12), p63 and p40, while TTF-1, napsin A, CK20, S100, smooth muscle actin, synaptophysin and chromogranin were negative. Mucicarmine stain also was negative in the lesional cells. Fluorescence in situ hybridization using break apart probes revealed rearrangement of the Ewing Sarcoma Breakpoint Region 1 gene locus. The morphologic, immunophenotypic and cytogenetic findings confirmed the diagnosis of HCCC, most likely of bronchial submucosal gland origin. To our knowledge, only two other reports of primary pulmonary HCCC are available in English literature.
http://ift.tt/2yrGer9
Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants
Source:Molecular Immunology, Volume 92
Author(s): Oyeleye Alabi, Jessica Dement-Brown, Mate Tolnay
Human Fc receptor-like 5 (FCRL5) is a novel IgG receptor. We reported that IgG2 samples display a thousand-fold range affinity for FCRL5, indicating that attributes beyond the isotype affect binding. We hypothesized that the complex interaction could be exploited to identify distinct changes in the IgG2 molecule. We investigated using surface plasmon resonance two factors that might affect the interaction between IgG2 and FCRL5; heterogeneity related to disulfide isoforms and charge variants. We found that panitumumab and denosumab samples enriched for the more flexible A disulfide isoform bound FCRL5 with two-fold and 82-fold higher apparent affinity, respectively, than the B isoform. We next assessed whether FCRL5 binding can distinguish panitumumab charge variants which increase during storage, using two approaches. First, samples were stored at 40°C to promote acidic variants. Heat stressed panitumumab had up to four-fold higher apparent affinity for FCRL5. Next, we used conditions that promoted deamidation, a common cause of acidic variants. We found that deamidated panitumumab had up to 14-fold higher apparent affinity for FCRL5, indicating that deamidation promotes the interaction. Statistical analyses of kinetic parameters and similarity scores obtained from sensogram comparisons indicated that IgG2 disulfide isoforms, heat stressed and deamidated samples each bind FCRL5 differently. We conclude that based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand.
http://ift.tt/2yrsInF
Molecular characterization of the bovine IER3 gene: Down-regulation of IL-8 by blocking NF-κB activity mediated by IER3 overexpression in MDBK cells infected with bovine viral diarrhea virus-1
Source:Molecular Immunology, Volume 92
Author(s): Melina Villalba, Fernanda Fredericksen, Carola Otth, Víctor H. Olavarría
The immediate early response 3 (IER3) is a key regulatory factor in the immune response, particularly as related to homeostasis immunomodulation via the nuclear factor kappa B (NF-κB) signaling pathway. The IER3 gene has been identified in mammals and, more recently, in other higher vertebrates. Nevertheless, relatively little is known about this regulator in bovines. Therefore, this study explored, characterized, and compared the genetic context of bovine IER3 to homologous genes in the human, mouse, and canine chromosomes. In silico analysis identified several regions of interest preserved in phylogenetically distant species. Similar analyses were also conducted for interleukin-8, a cytokine in which several putative cis elements were identified for the inducible transcription factor NF-κB. Subsequent challenge assays against the bovine viral diarrhea virus-1 revealed NF-κB signaling pathway activation just 15min post-infection, a process blocked by the BAY-117085 inhibitor. Similarly, infection strongly increased IER3 expression. Interestingly, IER3 down-regulated interleukin-8 expression, as confirmed by IER3 gene inhibition using small interfering RNA, RT-qPCR, and luciferase assays. In conclusion, this is the first report to present data indicating that bovine IER3 is a strong regulator of immune-marker expression, specifically modulating bovine interleukin-8 activation through the NF-κB/IER3 pathway in response to the bovine viral diarrhea virus.
http://ift.tt/2lJWptY
MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3σ expression
Source:Molecular Immunology, Volume 92
Author(s): Fei Li, Yi Huang, You-Ying Huang, Yan-Song Kuang, Yong-Jian Wei, Li Xiang, Xing-Ju Zhang, Zheng-Cai Jia, Shan Jiang, Jing-Yi Li, Ying Wan
B cells play a critical role in immune responses both in physiological and pathological conditions, and microRNAs have been shown to play important roles in regulating B cell proliferation and function. MiR-146a has been shown to modulate T cell immunity, but its function in regulating B cell response remains partially understood. Our previous studies indicated that germinal center (GC) B cells are significantly expanded in miR-146a-overexpressing (TG) mice. In this study, we further characterized the roles of miR-146a in regulating humoral immune responses to specific antigens. We found that the production of IgE antibody were significantly elevated in TG mice, while the antibody affinity maturation of IgM and IgG were similar between TG mice and the normal controls. We further found higher IgE antibody levels in TG B cell culture supernatant than that in normal controls. A global protein expression comparison of B cells from TG mice and the normal controls through TMT proteomic assay showed that 14-3-3σ, a key factor of immunoglobulin class switch DNA recombination (CSR) in B cells, was highly up-regulated in B cells with overexpression of miR-146a, while Smad4, the target of miR-146a, was decreased. Using an asthma model induced by OVA immunization, we further confirmed the increased level of OVA specific IgE antibodies in TG mice. These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3σ expression, and suggest that miR-146a may be a potential target for asthma therapy.
http://ift.tt/2yrRqV2
Corrigendum to “Respiratory Syncytial virus infection compromises asthma tolerance by recruiting interleukin-17A-producing cells via CCR6-CCL20 signaling” [Mol. Immunol. 88 (2017) 45–57]
Source:Molecular Immunology
Author(s): Tianyun Shi, Yanchao He, Wei Sun, Yi Wu, Ling Li, Zhijun Jie, Xiao Su
http://ift.tt/2lM7qv5
The clinical relevance of lipid transfer protein
Abstract
Despite a huge number of studies, many aspects of the lipid transfer protein (LTP)-syndrome, the most frequent primary food allergy in Mediterranean countries, remain unclear. Its peculiar geographical distribution, along with the extreme variability of its clinical expression make this type of food allergy something unique in the panorama of IgE-mediated food-induced allergic reactions. The present review article tried to summarize the current knowledge about the most important aspects of LTP sensitization and allergy, along with the importance of positive and negative co-factors in the clinical expression of the syndrome as well as the issues regarding the cross-reactivity between LTPs present in botanically related and unrelated foods. Further, the possible absence of the protein from some plant foods is discussed.
This article is protected by copyright. All rights reserved.
http://ift.tt/2zg6Drk
Enhanced Antigen-presenting and T-cell Functions During Late-phase Allergic Responses in the Lung
Abstract
Background
Allergic inflammation is a common feature of asthma and may contribute to both development and perpetuation of disease. The interaction of antigen presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines may determine the inflammatory response. Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional studies in humans have been limited.
Objective
This study examined the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge (SAC).
Methods
15 allergic patients underwent SAC, and cells from bronchoalveolar lavage (BAL) were collected after 24 hours. APC and TC from the blood and BAL were purified based on expression of the monocyte marker, CD14; the plasmacytoid dendritic cell (pDC) marker, BDCA4, identifying neuropilin 1 (NRP1); and the helper T cell marker, CD4. Functional activity was assessed using allergen-induced T cell proliferation. Flow-cytometry identified cells expressing CD14 and NRP1.
Results
SAC resulted in a 12-fold increase of mononuclear cells having the morphologic appearance of blood monocytes. Most of these cells co-expressed CD14 and NRP1. After saline challenge, BAL mononuclear cells demonstrated little APC function Following SAC, BAL mononuclear cells showed function equal to pDC from blood and greater than blood monocytes. Purified NRP1+ cells from BAL had even greater function than pDC cells from blood (p = .008). Using consistent sources of APC, enhanced proliferation of TC from lung compared to blood was also demonstrated (p = .002).
Conclusions
The marked increase in APC function for allergen-specific TC proliferation during allergic inflammation is largely due to the recruitment of monocytes and dendritic cells. There is also an enhanced response in the lung TC population, consistent with recruitment of allergen-specific T cells. Interactions between recruited APC and TC may occur as an early event promoting allergic airway inflammation.
This article is protected by copyright. All rights reserved.
http://ift.tt/2zuHObR
The role of literacy in the association between educational attainment and depressive symptoms
Nguyen, TT; Tchetgen Tchetgen, EJ; Kawachi, I; Gilman, SE; Walter, S; Glymour, MM; (2017) The role of literacy in the association between educational attainment and depressive symptoms. SSM - Population Health , 3 pp. 586-593. 10.1016/j.ssmph.2017.07.002 . Green open access
http://ift.tt/2irZMkH
A gene therapy approach for Argininosuccinic aciduria
Baruteau, JC; (2017) A gene therapy approach for Argininosuccinic aciduria. Doctoral thesis , UCL (University College London).
http://ift.tt/2h0Z6Cn
Humoral responses to Cytomegalovirus glycoprotein B vaccine with MF59 adjuvant
Baraniak, Ilona Anna; (2017) Humoral responses to Cytomegalovirus glycoprotein B vaccine with MF59 adjuvant. Doctoral thesis , UCL (University College London). Green open access
http://ift.tt/2ipxXsU
CALF: Categorical automata learning framework
Van Heerdt, G; Sammartino, M; Silva, A; (2017) CALF: Categorical automata learning framework. In: Goranko, V and Dam, M, (eds.) Proceedings of the 26th EACSL Annual Conference on Computer Science Logic (CSL 2017). (pp. 29:1-29:24). Schloss Dagstuhl--Leibniz-Zentrum fuer Informatik: Dagstuhl, Germany. Green open access
http://ift.tt/2gXsnxQ
Syncope in a young man: Role of Purkinje fibres in idiopathic ventricular fibrillation
Martin, CA; Nunn, L; Lambiase, PD; (2017) Syncope in a young man: Role of Purkinje fibres in idiopathic ventricular fibrillation. Indian Pacing and Electrophysiology Journal , 17 (4) pp. 113-115. 10.1016/j.ipej.2017.05.006 . Green open access
http://ift.tt/2irZpXl
Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women
Vetter, C; Devore, EE; Wegrzyn, LR; Massa, J; Speizer, FE; Kawachi, I; Rosner, B; ... Schernhammer, ES; + view all Vetter, C; Devore, EE; Wegrzyn, LR; Massa, J; Speizer, FE; Kawachi, I; Rosner, B; Stampfer, MJ; Schernhammer, ES; - view fewer (2016) Association Between Rotating Night Shift Work and Risk of Coronary Heart Disease Among Women. JAMA , 315 (16) pp. 1726-1734. 10.1001/jama.2016.4454 . Green open access
http://ift.tt/2h1xxcf
Photodynamic Therapy in Breast Surgical Oncology: in vitro, in vivo and first human clinical study
Banerjee, Shramana Mitul; (2017) Photodynamic Therapy in Breast Surgical Oncology: in vitro, in vivo and first human clinical study. Doctoral thesis , UCL (University College London).
http://ift.tt/2irZiuT
Regions and regionalism in "new" European Union member states: the cases of Istria and Pirin Macedonia
Baeva-Motusic, Andreana Kirilova; (2017) Regions and regionalism in "new" European Union member states: the cases of Istria and Pirin Macedonia. Doctoral thesis , UCL (University College London). Green open access
http://ift.tt/2h0YCME
Association between religious service attendance and lower suicide rates among US women
VanderWeele, TJ; Li, S; Tsai, AC; Kawachi, I; (2016) Association between religious service attendance and lower suicide rates among US women. JAMA Psychiatry , 73 (8) pp. 845-851. 10.1001/jamapsychiatry.2016.1243 . Green open access
http://ift.tt/2irZbPZ
A Visionary Approach to Listening: Determining The Role Of Vision In Auditory Scene Analysis
Atilgan, Huriye; (2017) A Visionary Approach to Listening: Determining The Role Of Vision In Auditory Scene Analysis. Doctoral thesis , UCL (University College London).
http://ift.tt/2gZ4Jkg
The effect of Bisphosphonates on Human Mesenchymal Stem Cell Behaviour and its implication on Titanium Osseointegration
Alqhtani, NR; (2017) The effect of Bisphosphonates on Human Mesenchymal Stem Cell Behaviour and its implication on Titanium Osseointegration. Doctoral thesis , UCL (University College London).
http://ift.tt/2irZ9aP
Composition of the low seismic velocity E layer at the top of Earth's core
Brodholt, J; Badro, J; (2017) Composition of the low seismic velocity E layer at the top of Earth's core. Geophysical Research Letters , 44 (16) pp. 8303-8310. 10.1002/2017GL074261 . Green open access
http://ift.tt/2gZYg8L
Preface
Lindenbergh, R; Yang, B; Boehm, J; Rutzinger, M; Yao, W; Weinmann, M; (2017) Preface. ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences , 4 (2W4) pp. 31-33. 10.5194/isprs-annals-IV-2-W4-31-2017 . Green open access
http://ift.tt/2iqVZDX
An MILP formulation for the optimal management of microgrids with task interruptions
Silvente Saiz, J; Papageorgiou, LG; (2017) An MILP formulation for the optimal management of microgrids with task interruptions. Applied Energy (206) pp. 1131-1146. 10.1016/j.apenergy.2017.08.147 .
http://ift.tt/2h0YAUX
Community Vulnerability to Landslides in Bangladesh
Ahmed, Bayes; (2017) Community Vulnerability to Landslides in Bangladesh. Doctoral thesis , UCL (University College London).
http://ift.tt/2iqVQAp
Dietary patterns and the risk of CVD and all-cause mortality in older British men
Atkins, JL; Whincup, PH; Morris, RW; Lennon, LT; Papacosta, O; Wannamethee, SG; (2016) Dietary patterns and the risk of CVD and all-cause mortality in older British men. The British Journal of Nutrition , 116 (7) pp. 1246-1255. 10.1017/S0007114516003147 . Green open access
http://ift.tt/2h0HtTk
“Ghost ponds” : Resurrecting lost ponds and species to assist aquatic biodiversity conservation
Alderton, Emily; (2017) "Ghost ponds" : Resurrecting lost ponds and species to assist aquatic biodiversity conservation. Doctoral thesis , UCL (University College London).
http://ift.tt/2iqtKFy
Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation
Boyd, CM; Parsons, ES; Smith, RAG; Seddon, JM; Ces, O; Bubeck, D; (2016) Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation. Scientific Reports , 6 (1) , Article 38446. 10.1038/srep38446 . Green open access
http://ift.tt/2gZvLrW
Communication: Influence of external static and alternating electric fields on water from long-time non-equilibrium ab initio molecular dynamics
Futera, Z; English, NJ; (2017) Communication: Influence of external static and alternating electric fields on water from long-time non-equilibrium ab initio molecular dynamics. The Journal of Chemical Physics , 147 (3) , Article 031102. 10.1063/1.4994694 . Green open access
http://ift.tt/2iqtDK8
Randomised controlled trial of the clinical and cost-effectiveness of a peer-delivered self-management intervention to prevent relapse in crisis resolution team users: study protocol
Johnson, S; Mason, O; Osborn, D; Milton, A; Henderson, C; Marston, L; Ambler, G; ... Lloyd-Evans, B; + view all Johnson, S; Mason, O; Osborn, D; Milton, A; Henderson, C; Marston, L; Ambler, G; Hunter, R; Pilling, S; Morant, N; Gray, R; Weaver, T; Nolan, F; Lloyd-Evans, B; - view fewer (2017) Randomised controlled trial of the clinical and cost-effectiveness of a peer-delivered self-management intervention to prevent relapse in crisis resolution team users: study protocol. BMJ Open , 7 (10) , Article e015665. 10.1136/bmjopen-2016-015665 . Green open access
http://ift.tt/2h0BspC
Allergy and immunology practice parameters and guidelines
Source:Annals of Allergy, Asthma & Immunology
Author(s): David M. Lang, Jay M. Portnoy
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Treatment of seasonal allergic rhinitis
Source:Annals of Allergy, Asthma & Immunology
Author(s): Mark S. Dykewicz, Dana V. Wallace, Fuad Baroody, Jonathan Bernstein, Tim Craig, Ira Finegold, Faith Huang, Desiree Larenas-Linnemann, Eli Meltzer, Gary Steven, David I. Bernstein, Joann Blessing-Moore, Chitra Dinakar, Matthew Greenhawt, Caroline C. Horner, David A. Khan, David Lang, John Oppenheimer, Jay M. Portnoy, Christopher R. Randolph, Matthew A. Rank, Mark S. Dykewicz, Dana V. Wallace
http://ift.tt/2h1yCAR
Guiding principles for use of newer biologics and bronchial thermoplasty for patients with severe asthma
Source:Annals of Allergy, Asthma & Immunology
Author(s): Michael S. Blaiss, Mario Castro, Bradley E. Chipps, Myron Zitt, Reynold A. Panettieri, Michael B. Foggs
BackgroundSevere asthma poses significant disease-related and economic burdens in the United States. Challenges in practice include how to define "severe asthma" for a given patient, knowing which are the right tests to perform and when, and having a better understanding of a patient's asthma phenotype. Furthermore, current guidelines do not address a clear, practical approach to treatment that is based on a patient's asthma phenotype.ObjectiveTo develop a consensus on the definition of severe asthma, the role of biomarkers and phenotyping severe asthma, and the use of newer biologic therapies and bronchial thermoplasty to help guide practicing clinicians.MethodsA roundtable meeting was convened with a panel of severe asthma experts to discuss areas in practice that are not adequately addressed by current guidelines, specifically phenotype-guided treatment.ResultsWe describe a consensus on the definition of severe asthma, asthma phenotyping with the use of available biomarkers, and guiding principles for newer biologic therapies and bronchial thermoplasty.ConclusionTo optimize therapy and improve outcomes such as daily symptoms, quality of life, exacerbations, and hospitalizations, a clear picture of a patient's asthma phenotype is needed to guide therapy. Determining asthma phenotypes is the foundation of precision medicine for this persistent, often difficult-to-treat disease.
http://ift.tt/2iqnU76
American College of Allergy, Asthma & Immunology Position Paper on the Use of Telemedicine for Allergists
Source:Annals of Allergy, Asthma & Immunology
Author(s): Tania Elliott, Jennifer Shih, Chitra Dinakar, Jay Portnoy, Stanley Fineman
The integration of telecommunications and information systems in health care first began 4 decades ago with 500 patient consultations performed via interactive television. The use of telemedicine services and technology to deliver health care at a distance is increasing exponentially. Concomitant with this rapid expansion is the exciting ability to provide enhancements in quality and safety of care. Telemedicine enables increased access to care, improvement in health outcomes, reduction in medical costs, better resource use, expanded educational opportunities, and enhanced collaboration between patients and physicians. These potential benefits should be weighed against the risks and challenges of using telemedicine. The American College of Allergy, Asthma, and Immunology advocates for incorporation of meaningful and sustained use of telemedicine in allergy and immunology practice. This article serves to offer policy and position statements of the use of telemedicine pertinent to the allergy and immunology subspecialty.
http://ift.tt/2h1ypxz
Early experience with a patient-specific virtual surgical simulation for rehearsal of endoscopic skull-base surgery
Background
With the help of contemporary computer technology it is possible to create a virtual surgical environment (VSE) for training. This article describes a patient-specific virtual rhinologic surgical simulation platform that supports rehearsal of endoscopic skull-base surgery. We also share our early experience with select cases.
Methods
A rhinologic VSE was developed, featuring a highly efficient direct 3-dimensional (3D) volume renderer with simultaneous stereoscopic feedback during surgical manipulation of the virtual anatomy, as well as high-fidelity haptic feedback. We conducted a retrospective analysis on 10 patients who underwent various forms of sinus and ventral skull-base surgery to assess the ability of the rhinologic VSE to replicate actual intraoperative findings.
Results
In all 10 cases, the simulation experience was realistic enough to perform dissections in a similar manner as in the actual surgery. Excellent correlation was found in terms of surgical exposure, anatomical features, and the locations of pathology.
Conclusion
The current rhinologic VSE shows sufficient realism to allow patient-specific surgical rehearsal of the sinus and ventral skull base. Further validation studies are needed to assess the benefits of performing patient-specific rehearsal.
http://ift.tt/2xW7REo
Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin-exacerbated respiratory disease
Background
In this study we assessed patient outcomes after complete endoscopic sinus surgery (ESS) and aspirin desensitization for patients with aspirin-exacerbated respiratory disease (AERD).
Methods
A retrospective chart review was conducted for patients with aspirin challenge–proven AERD who underwent complete ESS followed by aspirin desensitization. Outcomes assessed included need for revision surgery and quality-of-life measures using the 22-item Sino-Nasal Outcomes Test (SNOT-22). Data were collected preoperatively, postoperatively prior to desensitization, and then at intervals post-desensitization through 30 months after aspirin desensitization. A longitudinal linear mixed-effects model was used for data analysis.
Results
Thirty-four patients met the inclusion criteria for this study. Thirty-two patients successfully completed aspirin desensitization and were subsequently followed for 30 months after desensitization. Two patients were unable to complete desensitization. Five patients discontinued aspirin maintenance therapy due to gastrointestinal and respiratory side effects. Within the follow-up period, there were only 3 (9.4%) revision sinus surgeries. Notably, 1 of these revision cases occurred in a patient who had discontinued aspirin maintenance therapy. After surgical treatment and prior to desensitization patients had significant reductions in SNOT-22 scores. Our results demonstrate that total SNOT-22 scores remained statistically unchanged from immediate post-desensitization throughout the 30-month follow-up period.
Conclusion
Complete sinus surgery followed by timely aspirin desensitization and maintenance therapy is an effective combination in the long-term management of sinus disease in patients with AERD.
http://ift.tt/2AfdDCW
CD8+CD28−CD127loCD39+ regulatory T-cell expansion: A new possible pathogenic mechanism for HIV infection?
Publication date: Available online 2 November 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Daniela Fenoglio, Chiara Dentone, Alessio Signori, Antonio Di Biagio, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Monica Curto, Giovanni Cenderello, Pasqualina De Leo, Valentina Bartolacci, Giancarlo Orofino, Laura Ambra Nicolini, Lucia Taramasso, Edoardo Fiorillo, Valeria Orrù, Paolo Traverso, Bianca Bruzzone, Federico Ivaldi, Eugenio Mantia, Michele Guerra, Simone Negrini, Mauro Giacomini, Sanjay Bhagani, Gilberto Filaci
BackgroundHIV-associated immunodeficiency is related to loss of CD4+ T cells. This mechanism does not explain certain manifestations of HIV disease, such as immunodeficiency events in patients with greater than 500 CD4+ T cells/μL. CD8+CD28−CD127loCD39+ T cells are regulatory T (Treg) lymphocytes that are highly concentrated within the tumor microenvironment and never analyzed in the circulation of HIV-infected patients.ObjectivesWe sought to analyze the frequency of CD8+CD28−CD127loCD39+ Treg cells in the circulation of HIV-infected patients.MethodsThe frequency of circulating CD8+CD28−CD127loCD39+ Treg cells was analyzed and correlated with viral load and CD4+ T-cell counts/percentages in 93 HIV-1–infected patients subdivided as follows: naive (n = 63), elite controllers (n = 19), long-term nonprogressors (n = 7), and HIV-infected patients affected by tumor (n = 4). The same analyses were performed in HIV-negative patients with cancer (n = 53), hepatitis C virus–infected patients (n = 17), and healthy donors (n = 173).ResultsHIV-infected patients had increased circulating levels of functional CD8+CD28−CD127loCD39+ Treg cells. These cells showed antigen specificity against HIV proteins. Their frequency after antiretroviral therapy (ART) correlated with HIV viremia, CD4+ T-cell counts, and immune activation markers, suggesting their pathogenic involvement in AIDS- or non–AIDS-related complications. Their increase after initiation of ART heralded a lack of virologic or clinical response, and hence their monitoring is clinically relevant.ConclusionHIV infection induces remarkable expansion of CD8+CD28−CD127loCD39+ Treg cells, the frequency of which correlates with both clinical disease and signs of chronic immune cell activation. Monitoring their frequency in the circulation is a new marker of response to ART when effects on viremia and clinical response are not met.
Graphical abstract
http://ift.tt/2A4KYzk
Sonifying Urban Rhythms: Towards the spatio-temporal composition of the urban environment
Adhitya, Sara; (2013) Sonifying Urban Rhythms: Towards the spatio-temporal composition of the urban environment. Doctoral thesis (Ph.D), Università Iuav di Venezia & École des Hautes Études en Sciences Sociales. Green open access
http://ift.tt/2zsQnnM
Choosing the right bar: a complex problem
Morimoto, MM; Saleem, AB; (2017) Choosing the right bar: a complex problem. Nature Neuroscience , 20 (10) pp. 1323-1324. 10.1038/nn.4646 .
http://ift.tt/2zg9JeS
Oral health-related quality of life of children and teens with sickle cell disease
da Matta Felisberto Fernandes, ML; Kawachi, I; Fernandes, AM; Corrêa-Faria, P; Paiva, SM; Pordeus, IA; (2016) Oral health-related quality of life of children and teens with sickle cell disease. Revista Brasileira de Hematologia e Hemoterapia , 38 (2) pp. 106-112. 10.1016/j.bjhh.2016.01.004 . Green open access
http://ift.tt/2ztABsW
Significant range extensions for two fish species at Pitcairn Island, South Pacific
Duffy, HJ; Letessier, TB; Irving, RA; (2017) Significant range extensions for two fish species at Pitcairn Island, South Pacific. Journal of Fish Biology , 91 (2) pp. 669-672. 10.1111/jfb.13359 .
http://ift.tt/2zg9Eb4
Enhanced pelagic biomass around coral atolls
Letessier, TB; Cox, MJ; Meeuwig, JJ; Boersch-Supan, PH; (2016) Enhanced pelagic biomass around coral atolls. Marine Ecology Progress Series , 546 pp. 271-276. 10.3354/meps11675 . Green open access
http://ift.tt/2ztZjsP
Tre casi di miglioramento sismico, niente «formule magiche»: si deve sempre partire dall'analisi caso per caso
Prandi, C; Bonetti, S; Freddi, F; (2017) Tre casi di miglioramento sismico, niente «formule magiche»: si deve sempre partire dall'analisi caso per caso. Edilizia e Territorio: Dossier SISMABONUS: Guida alla diagnosi e agli interventi , 2017 (3) pp. 27-35.
http://ift.tt/2zg9ArQ
La valutazione della vulnerabilità con il metodo semplificato: sistema più rapido, ma non accurato
Freddi, F; Dall'Asta, A; (2017) La valutazione della vulnerabilità con il metodo semplificato: sistema più rapido, ma non accurato. Edilizia e Territorio: Dossier SISMABONUS: Guida alla diagnosi e agli interventi , 2017 (3) pp. 19-22.
http://ift.tt/2zsQkbA
Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries
Smith, ER; Shankar, AH; Wu, LS-F; Aboud, S; Adu-Afarwuah, S; Ali, H; Agustina, R; ... Sudfeld, CR; + view all Smith, ER; Shankar, AH; Wu, LS-F; Aboud, S; Adu-Afarwuah, S; Ali, H; Agustina, R; Arifeen, S; Ashorn, P; Bhutta, ZA; Christian, P; Devakumar, D; Dewey, KG; Friis, H; Gomo, E; Gupta, P; Kaestel, P; Kolsteren, P; Lanou, H; Maleta, K; Mamadoultaibou, A; Msamanga, G; Osrin, D; Persson, L-A; Ramakrishnan, U; Rivera, JA; Rizvi, A; Sachdev, HPS; Urassa, W; West, KP; Zagre, N; Zeng, L; Zhu, Z; Fawzi, WW; Sudfeld, CR; - view fewer (2017) Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. The Lancet Global Health , 5 (11) e1090-e1100. 10.1016/S2214-109X(17)30371-6 . Green open access
http://ift.tt/2zeAMay
Evaluating 17 years of latent tuberculosis infection screening in north-west England: a retrospective cohort study of reactivation
Zenner, D; Loutet, MG; Harris, R; Wilson, S; Ormerod, LP; (2017) Evaluating 17 years of latent tuberculosis infection screening in north-west England: a retrospective cohort study of reactivation. European Respiratory Journal , 50 (1) , Article 1602505. 10.1183/13993003.02505-2016 . Green open access
http://ift.tt/2zstyQW
Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model
holt, IJ; Dalla Rosa, I; Spinazzola, A; (2017) Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model. Nucleic Acids Research 10.1093/nar/gkx1009 . (In press). Green open access
http://ift.tt/2zfb8Cu
Relative Genetic and Environmental Contributions to Variations in Human Retinal Electrical Responses Quantified in a Twin Study
Bhatti, T; Tariq, A; Shen, T; Williams, KM; Hammond, CJ; Mahroo, OA; (2017) Relative Genetic and Environmental Contributions to Variations in Human Retinal Electrical Responses Quantified in a Twin Study. Ophthalmology , 124 (8) pp. 1175-1185. 10.1016/j.ophtha.2017.03.017 . Green open access
http://ift.tt/2zuqQKZ
Living systematic review: 1. Introduction-the why, what, when, and how
Elliott, JH; Synnot, A; Turner, T; Simmonds, M; Akl, EA; McDonald, S; Salanti, G; ... Living Systematic Review Network, .; + view all Elliott, JH; Synnot, A; Turner, T; Simmonds, M; Akl, EA; McDonald, S; Salanti, G; Meerpohl, J; MacLehose, H; Hilton, J; Tovey, D; Shemilt, I; Thomas, J; Living Systematic Review Network, .; - view fewer (2017) Living systematic review: 1. Introduction-the why, what, when, and how. Journal of Clinical Epidemiology 10.1016/j.jclinepi.2017.08.010 . (In press).
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IV Brazilian Consensus on Rhinitis: 2017 update
Publication date: Available online 2 November 2017
Source:Brazilian Journal of Otorhinolaryngology
Author(s): Eulalia Sakano, Emanuel S.C. Sarinho, Alvaro A. Cruz, Antonio C. Patorino, Edwin Tamashiro, Fábio Kuschnir, Fábio F.M. Castro, Fabrizio R. Romano, Gustavo F. Wandalsen, Herberto J. Chong-Neto, João F. de Mello, Luciana R. Silva, Maria Cândida Rizzo, Mônica A.M. Miyake, Nelson A. Rosário Filho, Norma de Paula M. Rubini, Olavo Mion, Paulo A. Camargos, Renato Roithmann, Ricardo N. Godinho, Shirley Shizue N. Pignatari, Tania Sih, Wilma T. Anselmo-Lima, Dirceu Solé
IntroductionThe guidelines on allergic rhinitis aim to update knowledge about the disease and care for affected patients. The initiative called "Allergic Rhinitis and its Impact on Asthma", initially published in 2001 and updated in 2008 and 2010, has been very successful in disseminating information and evidence, as well as providing a classification of severity and proposing a systemized treatment protocol. In order to include the participation of other medical professionals in the treatment of allergic rhinitis, it is important to develop algorithms that accurately indicate what should and can be done regionally.ObjectiveTo update the III Brazilian Consensus on Rhinitis – 2012, with the creation of an algorithm for allergic rhinitis management.MethodsWe invited 24 experts nominated by the Brazilian Association of Allergy and Immunology, Brazilian Association of Otorhinolaryngology and Head and Neck Surgery and Brazilian Society of Pediatrics to update the 2012 document.ResultsThe update of the last Brazilian Consensus on Rhinitis incorporated and adapted the relevant information published in all "Allergic Rhinitis and its Impact on Asthma" Initiative documents to the Brazilian scenario, bringing new concepts such as local allergic rhinitis, new drugs and treatment evaluation methods.ConclusionA flowchart for allergic rhinitis treatment has been proposed.
http://ift.tt/2A2kfUl
Button battery ingestion in children
Purpose of review: As the demand for small electronics continues to grow so does the risk of oesophageal ingestion of button batteries. These small but powerful sources of energy are ubiquitous in every household and when swallowed, especially in small children, have been shown to create significant injury in a short amount of time leading to long-term morbidity and possible death. This review highlights the latest findings regarding epidemiology, pathophysiology, diagnosis and management of ingested button batteries. Recent findings: Updated epidemiology from the National Capital Poison Center, new bench research looking at injury patterns and possible mitigation strategies, updated ideas on management algorithms including the use of a trauma protocol, close-look second endoscopy and management of button batteries in the lower gastrointestinal tract are reviewed in this paper. Summary: Despite advances in the understanding of injury mechanics and innovations leading to early diagnosis and improved management of button battery ingestion, parental and provider education remain the most important tools to keep children well tolerated from the sequelae of these potentially fatal events. Collaboration between healthcare experts, public health and industry is essential to find a safe answer to this ongoing threat.http://ift.tt/2h7hj4V
Otolaryngologic management of Down syndrome patients: what is new?
Purpose of review: The management of children with Down syndrome as it pertains to the otolaryngologist continues to evolve. Obstructive sleep apnea (OSA) has dominated the recent literature, but other topics including hearing loss, swallowing, and perioperative considerations are also reported. Recent findings: The prevalence of OSA in children with Down syndrome ranges from 57 to 73% in certain cohorts, and, whereas adentonsillectomy can decrease Apnea–Hypopnea Index, up to 80% may have persistent OSA. Surgical techniques involving reduction of the base of tongue are effective for those who fail adenotonsillectomy, and it is expected that drug-induced sleep endoscopy may improve outcomes. New technology is also on the horizon that can assist with diagnosis and treatment including computational modelling and upper airway stimulation. Children with Down syndrome may not respond to medical management of eustachian tube dysfunction as well as normally developing children. In addition, there is a high prevalence of inner ear anomalies, increasing the risk for sensorineural hearing loss. Summary: Questions remain pertinent to the otolaryngologist regarding the ideal management of children with Down syndrome. Additional studies are necessary, to optimize understanding and treatment of this complex population, in particular as opportunities develop with technological advances.http://ift.tt/2h8EmMI
Role of reinnervation in the management of recurrent laryngeal nerve injury: current state and advances
Purpose of review: To present the current state of knowledge concerning different laryngeal reinnervation procedures for unilateral and bilateral vocal palsy. Recent findings: Recent reports show positive outcomes on both unilateral and bilateral reinnervations. The phrenic nerve is the most commonly used donor for bilateral vocal palsy, but use of the superior laryngeal nerve has also been suggested. Summary: Reinnervation of the larynx is a complex undertaking that can be performed by ENT surgeons with skills in microsurgery. Advances in this this field represent a paradigm shift in laryngeal rehabilitation and a prerequisite for laryngeal transplantation. Advances in basic understanding of nerve regeneration and in particular the need to surgically manage competitive reinnervation make the results of laryngeal reinnervation more predictable.http://ift.tt/2zbp3Kg
Emerging techniques in assessment and treatment of muscle tension dysphonia
Purpose of review: The purpose of this review is to summarize current evidence regarding treatment for muscle tension dysphonia (MTD) and to present recent advances in evaluation and management. Recent findings: It is generally accepted that voice therapy for MTD is effective, but current systematic reviews report limited evaluation specific to MTD patients with moderate evidence, at best, available to support voice therapy techniques. Individual studies are difficult to compare because of heterogeneity. Considerable work is underway to identify most important metrics to include in assessment, and to advance and define direct voice therapy approaches. Summary: Further standardization of assessment and treatment protocols for MTD will improve future research. Novel therapeutic techniques are under investigation. In small studies, these have found value in improving voice outcomes and measures compared with pretreatment values but have not met success greater than existing therapeutic methods.http://ift.tt/2zaDA8Q
Management of Type I and Type II laryngeal clefts: controversies and evidence
Purpose of review: To summarize the pediatric Type I and Type II laryngeal cleft literature, paying special attention to recent trends, including evolution of surgical techniques, standardization of outcome assessments, and utilization of management algorithms. Recent findings: There are a variety of options to choose from whenever considering Type I and Type II cleft repair, including endoscopic repair, transoral robotic surgery, and injection laryngoplasty. Conservative management including feeding therapy and treatment of comorbid medical conditions is recommended prior to repair. Validated outcome measures have arisen for swallow study interpretation and timing, as well as caregiver quality-of-life assessment. In addition, a series of medical algorithms have been proposed, which provide specific recommendations for diagnosis, treatment, and follow-up. Summary: For clefts that fail conservative management, endoscopic repair has become the gold standard. In addition, injection laryngoplasty appears to provide both a diagnostic and therapeutic option in the management of these patients. Transoral robotic-assisted endoscopic repair appears well tolerated and feasible, although broader implementation of this technology remains limited. The development and refinement of best practice algorithms can help standardize management and improve decision-making. Furthermore, incorporating validated outcome measures, recorded and followed over time, will improve both patient care and research efforts moving forward.http://ift.tt/2zbp156
Benign vocal fold lesions: update on nomenclature, cause, diagnosis, and treatment
Purpose of review: The management of benign vocal fold lesions (BVFLs) continues to evolve. This article will review the recent literature surrounding the nomenclature, cause, diagnosis, and treatment of BVFLs, including polyps, nodules, cysts, and reactive lesions. Recent findings: The taxonomy of vocal fold lesions has been refined, and it serves as a common descriptive language for diagnosis, treatment algorithms, and reporting of outcomes. Though these lesions are known to be the result of phonotrauma, investigation into inflammatory mediators, apoptosis, and laryngopharyngeal reflux provide further elucidation of their underlying pathophysiology. The future of diagnosis, for which direct fiberoptic visualization and stroboscopy are the current gold standard, may utilize narrow-band imaging and videokymography; the clinical utility of ultrasound and optical coherence tomography is more remote. Angiolytic laser therapy and intralesional steroid injection are acceptable options for treatment of BVFLs. Voice therapy and microsurgical excision are mainstays of treatment. Summary: Recent clinical and basic science research has expanded upon an extensive literature surrounding the nomenclature, cause, diagnosis, and treatment of benign subepithelial vocal fold lesions. There remains a strong need for the advancement of rigorous diagnostic principles, evaluation of therapeutic interventions, and development of best practices guidelines.http://ift.tt/2zbp012
Voice rest after laryngeal surgery: what's the evidence?
Purpose of review: This article aims to review previous research reports and to summarize current strategies for the optimal duration of voice rest and the effect of phonatory stimulation after phonomicrosurgery. Recent findings: Voice rest is commonly recommended after laryngeal surgery to prevent worsening of vocal fold injuries. However, there are no established standard protocol for voice rest, and the type and duration of voice rest vary among clinicians. The most effective duration of voice rest is unknown. Recently, early vocal stimulation was recommended as a means to improve wound healing, on the basis of the basic and clinical researches. Summary: It seems that early vocal stimulation may enhance the wound healing process in the vocal fold. More basic and clinical researches are warranted to investigate appropriate timing of initiation of stimulation, as well as the type and amount of stimulation that are available for human.http://ift.tt/2zboX5m
Update on pediatric sinus surgery: indications and outcomes
Purpose of review: To review the recent literature of pediatric endoscopic sinus surgery (ESS). Recent findings: Sinus balloon catheter dilation is an important addition to the surgical treatment tools for pediatric chronic rhinosinusitis (PCRS). ESS is a safe and effective therapeutic modality for uncomplicated PCRS. For PCRS complicated by comorbidities including cystic fibrosis and primary ciliary dyskinesia, ESS and adjuvant medical therapy confers significant sinus, pulmonary, and quality of life benefits to pediatric patients. Summary: ESS is a safe and effective treatment modality in the management of pediatric acute and chronic sinus disorders.http://ift.tt/2zboVKM
Vocal fold leukoplakia: incidence, management, and prevention
Purpose of review: The purpose of this article is to provide an update on English-language literature evaluating the current understanding of incidence, management, and prevention of vocal fold leukoplakia focusing on premalignancy. Recent findings: Recent studies have continued to try to elucidate factors influencing recurrence and progression of dysplastic disease, though results vary. Although advanced diagnostic techniques have attempted to predict disease behavior, tissue diagnosis continues to be essential. Studies reinforce the necessity of removal of disease as the primary treatment, whereas use of photoangiolytic lasers via the ablative technique has increased, as has transition of some patients into the office-based settings for treatment. Although genetic and molecular testing may hold promise for predictive purposes, further study is necessary, and chemotherapy for recalcitrant disease continues to be an area of study with few case studies being reported. Summary: Management of vocal fold leukoplakia continues to progress in terms of identification and treatment. Although many work to advance our knowledge in the field and push treatment strategies toward newer avenues, pathologic diagnosis, eradiation of disease on the basis of experience and skill, and close surveillance continue to be paramount.http://ift.tt/2zboT5C
Postoperative care after tonsillectomy: what's the evidence?
Purpose of review: The purpose of this review is to evaluate the current literature regarding postoperative management after tonsillectomy in children. Recent findings: Controversy remains regarding the ideal medication regimen to manage pain after tonsillectomy. Acetaminophen and ibuprofen are routinely used, although concerns of more severe postoperative hemorrhage with ibuprofen remain. Narcotics are prescribed commonly, but with extreme caution in children with severe obstructive sleep apnea. Although not always utilized by the authors, additional adjunctive medications such as perioperative dexamethasone, ketamine, and local infiltration of lidocaine into tonsillar pillars may decrease postoperative pain. Systematic reviews have shown that dexamethasone does not increase risk of posttonsillectomy bleeding. Summary: Adenotonsillectomy is one of the most common procedures performed on children and may have significant morbidity from postoperative pain and bleeding. Managing pain remains challenging and the optimal treatment regimen has not been definitively identified. Many medications and alternative therapies have been studied and suggest possible benefit.http://ift.tt/2zboQXu
Pharyngolaryngeal symptoms associated with thyroid disease
Purpose of review: The current review summarizes previous reports on laryngopharyngeal symptoms associated with thyroid disease. This review also includes pharyngolaryngeal symptoms caused by thyroidectomy. However, we focus on pharyngolaryngeal symptoms following uncomplicated thyroidectomy, as this is an important issue in the fields of otolaryngology. Recent findings: An enlarged thyroid gland, as in thyroiditis, multinodular goiter, or large nodules, can cause compressive symptoms. Malignant nodules invading the recurrent laryngeal nerve and benign nodules compressing the nerve can cause vocal cord paralysis and hoarseness. Pharyngolaryngeal symptoms are known to develop after a thyroidectomy, generally as a result of injury to the superior or recurrent laryngeal nerve. However, recent studies have shown that various pharyngolaryngeal symptoms, such as globus symptoms and voice changes, occur after thyroidectomy in the absence of laryngeal nerve injury. These symptoms are known collectively as postthyroidectomy syndrome. Several possible explanations have been proposed and evaluated for postthyroidectomy syndrome. Summary: Several thyroid disorders can cause compressive symptoms and hoarseness. Superior and/or recurrent laryngeal nerve injury during thyroidectomy is the main cause of various pharyngolaryngeal symptoms. However, other pharyngolaryngeal symptoms that arise following thyroidectomy in the absence of nerve injury, a condition known as postthyroidectomy syndrome, are becoming more common.http://ift.tt/2zaJ2IT
Binaural integration: a challenge to overcome for children with hearing loss
Purpose of review: Access to bilateral hearing can be provided to children with hearing loss by fitting appropriate hearing devices to each affected ear. It is not clear, however, that bilateral input is properly integrated through hearing devices to promote binaural hearing. In the present review, we examine evidence indicating that abnormal binaural hearing continues to be a challenge for children with hearing loss despite early access to bilateral input. Recent findings: Behavioral responses and electrophysiological data in children, combined with data from developing animal models, reveal that deafness in early life disrupts binaural hearing and that present hearing devices are unable to reverse these changes and/or promote expected development. Possible limitations of hearing devices include mismatches in binaural place, level, and timing of stimulation. Such mismatches could be common in children with hearing loss. One potential solution is to modify present device fitting beyond providing audibility to each ear by implementing binaural fitting targets. Summary: Efforts to better integrate bilateral input could improve spatial hearing in children with hearing loss.http://ift.tt/2zboMac
Vocal tremor: where are we at?
Purpose of review: Vocal tremor in movement disorders is often overlooked, although it has a significant impact on quality of life. Careful observation of tremor phenomenology allows for accurate diagnosis and tailored treatment. Recent findings: The central pathways associated with various vocal tremor-associated diseases have been further elucidated. Summary: Patients are likely to benefit from a combination of medical and interventional treatments delivered within a multidisciplinary settinghttp://ift.tt/2zboLmE
Current opinion in otolaryngology: update on vascular injuries in craniomaxillofacial fractures
Purpose of review: The primary purpose of this chapter is to define current recommendations for vascular work-up of patients with craniomaxillofacial (CMF) trauma with emphasis on imaging to include intraoperative fluorescence, angiography, and surgical exploration. The second goal is to review current management recommendations for observation versus surgical exploration based on the neck zones of injury. Recent findings: Over the past two decades, endovascular techniques are increasingly utilized, particularly in zones I and III of the neck. Additionally, modern advances in radiographic technology have allowed for selective exploration of penetrating zone II injuries. A high suspicion for blunt cerebrovascular injury should be maintained for patients with high-speed deceleration mechanisms of injury, with a majority of patients managed with medical therapy or conservative monitoring over surgical intervention. Summary: CMF fractures are associated with vascular injuries to the intracranial carotid system, extracranial carotid system, or vertebral artery system. A thorough understanding of at risk patients, optimal work-up, and timely treatment algorithms is imperative given the devastating sequellae of stroke and death.http://ift.tt/2AevkCi
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