Michael S. Benninger, Andrea Campagnolo
Braz J Otorhinolaryngol.2018;84:401-3
Texto Completo - PDF
https://ift.tt/2uITvXV
Αρχειοθήκη ιστολογίου
-
►
2020
(289)
- ► Φεβρουαρίου (28)
-
►
2019
(9071)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3642)
- ► Ιανουαρίου (3200)
-
▼
2018
(39872)
- ► Δεκεμβρίου (3318)
- ► Σεπτεμβρίου (3683)
-
▼
Ιουλίου
(3378)
-
▼
Ιουλ 18
(157)
- Chronic laryngopharyngeal vagal neuropathy
- Comparison of the recovery rate of otomycosis usin...
- Body mass index and acoustic voice parameters: is ...
- Free tissue flaps in head and neck reconstruction:...
- Outcomes of external septorhinoplasty in a Turkish...
- Turkish validity and reliability of Eustachian tub...
- Evaluating the ototoxicity of an anti‐MRSA peptide...
- Influence of chronic lymphocytic thyroiditis on th...
- 25 (OH) D3 levels, incidence and recurrence of dif...
- Performance of the phonatory deviation diagram in ...
- IRF6 rs2235375 single nucleotide polymorphism is a...
- Short‐term evaluation of tegumentary changes of th...
- Anthropometric study of the caucasian nose in the ...
- Quality of life and cochlear implant: results in a...
- Water protection after tympanostomy (Shepard) tube...
- Factors associated with voice disorders among the ...
- Degree of tinnitus improvement with stapes surgery...
- A rare laryngeal tumor in a patient with thyroid p...
- Parotid Masson's tumor: case report
- A case of bilateral inferior concha bullosa connec...
- A murine model of wheat versus potato allergy: Pat...
- VAX1 Gene Associated Non-syndromic Cleft lip with ...
- Effect of Metformin on Dental Pulp Stem Cells Atta...
- Effect of palm oil alone or associated to stannous...
- Buccal space tumours
- Electrophysiological Monitoring During Percutaneou...
- Antiviral RNA interference in mammals
- Gutartige Parotistumore: moderne Therapiekonzepte
- Transorale videoendoskopische Resektion von Kopf-H...
- Successful Percutaneous Coronary Intervention for ...
- Pearls for the middle fossa approach in acoustic n...
- Functional considerations in oral cavity reconstru...
- Conjunctival provocation tests: prediction of seas...
- Globalization and anaphylaxis
- Seasonal ocular allergy and pollen counts
- Cosmetics and ocular allergy
- Topical antihistamines, mast cell stabilizers, and...
- Adults and children with anaphylaxis in the emerge...
- Pearls for the middle fossa approach in acoustic n...
- Functional considerations in oral cavity reconstru...
- Interplay between acute phase response and coagula...
- Summary of the updated international consensus dia...
- Long-term sheltering mustaches reduce incidence of...
- Journal of the American Academy of Dermatology: Or...
- Blunt trauma to the antecubital fossa causing brac...
- Buccal space tumours
- Pediatric Nasal Obstruction
- Efficacy & Safety of OPN-375 Adults With Bilateral...
- A Phase 1b Dose Escalation/Expansion Study of Abex...
- Papuloerythroderma of Ofuji successfully treated w...
- Hyaluronic acid filler for skin rejuvenation: The ...
- Efficacy and safety of rupatadine in Japanese adul...
- Human Th9 differentiation is dependent upon STAT3 ...
- Immunomodulatory effect of thymoquinone on atopic ...
- Molecular identification and gene expression profi...
- A novel Aβ epitope vaccine based on bacterium-like...
- Myeloid-derived suppressor cells exacerbate Sjögre...
- Humanin prevents high glucose-induced monocyte adh...
- Summary of the updated international consensus dia...
- Delayed Adverse Skin Effects After PD-1-Inhibitor ...
- Sunscreen Use and Melanoma Risk Among Young Austra...
- Spiky Skin in a Renal Transplant Recipient
- Timing of Onset of Adverse Cutaneous Reactions Ass...
- A Comparison of Tanning Habits Among Gym Tanners a...
- Effect of Stress Ball Use or Hand-holding on Anxie...
- Scabies—An Ancient Disease With Unanswered Questio...
- Venous air embolism in a patient with a massive up...
- Splenic torsion: a rare cause of abdominal pain
- Aggressive myxoinflammatory fibroblastic sarcoma w...
- Rare cause for a common presentation: isolated pul...
- Metastasis of malignant myoepithelial carcinoma to...
- The successful treatment of a multidrug-resistant ...
- Caseous calcification of the mitral valve annulus:...
- Cryptococcus neoformans empyema in a patient recei...
- Transformation of jejunoileal follicular lymphoma ...
- Aortocaval fistula: an unusual complication of rup...
- Laryngoceles with airway compromise complicating m...
- Primary bladder amyloidosis as a cause of haematuria
- Polypoidal lesions associated to choroidal naevus:...
- Acute infection-related glomerulonephritis with di...
- Two for the price of one: emerging carbapenemases ...
- Efficacy of 4-year treatment of icon infiltration ...
- Unruptured giant left ventricular pseudoaneurysm a...
- Hypophosphataemia: an important cause of collapse
- Extravasation of contrast beneath the preputial sk...
- Purple urinary bag syndrome: what every primary he...
- Influence of hearing on vestibulospinal control in...
- Pilotstudie: Bestimmung der subjektiven Rumpfverti...
- Effects of built environment morphology on wind tu...
- Disaggregated optical data center in a box network...
- Angular Independence of Break Position for Magneti...
- Quantum arithmetics via computation with minimized...
- Demonstration of NFV for mobile edge computing on ...
- Fathers against sons/sons against fathers: The pro...
- Accessing new 2D semiconductors with optical band ...
- ECEL1 gene related contractural syndrome: long-ter...
- A note on exponential-Möbius sums over F_{q}[t]
- Comparison of SDM-WDM based Data Center Networks w...
- dReDBox: Materializing a Full-stack Rack-scale Sys...
- Synchronizing reconfiguration of coherent function...
-
▼
Ιουλ 18
(157)
- ► Φεβρουαρίου (2693)
- ► Ιανουαρίου (3198)
-
►
2017
(41099)
- ► Δεκεμβρίου (3127)
- ► Σεπτεμβρίου (2173)
-
►
2016
(13807)
- ► Δεκεμβρίου (700)
- ► Σεπτεμβρίου (600)
- ► Φεβρουαρίου (1350)
- ► Ιανουαρίου (1400)
-
►
2015
(1500)
- ► Δεκεμβρίου (1450)
Ετικέτες
Τετάρτη 18 Ιουλίου 2018
Chronic laryngopharyngeal vagal neuropathy
Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment
Mohammad Reza Mofatteh, Zahra Naseripour Yazdi, Masoud Yousefi, Mohammad Hasan Namaei
Braz J Otorhinolaryngol.2018;84:404-9
Resume - Texto Completo - PDF
https://ift.tt/2mvKPjD
Body mass index and acoustic voice parameters: is there a relationship?
Lourdes Bernadete Rocha de Souza, Marquiony Marques dos Santos
Braz J Otorhinolaryngol.2018;84:410-5
Resume - Texto Completo - PDF
https://ift.tt/2uMD24Z
Free tissue flaps in head and neck reconstruction: clinical application and analysis of 93 patients of a single institution
Jiwang Liang, Tao Yu, Xu Wang, Yuejiao Zhao, Fengqin Fang, Wei Zeng, Zhendong Li
Braz J Otorhinolaryngol.2018;84:416-25
Resume - Texto Completo - PDF
https://ift.tt/2mvKMnX
Outcomes of external septorhinoplasty in a Turkish male population
Gamze Didem Kilci, Engin Başer, Ayşegül Verim, Ömer Faruk Çalim, Bayram Veyseller, Orhan Özturan, Ahmet Altintaş, Mustafa Çelik
Braz J Otorhinolaryngol.2018;84:426-34
Resume - Texto Completo - PDF
https://ift.tt/2zRs9EK
Turkish validity and reliability of Eustachian tube dysfunction questionnaire‐7
Erdoğan Özgür, Cem Bilgen, Beyhan Cengiz Özyurt
Braz J Otorhinolaryngol.2018;84:435-40
Resume - Texto Completo - PDF
https://ift.tt/2mtZufa
Evaluating the ototoxicity of an anti‐MRSA peptide KR‐12‐a2
Chung Man Sung, Hong Chan Kim, Yong Beom Cho, Song Yub Shin, Chul Ho Jang
Braz J Otorhinolaryngol.2018;84:441-7
Resume - Texto Completo - PDF
https://ift.tt/2uHzYqw
Influence of chronic lymphocytic thyroiditis on the risk of persistent and recurrent disease in patients with papillary thyroid carcinoma and elevated antithyroglobulin antibodies after initial therapy
Marina Carvalho S. Côrtes, Pedro Weslley Rosario, Gabriela Franco Mourão, Maria Regina Calsolari
Braz J Otorhinolaryngol.2018;84:448-52
Resume - Texto Completo - PDF
https://ift.tt/2mtZoUQ
25 (OH) D3 levels, incidence and recurrence of different clinical forms of benign paroxysmal positional vertigo
Sinisa Maslovara, Silva Butkovic Soldo, Anamarija Sestak, Katarina Milinkovic, Jasna Rogic‐Namacinski, Anamarija Soldo
Braz J Otorhinolaryngol.2018;84:453-9
Resume - Texto Completo - PDF
https://ift.tt/2uPyN8S
Performance of the phonatory deviation diagram in the evaluation of rough and breathy synthesized voices
Leonardo Wanderley Lopes, Jonas Almeida de Freitas, Anna Alice Almeida, Priscila Oliveira Costa Silva, Giorvan Ânderson dos Santos Alves
Braz J Otorhinolaryngol.2018;84:460-72
Resume - Texto Completo - PDF
https://ift.tt/2mvKBZP
IRF6 rs2235375 single nucleotide polymorphism is associated with isolated non‐syndromic cleft palate but not with cleft lip with or without palate in South Indian population
Venkatesh Babu Gurramkonda, Altaf Hussain Syed, Jyotsna Murthy, Bhaskar V.K.S. Lakkakula
Braz J Otorhinolaryngol.2018;84:473-7
Resume - Texto Completo - PDF
https://ift.tt/2zQYKuh
Short‐term evaluation of tegumentary changes of the nose in oral breathers undergoing rapid maxillary expansion
Fauze Ramez Badreddine, Reginaldo Raimundo Fujita, Mario Cappellette
Braz J Otorhinolaryngol.2018;84:478-85
Resume - Texto Completo - PDF
https://ift.tt/2mvKzkF
Anthropometric study of the caucasian nose in the city of Curitiba: relevance of population evaluation
Annelyse Cristine Ballin, Bettina Carvalho, José Eduardo Lutaif Dolci, Renata Becker, Cezar Berger, Marcos Mocellin
Braz J Otorhinolaryngol.2018;84:486-93
Resume - Texto Completo - PDF
https://ift.tt/2uOujz0
Quality of life and cochlear implant: results in adults with postlingual hearing loss
Aline Faria de Sousa, Maria Inês Vieira Couto, Ana Claudia Martinho‐Carvalho
Braz J Otorhinolaryngol.2018;84:494-9
Resume - Texto Completo - PDF
https://ift.tt/2mu03Wk
Water protection after tympanostomy (Shepard) tubes does not decrease otorrhea incidence ‐ retrospective cohort study
João Subtil, Ana Jardim, André Peralta Santos, João Araújo, José Saraiva, João Paço
Braz J Otorhinolaryngol.2018;84:500-5
Resume - Texto Completo - PDF
https://ift.tt/2zNkJ5n
Factors associated with voice disorders among the elderly: a systematic review
Amanda Cibelly Brito Gois, Leandro de Araújo Pernambuco, Kenio Costa de Lima
Braz J Otorhinolaryngol.2018;84:506-13
Resume - Texto Completo - PDF
https://ift.tt/2mtZZG4
Degree of tinnitus improvement with stapes surgery – a review
Aliciane Mota G. Cavalcante, Isabella Monteiro de Castro Silva, Bianca Jessica Neves, Carlos Augusto Oliveira, Fayez Bahmad Jr
Braz J Otorhinolaryngol.2018;84:514-8
Resume - Texto Completo - PDF
https://ift.tt/2uPy7QS
A rare laryngeal tumor in a patient with thyroid papillary cancer: granular cell tumor
Sheng‐Yao Cheng, Li‐Hsiang Cheng, Yi‐Shu Liao, Wen‐Sen Lai
Braz J Otorhinolaryngol.2018;84:519-22
Texto Completo - PDF
https://ift.tt/2mtZgok
Parotid Masson's tumor: case report
Filippo Carta, Sara Sionis, Valeria Ledda, Clara Gerosa, Roberto Puxeddu
Braz J Otorhinolaryngol.2018;84:523-5
Texto Completo - PDF
https://ift.tt/2zNClxO
A case of bilateral inferior concha bullosa connecting to maxillary sinus
Soo Kweon Koo, Ji Seung Moon, Sung Hoon Jung, Mi Jin Mun
Braz J Otorhinolaryngol.2018;84:526-8
Texto Completo - PDF
https://ift.tt/2mtZdJa
A murine model of wheat versus potato allergy: Patatin and 53kDa protein are the potential allergen from potato
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Ibtessam Tahir Ansari, Taihua Mu
Abstract
Wheat allergy is the most common around the world as gluten is the potential allergen. People diagnosed with wheat allergy were mainly substitute with other novel food such as potato though it is also being reported for allergenic manifestations. Thus there is an increasing demand for developing a BALB/c mice model to empathize the allergic properties of potato protein and its fractions. Purified potato protein showed lower IgE-binding capacity (474.39 ± 0.6 ng/mL) even in higher concentration (30 mg/mL) compared to wheat gluten (1418.28 ± 0.17 ng/mL, 5mg/mL). Immediate active cutaneous hypersensitivity reaction, vascular leakage, intestinal permeability and lung's inflammatory cell infiltration was also ascertained comparatively lower in potato protein than wheat gluten. Furthermore, patatin (43 kDa) and protease inhibitors (∼21 kDa) were purified and separated, and patatin exhibited higher hypersensitivity score than that of protease inhibitors. Immuno-detection assays indicated that patatin and 53 kDa protein in potato protein showed specific Ig-E binding capacity, and 53 kDa was adenosyl homocysteinase identified by LC–MS/MS.
Graphical abstract
https://ift.tt/2mrzj99
VAX1 Gene Associated Non-syndromic Cleft lip with or without Palate in Western Han Chinese
Publication date: Available online 18 July 2018
Source: Archives of Oral Biology
Author(s): Bi-He Zhang, Jia-Yu Shi, Yan-Song Lin, Bing Shi, Zhong-Lin Jia
ABSTRACT
Objective
Non-syndromic cleft lip with or without palate (NSCL/P) is one of the most common human birth defects, it results from multiple genetic and environmental risk factors. Recently, GWA studies identified associations between NSCL/P and two genetic risk loci, rs7078160 and rs4752028, at VAX1.
Design
Currently, we tried to investigate the roles of the two loci among 302 NSCL/P trios (129 non-syndromic cleft lip only (NSCLO) trios and 173 non-syndromic cleft lip and cleft palate (NSCLP) trios) from Western Han Chinese. The two SNPs were genotyped by SNPscan method; Hardy–Weinberg equilibrium test, allelic TDT and parent-of-origin effect were performed by PLINK software, and genotypic TDT and haplotype by FBAT software.
Results
Allelic TDT analysis revealed allele A at rs7078160 was over-transmitted among NSCL/P group (P = 0.0086, ORtransmission = 1.36, 95%CI: 1.08-1.72). Parent-of-origin effect analysis revealed a paternal special over-transmission of allele A at rs708260 in NSCL/P group (P = 0.0079). Haplotype AC of rs7078160-rs4752028 was significant over-transmitted in the NSCL/P group.
Conclusions
Our study firstly confirmed that allele A at rs7078160 at VAX1 gene was a risk factor for NSCL/P in Western Han Chinese population.
https://ift.tt/2zNyVLu
Effect of Metformin on Dental Pulp Stem Cells Attachment, Proliferation and Differentiation Cultured on Biphasic Bone Substitutes
Publication date: Available online 18 July 2018
Source: Archives of Oral Biology
Author(s): Behzad Houshmand, Zohreh Tabibzadeh, Saeed Reza Motamedian, Farnaz Kouhestani
Abstract
Objective
To evaluate to the effect of metformin on attachment of human dental pulp stem cells (hDPSCs) and their proliferation and osteogenic differentiation on biphasic hydroxyapatite/beta-tricalcium phosphate granules of macro-porous biphasic calcium phosphate (MBCP).
Materials and methods
This in vitro study included four groups: A:hDPSCs + MBCP + Metfromin, B:hDPSCs + MBCP, C:hDPSCs + Metformin and D:hDPSCs (control). Attachment of hDPSCs to bone granules in groups A and B was observed by scanning electron microscopy on days 1 and 7 of cultivation. Cell viability was assessed by MTT assay on days 1, 3, and 7 after cell seeding. Differentiation of the hDPSCs was assessed by measurement of alkaline phosphatase activity on days 3, 7, 14 and 21 after cell culturing in standard and osteogenic media. The data was analyzed by two-way ANOVA at a significance level of p = 0.05.
Results
The hDPSCs had firmly attached to the surface of MBCP granules, especially in group A. The MTT values increased in all groups from day 1 to day 7 (p < 0.001). The highest MTT values were observed in group C followed by the control group and groups A and B (p < 0.001). Alkaline phosphatase activity also increased in all groups between days 3 to 21 (p < 0.001) except between days 7 and 14 in standard media (p = 0.094). In standard media, groups with MBCP granules (A and B) showed higher activity (p < 0.05). In osteogenic media, the groups with metformin (A and C) showed higher alkaline phosphatase activity (p < 0.05).
Conclusion
This in vitro study showed that 100 Mol/L metformin increased attachment and proliferation of hDPSCs on biphasic granules. Osteogenic differentiation of hDPSCs also increased in the presence of metformin.
https://ift.tt/2uxHrt4
Effect of palm oil alone or associated to stannous solution on enamel erosive-abrasive wear: a randomized in situ/ex vivo study
Publication date: Available online 18 July 2018
Source: Archives of Oral Biology
Author(s): Franciny Querobim Ionta, Catarina Ribeiro Barros de Alencar, Natália Mello dos Santos, Bianca Tozi Portaluppe Bergantin, Poliana Pacifico Val, Heitor Marques Honório, Thais Marchini de Oliveira, Daniela Rios
Abstract
Objective
Palm oil has demonstrated preventive potential against initial erosive demineralization in vitro. This in situ study evaluated the effect of palm oil alone or associated with stannous-containing (Sn) solution on preventing enamel loss from an erosive/abrasive challenge.
Design
This single-blind, randomized, crossover in situ/ex vivo study was developed in four phases (one per group of five days) with sixteen volunteers. Enamel blocks (n = 256) were allocated to groups according to the treatment: Palm oil; Palm oil plus Sn solution; Sn solution – positive control; and Deionized water - negative control. Half of the enamel blocks of each group was subjected to erosion and the other half to erosion + abrasion. The daily ex vivo protocol consisted of four citric acid immersions (2 minutes). Before the first and third acid exposure, the blocks were treated with the test solutions (1 drop/block) for 1 minute followed by acid immersion and abrasive challenge (toothpaste was applied on all blocks and half were brushed for 15 seconds/block). Enamel loss was quantified profilometrically and data were analyzed by two-way ANOVA and Tukey's test (p < 0.05).
Results
A significant difference was found for type of treatment (p < 0.001); wear condition (p = 0.38) and the treatment x condition interaction (p = 0.33) was non-significant. Palm oil associated or not to Sn solution significantly reduced enamel wear in comparison with the negative control but did not differ from the positive control (p > 0.05).
Conclusions
Palm oil was able to prevent enamel loss under erosive and erosive + abrasive challenges in a similar extend to stannous-containing commercial solution.
https://ift.tt/2zQ7XDj
Buccal space tumours
Publication date: Available online 18 July 2018
Source: Auris Nasus Larynx
Author(s): Zubair Hasan, Darius Tan, Malcolm Buchanan, Carsten Palme, Faruque Riffat
Abstract
Objective
To review the available literature as it pertains to the buccal space with a specific focus on the pathologies encountered within this space. Clinical presentation, investigations, and surgical approaches to the region are also reviewed.
Methods
A systematic review of the available literature was performed on buccal space tumours from 1980 to 2017. Data was extracted on clinical presentation, investigations and surgical approaches to the buccal space. The pathologies encountered in the buccal space were reviewed and presented.
Results
Forty-nine unique articles were reviewed, with a total 217 patients. The age of the patients ranged from 0 to 83 with a mean age of 45.8. A total of 51 pathologies were reported. The majority of these were vascular and salivary gland pathologies. The majority of salivary gland neoplasms were malignant. However a wide variety of benign and malignant soft tissue tumours were also reported to occur in this region.
Conclusions
The buccal space is a small and complex region with a variety of pathologies occurring within it. This review clarifies the differential diagnosis of a mass which presents in this area and the pathologies which occur within it.
https://ift.tt/2zY9AyS
Antiviral RNA interference in mammals
Shou-Wei Ding | Qingxia Han | Jinyan Wang | Wan-Xiang Li
https://ift.tt/2NsCR6A
Gutartige Parotistumore: moderne Therapiekonzepte
Laryngo-Rhino-Otol
DOI: 10.1055/a-0633-0820
Bei gutartigen Parotistumoren ist es ein vorrangiges Behandlungsziel, die Morbidität des operativen Eingriffs zu senken. Standardisiertes intraoperatives Vorgehen und Verfahren zur Minimierung des Operationsumfangs konnten das Risiko einer bleibenden Fazialisparese deutlich senken. Aktuelle evidenzbasierte Therapieverfahren und mögliche Komplikationen nach Parotidektomie werden in diesem Beitrag näher erläutert.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2uMcVLd
Transorale videoendoskopische Resektion von Kopf-Hals-Tumoren in 4-Hand-Technik
Laryngo-Rhino-Otol
DOI: 10.1055/a-0654-5376
Einleitung Videoendoskopische Operationsverfahren in 4-Hand-Technik sind bereits in der Visceralchirurgie bei laparoskopischen Eingriffen sowie bei der Hypophysenchirurgie etabliert. Auch in der Tumorchirurgie im Kopf-Hals-Bereich gewinnt die transorale videoendoskopische Resektion von Tumoren in 4-Hand-Technik (TOVR) zunehmend an Bedeutung. Material und Methoden Seit März 2013 wurden erfolgreich 28 transorale videoendoskopische Tumorresektionen von Oropharynx (n = 5) –, Hypopharynx (n = 12) – und Larynxkarzinomen (n = 11) in 4-Hand-Technik durchgeführt. Ergebnisse In allen 28 Fällen wurde transoral eine R0-Resektion ohne Erweiterung des Eingriffs durch einen Zugang von transcervikal erreicht. Auch bei Patienten mit schlechter Beweglichkeit im HWS-Bereich (n = 9) gelang durch den Einsatz von Winkeloptiken über ein Kleinsasser- oder Weerda-Rohr per TOVR eine transorale R0-Tumorresektion. Schlußfolgerungen Die TOVR ist ein effektives, preisgünstiges und minimalinvasives Operationsverfahren bei Tumoren im Kopf-Hals-Bereich mit zahlreichen Vorteilen im Vergleich zur CO2-Laserresektion und stellt eine echte Alternative zu den herkömmlichen Resektionsverfahren dar.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
https://ift.tt/2LkHKRO
Successful Percutaneous Coronary Intervention for Atherosclerotic Coronary Lesion with Anomalous Origin of the Right Coronary Artery
Congenital coronary artery anomalies, including anomalous origin of a coronary artery, can manifest as life-threatening conditions, such as myocardial infarction or arrhythmia, and may even lead to sudden death associated with specific congenital anatomical features. Such arteries can also develop atherosclerotic lesions. This report describes the case of a 75-year-old man who was admitted to our hospital due to exertional dyspnea. The right coronary artery was found to originate from the left coronary sinus and exhibit tight stenosis due to atherosclerosis, causing effort angina pectoris. This case highlights the fact that coronary artery anomalies can cause angina pectoris via both atherosclerotic and nonatherosclerotic effects, and successful revascularization was achieved noninvasively via percutaneous coronary angioplasty.
https://ift.tt/2LjxLMu
Pearls for the middle fossa approach in acoustic neuroma surgery
https://ift.tt/2uzmLkv
Functional considerations in oral cavity reconstruction
https://ift.tt/2zRx8VL
Conjunctival provocation tests: prediction of seasonal allergy
https://ift.tt/2zNz9lR
Globalization and anaphylaxis
https://ift.tt/2uxxR9v
Seasonal ocular allergy and pollen counts
https://ift.tt/2zPdnhz
Cosmetics and ocular allergy
https://ift.tt/2uvpKdT
Topical antihistamines, mast cell stabilizers, and dual-action agents in ocular allergy: current trends
https://ift.tt/2zUYYRk
Adults and children with anaphylaxis in the emergency room: why it is not recognized?
https://ift.tt/2uw1bxp
Pearls for the middle fossa approach in acoustic neuroma surgery
https://ift.tt/2uzmLkv
Functional considerations in oral cavity reconstruction
https://ift.tt/2zRx8VL
Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria
Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis.
https://ift.tt/2O49Y1I
Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference,
EoE is a global health condition that has steady increased over the last few decades and is now reported on all continents, with an estimated incidence of 4 per 100,000. Diagnostic Guidelines on eosinophilic esophagitis (EoE) were published in 2007 and updated in 2011.1,2 EoE is defined as a clinicopathological condition that is likely immune or antigen driven, and characterized clinically by symptoms of esophageal dysfunction and histologically by ≥15 eosinophils per high power field (eos/hpf).
https://ift.tt/2NpDDBa
Journal of the American Academy of Dermatology: Original article Comorbidities in alopecia areata: A systematic review and meta-analysis
Alopecia areata (AA) may be associated with various systemic diseases according to several studies.
https://ift.tt/2Jz8kSb
Blunt trauma to the antecubital fossa causing brachial artery injury and minor fractures around the elbow joint, an easily missed diagnosis with potential devastating consequences: a case report
Blunt trauma causing brachial artery injury in a young patient is very rare. Cases of brachial artery injury may be associated with closed elbow dislocation or instability. Elbow dislocation may not be evident...
https://ift.tt/2JzboOj
Buccal space tumours
To review the available literature as it pertains to the buccal space with a specific focus on the pathologies encountered within this space. Clinical presentation, investigations, and surgical approaches to the region are also reviewed.
https://ift.tt/2LtL7mc
Pediatric Nasal Obstruction
Nasal obstruction is one of the most common problems seen by pediatric otolaryngologists. Prompt treatment of nasal obstruction can be critical in newborns and infants because of their obligatory nasal breathing. Older children will typically have more inflammatory, infectious, or traumatic causes of nasal obstruction. Nasal obstruction can lead to a significant decrease in the quality of life in children along with an increase health care expenditures.
https://ift.tt/2utNb7h
Efficacy & Safety of OPN-375 Adults With Bilateral Nasal Polyps Using Nasoendoscopic Video
Intervention: Drug: OPN-375
Sponsor: Optinose US Inc.
Recruiting
https://ift.tt/2zO4vZR
A Phase 1b Dose Escalation/Expansion Study of Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies
Interventions: Drug: Abexinostat; Biological: Pembrolizumab
Sponsors: Rahul Aggarwal; Xynomic Pharmaceuticals, Inc.
Not yet recruiting
https://ift.tt/2mswQLL
Papuloerythroderma of Ofuji successfully treated with methotrexate
Dermatologic Therapy, EarlyView.
https://ift.tt/2uLplD7
Hyaluronic acid filler for skin rejuvenation: The role of diet on outcomes. A pilot study
Dermatologic Therapy, EarlyView.
https://ift.tt/2LhqLQ5
Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial
Publication date: Available online 18 July 2018
Source: Allergology International
Author(s): Michihiro Hide, Takamasa Suzuki, Ayaka Tanaka, Hiroshi Aoki
Abstract
Background
Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown.
Methods
We conducted a prospective, multicenter, randomized, placebo-controlled, double-blind study in adolescent and adult CSU outpatients aged 12 to < 65 years (JAPIC-CTI No. 152786). Overall, 94, 91, and 92 eligible patients orally received placebo, rupatadine 10 mg, and 20 mg once daily for 2 weeks, respectively. The primary endpoint was change from baseline to the second week of treatment in total pruritus score (TPS, sum of daytime and nighttime pruritus scores).
Results
The results yielded a least squares mean TPS difference of −1.956 between rupatadine 10 mg versus placebo, and −2.121 between rupatadine 20 mg versus placebo (analysis of covariance, both P < 0.001). The incidence of adverse events was 8.5% for placebo, 20.9% for rupatadine 10 mg, and 17.4% for rupatadine 20 mg. Somnolence was the only adverse drug reaction to rupatadine reported in 2 or more subjects. No serious or clinically significant adverse events were observed.
Conclusions
The primary and secondary efficacy endpoints consistently favored rupatadine 10 and 20 mg doses over the placebo. No noteworthy dose-related increase in the incidence of adverse drug reactions was observed. Rupatadine is safe and effective at a dose of 10 mg once daily, and can be safely increased to 20 mg once daily, as necessary.
https://ift.tt/2JxY5xz
Human Th9 differentiation is dependent upon STAT3 to restrain STAT1-mediated inhibition
Publication date: Available online 18 July 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Yuan Zhang, Andrea M. Siegel, Guangping Sun, Tom Dimaggio, Alexandra F. Freeman, Joshua D. Milner
Abstract
Background
Patients with loss of function (LOF) signal transducer and activator of transcription 3 (STAT3) mutations have dermatitis, enhanced IgE production despite a relative lack of immediate hypersensitivity, recurrent infection, and an increased rate of lymphoma, in addition to a number of skeletal and connective tissue abnormalities. Gain of function (GOF) STAT1 mutant patients also have susceptibility to candidiasis and sinopulmonary infection, as well as autoimmunity and squamous cell carcinoma, in addition to even more broad phenotypes.
Objective
Because of the link between Th9 cells and allergic inflammation, autoimmunity and anti-tumor surveillance, and because evidence shows either the role for STAT3 or STAT1 in Th9 differentiation conflicts, we wished to determine the status on this lineage of STAT1GOF and STAT3LOF in humans.
Methods
We detected IL-9 levels and Th9 differentiation of STAT3LOF and STAT1GOF patients, together with Th9 transcript factors, and partially rescued their deficiency in vitro by adding cytokines they lacked or transfecting key molecules.
Results
We found that PBMCs or sorted naïve CD4+ T cells from STAT3LOF and STAT1GOF patients had impaired Th9 generation/differentiation. STAT3 inhibition in normal Th9 cultures diminished early IL-21 induction and late IL-9 production, while exogenous IL-21 enhanced Th9 differentiation even with STAT3 inhibition, by restoring SOCS3 expression and thus inhibiting excessive p-STAT1 activation. Furthermore, exogenous expression of SOCS3 or either T-bet or STAT1 RNAi in STAT3 LOF cells partially rescued IL-9 differentiation.
Conclusion
Collectively, these results suggest that human Th9 differentiation depends on normal p-STAT3 and IL-21 production to suppress p-STAT1 activation and T-bet transcription.
Graphical abstract
https://ift.tt/2Noip6U
Immunomodulatory effect of thymoquinone on atopic dermatitis
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Hina Aslam, Muhammad Shahzad, Arham Shabbir, Sabeen Irshad
Abstract
Background
Atopic dermatitis (AD) or atopic eczema is a skin disease characterized with itching, increased serum level of immunoglobulin E, and peripheral eosinophilia. Thymoquinone (TQ) is an important ingredient of Nigella sativa seeds having antioxidant and anti-inflammatory effects.
Objective
Present study investigates the immunomodulatory effects of Thymoquinone (TQ) in mice model of atopic dermatitis.
Methods
Ear pinnas of mice were sensitized and challenged with DNCB (2–4 di nitro chloro benzene) to induce AD-like lesions. The mice were then treated with TQ and tacrolimus, both orally and topically. Ear thickness and weight were measured along with gross changes. Total and differential leukocyte counts were measured in blood. Total serum IgE levels were measured by enzyme linked immunosorbent assay (ELISA). The mRNA expression levels of IL-4, IL-5, and IFN-γ in ear tissue were measured using reverse transcription polymerase chain reaction (RT-PCR).
Results
Both oral and topical thymoquinone showed the potential to improve atopic dermatitis by significantly reducing the inflammatory cells infiltration in the blood (p < 0.001) and improving the dermatitis score (p < 0.001). Significant reduction in ear thickness (p < 0.001) and IgE levels (p < 0.001) were also observed. TQ and tacrolimus also significantly attenuated mRNA expression levels of IL-4, IL-5 and IFN-γ (p < 0.001).
Conclusions & clinical relevance
Taken together, our results showed that oral and topical application of thymoquinone exerts immunomodulatory effects in animal model of atopic dermatitis, suggesting further studies and clinical trials to establish it as a candidate nutraceutical for the treatment of AD.
https://ift.tt/2zQ6woi
Molecular identification and gene expression profiles of the T cell receptors and co-receptors in developing red-tailed phascogale (Phascogale calura) pouch young
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Casey R. Borthwick, Lauren J. Young, Julie M. Old
Abstract
Expressed coding sequences were identified for the T cell receptors TCRα, TCRβ, TCRγ, TCRδ, TCRμ, and co-receptors CD3ε, CD4, and CD8α in the red-tailed phascogale (Phascogale calura). Expression of these genes was examined in the developing thymus and spleen of pouch young and juvenile individuals to detect any changes in expressionrelative to developmental stages. Transcripts of CD3ε, CD4, TCRδ and TCRμ were first detected in the thorax at 1 day postpartum (dpp), and transcripts of all target genes were detected in the thymus from 3 dpp, and the spleen from 17 dpp. The relative expression of all target genes changed significantly over the course of pouch life and was associated with histological milestones of both the thymus and the spleen. Peak gene expression was observed early in pouch life in the thymus, with a decrease in expression associated with timing of thymic involution, while expression peaked later in the spleen and was associated with the initial differentiation of the red and white pulp and a population of T cells forming the periarterial lymphatic sheath (PALS). Active expression of these target genes within the thymus and spleen indicates that the young marsupials are actively developing immunocompetence during pouch life.
https://ift.tt/2mqpdp1
A novel Aβ epitope vaccine based on bacterium-like particle against Alzheimer’s disease
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Lu Fu, Yongqing Guo, Yao Sun, Yue Dong, Jiaxin Wu, Bin Yu, Haihong Zhang, Xianghui Yu, Hui Wu, Wei Kong
Abstract
Amyloid-beta (Aβ) plaque accumulation in the brain is one of the hallmarks of Alzheimer's disease (AD). Immunotherapy against Aβ was considered a potential strategy for reducing the Aβ load in the brain. However, none of the Aβ immunotherapies have produced clinically meaningful results to date, due to poor safety or lack of efficacy. Thus, we aimed to design a safe and effective vaccine against AD. In this study, we used bacterium-like particles (BLPs) as carriers and different copy numbers of the Aβ 1-6 peptide as epitopes to design four Aβ active immunization vaccines. The epitopes containing different copy numbers of the Aβ 1-6 peptide were specifically loaded on the surface of BLPs via fusion with a peptidoglycan anchoring domain. These four BLP-based Aβ vaccines successfully induced high levels of Aβ42-specific antibodies in mice. However, none of the vaccines induced a T-cell-mediated immune response. Importantly, the antibodies induced by these four vaccines were effective in blocking Aβ42 oligomer toxicity at the cellular level. Among the four vaccines, 6copy-Aβ 1-6 -PA-BLP was the most effective in inducing Aβ-specific antibodies, indicating that a suitable epitope copy number is critical for high immunogenicity of the BLP-based vaccine. Furthermore, high levels of serum Aβ-specific antibodies could still be detected 3 months after the final administration of 6copy-Aβ 1-6 -PA-BLP. Thus, 6copy-Aβ 1-6 -PA-BLP may be a potential therapeutic treatment for AD.
https://ift.tt/2uMch0n
Myeloid-derived suppressor cells exacerbate Sjögren’s syndrome by inhibiting Th2 immune responses
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Jingjing Qi, Dan Li, Guoping Shi, Xuefang Zhang, Yuchen Pan, Huan Dou, Genhong Yao, Yayi Hou
Abstract
Myeloid-derived suppressor cells (MDSCs) can regulate various aspects of immune responses based on their potent immune-suppressive activity. Studies reported that MDSCs participated in many autoimmune diseases. However, the role of MDSCs in Sjögren's syndrome (SS) is unknown. In this study, we determined the frequencies and function of MDSCs in non-obese diabetic (NOD) mice and SS patients. The NOD mice were adoptively transferred with MDSCs or treated with anti-Gr1 antibody. Results showed that peripheral MDSCs increased significantly with the development of SS-like syndrome in NOD mice and the percentage of MDSCs was higher in SS patients than healthy controls. The SS-like syndrome aggravated after transfer of MDSCs in NOD mice. The deletion of MDSCs in NOD mice alleviated SS-like syndrome. Mechanistically, MDSCs down-regulated the percentages of Th2 cells in NOD mice and SS patients. In summary, our findings suggested that MDSCs exacerbated Sjögren's syndrome by inhibiting Th2 cells.
https://ift.tt/2mqwkO4
Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2
Publication date: September 2018
Source: Molecular Immunology, Volume 101
Author(s): Xiaohui Wang, Ziheng Wu, Yangyan He, Hongkun Zhang, Lu Tian, Chengfei Zheng, Tao Shang, Qianqian Zhu, Donglin Li, Yunjun He
Abstract
Endothelial dysfunction and vascular complications induced by hyperglycemia play an important role in the pathological development of atherosclerosis in diabetes. Humanin, a 24-amino acid mitochondria-derived polypeptide, has displayed its cytoprotective effects in diverse cell types and tissues. In the current study, we aimed to characterize the effects of humanin on high glucose-induced endothelial dysfunction. Firstly, we found that humanin treatment induced the expression of Krüppel-like factor 2 (KLF2), an essential transcriptional regulator of endothelial function, at the transcriptional level in human umbilical vein endothelial cells (HUVECs). Additionally, our results indicate that humanin treatment regulated the expression of KLF2 target genes such as endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1). Evidence demonstrated that the effects of humanin on KLF2 expression was mediated by the phosphorylation of extracellular signal regulated kinase 5 (ERK5). Furthermore, humanin restored high glucose-induced reduction of KLF2 expression. We also showed that humanin significantly reduced the expression of vascular cell adhesion molecule 1 (VCAM-1) and E-selectin. Notably, humanin treatment markedly prevented high glucose-induced attachment of the monocyte THP-1 cells to HUVECs. However, knockdown of KLF2 abolished these effects. Lastly, we report that humanin treatment inhibited high glucose-induced secretion of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). These findings suggest that humanin may have therapeutic potential for the treatment of hyperglycemia-associated endothelial dysfunction.
https://ift.tt/2uMcaSv
Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference,
Publication date: Available online 18 July 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Jonathan M. Spergel, Evan S. Dellon, Chris A. Liacouras, Ikuo Hirano, Javier Molina-Infante, Albert J. Bredenoord, Glenn T. Furuta, On behalf of the participants of AGREE
https://ift.tt/2L6uAZm
Delayed Adverse Skin Effects After PD-1-Inhibitor Therapy
Eczema, psoriasis, and lupuslike reactions can occur even months after starting or stopping these drugs, so patients need to be monitored on an ongoing basis.
Medscape Medical News
https://ift.tt/2NoaBC2
Sunscreen Use and Melanoma Risk Among Young Australian Adults
https://ift.tt/2mqvmSb
Spiky Skin in a Renal Transplant Recipient
https://ift.tt/2uFGJsU
Timing of Onset of Adverse Cutaneous Reactions Associated With PD-1 Inhibitor Therapy
https://ift.tt/2mwXNxX
A Comparison of Tanning Habits Among Gym Tanners and Other Tanners
https://ift.tt/2uIrdwI
Effect of Stress Ball Use or Hand-holding on Anxiety During Skin Cancer Excision
https://ift.tt/2moXlBs
Scabies—An Ancient Disease With Unanswered Questions in Modern Times
https://ift.tt/2uIr2S4
Venous air embolism in a patient with a massive upper gastrointestinal bleeding
Description
Emergency medical responders (EMS) were called in for a subject who developed multiple generalised tonic-clonic seizures attributed to hydrocodone-acetaminophen overdose and possible upper gastrointestinal (GI) bleeding. His medical history was significant for peptic ulcer disease status post partial gastrectomy, chronic alcoholism, polysubstance abuse, factor V Leiden mutation with recurrent deep venous thrombosis and pulmonary embolism on warfarin treatment. On his way to the hospital, EMS had difficulty obtaining an intravenous access, and was only successful after three attempts, and the patient was started on intravenous fluids and naloxone. In the emergency room he had an episode of massive bleeding per rectum and was haemodynamically unstable. Fluid resuscitation was started, second intravenous access was obtained and nasogastric tube was placed. CT of the chest, abdomen and pelvis without contrast (figure 1) demonstrated a small amount of air in the right atrium, main pulmonary artery, and right lower lobe segmental and...
https://ift.tt/2Jva4Mh
Splenic torsion: a rare cause of abdominal pain
Splenic torsion is an exceedingly rare but clinically important disease process that should be recognised promptly by the treating physician. In this condition, there is twisting of the spleen along its vascular pedicle, subsequently leading to abdominal pain in the setting of organ ischaemia. Vascular thrombosis and splenic infarction may ensue. Torsion has been described in cases of a known wandering spleen. Abnormal development of the splenic suspensory ligaments may predispose a patient to a wandering spleen. Treatment of splenic torsion is typically surgical, with goals of preservation of the spleen if possible.
We present a case of a young woman who presented with left-sided chest and abdominal pain and was found to have splenic torsion with complete splenic infarction. Surgical intervention was required, and splenectomy was performed. In this case presentation, we outline the multidisciplinary approach needed to care for the patient with this rare condition.
https://ift.tt/2L5nPqr
Aggressive myxoinflammatory fibroblastic sarcoma with multiple site metastases
Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare soft tissue sarcoma which was initially observed in acral sites and characterised by spindle cells, pleomorphic bizarre cells and distinctive large Reed-Sternberg–like cells admixed with an intense inflammatory cell infiltrates. MIFS manifests as a slow growing often superficial lesion which can be mistaken as infectious or chronic inflammatory process or benign tumours such as nodular fasciitis, giant cell tumour of tendon sheath or synovial pseudocyst. We report a rare presentation of a MIFS in a 38-year-old man with extensive local spread from subcutaneous tissue to the ankle joint and bones as well as multiple synchronous metastases to lung, sixth rib and vertebra. Our case is peculiar for its aggressive clinical behaviour with short duration, fast growth and extensive metastases, a feature infrequent in MIFS.
https://ift.tt/2Jzlyy7
Rare cause for a common presentation: isolated pulmonary valve endocarditis yet another mimicker
Isolated pulmonary valve endocarditis (PVE) is a rare condition. Known risk factors in previous case reports were intravenous drug abuse and congenital heart disease. Epidemiology of PVE has been changing. It is now being reported specially following invasive healthcare-related procedures even in patients with structurally normal heart. Vast majority of patients present with respiratory symptoms and diagnosis of endocarditis may be challenging unless there is high index of suspicion. Various microorganisms had been isolated as aetiological agents; however, Enterococcus faecalis is being increasingly isolated. PVE mostly managed conservatively with intravenous antibiotics with option for surgical intervention in specific situations. We present a patient with isolated PVE due to E. faecalis following colonoscopy and polypectomy with predisposing risk factor of alcohol excess, mimicking clinically as pneumonia and radiologically as a neoplastic lesion.
https://ift.tt/2L79xWg
Metastasis of malignant myoepithelial carcinoma to the brain
Myoepithelial tumours are a rare form of salivary gland neoplasm and intracranial metastases have rarely been described. The authors present the case of a 61-year-old patient with a history of primary myoepithelial carcinoma of the right foot. Metastases were found in the third ventricle, left temporal lobe and right frontal lobe. The third ventricular and left temporal lobe tumours were resected in a two-stage operation. Pathology of the third ventricular lesion was most consistent with metastasis. MRI of the spine 2 weeks after his operation revealed an intradural mass with several lesions in the lumbar thecal space suggesting further metastases. The patient succumbed to his disease 2 months after his two-stage operation and 5 years after his initial diagnosis. This appears to be the first case in the literature of multiple primary myoepithelial carcinoma metastases to the brain. Further information is needed to provide diagnostic and therapeutic recommendations.
https://ift.tt/2Jy3qVF
The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem
Microbial keratitis is a common corneal condition, with many known risk factors. We present a case of an 88-year-old female patient with a multidrug-resistant Achromobacter xylosoxidans corneal ulcer in a previously failed second penetrating keratoplasty, successfully managed with topical meropenem drops administered hourly around the clock, for five days preceding and then hourly day only, for five days following a repeat third penetrating keratoplasty. Topical meropenem 50 mg/mL was prepared by mixing a 500 mg vial of meropenem with 10 mL of sterile water with pharmacy advice that administration should be within an hour. To the best of our knowledge, this is the first report of the use of topical meropenem in the management of A.xylosoxidans keratitis. This case highlights the importance of the mean inhibitory concentrations for antibiotics when considering sensitivities. Topical meropenem may be a useful treatment option for multidrug-resistant bacterial corneal ulcers that are resistant to conventional therapy.
https://ift.tt/2L40oy3
Caseous calcification of the mitral valve annulus: a rare cause of bilateral cerebral and ocular embolisation
A 65-year-old woman presented with sudden bilateral visual loss of recent onset. She was recently diagnosed with multiple acute stroke syndrome for which she was commenced on antiplatelet therapy. Funduscopic examination revealed bilateral inferotemporal retinal artery occlusions. The recent history of multiple cerebral infarcts combined with the current ocular findings prompted a transoesophageal echocardiogram which successfully revealed caseous calcification of the mitral valve annulus as the source of the numerous sequential emboli, a finding which the conventional transthoracic echocardiogram had failed to disclose as a result of suboptimal image quality. Transoesophageal echocardiography should always be considered as part of the diagnostic workup of retinal arterial occlusive disease, particularly in bilateral lesions, due to its higher yield in identifying posteriorly located cardiac valvular and aortic lesions.
https://ift.tt/2Lppovx
Cryptococcus neoformans empyema in a patient receiving ibrutinib for diffuse large B-cell lymphoma and a review of the literature
We report a case of Cryptococcus neoformans pulmonary infection complicated by empyema in a 79-year-old man with diffuse large B-cell lymphoma treated with R-CHOP and ibrutinib. A literature review identified 25 cases of cryptococcal pleural disease published since 1980. Most cases were caused by the C. neoformans species in immunocompromised hosts with an exudative pleural effusion and lymphocyte-predominant infiltrate. The cryptococcal antigen test was often positive when pleural fluid and serum were tested. The outcome was favourable in most cases with antifungal therapy and either thoracocentesis or surgical resection. We also identified 40 cases of opportunistic infections, most commonly aspergillosis, cryptococcosis and Pneumocystis jirovecii pneumonia, in patients treated with ibrutinib. In vitro studies indicate Bruton tyrosine kinase inhibition impairs phagocyte function and offer a mechanism for the apparent association between ibrutinib and invasive fungal infections.
https://ift.tt/2L7aTQS
Transformation of jejunoileal follicular lymphoma into diffuse large B-cell lymphoma detected using double-balloon enteroscopy
Jejunoileal follicular lymphomas (FLs) are rare and have been reported to undergo histological transformation (HT). We report a case of jejunoileal FL transformation into diffuse large B-cell lymphoma (DLBCL). An 82-year-old woman presented with a 5.5 cm ulcerated jejunal mass, identified through double-balloon enteroscopy. The histopathology report revealed diffuse atypical lymphoid cells, which confirmed the presence of DLBCL. Neoplastic follicles confirmed the presence of FL. Genetic analysis revealed a match between the FL and DLBCL. Following a segmentectomy and chemotherapy, the patient is in remission. Based on this case, we should consider the possibility of jejunoileal FLs transforming into DLBCL.
https://ift.tt/2JwIqyw
Aortocaval fistula: an unusual complication of ruptured abdominal aortic aneurysm
Aortocaval fistula (ACF) is a rare complication of abdominal aortic aneurysm, which erodes into the wall of the inferior vena cava, resulting in the formation of a fistula. ACF presents with various inconsistent symptoms and signs. ACF can be a diagnostic dilemma if not suspected and it is lethal if left untreated.
A 60-year-old man presented with abdominal and lower back pain of sudden onset. Renal and liver functions were impaired, without signs of cardiac failure. CT angiography revealed an abdominal aneurysm rupture into the inferior vena cava. Patient underwent a successful open repair: ACF ligation from within the aneurysmal sac and an aorto-bi-iliac bypass using a Dacron graft. Renal and liver functions improved and the patient was discharged on the eighth postoperative day. A month later, the patient was fit and well with normal liver and renal functions.
Despite progress made in the endovascular treatment of ACF, complications still persist with a reported endoleak rate of 50%. Open repair is still a valid method for ACF repair in patients fit to undergo laparotomy and general anaesthesia. In this case, the patient was fit and along the lack of a suitable stent graft, the vascular team performed an open repair with good results.
Open repair of an ACF is a valid treatment method for patients who are fit enough to undergo laparotomy and general anaesthesia, and avoids complications related to endovascular repair, such as endoleaks.
https://ift.tt/2L3Cmmx
Laryngoceles with airway compromise complicating mucous membrane pemphigoid
Mucous membrane pemphigoid (MMP) encompasses a group of autoantibody-mediated, subepithelial blistering diseases, which primarily affect mucosal surfaces including oral, ocular, skin, genital, nasopharyngeal and oesophageal sites. We present a first description of laryngoceles as a manifestation of mucous membrane pemphigoid resulting in dynamic airway closure. Mucosal injury at other sites had previously resulted in pathergy and localised cicatrisation. We discuss successful combined medical and transcutaneous surgical intervention designed to avoid tracheostomy and minimise iatrogenic laryngeal cicatrisation.
https://ift.tt/2LtI8tO
Primary bladder amyloidosis as a cause of haematuria
We report the case of a 46-year-old man who initially presented with macroscopic haematuria. Although initially concerning for a malignancy in the bladder, histology demonstrated a primary bladder amyloidosis that has remained stable for 6 years since the initial diagnosis. Primary bladder amyloidosis is an important clinical entity that can mimic bladder malignancy on clinical history, radiological investigation and cystoscopic evaluation. Although uncommon, it should not be neglected as a possible diagnosis in patients presenting with haematuria.
https://ift.tt/2L4Ni3q
Polypoidal lesions associated to choroidal naevus: spectrum of pachychoroid disease?
A 78-year-old woman was referred by an optician for an incidental finding of peripapillary naevus in the absence of visual symptoms. On examination, the right eye showed a choroidal naevus of around 1.5 disc diameter, adjacent to the optic disc. Optical coherence tomography detected the presence of pigment epithelium detachment and subretinal fluid within the context of the naevus. Fundus fluorescein angiography and indocyanine green showed multiple polypoidal lesions (Polypoidal Choroidal Vasculopathy, PCV) in the choroid within the spectrum of a pachychoroid, without any sign of malignancy related to neovascularisation. The patient underwent a follow-up of 6 months, showing stability of the lesions over this timeframe. No treatment has been required since the polypoidal lesions were outside the fovea and visual acuity remained stable. The association between choroidal naevi and polypoidal lesions is rare1; however, this seems to confirm that these findings are part of the spectrum of pachychoroid disease.
https://ift.tt/2JwI3UE
Acute infection-related glomerulonephritis with disseminated gonococcal infection in a 13-year-old girl
Infection-related glomerulonephritis results from glomerular immune complex deposition due to a variety of potential pathogens. Poststreptococcal glomerulonephritis is the best known example. We present a case of acute infection-related glomerulonephritis associated with disseminated gonococcal infection in a sexually active 13-year-old girl, the first report of such an association in the absence of endocarditis. The patient presented with features of acute disseminated gonococcal infection including fever, hypotension, tenosynovitis, polyarthralgias and petechiae. She developed hypocomplementemic glomerulonephritis synchronous with the acute infection. The renal biopsy revealed a diffuse endocapillary proliferative and exudative glomerulonephritis with subepithelial electron-dense humps and granular glomerular capillary wall staining for C3 and IgG, typical of acute postinfectious glomerulonephritis. After treatment and resolution of the gonococcal infection, the serum creatinine, complement levels and urine sediment normalised. The only residual renal damage 16 months later was low-grade proteinuria.
https://ift.tt/2L6BjlV
Two for the price of one: emerging carbapenemases in a returning traveller to New York City
We report a case of a complex orthopaedic infection in a patient returning to New York City from Bangladesh where he was involved in a serious motor vehicle accident. He developed extensive osteomyelitis with a carbapenem-resistant Klebsiella pneumoniae. The isolate was unique due to the coexistence of New Delhi metallo-β-lactamase-1 and Oxacillinase type-181 carbapenemases, which are relatively uncommon in North America and were presumably acquired in Bangladesh. Herein, we explore challenges associated with management of carbapenem-resistant Enterobacteriaceae infections, including limited available data on effective antimicrobial therapy. We also highlight the added value of rapid diagnostic technology in guiding clinical management. Ultimately, the patient required both aggressive surgical management and combination therapy with aztreonam and ceftazidime-avibactam for true source control and favourable clinical outcome.
https://ift.tt/2Lv3XcK
Efficacy of 4-year treatment of icon infiltration resin on postorthodontic white spot lesions
White spot lesions are defined as enamel surface and sub surface demineralisation, although these lesions can be reversed and do not form cavities. Infiltration using fluid resin proved to be a valid micro-invasive alternative compared with traditional conservative therapy. This has allowed treatment without any trauma (no use of local anaesthesia and cavity preparation) of numerous lesions in only one session with stable clinical (mechanical stability, enamel hardness, conservation of sound tissue) and aesthetic results (disappearance of lesions) over the time. The present report evaluates the effectiveness of Icon infiltration resin on postorthodontic white spots at 6 months, 1 and 4 years.
https://ift.tt/2L9b9iE
Unruptured giant left ventricular pseudoaneurysm after silent myocardial infarction
Description
An 88-year-old woman presented with complaints of class 2 dyspnoea for the last 6 months with episodes of paroxysmal nocturnal dyspnoea. Except for her age, she had no other risk factor for coronary artery disease. On cardiovascular examination, she had double apical impulse with a pan-systolic murmur at the apex and her ECG showed Q waves in inferior leads. She had one episode of resting typical chest pain 2 years back for which she did not seek medical consultation; afterwards, she never experienced angina pain.
Transthoracic echocardiography revealed giant aneurysm involving the lateral wall of the left ventricle (figure 1, videos 1 and 2). The ratio of the maximum diameter of the orifice to the maximum internal dimensions of the aneurysmal cavity was less than 0.5 (figure 2). There was large clot in the aneurysm involving the posterior wall of the left ventricle (
https://ift.tt/2JxHmKK
Hypophosphataemia: an important cause of collapse
We present a case of a 44-year-old man, civil servant, who presented to the emergency department (ED) following an episode of collapse. He was usually fit and well and while at work he had developed a headache with pins and needles over his face and subsequently collapsed. On arrival to ED, he had a Glasgow Coma Scale (GCS) of 4/15. There was no history of note apart from being prescribed citalopram for depression. Laboratory investigations revealed severe hypophosphataemia (phosphate 0.19 mmol/L) and no other electrolyte abnormality. He was commenced on intravenous phosphate and his GCS improved to 15 within 4 hours. Further investigations revealed no cause for his severe hypophosphataemia and repeat bloods in clinic follow-up showed a normal phosphate level.
https://ift.tt/2L3xJsO
Extravasation of contrast beneath the preputial skin due to improper technique of retrograde urethrogram
Description
A 22-year-old uncircumcised male patient had a thin stream of urine and had to exert pressure while voiding. He had a history of some instrumentation in his penis during childhood, but no records were available. He was first seen by a primary care physician, who made a provisional diagnosis of stricture urethra and advised for a retrograde urethrogram (RUG). His RUG had a contrast shadow, which was thought to be possible dilated distal urethra due to proximal obstruction (stricture), and the patient was referred to us for further management (figure 1). When we examined the patient, he was found to have phimosis. A dorsal slit was done and the meatus was examined, which was normal. A gentle calibration was done with a 14F Foley catheter that was normal. He voided with a good stream after surgery. The radio-opaque shadow that was seen on the RUG...
https://ift.tt/2LpCAAF
Purple urinary bag syndrome: what every primary healthcare provider should know
Description
A 70-year-old man with bladder outlet obstruction due to benign prostatic hyperplasia who was on urethral (Foley) catheter presented to us with complaint of purple discoloration of his urine collection bag (figure 1). He had history of multiple failed trials of voiding without catheter. Along with this he had constipation for which he was already taking laxatives. He was on Foley catheter for 6 months (which was changed every 3 weeks) and now was planned for transurethral resection of prostate (TURP). He was alarmed by this discolouration. His urine was clear but the urine collection bag had a purple discolouration. On microscopic examination, his urine had plenty of leucocytes and his urinary pH was 8. His urine culture was positive for Escherichia coli (>105 colony forming units/mL). His serum creatinine was 0.9 mg/dL. A diagnosis of purple urinary bag syndrome (PUBS) was made. His catheter was replaced...
https://ift.tt/2L9aXzW
Influence of hearing on vestibulospinal control in healthy subjects
Abstract
Background
Balance control is based on multisensory interaction. In addition to vestibular, proprioceptive and visual information, it seems that auditory input also plays an important role.
Objectives
The aim of the study was to investigate the effect of hearing on vestibulospinal coordination and to obtain deeper knowledge about mechanisms of audiovestibular interaction.
Materials and methods
In normal hearing, healthy subjects who performed the Unterberger (Fukuda) stepping test with and without frontal presentation of noise, the distance of displacement, the angle of displacement and the angle of rotation were measured by means of ultrasound based cranio-corpo-graphy (CCG). Additionally, subjective estimation of the effect of auditory input was compared to objective test results.
Results
In the noise condition, there was a significant improvement in the distance of displacement (mean with noise 66.9 cm± 33.5 standard deviation, SD, mean without noise 77.0 cm±32.7 SD, p< 0.001) and in the angle of rotation (mean with noise 14.2°± 10.1 SD, mean without noise 28.3°± 20.2 SD, p< 0.001), while no difference was found within the conditions regarding the angle of displacement (mean with noise 29.1°± 33.5 SD, mean without noise 30.0°± 34.0 SD, p= 0.641). Side-specific analysis revealed a positive correlation between angle of displacement and angle of rotation in the condition without noise (Spearman r = 0.441, p< 0.001). The rate of agreement between subjective estimation of noise influence and objective test results ranged between only 43% and 63%, depending on the question and endpoint.
Conclusion
Hearing had a clearly beneficial effect of auditory inputs on vestibulospinal coordination, especially for distance of displacement and angle of rotation.
https://ift.tt/2JDaMHc
Pilotstudie: Bestimmung der subjektiven Rumpfvertikalen in lotrechter Kopfposition
Zusammenfassung
Hintergrund
Übereinstimmende Annahme ist, dass die subjektive Vertikale (SV) aus einer multimodalen Sensorintegration resultiert. Um die zervikalvestibuläre Sensorkompetenz für die SV besser einschätzen zu können, war es Ziel der Pilotstudie, unter lotrechter Kopffixierung eine isolierte subjektive Rumpfvertikale (SRV) zu bestimmen.
Material und Methoden
Unter lotrechter Kopffixierung wurde eine SRV im Altersvergleich und nach monophasischer zervikaler transkutaner elektrischer Nervenstimulation (C-TENS) exploriert. Auf einem dreidimensional auslenkbaren (Kippung, Torsion, Flexion) Rumpfexkursionsstuhl (3-D-RES) wurden junge gesunde Probanden untersucht (n = 49) und mit älteren gesunden Probanden (n = 50) verglichen. Eine weitere junge gesunde Gruppe wurde in Placebo- (n = 27) und C‑TENS-Gruppe (n = 22) unterschieden und in ihrer Vertikalitätswahrnehmung verglichen.
Ergebnisse
In der SRV nach Rumpfflexion zeigte sich das Alter als signifikante Variable (p = 0,021). Die ältere Probandengruppe verfehlte im Mittel um 1,8° die physikalische Vertikale mehr als die jüngere. Im Durchgangsvergleich zeigte nur die Placebogruppe eine Verbesserung der SRV im Durchschnitt von 4,3° nach Rumpftorsion.
Schlussfolgerung
Bei der Erhebung einer Vertikalitätsbestimmung sind nicht nur die Makulaorgane beteiligt, sondern ebenfalls zervikovestibuläre Sensorafferenzen. Ein Altersunterschied zuungunsten der älteren gesunden Probanden sowie ein ausbleibender Lernerfolg nach angewandter C‑TENS wurden festgestellt. In der Pilotstudie zeigten sich in lotrechter Kopfposition Hinweise auf eine korrekte Empfindung der Rumpfvertikalen, hervorgerufen durch zervikalvestibuläre Sensorafferenz.
https://ift.tt/2L3vi9v
Effects of built environment morphology on wind turbine noise exposure at building facades
Qu, F; Kang, J; (2017) Effects of built environment morphology on wind turbine noise exposure at building facades. Renewable Energy , 107 pp. 629-638. 10.1016/j.renene.2017.02.037 . Green open access
https://ift.tt/2NZorf3
Disaggregated optical data center in a box network using parallel OCS topologies
Yuan, H; Saljoghei, A; Peters, A; Zervas, G; (2018) Disaggregated optical data center in a box network using parallel OCS topologies. In: (Proceedings) Optical Fiber Communication Conference 2018. The Optical Society of America (OSA)
https://ift.tt/2NogVcE
Angular Independence of Break Position for Magnetic Power Spectra Density in Solar Wind Turbulence and Its Relation with the Breakdown of the Frozen-in Condition in the Wavenumber Space
Duan, D; He, J; Pei, Z; Huang, S; Wu, H; Verscharen, D; Wang, L; (2018) Angular Independence of Break Position for Magnetic Power Spectra Density in Solar Wind Turbulence and Its Relation with the Breakdown of the Frozen-in Condition in the Wavenumber Space. The Astrophysical Journal (In press).
https://ift.tt/2O08hSX
Quantum arithmetics via computation with minimized external control: The half-adder
Eloie, L; Banchi, L; Bose, S; (2018) Quantum arithmetics via computation with minimized external control: The half-adder. Physical Review A , 97 (6) , Article 062321. 10.1103/PhysRevA.97.062321 . Green open access
https://ift.tt/2NmydXJ
Demonstration of NFV for mobile edge computing on an optically disaggregated datacentre in a box
Enrico, M; Mishra, V; Saljoghei, A; Bielski, M; Pap, E; Syrigos, I; de Dios, OG; ... Katrinis, K; + view all Enrico, M; Mishra, V; Saljoghei, A; Bielski, M; Pap, E; Syrigos, I; de Dios, OG; Theodoropoulos, D; Pnevmatikatos, DN; Reale, A; Syrivelis, D; Zervas, G; Parsons, N; Katrinis, K; - view fewer (2018) Demonstration of NFV for mobile edge computing on an optically disaggregated datacentre in a box. In: (Proceedings) Optical Fiber Communication Conference 2018. The Optical Society of America (OSA)
https://ift.tt/2NWxT2R
Fathers against sons/sons against fathers: The problem of generations in the early Soviet workplace
Koenker, DP; (2001) Fathers against sons/sons against fathers: The problem of generations in the early Soviet workplace. Journal of Modern History , 73 (4) pp. 781-810. 10.1086/340146 . Green open access
https://ift.tt/2Nr3Zms
Accessing new 2D semiconductors with optical band gap: synthesis of iron-intercalated titanium diselenide thin films via LPCVD
Sanchez-Perez, C; Knapp, CE; Colman, RH; Sotelo-Vazquez, C; Oilunkaniemi, R; Laitinen, RS; Carmalt, CJ; (2018) Accessing new 2D semiconductors with optical band gap: synthesis of iron-intercalated titanium diselenide thin films via LPCVD. RSC Advances , 8 (40) pp. 22552-22558. 10.1039/c8ra03174f . Green open access
https://ift.tt/2NYkF5K
ECEL1 gene related contractural syndrome: long-term follow-up and update on clinical and pathological aspects
Ullmann, U; D'Argenzio, L; Mathur, S; Whyte, T; Quinlivan, R; Longman, C; Farrugia, ME; ... Muntoni, F; + view all Ullmann, U; D'Argenzio, L; Mathur, S; Whyte, T; Quinlivan, R; Longman, C; Farrugia, ME; Manzur, A; Willis, T; Jungbluth, H; Pitt, M; Cirak, S; UK10K consortium, .; Feng, L; Stewart, W; Mein, R; Phadke, R; Sewry, C; Sarkozy, A; Muntoni, F; - view fewer (2018) ECEL1 gene related contractural syndrome: long-term follow-up and update on clinical and pathological aspects. Neuromuscular Disorders (In press).
https://ift.tt/2Nq35GF
A note on exponential-Möbius sums over F_{q}[t]
Porritt, SM; (2018) A note on exponential-Möbius sums over F_{q}[t]. Finite Fields and Their Applications , 51 pp. 298-305. 10.1016/j.ffa.2018.02.005 . Green open access
https://ift.tt/2O08fuj
Comparison of SDM-WDM based Data Center Networks with equal/unequal core pitch Multi-Core Fibers
Yuan, H; Saljoghei, A; Peters, A; Zervas, G; (2018) Comparison of SDM-WDM based Data Center Networks with equal/unequal core pitch Multi-Core Fibers. In: (Proceedings) Optical Fiber Communication Conference 2018. The Optical Society of America (OSA)
https://ift.tt/2NnILG8
dReDBox: Materializing a Full-stack Rack-scale System Prototype of a Next-Generation Disaggregated Datacenter
Bielski, M; Syrigos, L; Katrinis, K; Syrivelis, D; Reale, A; Theodoropoulos, D; Alachiotis, N; ... Gonzalez de Dios, O; + view all Bielski, M; Syrigos, L; Katrinis, K; Syrivelis, D; Reale, A; Theodoropoulos, D; Alachiotis, N; Pnevmatikatos, D; Pap, EH; Zervas, G; Mishra, V; Saljoghei, A; Rigo, A; Fernando Zazo, J; Lopez-Buedo, S; Torrents, M; Zyulkyarov, F; Enrico, M; Gonzalez de Dios, O; - view fewer (2018) dReDBox: Materializing a Full-stack Rack-scale System Prototype of a Next-Generation Disaggregated Datacenter. In: Proceedings of 2018 Design, Automation & Test in Europe Conference & Exhibition (DATE). (pp. pp. 1093-1098). IEEE: Dresden, Germany. Green open access
https://ift.tt/2O0JHRZ
Synchronizing reconfiguration of coherent functions on disaggregated FPGA resources
Chen, Q; Mishra, V; Nunez-Yanez, J; Zervas, G; (2017) Synchronizing reconfiguration of coherent functions on disaggregated FPGA resources. In: Athanas, P and Cumplido, R and Feregrino, C and Sass, R, (eds.) Proceedings of the International Conference on Reconfigurable Computing and FPGAs 2017. IEEE: Cancun, Mexico. Green open access
https://ift.tt/2Nq2wN3
SLC25A46 Mutations Underlie Progressive Myoclonic Ataxia With Optic Atrophy and Neuropathy
Charlesworth, G; Balint, B; Mencacci, NE; Carr, L; Wood, NW; Bhatia, KP; (2016) SLC25A46 Mutations Underlie Progressive Myoclonic Ataxia With Optic Atrophy and Neuropathy. Movement Disorders , 31 (8) pp. 1249-1251. 10.1002/mds.26716 .
https://ift.tt/2NWVeS6
Copper deficiency and myelopathy after bariatric surgery - Authors' reply
Oben, J; Cordero, P; (2018) Copper deficiency and myelopathy after bariatric surgery - Authors' reply. [Letter]. The Journal of the Royal College of Physicians of Edinburgh , 48 (1) p. 92. 10.4997/JRCPE.2018.120 . Green open access
https://ift.tt/2NssqQz
Cows, Cabins and Tweets: Posthuman Intra-acting Affect and Feminist Fires in Secondary School
Ringrose, JL; Renold, E; (2016) Cows, Cabins and Tweets: Posthuman Intra-acting Affect and Feminist Fires in Secondary School. In: Taylor, C and Hughes, C, (eds.) Posthuman Research Practices in Education. Springer
https://ift.tt/2O0jXoG
SiP-enabled FPGA network interface for programmable access to disaggregated data centre resources
Chen, Q; Mishra, V; De Dobbelaere, P; Enrico, M; Parsons, N; Nunez-Yanez, J; Zervas, G; (2017) SiP-enabled FPGA network interface for programmable access to disaggregated data centre resources. In: Proceedings of the Asia Communications and Photonics Conference. (pp. Su2A.78). OSA Publishing: Guangzhou, Guangdong China.
https://ift.tt/2NqDcGZ
A quasi-experimental study of impacts of Tanzania's wildlife management areas on rural livelihoods and wealth
Bluwstein, J; Homewood, K; Lund, JF; Nielsen, MR; Burgess, N; Msuha, M; Olila, J; ... Keane, A; + view all Bluwstein, J; Homewood, K; Lund, JF; Nielsen, MR; Burgess, N; Msuha, M; Olila, J; Sankeni, SS; Millia, SK; Laizer, H; Elisante, F; Keane, A; - view fewer (2018) A quasi-experimental study of impacts of Tanzania's wildlife management areas on rural livelihoods and wealth. Scientific Data , 5 , Article 180087. 10.1038/sdata.2018.87 . Green open access
https://ift.tt/2NVc2sC
The contribution of cool and hot executive function to academic achievement, learning-related behaviours, and classroom behaviour
O'Toole, S; Monks, CP; Tsermentseli, S; Rix, K; (2018) The contribution of cool and hot executive function to academic achievement, learning-related behaviours, and classroom behaviour. Early Child Development and Care 10.1080/03004430.2018.1494595 . (In press).
https://ift.tt/2No1n8S
Crystal structure prediction of flexible pharmaceutical-like molecules: Density functional tight-binding as an intermediate optimization method and for free energy estimation
Iuzzolino, L; McCabe, P; Price, SL; Brandenburg, JG; (2018) Crystal structure prediction of flexible pharmaceutical-like molecules: Density functional tight-binding as an intermediate optimization method and for free energy estimation. Faraday Discussions 10.1039/C8FD00010G . (In press). Green open access
https://ift.tt/2NVbRxs
Cool and hot executive functions at 5-years-old as predictors of physical and relational aggression between 5- and 6-years-old
O'Toole, S; Tsermentseli, S; Humayun, S; Monks, CP; (2018) Cool and hot executive functions at 5-years-old as predictors of physical and relational aggression between 5- and 6-years-old. International Journal of Behavioral Development (In press).
https://ift.tt/2NpsaS4
Gender differences in first-year students' expectations towards a new engineering multidisciplinary curriculum
Direito, I; Tilley, E; Mitchell, JE; (2018) Gender differences in first-year students' expectations towards a new engineering multidisciplinary curriculum. In: (Proceedings) CISPEE 2018, Third International Conference of the Portuguese Society for Engineering Education, 27-29 June, 2018, Aveiro, Portugal. (In press).
https://ift.tt/2uyscQy
Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial
Chingono, R; Mebrahtu, H; Mupambireyi, Z; Simms, V; Weiss, HA; Ndlovu, P; Charasika, F; ... Sherr, L; + view all Chingono, R; Mebrahtu, H; Mupambireyi, Z; Simms, V; Weiss, HA; Ndlovu, P; Charasika, F; Tomlinson, M; Cluver, LD; Cowan, FM; Sherr, L; - view fewer (2018) Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial. BMC Pediatrics , 18 , Article 222. 10.1186/s12887-018-1201-0 . Green open access
https://ift.tt/2Lv4jjk
In Compute/Memory Dynamic Packet/Circuit Switch Placement for Optically Disaggregated Data Centers
Peters, A; Oikonomou, G; Zervas, G; (2018) In Compute/Memory Dynamic Packet/Circuit Switch Placement for Optically Disaggregated Data Centers. Journal of Optical Communications and Networking , 10 (7) B164-B178. 10.1364/JOCN.10.00B164 .
https://ift.tt/2uwTGpT
Sharing data from the Ecosystem Services for Poverty Alleviation programme
Homewood, K; Schreckenberg, K; (2018) Sharing data from the Ecosystem Services for Poverty Alleviation programme. Scientific Data , 5 , Article 180137. 10.1038/sdata.2018.137 . Green open access
https://ift.tt/2zQ0VOH
Band gap temperature-dependence and exciton-like state in copper antimony sulphide, CuSbS2
Birkett, M; Savory, CN; Rajpalke, MK; Linhart, WM; Whittles, TJ; Gibbon, JT; Welch, AW; ... Veal, TD; + view all Birkett, M; Savory, CN; Rajpalke, MK; Linhart, WM; Whittles, TJ; Gibbon, JT; Welch, AW; Mitrovic, IZ; Zakutayev, A; Scanlon, DO; Veal, TD; - view fewer (2018) Band gap temperature-dependence and exciton-like state in copper antimony sulphide, CuSbS2. APL Materials , 6 (8) , Article 084904. 10.1063/1.5030207 . Green open access
https://ift.tt/2uuWjZi
Investment Strategy and Selection Bias: An Equilibrium Perspective on Overoptimism
Jehiel, P; (2018) Investment Strategy and Selection Bias: An Equilibrium Perspective on Overoptimism. American Economic Review , 108 (6) pp. 1582-1597. 10.1257/aer.20161696 . Green open access
https://ift.tt/2LqeIwB
Mediterranean diet and physical functioning trajectories in Eastern Europe: Findings from the HAPIEE study
Stefler, D; Hu, Y; Malyutina, S; Pajak, A; Kubinova, R; Peasey, A; Pikhart, H; ... Bobak, M; + view all Stefler, D; Hu, Y; Malyutina, S; Pajak, A; Kubinova, R; Peasey, A; Pikhart, H; Rodriguez-Artalejo, F; Bobak, M; - view fewer (2018) Mediterranean diet and physical functioning trajectories in Eastern Europe: Findings from the HAPIEE study. PLoS One , 13 (7) , Article e0200460. 10.1371/journal.pone.0200460 . Green open access
https://ift.tt/2uy1wiR
Quasi-markets, school diversity and social selection: Analysing the case of free schools in England, five years on
Allen, R; Higham, R; (2018) Quasi-markets, school diversity and social selection: Analysing the case of free schools in England, five years on. London Review of Education , 16 (2) 10.18546/LRE.16.2.02 . Green open access
https://ift.tt/2Lv3NSq
Is the national professional qualification for headship making a difference
Male, T; (2001) Is the national professional qualification for headship making a difference. School Leadership and Management , 21 (4) pp. 463-477. 10.1080/13632430120108961 . Green open access
https://ift.tt/2utyCke
Dynamic Changes in Schlemm Canal and Iridocorneal Angle Morphology During Accommodation in Children With Healthy Eyes: A Cross-Sectional Cohort Study
Moritz, CD; Dubis, AM; Quartilho, A; Al-Hayouti, H; Khaw, PT; Theodorou, M; Dahlmann-Noor, A; (2018) Dynamic Changes in Schlemm Canal and Iridocorneal Angle Morphology During Accommodation in Children With Healthy Eyes: A Cross-Sectional Cohort Study. Investigative Ophthalmology and Visual Science , 59 (8) pp. 3497-3502. 10.1167/iovs.17-23189 . Green open access
https://ift.tt/2Lv3B5E
Micro-imaging of buried layers and interfaces in ultrathin films by X-ray reflectivity
Jiang, J; Hirano, K; Sakurai, K; (2016) Micro-imaging of buried layers and interfaces in ultrathin films by X-ray reflectivity. Journal of Applied Physics , 120 (11) , Article 115301. 10.1063/1.4962311 . Green open access
https://ift.tt/2utFcHq
The Impact on Disaster Governance of the Intersection of Environmental Hazards, Border Conflict and Disaster Responses in Ladakh, India
Field, J; Kelman, I; (2018) The Impact on Disaster Governance of the Intersection of Environmental Hazards, Border Conflict and Disaster Responses in Ladakh, India. International Journal of Disaster Risk Reduction 10.1016/j.ijdrr.2018.07.001 . (In press).
https://ift.tt/2zPpawv
High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS
Blomqvist, M; Boren, J; Zetterberg, H; Blennow, K; Mansson, J-E; Stahlman, M; (2017) High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS. Journal of Lipid Research , 58 (7) pp. 1482-1489. 10.1194/jlr.D076588 . Green open access
https://ift.tt/2utEY32
Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
Wang, Z; Stuckey, DJ; Murdoch, CE; Camelliti, P; Lip, GYH; Griffin, M; (2018) Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor. Cell Death and Disease , 9 (6) , Article 613. 10.1038/s41419-018-0573-2 . Green open access
https://ift.tt/2Lqnk6t
Medicare Will Likely Face Pushback on Physician Pay Changes
CMS has unveiled a proposed overhaul of evaluation and management billing that may create 'winners and losers' among specialties, while leaving the 2018 MIPS reporting period unchanged.
Medscape Medical News
https://ift.tt/2zKIN8Z
Comparison of a novel clinical score to estimate the risk of REsidual neuromuscular block Prediction Score and the last train-of-four count documented in the electronic anaesthesia record: A retrospective cohort study of electronic data on file
https://ift.tt/2LfQoRj
Near-infrared spectroscopy in vegetables and humans: An observational study
https://ift.tt/2JD1Guk
Superior sealing effect of a three-dimensional printed modified supraglottic airway compared with the i-gel in a three-dimensional printed airway model
Abstract
Purpose
The aim of this study was to compare the force exerted by a three-dimensional (3D) printed modified supraglottic airway (mSGA) vs. that exerted by the i-gel on a 3D printed airway model.
Methods
After a preliminary experiment in Thiel embalmed cadavers, we created a 3D printed mSGA and five 3D printed airway models based on computed tomography data from five female Japanese patients. We compared the force exerted by the i-gel and mSGA on the larynx of the 3D printed airway models. In addition, tidal volumes with insertion of the airway devices into the 3D printed airway model and administration of different levels of pressure-controlled ventilation (PCV) were compared.
Results
The values below indicate mean values ± SD (p value, 95% confidence interval) for the mSGA and i-gel, respectively. The forces exerted by the cuff parts were as follows: ventral: 12.5 ± 5.4 vs. 20.7 ± 3.7 N (p = 0.0001, − 10.0 to − 6.5), proximal: 1.9 ± 1.4 vs. 1.7 ± 1.3 N (p = 0.322, − 0.26 to 0.74), and dorsal parts: 6.9 ± 2.2 vs. 12.5 ± 4.8 N (p = 0.0001, − 7.9 to − 3.4), respectively. We also found significantly higher tidal volumes with the mSGA under PCV of 10, 15, and 20 cmH2O.
Conclusions
The method of creating the mSGA that we proposed in this study can be applied to development of novel SGAs that is anatomically more suitable for pharyngolaryngeal structure.
https://ift.tt/2Lp96X2
Successful Treatment of Methampyrone-Induced Toxic Epidermal Necrolysis with Therapeutic Plasma Exchange
The toxic epidermal necrolysis (TEN) is a severe cutaneous adverse reaction frequently caused by drug exposure. A 58-year-old male was admitted to the hospital after administration of methampyrone. He developed sloughing of the total epidermis which rapidly extended over the trunk and limbs. The presumptive diagnosis was drug-induced TEN. Despite the treatment with pulsed glucocorticoid and cyclosporine, the skin lesions extended over the entire body. Strikingly, the progression of blistering was stopped by therapeutic plasma exchange (TPE). TPE was discontinued after the signs of skin inflammation had been overcome. He recovered in 8 days of hospitalization. We present here a case of a methampyrone-induced TEN which was successfully treated with TPE.
https://ift.tt/2LgyoGv