Genetics of perioperative pain management

Purpose of review The current review will discuss the current literature on genetics of pain and analgesia, with special emphasis on perioperative setting. We will also discuss pharmacogenetics-based management guidelines, current clinical status and future perspectives. Recent findings Recent literature suggests that the interindividual variability in pain and postoperative analgesic response is at least in part because of one's genetic make-up. Some of the well characterized polymorphisms that are associated with surgical pain and opioid-related postoperative adverse outcomes are described in catechol-O-methyl transferase, CYP2D6 and μ-opioid receptor (OPRM1), ATP-binding cassette subfamily B member 1, ABCC3, organic cation transporter 1 genes. Clinical Pharmacogenetics Implementation Consortium has put forth recommendations on CYP2D6 genotype-based opioid selection and dosing. The list of drug–gene pairs studied continue to expand. Summary Pharmacogenetic approach marks the dawn of personalized pain medicine both in perioperative and chronic pain settings. Correspondence to Senthilkumar Sadhasivam, MD, MPH, Gopal Krishna Professor and Chief of Anesthesia, Department of Anesthesia, Riley Hospital for Children at Indiana University Health, RH 2835, 705 Riley Hospital Drive, Indianapolis, IN 46202, USA. Tel: +1 317 948 3845; fax: +1 317 944 0282; e-mail: ssadhasivam@iuhealth.org Copyright © 2018 YEAR Wolters Kluwer Health, Inc. All rights reserved.

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False negative computed tomography scan due to pelvic binder in a patient with pelvic disruption: a case report and review of the literature

Pelvic binders are routinely used in the prehospital setting for stabilization of pelvic injuries in patients with trauma. Emergency department trauma management relies on primary and secondary survey assessme...

https://ift.tt/2OIojkc

Clinical Thyroidology®for the Public – Highlighted Article

From Clinical Thyroidology^® for the Public: Treatment-free survival, which is living without the need for treatment for recurrent cancer, is an important outcome for thyroid cancer patients. The goal of this study was to understand factors associated with treatment-free survival in the general population, because this will enable the care teams to tailor long term follow up to a particular situation, and, many times, help decrease patient worry. Read More…

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The post Clinical Thyroidology^®for the Public – Highlighted Article appeared first on American Thyroid Association.

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Induction of innate immune memory: the role of cellular metabolism

Jorge Domínguez-Andrés | Leo AB Joosten | Mihai G Netea

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Thyroid® High-Impact Articles

FREE ACCESS through October 2, 2018.

Read now:

Latest Impact Factor: 7.557
The Official Journal of: American Thyroid Association^®

Impact of Hypothyroidism and Heart Failure on Hospitalization Risk
Kevin Ro, Alexander D. Yuen, Lin Du, Clarissa C. Ro, Christian Seger, Michael W. Yeh, Angela M. Leung, and Connie M. Rhee

Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies
Shinje Moon, Min Joo Kim, Jae Myung Yu, Hyung Joon Yoo, and Young Joo Park 

Cardiovascular Morbidity and Mortality After Treatment of Hyperthyroidism with Either Radioactive Iodine or Thyroidectomy
Ryödi Essi, Metso Saara, Huhtala Heini, Välimäki Matti, Auvinen Anssi, and Jaatinen Pia 

Decreasing Disease-Specific Mortality of Differentiated Thyroid Cancer in Korea: A Multicenter Cohort Study
Min Ji Jeon, Hee Kyung Kim, Eun Heui Kim, Eun Sook Kim, Hyon-Seung Yi, Tae Yong Kim, Ho-Cheol Kang, Young Kee Shong, Won Bae Kim, Bo Hyun Kim, and Won Gu Kim  

Incidence and Survival of Thyroid Cancer in Children, Adolescents, and Young Adults in Denmark: A Nationwide Study from 1980 to 2014
Jakob Schmidt Jensen, Christian Grønhøj, Christian Mirian, David Hebbelstrup Jensen, Jeppe Friborg, Christoffer Holst Hahn, Tina Klitmøller Agander, and Thomas Hjuler 

Sonographically Estimated Risks of Malignancy for Thyroid Nodules Computed with Five Standard Classification Systems: Changes over Time and Their Relation to Malignancy
Giorgio Grani, Livia Lamartina, Marco Biffoni, Laura Giacomelli, Marianna Maranghi, Rosa Falcone, Valeria Ramundo, Vito Cantisani, Sebastiano Filetti, and Cosimo Durante 

Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain
Soledad Bárez-López, Meredith D. Hartley, Carmen Grijota-Martínez, Thomas S. Scanlan, and Ana Guadaño-Ferraz  

The post <i>Thyroid^®</i> High-Impact Articles appeared first on American Thyroid Association.

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Nodular Mass in the Upper Lip

A man presents with a firm, painless, slow-growing mass in his upper lip. What is your diagnosis?

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September 2018 Issue Highlights

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Association of the Anterolateral Thigh Osteomyocutaneous Flap With Femur Structural Integrity

This laboratory analysis of synthetic femurs investigates the association of anterolateral thigh osteomyocutaneous flap harvest, with and without prophylactic fixation, with femur structural integrity as measured by 4-point bend and torsional biomechanical testing.

https://ift.tt/2vfHBVN

Reversible Auricular Necrosis Secondary to Systemic Thrombosis

This report describes a woman diagnosed with a rare case of concomitant heparin-induced thrombocytopenia and antiphospholipid antibody syndrome that presented with auricular necrosis.

https://ift.tt/2o4vTtG

Dornase Alfa Ototoxic Effects in Animals and Efficacy for Clogged Tympanostomy Tubes in Children

This pilot study investigates the ototoxic effects of dornase alfa in a chinchilla model and its efficacy vs ofloxacin in a randomized clinical trial of children with clogged tympanostomy tubes.

https://ift.tt/2LLE10w

Prevalence and Risk Factors for Olfactory Hallucinations in the United States

Olfactory dysfunction can result in substantial reductions in quality of life if left untreated. The presence of phantom smells, or phantosmia, is a clinically distinct olfactory dysfunction where patients sense odors when no odor source is present. The cause of phantosmia is not completely understood and has been most commonly associated with head trauma, psychiatric conditions, chronic rhinosinusitis, epilepsy, and a number of neurologic and neurodegenerative disorders.

https://ift.tt/2BiN18s

Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus

This randomized clinical trial investigates whether inhaled nitrous oxide and oxygen vs inhaled nitrogen and oxygen can reduce bothersome tinnitus among adults with subjective, idiopathic, nonpulsatile tinnitus of 6 months' duration or longer.

https://ift.tt/2O3f1OY

Physician Adherence to Guidelines for Benign Paroxysmal Positional Vertigo in Ambulatory Care Settings

This cohort study uses data from the National Ambulatory Medical Care Survey to evaluate the prevalence of patient visits to ambulatory care clinics for benign paroxysmal positional vertigo and whether physicians' diagnostic and treatment recommendations adhered to clinical practice guidelines over time.

https://ift.tt/2MuqKZD

Association of Cytologically Indeterminate Thyroid Nodule Size With Histologic and Clinical Outcomes

This study assesses the association of indeterminate thyroid nodule size among adults with histologic and clinical outcomes such as cancer rates and response to therapy in considering a surgical approach.

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Errors in Figure 2 and Figure 3

In the Original Investigation titled "Effect of Nitrous Oxide as a Treatment for Subjective, Idiopathic, Nonpulsatile Bothersome Tinnitus: A Randomized Clinical Trial," published online August 2, 2018, there was an error the x-axis label and caption of Figure 2 and the key in Figure 3. In the x-axis, the labels read "Nitrous Oxide First" and "Placebo First." They should have been "Nitrous Oxide" and "Placebo." The caption included expansions of GBS and PI, which should not have been included. In Figure 3, the key indicates 'Nitrous oxide first" and "Placebo first." The key should have been "Nitrous oxide" and "Placebo." This article was corrected online.

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Safety of Drilling 3-Dimensional–Printed Temporal Bones

This occupational safety assessment evaluates a surgeon's exposure to volatile organic compounds when drilling 3 commonly used materials in 3-dimensional–printed temporal bone implants using a standard Office of Safety and Health Administration protocol.

https://ift.tt/2o23Eff

Revisiting the 2015 American Thyroid Association Guidelines in the NIFTP Era

The incidence of thyroid cancer and subsequent thyroid surgery has increased significantly during the past decade in the United States. Mortality rates have remained unchanged, supporting the widely accepted hypothesis that this finding can, in part, be explained by increased detection of small, nonaggressive nodules, resulting in potential overdiagnosis and treatment.

https://ift.tt/2LtutGI

Evaluation of Social Media Presence of Otolaryngology Residency Programs in the United States

This cross-sectional study examines the presence and activity of otolaryngology residency programs on social media sites.

https://ift.tt/2BDQDlS

Bilateral Painless Cervical Lymphadenopathy in a Child

A child younger than 10 years presented with an 8-week history of bilateral cervical lymphadenopathy unresponsive to a 10-day course of drug treatment and no relevant medical history. What is your diagnosis?

https://ift.tt/2uOrwG1

Factors Associated With Phantom Odor Perception Among US Adults

This cross-sectional study of data from the National Health and Nutrition Examination Survey examines the prevalence of phantom odor perception among US adults and evaluates differences by age, sex, socioeconomic position, health status, health behaviors, smell function, and oral and sinonasal symptoms.

https://ift.tt/2MAub0W

Management of Hoarseness

This guideline summary presents American Academy of Otolaryngology–Head and Neck Surgery recommendations for assessing and treating patients with hoarseness (dysphonia).

https://ift.tt/2Ln04ul

Preoperative Tranexamic Acid for Rhinoplasty

This systematic review and meta-analysis of randomized clinical trials evaluates the preoperative use of tranexamic acid for reduction of bleeding, eyelid edema, and periorbital ecchymosis in patients undergoing rhinoplasty.

https://ift.tt/2vvLuXo

Cocaine-Induced Midline Destructive Lesions and Erosion of the Eustachian Tube

This case report describes a 43-year-old woman with eustachian tube erosion associated with cocaine use.

https://ift.tt/2MxcTih

Artificial Saliva vs Saline Solution and Suture Degradation in Oropharyngeal Surgery

This in vitro study examines artificial saliva vs saline solution and their association with the strength of common types of absorbable sutures used in oral surgery.

https://ift.tt/2MuaMis

Pleomorphic Adenoma of the Nasolacrimal Duct

This study describes the case of a man in his 60s with a 2-year medical history of right epiphora with recent 6-week onset of hemolacrima who presented with an incidental soft tissue lesion along the left inferior turbinate with associated nasolacrimal duct dilatation above the mass.

https://ift.tt/2LtQRAA

Device Safety

Medical devices are essential in the diagnosis and treatment of otolaryngologic disease. The US Food and Drug Administration (FDA) is tasked with assuring the safety and effectiveness of these devices. Otolaryngologists, in turn, are often responsible for helping patients understand risks, benefits, and alternatives when deciding whether to rely on devices in their care. To best counsel patients, otolaryngologists should be aware of the strengths and limitations of device regulation by the FDA. This article reviews the FDA regulatory framework for medical devices, premarket evidentiary standards for marketing devices, and postmarket methods of safety surveillance.

https://ift.tt/2xtaLCC

Systems Science

In the 21st century, most medical care is not delivered by a single physician but rather, by a team. A team is a type of system, a set of people and things interacting together for a defined aim. The discipline of systems science concerns itself with how complex teams or organizations function. The application of systems science has had a major positive impact on safety and quality in such diverse disciplines as auto manufacturing, airline safety, and nuclear power generation. A modest understanding of how systems science applies to medical care can help improve safety and quality of care.

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The Impact of Cognitive and Implicit Bias on Patient Safety and Quality

Humans use cognitive shortcuts, or heuristics, to quickly assess and respond to situations and data. When applied inappropriately, heuristics have the potential to redirect analysis of available information in consistent ways, creating systematic biases resulting in decision errors. Heuristics have greater effect in high-pressure, high-stakes decisions, particularly when dealing with incomplete information, in other words, daily medical and surgical practice. This article discusses 2 major categories: cognitive biases, which affect how we perceive and interpret clinical data; and implicit biases, which affect how we perceive and respond to other individuals, and also discusses approaches to recognize and alleviate bias effects.

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A Critical Need: Increasing Interest in the Field of Allergy and Immunology in Medical Students and Residents

It is vital for any field in medicine to attract the best and brightest learners to ensure that the specialty continues to provide outstanding clinical care and cutting-edge research. This is especially true for the field of Allergy and Immunology (AI) as graduates of AI training programs have a very large depth and breadth of environments in which to practice, from private practice to faculty at a large tertiary care medical center to working in industry, integrated healthcare organizations, or for the government.

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Omalizumab as single-dose therapy for vernal keratoconjunctivitis

Vernal keratoconjunctivitis (VKC) is a bilateral inflammatory ocular condition often brought on by an allergic response. Patients with VKC commonly exhibit ocular symptoms such as photophobia, redness of the eyes, itching, discharge, and lacrimation, which can have profound effects on quality of life. The pathogenesis of the disease is both immunoglobulin E (IgE) and non-IgE mediated, invoking several hypersensitivity mechanisms. The treatment for VKC is mainly centered on symptom control with the use of antihistamines, calcineurin inhibitors, and corticosteroids.

https://ift.tt/2O1iMYI

Diagnostic Approach to Chronic Eosinophilic Pneumonia in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 184-185, September 2018.


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Current State and Future of Biologic Therapies in the Treatment of Asthma in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 119-131, September 2018.


https://ift.tt/2PQFL6o

Asthma Guidelines Priority Topic: Long-Acting Anti-Muscarinic Agents in Asthma Management as Add-On to Inhaled Corticosteroids

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 199-203, September 2018.


https://ift.tt/2PP9Y5J

Bethanechol in Tracheomalacia: Two Case Series and a Review of the Literature

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 180-183, September 2018.


https://ift.tt/2xsIWtX

Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 158-165, September 2018.


https://ift.tt/2PTBVt3

Minocycline-Induced Eosinophilic Pneumonia in a Pediatric Patient

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 194-198, September 2018.


https://ift.tt/2xtLfNo

Current State and Future of Biologic Therapies in the Treatment of Asthma in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 119-131, September 2018.


https://ift.tt/2NoGIG2

Diagnostic Approach to Chronic Eosinophilic Pneumonia in Children

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 184-185, September 2018.


https://ift.tt/2DiqGZL

Bethanechol in Tracheomalacia: Two Case Series and a Review of the Literature

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 180-183, September 2018.


https://ift.tt/2DeFMzi

Asthma Guidelines Priority Topic: Long-Acting Anti-Muscarinic Agents in Asthma Management as Add-On to Inhaled Corticosteroids

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 199-203, September 2018.


https://ift.tt/2NoGGxU

Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 158-165, September 2018.


https://ift.tt/2Nuq8Vc

Minocycline-Induced Eosinophilic Pneumonia in a Pediatric Patient

Pediatric Allergy, Immunology, and Pulmonology, Volume 31, Issue 3, Page 194-198, September 2018.


https://ift.tt/2DhdULa

JESREC score and mucosal eosinophilia can predict endotypes of chronic rhinosinusitis with nasal polyps

Publication date: Available online 19 September 2018

Source: Auris Nasus Larynx

Author(s): Tsuguhisa Nakayama, Naoki Sugimoto, Naoko Okada, Tadao Tsurumoto, Ryoto Mitsuyoshi, Shinya Takaishi, Daiya Asaka, Hiromi Kojima, Mamoru Yoshikawa, Yasuhiro Tanaka, Shin-ichi Haruna

Abstract

Objective

Recently, JESREC score and mucosal eosinophil count have been used to diagnose eosinophilic chronic rhinosinusitis (ECRS) in Japan. However, it remains unknown whether the subtypes of CRS diagnosed by these criteria have different endotypes. In the present study, we investigated whether JESREC score and mucosal eosinophil count were appropriate for classification of CRS subgroups into endotypes.

Methods

A cross-sectional study involving 71 consecutive patients with CRS with nasal polyps (CRSwNP) and 13 control patients was performed. Nasal polyp tissues from CRSwNP patients and uncinate process tissues from control patients were collected for analysis of inflammatory cells by immunohistochemistry and measurement of cytokines and chemokines by ELISA and quantitative real-time PCR. We compared the differences between subtypes according to JESREC score and mucosal eosinophil count and investigated the subgroups with different endotypes by cluster analysis and principal component analysis.

Results

In the 71 CRSwNP patients, 9 patients had JESREC score <11 and mucosal eosinophil count <70/HPF (Group A), 20 patients had JESREC score ≥11 and mucosal eosinophil count <70/HPF (Group C), and 42 patients had JESREC score ≥11 and mucosal eosinophil count ≥70/high-power field (HPF) (Group D). Semiquantitative analysis of inflammatory cells showed that eosinophils, neutrophils, macrophages, mast cells, and basophils differed significantly between the subgroups. At the mRNA level, CLC, IL5, IL13, CCL11, CCL24, CCL26, POSTN, CSF3, and IL8 showed significant differences. At the protein level, eotaxin-2/CCL24, eotaxin-3/CCL26, and G-CSF had significant differences. Cluster analysis using gene expression levels in 55 CRS patients and 11 control patients revealed that the patients could be classified into five clusters. Cluster 1 (n = 27) contained all patients with Group D. Cluster 2 (n = 11) comprised all control patients. Cluster 3 (n = 4) included mixed subtypes: one with Group A and three with Group D. Cluster 4 (n = 7) and Cluster 5 (n = 17) contained all patients with Groups A and C, respectively. Furthermore, the principal component analysis revealed that the subtypes had different characteristics.

Conclusion

CRS subtypes based on JESREC score and mucosal eosinophil count showed different inflammatory patterns, and unsupervised statistical analyses supported the classification that can predict endotypes. From these results, we concluded that the classification based on JESREC score and mucosal eosinophil count was useful for predicting CRS endotypes.

https://ift.tt/2Dja9F7

The Masked ABR (mABR): a New Measurement Method for the Auditory Brainstem Response

Abstract

The auditory brainstem response (ABR) is relatively non-invasive, and in many species, the only practical way to assess auditory sensitivity. The two main methods for measuring ABR are using either transients or tone bursts as a stimulus. The transient stimulus produces strong neural responses that contain no frequency information. In contrast, tone bursts stimulate only a small part of the auditory system, eliciting weaker neural responses but supplying frequency information. Furthermore, short tone bursts become less and less frequency specific with increasing stimulus wavelength, making them unsuitable for testing low-frequency hearing. Here, we develop a method that can measure sensitivity to both low and high-frequency stimuli. The method is based on masking of a transient response by long-duration sinusoids. The measurement system is developed as a highly portable system that runs on battery power. It has been used in a variety of animals in our lab and in the field, including squid (Mooney et al. in J Exp Biol 213: 3748–3759, 2010), lungfish (Christensen-Dalsgaard et al. in J Neurophys 105: 1992–2004, 2011b), alligators (Bierman et al. in J Exp Biol 217: 1094–1107, 2014), and mink (Brandt et al. in J Exp Biol 216: 3542–3550, 2013). Here, we present data recorded from Tokay geckos and compare the results with tone burst ABR measurements. This method produces results comparable to tone burst stimulations at higher frequencies (above 1 kHz) but has several advantages: it is relatively insensitive to fluctuations in neural signal level, it allows measurements at very low frequencies, it allows constant monitoring of the state of the animal, and can be used to measure directional hearing.

https://ift.tt/2NWjeaR

Editorial Board

Publication date: October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 5

Author(s):

https://ift.tt/2xA9Ort

Contents

Publication date: October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases, Volume 135, Issue 5

Author(s):

https://ift.tt/2QMHlHG

The Masked ABR (mABR): a New Measurement Method for the Auditory Brainstem Response

Abstract

The auditory brainstem response (ABR) is relatively non-invasive, and in many species, the only practical way to assess auditory sensitivity. The two main methods for measuring ABR are using either transients or tone bursts as a stimulus. The transient stimulus produces strong neural responses that contain no frequency information. In contrast, tone bursts stimulate only a small part of the auditory system, eliciting weaker neural responses but supplying frequency information. Furthermore, short tone bursts become less and less frequency specific with increasing stimulus wavelength, making them unsuitable for testing low-frequency hearing. Here, we develop a method that can measure sensitivity to both low and high-frequency stimuli. The method is based on masking of a transient response by long-duration sinusoids. The measurement system is developed as a highly portable system that runs on battery power. It has been used in a variety of animals in our lab and in the field, including squid (Mooney et al. in J Exp Biol 213: 3748–3759, 2010), lungfish (Christensen-Dalsgaard et al. in J Neurophys 105: 1992–2004, 2011b), alligators (Bierman et al. in J Exp Biol 217: 1094–1107, 2014), and mink (Brandt et al. in J Exp Biol 216: 3542–3550, 2013). Here, we present data recorded from Tokay geckos and compare the results with tone burst ABR measurements. This method produces results comparable to tone burst stimulations at higher frequencies (above 1 kHz) but has several advantages: it is relatively insensitive to fluctuations in neural signal level, it allows measurements at very low frequencies, it allows constant monitoring of the state of the animal, and can be used to measure directional hearing.

https://ift.tt/2NWjeaR

Outcomes of Open vs Endoscopic Skull Base Surgery in Older Patients

This cohort study compares outcomes of endoscopic and open skull base surgery to investigate associations between surgical approaches, patient age, disease process, and intraoperative and postoperative complications among patients 70 years or older.

https://ift.tt/2QNgUlg

Survival and Toxic Effects of Definitive Radiotherapy vs Primary Surgery in Oropharyngeal Squamous Cell Carcinoma

This cohort study examines the differences in overall survival and toxic effects in patients with oropharyngeal squamous cell carcinoma treated with radiotherapy vs primary surgery.

https://ift.tt/2xBDt3w

Three-Dimensional Printing Technology for Patients With Nasal Septal Deformities

This multicenter study examines the clinical application of a 3-D printed biomaterial implant in septoplasty for patients with caudal septal deviations.

https://ift.tt/2QNgHhY

An Unusual Entity Presenting as Bilateral Cervical Lymphadenopathy

A farmer in his 50s had bilateral periauricular swelling with no fever, weight loss, or loss of appetite. What is your diagnosis?

https://ift.tt/2xxoXti

Immune response mediated by Th1 / IL-17 / caspase-9 promotes evolution of periodontal disease

Publication date: Available online 19 September 2018

Source: Archives of Oral Biology

Author(s): M.E.L. Sommer, R.A. Dalia, A.V.B. Nogueira, J.A. Cirelli, M.A.R. Vinolo, J.L. Fachi, C.A. Oliveira, T.A.M. Andrade, F.A.S. Mendonça, M. Santamaria, M. Felonato

Abstract

Introduction

Periodontitis is characterized by inflammatory mediators beyond T lymphocyte function and phenotype (Th1/Th2/Th17). The clinical diversity in periodontitis makes it difficult to characterize the immune response in patients. This study evaluated the profile of the adaptive immune response in the periodontal disease model.

Methods

72 rats (Wistar) were divided into a control group (CTL/day 0) and periodontitis (PD15/15 days and PD60/60 days). In the PD15 and PD60 groups, periodontal disease was induced by ligature with a silk thread placed in the cervical region of the upper first molar. After euthanasia, the periodontal tissue was analyzed by flow cytometry (CD4, CD8, CD25, CD44), semi-quantitative RT-PCR (T-bet, GATA-3, RORγt), semi-quantitative RT-PCR and ELISA IFN-γ, TNF-α, IFN-γ, IL-4, IL-6, IL-10, IL-17) and by Western blotting (Caspase-9, PCNA).

Results

The number of CD4⁺CD25⁺, CD4⁺CD44⁺, CD8⁺CD25⁺ and CD8⁺CD44⁺ cells and expression levels of T-bet and GATA-3 are increased in the PD60 group compared to PD15 and CTL. The RORγ-t gene transcript increased in the PD15 group in relation to PD60 and CTL. The cytokines IFN-γ, TNF-α and IL-17 increased in the PD60 group in relation to PD15. The expression of Caspase-9 was higher in the PD60 group than in PD15.

Conclusions

The results suggest that the evolution of gingivitis to periodontitis is related to the accumulation of activated Th1 cells (IFN-γ and TNF-α) associated with the presence of increased IL-17. Studies with inhibitors of these cytokines in periodontal disease may lead to therapy directed at blocking the inflammatory process in this pathology, interrupting bone loss.

https://ift.tt/2MNPEzD

Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2OMaYXW

The Dangers of Juuling | Keeping Your Teen Safe

Juuling is the new "cool" thing to do among teenagers. Have you heard of it? If you're like many parents, the answer is probably no. So, could you spot this new e-cigarette or would you mistake it for a flash drive? Dr. Sarah Garwood explains what exactly juuling is and why it's so dangerous for teenagers.

The post The Dangers of Juuling | Keeping Your Teen Safe appeared first on ChildrensMD.

https://ift.tt/2PUCfYH

Albizia Adianthifolia: Botany, Medicinal Uses, Phytochemistry, and Pharmacological Properties

The bark, leaves, and roots of Albizia adianthifolia are highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia was undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis. Preelectronic literature search of conference papers, scientific articles, books, book chapters, dissertations, and theses was carried out at the University library. Literature search revealed that A. adianthifolia is used as purgative and herbal medicine for diabetes, eye problems, gastrointestinal problems, haemorrhoids, headache, neurodegenerative disorders, reproductive problems in women, respiratory problems, wounds and pain, skin diseases, sexually transmitted infections, and ethnoveterinary medicine. Phytochemical compounds identified from the species include apocarotenoids, chalcone, dipeptide, elliptosides, essential oils, fatty acids, flavonoids, histamine, imidazolyl carboxylic acid, prosapogenins, steroids, triterpene saponins, and triterpenoids. Pharmacological studies revealed that A. adianthifolia extracts and compounds have acetylcholinesterase enzyme inhibitory, anthelmintic, antiamoebic, antibacterial, antimycobacterial, anti-sexually transmitted infections, antifungal, anti-inflammatory, antioxidant, anxiolytic, and antidepressant, cognitive-enhancing, haemolytic, hypoglycemic and antihyperglycemic, immunomodulatory, and cytotoxicity activities. Detailed studies on the pharmacokinetics, in vivo, and clinical research involving compounds isolated from A. adianthifolia and extracts of the species are required.

https://ift.tt/2xDKHDR

What do monoamines do in pain modulation

Bannister, K; Dickenson, AH; (2016) What do monoamines do in pain modulation. Current Opinion in Supportive and Palliative Care , 10 (2) pp. 143-148. 10.1097/SPC.0000000000000207 . Green open access

https://ift.tt/2xs6saG

Accurate estimation of microscopic diffusion anisotropy and its time dependence in the mouse brain

Ianuş, A; Jespersen, SN; Duarte, TS; Alexander, DC; Drobnjak, I; Shemesh, N; (2018) Accurate estimation of microscopic diffusion anisotropy and its time dependence in the mouse brain. NeuroImage , 183 pp. 934-949. 10.1016/j.neuroimage.2018.08.034 . (In press).

https://ift.tt/2PQExYE

Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer

Cheung, A; Opzoomer, JW; Ilieva, KM; Gazinska, P; Hoffmann, RM; Mirza, H; Marlow, R; ... Karagiannis, SN; + view all Cheung, A; Opzoomer, JW; Ilieva, KM; Gazinska, P; Hoffmann, RM; Mirza, H; Marlow, R; Francesch-Domenech, E; Fittall, MW; Dominguez Rodriguez, D; Clifford, A; Badder, L; Patel, N; Mele, S; Pellizzari, G; Bax, HJ; Crescioli, S; Petranyi, G; Larcombe-Young, D; Josephs, DH; Canevari, S; Figini, M; Pinder, SE; Nestle, FO; Gillett, C; Spicer, J; Grigoriadis, A; Tutt, A; Karagiannis, SN; - view fewer (2018) Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer. Clinical Cancer Research 10.1158/1078-0432.CCR-18-0652 . (In press).

https://ift.tt/2xq0YNw

Varying Contracts in the Supreme Court

Davies, PS; (2018) Varying Contracts in the Supreme Court. Cambridge Law Journal (In press). Green open access

https://ift.tt/2PREA6q

Molecular movies filmed at conical intersections

Fielding, HH; (2018) Molecular movies filmed at conical intersections. Science , 361 (6397) pp. 30-31. 10.1126/science.aat6002 .

https://ift.tt/2xq8oAw

Lend me your ears: Mass Observing contemporary adult reading aloud practices

Duncan, S; (2018) Lend me your ears: Mass Observing contemporary adult reading aloud practices. Changing English 10.1080/1358684X.2018.1504620 . (In press).

https://ift.tt/2POdNYT

Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age

Lonsdale, DO; Baker, EH; Kipper, K; Barker, C; Philips, B; Rhodes, A; Sharland, M; Lonsdale, DO; Baker, EH; Kipper, K; Barker, C; Philips, B; Rhodes, A; Sharland, M; Standing, JF; - view fewer (2018) Scaling beta-lactam antimicrobial pharmacokinetics from early life to old age. British Journal of Clinical Pharmacology 10.1111/bcp.13756 . (In press).

https://ift.tt/2xqsyKC

Depressive symptoms and emotion regulation strategies in children with and without developmental language disorder: a longitudinal study

van den Bedem, NP; Dockrell, JE; van Alphen, PM; de Rooij, M; Samson, AC; Harjunen, EL; Rieffe, C; (2018) Depressive symptoms and emotion regulation strategies in children with and without developmental language disorder: a longitudinal study. International Journal of Language and Communication Disorders 10.1111/1460-6984.12423 . (In press). Green open access

https://ift.tt/2PQypja

Reply: Dick et al.: Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative (Ophthalmology. 2018;125:757-773)

Dick, AD; Rosenbaum, JT; (2018) Reply: Dick et al.: Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative (Ophthalmology. 2018;125:757-773). Ophthalmology: Journal of The American Academy of Ophthalmology , 125 (8) e54. 10.1016/j.ophtha.2018.03.006 .

https://ift.tt/2xtD7MU

Bidirectional relationships between bullying, victimization and emotion experience in boys with and without autism

Novin, S; Broekhof, E; Rieffe, C; (2018) Bidirectional relationships between bullying, victimization and emotion experience in boys with and without autism. Autism 10.1177/1362361318787446 . (In press). Green open access

https://ift.tt/2PRExrg

Why we need new architectural and design paradigms to meet the needs of vulnerable people

Chrysikou, E; (2018) Why we need new architectural and design paradigms to meet the needs of vulnerable people. Palgrave Communications (In press).

https://ift.tt/2xtD6Zm

KiDS-450: Enhancing cosmic shear with clipping transformations

Giblin, B; Heymans, C; Harnois-Deraps, J; Joachimi, B; (2018) KiDS-450: Enhancing cosmic shear with clipping transformations. MNRAS , 480 (4) pp. 5529-5549. 10.1093/mnras/sty2271 . Green open access

https://ift.tt/2PQcFnk

How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract" by Catlin et al.; Food and Chemical Toxicology 118 (2018) 328-339

Heinrich, M; (2018) How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract" by Catlin et al.; Food and Chemical Toxicology 118 (2018) 328-339. [Letter]. Food and Chemical Toxicology , 121 pp. 252-253. 10.1016/j.fct.2018.09.006 . (In press).

https://ift.tt/2xqexwB

Memory and Forgetting

Brewin, CR; (2018) Memory and Forgetting. Current Psychiatry Reports , 20 , Article 87. 10.1007/s11920-018-0950-7 . Green open access

https://ift.tt/2PScecp

Repositioning UK Partnerships Post-Brexit

Highman, LAG; (2018) Repositioning UK Partnerships Post-Brexit. International Higher Education (95) 10.6017/ihe.2018.95.10725 . Green open access

https://ift.tt/2xq7rrW

Pressure dependence of structural properties of ice VII: An ab initio molecular-dynamics study

Futera, Z; English, NJ; (2018) Pressure dependence of structural properties of ice VII: An ab initio molecular-dynamics study. The Journal of Chemical Physics , 148 (20) , Article 204505. 10.1063/1.5022175 .

https://ift.tt/2PQEhsE

The Kindness of Strangers? An Investigation into the Interaction of Funder Motivations in Online Crowdfunding Campaigns

Cox, J; Thang, N; Kang, SM; (2018) The Kindness of Strangers? An Investigation into the Interaction of Funder Motivations in Online Crowdfunding Campaigns. KYKLOS , 71 (2) pp. 187-212. 10.1111/kykl.12167 .

https://ift.tt/2xruum9

Prime Focus Spectrograph (PFS) for the Subaru telescope: Ongoing integration and future plans

Tamura, N; Takato, N; Shimono, A; Moritani, Y; Yabe, K; Ishizuka, Y; Kamata, Y; ... Surace, C; + view all Tamura, N; Takato, N; Shimono, A; Moritani, Y; Yabe, K; Ishizuka, Y; Kamata, Y; Ueda, A; Aghazarian, H; Arnouts, S; Barkhouser, RH; Balard, P; Barette, R; Belhadi, M; Burnham, JA; Caplar, N; Carr, MA; Chabaud, PY; Chang, YC; Chen, HY; Chou, CY; Chu, YH; Cohen, JG; De Almeida, RP; De Oliveira, AC; De Oliveira, LS; Dekany, RG; Dohlen, K; Dos Santos, JB; Dos Santos, LH; Ellis, RS; Fabricius, M; Ferreira, D; Furusawa, H; Garcia-Carpio, J; Golebiowski, M; Gross, J; Gunn, JE; Hammond, R; Harding, A; Hart, M; Heckman, TM; Ho, PTP; Hope, SC; Hover, DJ; Hsu, SF; Hu, YS; Huang, PJ; Jamal, S; Jaquet, M; Jeschke, E; Jing, Y; Kado-Fong, E; Karr, JL; Kimura, M; King, ME; Koike, M; Komatsu, E; Le Brun, V; Le Fèvre, O; Le Fur, A; Le Mignant, D; Ling, HH; Loomis, CP; Lupton, RH; Madec, F; Mao, PH; Marchesini, D; Marrara, LS; Medvedev, D; Mineo, S; Minowa, Y; Murayama, H; Murray, GJ; Ohyama, Y; Onodera, M; Orndorff, J; Pascal, S; Peebles, J; Pernot, G; Pourcelot, R; Reiley, DJ; Reinecke, M; Roberts, M; Rosa, JA; Rousselle, J; Schmitt, A; Schwochert, MA; Seiffert, MD; Siddiqui, H; Smee, SA; Sodré, L; Steinkraus, AJ; Strauss, MA; Surace, C; - view fewer (2018) Prime Focus Spectrograph (PFS) for the Subaru telescope: Ongoing integration and future plans. In: Proceedings Volume 10702, Ground-based and Airborne Instrumentation for Astronomy VII; 107021C. SPIE: Austin, Texas, United States. Green open access

https://ift.tt/2PQDW9m

First insights into the expression of VAX2 in humans and its localization in the adult primate retina

Alfano, G; Shah, AZ; Jeffery, G; Bhattacharya, SS; (2016) First insights into the expression of VAX2 in humans and its localization in the adult primate retina. Experimental Eye Research , 148 pp. 24-29. 10.1016/j.exer.2016.05.008 . Green open access

https://ift.tt/2xrufrf

Reclaiming Proportionality: A Reply to Arthur Ripstein

Letsas, G; (2017) Reclaiming Proportionality: A Reply to Arthur Ripstein. Journal of Applied Philosophy , 34 (1) pp. 24-31. 10.1111/japp.12261 .

https://ift.tt/2PUsuK3

Effectiveness of preanesthetic administration of gabapentin on sedative action during intravenous sedation with propofol

Abstract

Purpose

There are no sufficient evidences for the sedative effect of gabapentin during anesthesia, especially intravenous sedation (IVS). The purpose of this study was to evaluate the sedative effect of gabapentin as preanesthetic medication during the IVS with propofol.

Methods

10 volunteer subjects joined this study. They underwent propofol IVS three times on separate days. On the first day, the IVS without gabapentin was performed as a control. On the second and the third day, gabapentin 200 mg and 400 mg were administered before the IVS, respectively. The target blood concentration (C_T) of propofol was gradually increased, and the bispectral index (BIS) value and Ramsay sedation score (RSS) were evaluated at each propofol C_T. Postanesthetic complications and influences on vital signs were also evaluated.

Results

Compared to the control group, the propofol C_Ts in the gabapentin 400 mg group significantly reduced at the BIS values of 60 and 70 (p = 0.031 and p = 0.043, respectively), and at RSS 3, 4, 5 and 6 (p = 0.040, p = 0.004, p = 0.001 and p = 0.004, respectively). There was no significant difference in propofol C_Ts between the control group and the gabapentin 200 mg group. There were no abnormality and no deterioration in circulation and respiration in all groups. There were no significant increases in complications with the administration of gabapentin.

Conclusion

The oral administration of 400 mg dose of gabapentin reduced the propofol C_Ts for achieving an adequate sedation level on IVS.

https://ift.tt/2OzSTfD

The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction

To determine the impact of Human Papillomavirus (HPV) status on speech, swallowing, and quality of life (QOL) outcomes after surgical treatment of oropharyngeal cancer (OPSCC).

https://ift.tt/2O0UmyA

Angioedema is an unfavorable factor for the response to omalizumab in chronic spontaneous urticaria: a retrospective study

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xrS1mX

Recurrent merkel cell carcinoma of the gluteal region: a case report

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PRpj5A

Atopic‐like dermatitis after Secukinumab injection: a case report

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xpFJLM

A preliminary study of fractional CO2 laser added to topical tacrolimus combined with 308 nm excimer lamp for refractory vitiligo

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PPVKRQ

New therapeutic vision of Nutrition in dermatology: Integrative Nutrition

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xpFFf0

ANGIOTENSIN‐CONVERTING‐ENZYME INHIBITORS AND ANGIOTENSIN II RECEPTOR BLOCKERS INDUCED PEMPHIGUS: A CASE SERIES AND LITERATURE REVIEW

Dermatologic Therapy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PMFZvc

Pomegranate chitinase III: Identification of a new allergen and analysis of sensitization patterns to chitinases

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Lisa Tuppo, Ivana Giangrieco, Claudia Alessandri, Teresa Ricciardi, Chiara Rafaiani, Michela Ciancamerla, Rosetta Ferrara, Danila Zennaro, Maria Livia Bernardi, Maurizio Tamburrini, Adriano Mari, Maria Antonietta Ciardiello

Abstract

Allergy to pomegranate is often associated with severe symptoms. Two allergens have previously been described: 9k-LTP Pun g 1 and pommaclein Pun g 7. This study describes the isolation of a chitinase III, identified by direct protein sequencing and mass spectrometry. It is a 29-kDa protein showing 69% sequence identity with the latex hevamine and IgE binding in dot blotting, immunoblotting and FABER^®test. Chitinase-specific IgE were detected in 69 of 357 patients sensitized to one or more pomegranate allergenic preparations present on the FABER^®test. Using this test, 19.2% of the patients sensitized to kiwifruit chitinase IV were also sensitized to pomegranate chitinase III, rather than to latex chitinase I (7.2%) with which it shares the N-terminal hevein-like domain. In conclusion, a new allergen has been identified, contributing to improving food allergy diagnosis. This study reveals the important role of chitinases III and IV as allergy sensitizers and prompts further investigations.

Graphical abstract

https://ift.tt/2xBTLcC

Clinical characteristics of internal carotid artery pseudoaneurysms in the sphenoid sinus

Publication date: Available online 19 September 2018

Source: American Journal of Otolaryngology

Author(s): Di Deng, Jintao Du, Feng Liu, Bing Zhong, Yixin Qiao, Yafeng Liu

Abstract

Background

Internal carotid artery (ICA) pseudoaneurysms are associated with high mortality if lack of proper management. Patients with ICA pseudoaneurysms in the sphenoid sinus often visit a hospital's ear, nose and throat (ENT) department due to nasal bleeding. In such cases, simple examination and therapy will lead to misdiagnosis.

Objective

This study sought to investigate the clinical characteristics, diagnostic methods and treatment of ICA pseudoaneurysms in the sphenoid sinus.

Methods

Various data, including clinical features, imaging examination results, and treatment and prognosis information, were collected and analyzed for 8 patients who visited the Department of Otolaryngology, Head & Neck Surgery of West China Hospital from March 2008 to January 2017.

Results

The patients included 6 males and 2 females (ages 16 to 56 years). Repeated epistaxis was a common symptom in six of the eight patients (6/8), whereas monocular blindness and binocular blindness were observed in the other two patients. Head trauma was found to play a role in the induction of ICA pseudoaneurysms, given that five patients (5/8) exhibited a specific history of head injury. CT examination tended to result in misdiagnosis, whereas MRI and digital subtraction angiography (DSA) were helpful for obtaining a definite diagnosis with all diagnoses were confirmed via DSA. Coated stent intervention was performed in five patients, while carotid artery ligation was performed in two patients in emergency situations: one of whom exhibited paraplegia, but recovery was ultimately observed after rehabilitation. Moreover, failure of coated stent intervention in one patient was resolved via additional unilateral common carotid artery ligation. Furthermore, one patient with vision loss experienced vision restoration. One patient discontinued treatment for personal reasons and was lost to follow-up. No recurrence was observed in the other 7 patients.

Conclusion

ICA pseudoaneurysms in the sphenoid sinus are uncommon. To accurately identify ICA pseudoaneurysms, collaboration between otolaryngologists and imaging specialists is essential. On the other hand, both surgical and interventional treatments can achieve good results; therefore, otolaryngologists should enhance their cooperation with neurosurgery and intervention departments. Accurate diagnosis and rapid treatment are keys to managing ICA pseudoaneurysms.

https://ift.tt/2NSNyTR

Au-delà des kératoses actiniques, le champ de cancérisation cutané

Publication date: Available online 20 September 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): P. Reygagne, G. Rostain

Résumé

Les kératoses actiniques (KA) forment des papules érythémateuses, squameuses et kératosiques apparaissant sur la peau chroniquement exposée au soleil sous l'effet des rayons ultraviolets. Elles correspondent à une prolifération de kératinocytes atypiques limitée à l'épiderme et sont susceptibles de progression vers le carcinome épidermoïde in situ et le carcinome épidermoïde cutané (CEC). S'il est faible, le risque métastatique associé au CEC ne doit pas pour autant être négligé. Le concept de champ de cancérisation a été introduit en 1953 à la suite d'études de lésions néoplasiques de la muqueuse buccale. Il est défini comme une zone prétumorale d'aspect normal, comportant des anomalies infracliniques multifocales qui peuvent faire le lit de nouvelles lésions néoplasiques. De tels champs sont fréquents dans les zones cutanées photo-exposées et en périphérie des KA et des CEC. Dans cette situation, le traitement ne devrait pas se limiter aux lésions visibles ou palpables de KA et, en cas de suspicion de champ de cancérisation, un traitement visant à la destruction physique ou à l'élimination des kératinocytes atypiques de la totalité de la zone devrait être envisagé. Une telle approche pourrait en théorie améliorer le pronostic à long terme en diminuant l'émergence de nouvelles lésions, voire diminuer le coût économique global lié à la prise en charge des KA et optimiser l'aspect cosmétique du champ de cancérisation ; cela mérite, cependant, d'être confirmé.

Summary

Lesions occurring in actinic keratoses (AK) form erythematous, squamous, crusty and keratotic papules that appear on skin chronically exposed to the sun due to ultraviolet radiation. They are formed by the proliferation of atypical keratinocytes limited to the epidermis and may progress to squamous cell carcinoma in situ and to cutaneous squamous cell carcinoma (CEC). Although low, the metastatic risk associated with the CEC is not negligible. The concept of field cancerization was introduced in 1953 following studies of neoplastic lesions of the oral mucosa. A cancer field is a normal-looking pre-tumoral zone with subclinical, multifocal anomalies, which may constitute a base for new neoplastic lesions. Such fields are frequently seen in areas of photo-exposed skin and around the edges of AK and CEC. In this event, treatment should not be limited to visible or palpable AK lesions, and if a cancer field is suspected, treatment involving the physical destruction or elimination of atypical keratinocytes from the entire area should be considered. Such an approach may improve the long-term prognosis, reduce treatment costs and ensure optimal cosmetic outcome.

https://ift.tt/2DdKjlG

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes

Ramachandra, CJA; Mehta, A; Wong, P; Ja, KPMM; Fritsche-Danielson, R; Bhat, RV; Hausenloy, DJ; ... Shim, W; + view all Ramachandra, CJA; Mehta, A; Wong, P; Ja, KPMM; Fritsche-Danielson, R; Bhat, RV; Hausenloy, DJ; Kovalik, J-P; Shim, W; - view fewer (2018) Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes. International Journal of Cardiology 10.1016/j.ijcard.2018.08.069 . (In press).

https://ift.tt/2PTzjvr

Investigating the rotational phase of stellar flares on M dwarfs using K2 short cadence data

Doyle, L; Ramsay, G; Doyle, JG; Wu, K; Scullion, E; (2018) Investigating the rotational phase of stellar flares on M dwarfs using K2 short cadence data. Monthly Notices of the Royal Astronomical Society , 480 (2) pp. 2153-2164. 10.1093/mnras/sty1963 . Green open access

https://ift.tt/2xpFNen

The impact of basic skills education

Mallows, D; (2010) The impact of basic skills education. In: Proceedings of the Belgian EU presidency conference: Breaking the Cycle of Disadvantage: Inclusion in and through education. : Gent, Belgium.

https://ift.tt/2PMtbF0

Association of Residential Mobility Over the Life Course With Nonaffective Psychosis in 1.4 Million Young People in Sweden

Price, C; Dalman, C; Zammit, S; Kirkbride, JB; (2018) Association of Residential Mobility Over the Life Course With Nonaffective Psychosis in 1.4 Million Young People in Sweden. JAMA Psychiatry 10.1001/jamapsychiatry.2018.2233 . (In press).

https://ift.tt/2xpz3gG

Arthroscopic simulation using a knee model can be used to train speed and gaze strategies in knee arthroscopy

An, VVG; Mirza, Y; Mazomenos, E; Vasconcelos, F; Stoyanov, D; Oussedik, S; (2018) Arthroscopic simulation using a knee model can be used to train speed and gaze strategies in knee arthroscopy. The Knee 10.1016/j.knee.2018.05.019 . (In press).

https://ift.tt/2PTz6Zb

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E-2

O'Brien, AJ; Fullerton, JN; Massey, KA; Auld, G; Sewell, G; James, S; Newson, J; ... Gilroy, DW; + view all O'Brien, AJ; Fullerton, JN; Massey, KA; Auld, G; Sewell, G; James, S; Newson, J; Karra, E; Winstanley, A; Alazawi, W; Garcia-Martinez, R; Cordoba, J; Nicolaou, A; Gilroy, DW; - view fewer (2014) Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E-2. Nature Medicine , 20 (5) pp. 518-523. 10.1038/nm.3516 . Green open access

https://ift.tt/2xpyZ0q

Two new methods to fit models for network meta-analysis with random inconsistency effects

Law, M; Jackson, D; Turner, R; Rhodes, K; Viechtbauer, W; (2016) Two new methods to fit models for network meta-analysis with random inconsistency effects. BMC Medical Research Methodology , 16 (1) , Article 87. 10.1186/s12874-016-0184-5 . Green open access

https://ift.tt/2PSj4yn

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Migliore, R; Lupascu, CA; Bologna, LL; Romani, A; Courcol, JD; Antonel, S; Van Geit, WAH; ... Migliore, M; + view all Migliore, R; Lupascu, CA; Bologna, LL; Romani, A; Courcol, JD; Antonel, S; Van Geit, WAH; Thomson, A; Mercer, A; Lange, S; Falck, J; Rossert, CA; Shi, Y; Hagens, O; Pezzoli, M; Freund, TF; Kali, S; Muller, EB; Schurmann, F; Markram, H; Migliore, M; - view fewer (2018) The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow. PLoS Computational Biology 10.1371/journal.pcbi.1006423 . (In press). Green open access

https://ift.tt/2xpyRxY

A comparative study of metal (Ni, Co, or Mn)-borate catalysts and their photodeposition on rGO/ZnO nanoarrays for photoelectrochemical water splitting

Zhang, H; Tian, W; Li, Y; Sun, H; Tadé, MO; Wang, S; (2018) A comparative study of metal (Ni, Co, or Mn)-borate catalysts and their photodeposition on rGO/ZnO nanoarrays for photoelectrochemical water splitting. Journal of Materials Chemistry A 10.1039/c8ta06921b . (In press).

https://ift.tt/2PMtakq

Magic Darts and Messenger Molecules: A sensory ecology of shamanic plants in indigenous Amazonia

Daly, LJ; Shepard Jr., GH; (2018) Magic Darts and Messenger Molecules: A sensory ecology of shamanic plants in indigenous Amazonia. Anthropology Today (In press).

https://ift.tt/2xmQcrm

Comparison of self-reported and directly measured weight and height among women of reproductive age: a systematic review and meta-analysis

Seijo, M; Minckas, N; Cormick, G; Comande, D; Ciapponi, A; Belizan, JM; (2018) Comparison of self-reported and directly measured weight and height among women of reproductive age: a systematic review and meta-analysis. [Review]. Acta Obstetricia et Gynecologica Scandinavica , 97 (4) pp. 429-439. 10.1111/aogs.13326 .

https://ift.tt/2PRtdLN

Access to Justice: Patterns, Perspectives and Capability

Pleasence, PT; Balmer, N; (2019) Access to Justice: Patterns, Perspectives and Capability. Daedalus (In press).

https://ift.tt/2xpycfY

Non-smoking, non-drinking elderly females, a 5 year follow-up of a clinically distinct cohort of oral squamous cell carcinoma patients

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Adrian DeAngelis, Omar Breik, Kendrick Koo, Tim Iseli, Alf Nastri, Tsien Fua, Danny Rischin, Michael McCullough, David Wiesenfeld

Abstract

Objectives

To examine differences in survival and clinical outcomes of elderly patients without traditional risk factors presenting with oral squamous cell carcinoma.

Materials & methods

Retrospective review of 287 consecutive patients divided into 2 treatment period cohorts treated for oral SCC between the 1st Jan 2007 and 31st Dec 2012. Patients were classified as either smoker-drinkers (SD) or non-smoking, non-drinking (NSND). Only patients with oral sub-site primaries according to ICD-10 were included. Carcinomas of the lip, tonsil, base of tongue and oro-pharyngeal subsites were excluded.

Results

Of the study population (N = 287), 24.4% were NSND and 9.75% were NSND elderly (older than 70 years) females. >50% of tumours arose from the oral tongue in NSND patients (p = 0.022) and there was a higher rate of recurrent and persistent disease (42.9% vs 27.6%, p = 0.005). Disease specific survival at 5 years was significantly reduced when NSND elderly females were compared to all other patients (p < 0.001) as well as age matched controls (p = 0.006). This effect was verified independently in each cohort.

Conclusions

The results of this study suggest that NSND elderly females are a distinct patient population with poorer disease specific survival outcomes.

https://ift.tt/2pv1XI9

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Mushfiq H. Shaikh, Adi Idris, Newell W. Johnson, Sora Fallaha, Daniel T.W. Clarke, David Martin, Iain M. Morgan, Brian Gabrielli, Nigel A.J. McMillan

Abstract

Objectives

Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Current treatments for HPV cancers have not altered survival outcomes for 30 years and there is a significant lack of targeted therapeutic agents in the management of advanced HPV-related HNSCC. Here we show that survival and maintenance of HPV-positive HNC cells relies on the continuous expression of the major HPV oncogene, E7, and that Aurora kinases are critical for survival of high-risk HPV-positive HNC cells.

Materials and methods

To assess the role of HPV E7 on HNC cell survival, RNA interference (RNAi) of the E7 gene was initially performed. Using an Aurora kinase inhibitor, Alisertib, the role of Aurora kinases in the carcinogenesis of HPV E7 positive HNC tumour lines was then investigated. An in vivo HNC xenograft model was also utilised to assess loss of tumour volume in response to RNAi E7 gene silencing and Alisertib treatment.

Results

RNAi silencing of the HPV E7 gene inhibited the growth of HPV-positive HNC cells and in vivo tumour load. We show that HPV E7 oncogene expression confers sensitivity to Alisertib on HNC cells where Alisertib-mediated loss in in vitro cell viability and in vivo tumour load is dependent on E7 expression. Moreover, Aurora kinase inhibition induced degradation of MCL-1 in HPV E7-expressing HNC cells.

Conclusion

Overall, we show that Aurora kinases are a novel therapeutic target for HPV-positive HNCs. It might be feasible to combine Aurora kinase and MCL-1 inhibitors for future HNC therapies.

https://ift.tt/2MO6sXo

Survival for HPV-positive oropharyngeal squamous cell carcinoma with surgical versus non-surgical treatment approach: A systematic review and meta-analysis

Publication date: November 2018

Source: Oral Oncology, Volume 86

Author(s): Parul Sinha, Omar A. Karadaghy, Michelle M. Doering, Methodius G. Tuuli, Ryan S. Jackson, Bruce H. Haughey

Abstract

The optimal management of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) with primary surgical versus non-surgical treatment is unclear. The objective of this systematic review was to evaluate the literature and compare survival for primary surgical versus non-surgical treatment of HPV-positive OPSCC. We performed a comprehensive literature search of multiple electronic databases for relevant articles up to February, 2017. Studies reporting mortality or hazard ratio (HR) for overall survival (OS) in primary HPV-positive OPSCC patients were eligible. Seventy-three articles were eligible, of which 66 included single-modality (19 surgical, 47 non-surgical), and 7 included both surgical and non-surgical modalities. There were no randomized studies comparing outcomes between both modalities. In a meta-analysis of both-modality studies, OS with surgical treatment was not significantly different from non-surgical treatment (pooled HR 1.12; 95% CI: 0.35, 3.57). There was significant heterogeneity between studies (I² = 82.4%). Among single-modality studies, the mortality rate was lower with surgical [pooled proportion 0.15 (95% CI: 0.09, 0.21)] versus non-surgical treatment [0.20 (95% CI:0.15, 0.24)]. In a subgroup analysis, OS was higher for HPV-positive versus HPV-negative OPSCC, irrespective of the treatment modality. We conclude that there is an absence of high-quality studies that compare survival for HPV-positive OPSCC treated with primary surgical versus non-surgical approach. The available data suggest no statistical or clinically meaningful difference in survival between the two approaches. HPV-positivity was a key prognostic factor irrespective of treatment modality. Further high-quality studies with consistent data reporting are needed to inform the choice for optimal treatment modality for HPV-positive OPSCC.

https://ift.tt/2pnsdnF

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

Publication date: Available online 19 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Nathan K. Archer, Jay-Hyun Jo, Steven K. Lee, Dongwon Kim, Barbara Smith, Roger V. Ortines, Yu Wang, Mark C. Marchitto, Advaitaa Ravipati, Shuting S. Cai, Carly A. Dillen, Haiyun Liu, Robert J. Miller, Alyssa G. Ashbaugh, Angad S. Uppal, Michiko Oyoshi, Nidhi Malhotra, Sabine Hoff, Luis A. Garza, Heidi H. Kong

Abstract

Background

Atopic dermatitis (AD) is associated with epidermal barrier defects, dysbiosis and skin injury from scratching. In particular, the barrier defective epidermis of AD patients with loss-of-function filaggrin mutations has increased IL-1α and IL-1β levels but the mechanisms by which IL-1α and/or IL-1β are induced and whether they contribute to the aberrant skin inflammation in AD is unknown.

Objective

We sought to determine the mechanisms by which skin injury, dysbiosis and increased epidermal IL-1α and IL-1β contribute to the development of skin inflammation in a mouse model of injury-induced skin inflammation in filaggrin-deficient mice.

Methods

Skin injury of wild-type, filaggrin-deficient (ft/ft), and MyD88-deficient ft/ft mice was performed and ensuing skin inflammation was evaluated by digital photography, histologic analysis and flow cytometry. IL-1α and IL-1β protein expression was measured by ELISA and visualized by immunofluorescence and immuno-electron microscopy. The composition of skin microbiome was determined by 16S rDNA sequencing.

Results

Skin injury of ft/ft mice induced chronic skin inflammation involving dysbiosis-driven intracellular IL-1α release from keratinocytes. IL-1α was necessary and sufficient for skin inflammation in vivo and secreted from keratinocytes by various stimuli in vitro. Topical antibiotics or co-housing of ft/ft mice with unaffected wild-type mice to alter or intermix skin microbiota, respectively, resolved the skin inflammation and restored keratinocyte intracellular IL-1α localization.

Conclusions

Taken together, skin injury, dysbiosis and filaggrin deficiency triggered keratinocyte intracellular IL-1α release that was sufficient to drive chronic skin inflammation, which has implications for AD pathogenesis and for potential therapeutic targets.

Graphical abstract

https://ift.tt/2NUte4s

Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Publication date: Available online 19 September 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Andreas Kyburz, Angela Fallegger, Xiaozhou Zhang, Aleksandra Altobelli, Mariela Artola-Boran, Timothy Borbet, Sabine Urban, Petra Paul, Christian Münz, Stefan Floess, Jochen Huehn, Timothy L. Cover, Martin J. Blaser, Christian Taube, Anne Müller

Abstract

Background

The trans-maternal exposure to tobacco, microbes, nutrients and other environmental factors shapes the fetal immune system through epigenetic processes. The gastric microbe Helicobacter pylori represents an ancestral constituent of the human microbiota that causes gastric disorders on the one hand, and is inversely associated with allergies and chronic inflammatory conditions on the other.

Objective

Here, we investigate the consequences of trans-maternal exposure to H. pylori, in utero and/or during lactation, for susceptibility to viral and bacterial infection, predisposition to allergic airway inflammation, and the development of immune cell populations in the lung and lymphoid organs.

Methods

We use experimental models of house dust mite- or ovalbumin-induced airway inflammation and influenza A virus or Citrobacter infection along with metagenomics analyses, multi-color flow cytometry and bilsufite pyrosequencing to study the effects of H. pylori on allergy severity and immunological and microbiome correlates thereof.

Results

Perinatal exposure to H. pylori extract, or its immunomodulator VacA, confers robust protective effects against allergic airway inflammation not only in the first, but also the second offspring generation, but does not increase susceptibility to viral or bacterial infection. Immune correlates of allergy protection include skewing of regulatory over effector T-cells, expansion of Treg subsets expressing CXCR3 or RORγt, and demethylation of the FOXP3 locus. The composition and diversity of the gastrointestinal microbiota is measurably affected by perinatal H. pylori exposure.

Conclusion

We conclude that exposure to H. pylori has consequences not only for the carrier, but also for subsequent generations that may be exploited for interventional purposes.

Graphical abstract

https://ift.tt/2OzBXG5

Radiotherapy‐induced Pemphigus Foliaceous: a rare adverse effect of breast cancer therapy

International Journal of Dermatology, EarlyView.


https://ift.tt/2NVIXjH

Pseudodidymosis: nevus psiloliparus with aplasia cutis congenita, an initial manifestation of Haberland syndrome

International Journal of Dermatology, EarlyView.


https://ift.tt/2ODRTY1

Impact of Climate Change on Pollen and Respiratory Disease

Abstract

Purpose of Review

A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.

Recent Findings

Recent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend their ranges into northern areas where they have not previously been a problem. The shift and extension of pollen seasons with warmer springs and later frosts have already been observed. Recent severe hurricanes and flooding events may be just the harbinger of increasing damp housing exposure related to sea level rise. Evidence is accumulating that indicates the expected higher number of ozone alert days and increased pollution in populated areas is bringing increases in pollen potency. Finally, increased exposure to smoke and particles from wild fires, resulting from heat waves, will contribute to the general increase in respiratory disease.

Summary

The practice of allergy being closely aligned with environmental conditions will be especially impacted. Allergists should consider increasing educational activities aimed at making patients more aware of air quality conditions.

https://ift.tt/2MIfGo1

Impact of Climate Change on Pollen and Respiratory Disease

Abstract

Purpose of Review

A warming world will impact everyone and everything. The practice of allergic and respiratory disease will not be excepted. All the impacts will be impossible to anticipate. This review is intended to discuss significant factors related to individuals with allergic and respiratory disease.

Recent Findings

Recent findings include the increased growth of allergenic plants in response to higher carbon dioxide levels and warmer temperatures. This also contributes to the increased production of pollen as well as the appearance of allergenic species in new climactic areas. Stinging insects will extend their ranges into northern areas where they have not previously been a problem. The shift and extension of pollen seasons with warmer springs and later frosts have already been observed. Recent severe hurricanes and flooding events may be just the harbinger of increasing damp housing exposure related to sea level rise. Evidence is accumulating that indicates the expected higher number of ozone alert days and increased pollution in populated areas is bringing increases in pollen potency. Finally, increased exposure to smoke and particles from wild fires, resulting from heat waves, will contribute to the general increase in respiratory disease.

Summary

The practice of allergy being closely aligned with environmental conditions will be especially impacted. Allergists should consider increasing educational activities aimed at making patients more aware of air quality conditions.

https://ift.tt/2MIfGo1

A birch sublingual allergy immunotherapy (SLIT) tablet educes rhinoconjunctivitis symptoms when exposed to birch and oak and induces IgG4 to allergens from all trees in the birch homologous group

Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2PRmpOf

CVID enteropathy is characterized by exceeding low mucosal iga levels and interferon-driven inflammation possibly related to the presence of a pathobiont

Publication date: Available online 19 September 2018

Source: Clinical Immunology

Author(s): Natalia Shulzhenko, Xiaoxi Dong, Dariia Vyshenska, Renee L. Greer, Manoj Gurung, Stephany Vasquez-Perez, Ekaterina Peremyslova, Stanislav Sosnovtsev, Martha Quezado, Michael Yao, Kim Montgomery-Recht, Warren Strober, Ivan J. Fuss, Andrey Morgun

Abstract

Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID). The goal of this study was to investigate the immunological abnormalities in CVID patients that lead to enteropathy as well as the contribution of intestinal microbiota to this process. We found that, in contrast to noE-CVID patients (without enteropathy), E-CVID patients have exceedingly low levels of IgA in duodenal tissues. In addition, using transkingdom network analysis of the duodenal microbiome, we identified Acinetobacter baumannii as a candidate pathobiont in E-CVID. Finally, we found that E-CVID patients exhibit a pronounced activation of immune genes and down-regulation of epithelial lipid metabolism genes. We conclude that in the virtual absence of mucosal IgA, pathobionts such as A. baumannii, may induce inflammation that re-directs intestinal molecular pathways from lipid metabolism to immune processes responsible for enteropathy.

https://ift.tt/2xs7y6b

Norovirus-specific mucosal antibodies correlate to systemic antibodies and block norovirus virus-like particles binding to histo-blood group antigens

Publication date: Available online 19 September 2018

Source: Clinical Immunology

Author(s): Kirsi Tamminen, Maria Malm, Timo Vesikari, Vesna Blazevic

Abstract

The best acknowledged correlate of protection from norovirus (NoV) infection is the ability of serum antibodies to block binding of NoV virus-like particles (VLPs) to histo-blood group antigens (HBGAs). We investigated mucosal NoV-specific antibody levels in adult volunteers and used saliva from a single donor to determine whether purified saliva antibodies confer blocking. NoV-specific IgG and IgA levels in saliva and plasma samples were measured against four NoV genotype VLPs. NoV-specific IgG and IgA titers in saliva and plasma samples correlated significantly. Antibodies were detected against all VLPs with the highest level of antibodies directed against ancestral GII.4 99 genotype. Affinity chromatography purified salivary IgA and IgG blocked binding of GII.4 99 VLPs to HBGAs. Saliva sampling is a non-invasive alternative to blood drawing and an excellent biological fluid to study NoV-specific immune responses. Mucosal anti-NoV antibodies block binding of NoV VLPs to HBGAs, and may therefore be protective.

https://ift.tt/2PTnDsw

Identification of pathogenic genes and upstream regulators in allergic rhinitis

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Yanhua Lei, Ping Guo, Jun An, Chao Guo, Fengxiang Lu, Minglei Liu

Abstract

Background

Allergic rhinitis (AR) is the main cause of irreversible blindness in older individuals. Our study aims to identify the key genes and upstream regulators in AR.

Methods

To screen pathogenic genes of AR, an integrated analysis was performed by using the microarray datasets in AR derived from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were further discovered by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We constructed the AR-specific transcriptional regulatory network to find the crucial transcriptional factors (TFs) which target the DEGs in AR. Electronic validation was performed to verify the DEGs obtained by integrated analysis.

Results

From two GEO datasets obtained, we identified 793 DEGs (460 up-regulated and 333 down-regulated genes) between AR and normal control (NC). After GO and KEGG analysis, chronic inflammatory response and MAPK signaling pathway were significantly enriched pathways for DEGs. The expression of 6 genes (CLC, CST1, CRTAM, ILK, STAT1, and POSTN) was detected. The 6 genes in GEO: GSE51392 dataset played the same pattern with that in our integrated analysis.

Conclusions

The dysregulation of 3 genes (CST1, CLC and STAT1) may be involved in the pathogenesis of AR. AP-1 was associated with AR by regulating CST1 and CLC. Our finding can contribute to developing new potential biomarkers, revealing the underlying pathogenesis, and further raising new therapeutic targets for AR.

https://ift.tt/2xr5NGt

Dacryoendoscopy-Assisted Nasal Endoscopic Marsupialization for Congenital Dacryocystocele

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Tushar Sarbajna, Yasuhiro Takahashi, Ma. Regina Paula Valencia, Marian Grace Ana-Magadia, Eri Ishikawa, Hirohiko Kakizaki

Abstract

Objective

To examine the surgical outcome of dacryoendoscopy-assisted nasal endoscopic marsupialization for congenital dacryocystocele.

Methods

This is a retrospective, observational study that included 7 sides of 6 patients with congenital dacryocystocele. The surgical indication in 5 of the patients was acute dacryocystitis while one of the patients had no spontaneous resolution after long-term observation. Dacryoendoscopy was used for visualization of the lacrimal cavity, direct probing of the obstruction at the common canaliculus, and localisation of a deflated intranasal cyst after an initial incision of the cyst. Surgical success was defined when the following postoperative conditions were satisfied: no epiphora, normal tear meniscus height, and complete clearance of the dye 5 minutes after instilling a drop of 2% fluorescein solution into the inferior conjunctional fornix.

Results

Out of 6 patients, 2 patients were noted to have membranous common canalicular obstruction. Postoperative follow-up ranged from 11 days to 3 months. Surgical success was achieved in all patients without any complication.

Conclusions

Dacryoendoscopy-assisted nasal endoscopic marsupialization is an effective surgical management for congenital dacryocystocele.

https://ift.tt/2PSb6FE

Predictive ABILITY of bedside nasal endoscopy to diagnose invasive fungal sinusitis in a pediatric population

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Carolyn L. Mulvey, Mark D. Rizzi, Adva Buzi

Abstract

Introduction

Invasive fungal sinusitis (IFS) is a rare but deadly clinical entity that occurs in immunocompromised patients. Diagnosis in children typically requires operative biopsies under general anesthesia, which has associated risks. Findings on bedside nasal endoscopy (BNE) can be used with history, exam, and imaging to determine the need for surgery, however, the accuracy of this tool has not been established among pediatric patients.

Methods

Patients who underwent BNE for evaluation of IFS from 2008-2016 at the Children's Hospital of Philadelphia were identified using Current Procedural Terminology (CPT) codes. Retrospective chart analysis was performed and included underlying diagnoses, presenting signs and symptoms, imaging findings, endoscopic findings and outcomes.

Results

Nineteen patients were identified who underwent evaluation for IFS using BNE during the period studied. Eight patients had exam findings that were concerning for IFS, including debris or crusting, darkened or pale mucosa, or copious, thick and/or purulent secretions. Immediate operative biopsies and debridement revealed IFS in six of eight patients. Eleven patients had exam findings deemed not concerning for IFS including mucosal edema, mucous without purulence, or normal findings. Six of eleven patients underwent operative biopsy despite negative endoscopy, and five were observed clinically. None of the 11 patients with negative bedside endoscopy developed IFS.

Conclusions

All patients with IFS had concerning exam findings on endoscopy and were treated with immediate biopsies and debridement. No patient with normal or non-concerning findings on BNE progressed to have invasive fungal sinusitis. While suspicion for IFS in immunocompromised children must remain high, BNE is feasible and useful in its assessment.

https://ift.tt/2xrF4cP

Employing bioabsorbable grafts in two-stage laryngotracheal reconstruction of pediatric patient with severe subglottic stenosis and history of airway surgery

Publication date: Available online 19 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Elliot Le, Lenhanh Tran

Abstract

A 16-month old female was referred to our practice for laryngotracheal reconstruction (LTR) for acquired subglottic stenosis (SGS) diagnosed at 4 weeks of age due to prolonged intubation. She has a history of open thoracic repair of congenital tracheoesophageal fistula that was complicated by a pneumothorax and phrenic nerve paralysis. We performed a variation of an anterior and posterior cricoid split LTR with tracheal stenting in order to avoid risks of pulmonary morbidity from costochondral cartilage harvesting. We report the first LTR to use KLS Martin Resorb-XG bioabsorbable implant (poly-L-lactic acid & poly glycolic acid) as a substitute graft for autologous cartilage in a patient with severe SGS and a history of airway surgeries. The patient had an uncomplicated recovery and had a patent trachea on laryngobronchoscopy at 4, 13, and 22 months after surgery.

https://ift.tt/2PTCljf

Clinical use of dimethyl fumarate in moderate‐to‐severe plaque‐type psoriasis: a European expert consensus

Journal of the European Academy of Dermatology and Venereology, EarlyView.


https://ift.tt/2NUPxqO

Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2POBlwA

HIF‐1α‐mediated BMP6 down‐regulation leads to hyperproliferation and abnormal differentiation of keratinocytes in vitro

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xx9mer

Down‐regulated SHARPIN may accelerate the development of atopic dermatitis through activating interleukin‐33/ST2 signaling

Experimental Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2POBfFe

Fabrication and characterization of 3D‐printed elastic auricular scaffolds: A pilot study

The Laryngoscope, EarlyView.


https://ift.tt/2xoAGLN

Intranasal Corticosteroids Do Not Lead to Ocular Changes: A Systematic Review and Meta‐analysis

The Laryngoscope, EarlyView.


https://ift.tt/2PTcat3

In reference to accuracy and reliability of the flow coupler in postoperative monitoring of head and neck free flaps

The Laryngoscope, EarlyView.


https://ift.tt/2xpimSv

In Response to In Reference to Intervention for Elevated Intracranial Pressure Improves Success Rate After Repair of Spontaneous Cerebrospinal Fluid Leaks

The Laryngoscope, EarlyView.


https://ift.tt/2xsT99T

Patient‐reported olfaction improves following outside‐in Draf III frontal sinus surgery for chronic rhinosinusitis

The Laryngoscope, EarlyView.


https://ift.tt/2PTDVld

Readmission after surgery for oropharyngeal cancer: An analysis of rates, causes, and risk factors

The Laryngoscope, EarlyView.


https://ift.tt/2xrh49T

Long‐term outcomes of cartilage‐buttressed T‐tube tympanoplasty for prolonged middle ear ventilation

The Laryngoscope, EarlyView.


https://ift.tt/2PTDOWP

Evaluating bone remodeling by measuring Hounsfield units in a rabbit model of rhinosinusitis: is it superior to measuring bone thickness?

International Forum of Allergy &Rhinology, EarlyView.


https://ift.tt/2xsAU4k

“WHARE YE ENNEMY USED TO BURY THERE DEAD”: A NEW ENGLANDER BURIAL AT THE EIGHTEENTH CENTURY FORTRESS OF LOUISBOURG IN ATLANTIC CANADA

International Journal of Osteoarchaeology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xzsGXl

Metacarpal cortical bone loss and osteoporotic fractures in the Coimbra Identified Skeletal Collection

International Journal of Osteoarchaeology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xy0LqV

Trachelas tranquillus envenomation with presumed bacterial superinfection in a child

Pediatric Dermatology, EarlyView.


https://ift.tt/2xAA059

Successful treatment of refractory juvenile generalized pustular psoriasis with secukinumab monotherapy: A case report and review of published work

The Journal of Dermatology, EarlyView.


https://ift.tt/2xxqPT2

Distant recurrence of Merkel cell carcinoma after spontaneous regression

The Journal of Dermatology, EarlyView.


https://ift.tt/2xBqb77

Primary cutaneous diffuse large B‐cell lymphoma, leg type, localized in the right periorbital region

The Journal of Dermatology, EarlyView.


https://ift.tt/2QIrdqB

Bone scintigraphy analysis of 44 cases of pustulotic arthro‐osteitis associated with palmoplantar pustulosis

The Journal of Dermatology, EarlyView.


https://ift.tt/2xDWRwy

Acneiform eruptions: An unusual dermatological side effect of ribavirin

Dermatologic Therapy, EarlyView.


https://ift.tt/2NYPfz8

When side effect becomes the effect: Efficacy of capecitabine in refractory psoriasis

Dermatologic Therapy, EarlyView.


https://ift.tt/2OFdqQj

Successful treatment of erythrodermic pityriasis rubra pilaris with acitretin

Dermatologic Therapy, EarlyView.


https://ift.tt/2NYffuk

Cost‐effectiveness analysis of imaging strategy for an intensive follow‐up of patients with American Joint Committee on Cancer stage IIB, IIC and III malignant melanoma

British Journal of Dermatology, EarlyView.


https://ift.tt/2xqPk55

Subtype‐Specific Inherited Predisposition to Pemphigus in Chinese Population

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xx2TjF

Psoriasin (S100A7) and koebserisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2NZ3mEq

Multiple rapidly growing necrotic eruptions on the face

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2ODX2iU

Onycholysis and subungual purpura of nails

International Journal of Dermatology, EarlyView.


https://ift.tt/2OFasLE

What lengths for a lash?

International Journal of Dermatology, EarlyView.


https://ift.tt/2NYbGUY

Reflectance confocal microscopy of tinea capitis: comparing images with results of dermoscopy and mycological exams

International Journal of Dermatology, EarlyView.


https://ift.tt/2OHKh77

Predicting risk for seroma development after axillary or inguinal sentinel lymph node biopsy in melanoma patients

International Journal of Dermatology, EarlyView.


https://ift.tt/2OBm6ad

Plasma cell vulvitis: further confirmation of the diagnostic utility of dermoscopy

International Journal of Dermatology, EarlyView.


https://ift.tt/2NYgeL3

Asymptomatic indurated plaque on the tongue in an immunocompetent man

International Journal of Dermatology, EarlyView.


https://ift.tt/2OIBkKM

Aversion caused by skin diseases – a crowdsourcing study

International Journal of Dermatology, EarlyView.


https://ift.tt/2NVn6Jb

Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus

International Journal of Dermatology, EarlyView.


https://ift.tt/2OBm5Db

Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis

International Journal of Dermatology, EarlyView.


https://ift.tt/2NYgee1

Cutaneous collagenous vasculopathy induced by the vascular endothelial growth factor receptor inhibitor axitinib

International Journal of Dermatology, EarlyView.


https://ift.tt/2OIBjGI

Mutation in the SR6 region of desmoplakin is associated with pustular psoriasiform rash and left ventricular dysfunction

International Journal of Dermatology, EarlyView.


https://ift.tt/2O3wxGJ

Lymphoepithelioma‐like carcinoma of the skin: a possible culprit when biopsy indicates a benign inflammatory reaction

International Journal of Dermatology, EarlyView.


https://ift.tt/2OHJPWt

A novel cognitive stress management technique for acne vulgaris: a short report of a pilot experimental study

International Journal of Dermatology, EarlyView.


https://ift.tt/2O2Jtg0

The house dust mite allergen Der p 5 binds lipid ligands and stimulates airway epithelial cells through a TLR2‐dependent pathway

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xkEygL

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.


https://ift.tt/2xqP31T

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

Eelen, G; Dubois, C; Cantelmo, AR; Goveia, J; Brüning, U; DeRan, M; Jarugumilli, G; ... Carmeliet, P; + view all Eelen, G; Dubois, C; Cantelmo, AR; Goveia, J; Brüning, U; DeRan, M; Jarugumilli, G; van Rijssel, J; Saladino, G; Comitani, F; Zecchin, A; Rocha, S; Chen, R; Huang, H; Vandekeere, S; Kalucka, J; Lange, C; Morales-Rodriguez, F; Cruys, B; Treps, L; Ramer, L; Vinckier, S; Brepoels, K; Wyns, S; Souffreau, J; Schoonjans, L; Lamers, WH; Wu, Y; Haustraete, J; Hofkens, J; Liekens, S; Cubbon, R; Ghesquière, B; Dewerchin, M; Gervasio, FL; Li, X; van Buul, JD; Wu, X; Carmeliet, P; - view fewer (2018) Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature , 561 (7721) pp. 63-69. 10.1038/s41586-018-0466-7 .

https://ift.tt/2MNlvQY

Reducing Social Inequalities in Cancer: Setting Priorities for Research

Vaccarella, S; Lortet-Tieulent, J; Saracci, R; Fidler, MM; Conway, DI; Vilahur, N; Sarfati, D; ... Wild, CP; + view all Vaccarella, S; Lortet-Tieulent, J; Saracci, R; Fidler, MM; Conway, DI; Vilahur, N; Sarfati, D; Jemal, A; Mackenbach, JP; Marmot, MG; Straif, K; Wild, CP; - view fewer (2018) Reducing Social Inequalities in Cancer: Setting Priorities for Research. CA: A Cancer Journal for Clinicians 10.3322/caac.21463 . (In press).

https://ift.tt/2MHTqut

Bayesian models for weighted data with missing values: a bootstrap approach

Goldstein, H; Carpenter, J; Kenward, MG; (2018) Bayesian models for weighted data with missing values: a bootstrap approach. Journal of the Royal Statistical Society Series C-applied Statistics , 67 (4) pp. 1071-1081. 10.1111/rssc.12259 .

https://ift.tt/2ppr27a

The Role of Customer Investor Involvement in Crowdfunding Success

Cornelius, PB; Gokpinar, B; (2019) The Role of Customer Investor Involvement in Crowdfunding Success. Management Science (In press).

https://ift.tt/2MNG7bR

Soundscapes of buildings and built environments

Aletta, F; Astolfi, A; (2018) Soundscapes of buildings and built environments. [Editorial comment]. Building Acoustics , 25 (3) pp. 195-197. 10.1177/1351010X18793279 . Green open access

https://ift.tt/2ppzJhS

Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy

Johnson, TF; Bailey, JJ; Iacoviello, F; Welsh, JH; Levison, PR; Shearing, PR; Bracewell, DG; (2018) Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy. Journal of Chromatography A , 1566 pp. 79-88. 10.1016/j.chroma.2018.06.054 . Green open access

https://ift.tt/2MOSJzl

Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review

Tam, HH; Calderon, MA; Manikam, L; Nankervis, H; Nunez, IG; Williams, HC; Durham, SR; Tam, HH; Calderon, MA; Manikam, L; Nankervis, H; Nunez, IG; Williams, HC; Durham, SR; Boyle, RJ; - view fewer (2016) Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review. Allergy , 71 (9) pp. 1345-1356. 10.1111/all.12932 . Green open access

https://ift.tt/2ppE3O2

Insight and risk of suicidal behaviour in two first-episode psychosis cohorts: effects of previous suicide attempts and depression

Lopez-Morinigo, J-D; Di Forti, M; Ajnakina, O; Wiffen, B; Morgan, K; Doody, GA; Jones, PB; ... David, AS; + view all Lopez-Morinigo, J-D; Di Forti, M; Ajnakina, O; Wiffen, B; Morgan, K; Doody, GA; Jones, PB; Ayesa-Arriola, R; Canal-Rivero, M; Crespo-Facorro, B; Murray, RM; Dazzan, P; Morgan, C; Dutta, R; David, AS; - view fewer (2018) Insight and risk of suicidal behaviour in two first-episode psychosis cohorts: effects of previous suicide attempts and depression. Schizophrenia Research (In press).

https://ift.tt/2MNFor9

The UK Domestic Gas Electricity (Tariff Cap) Act: Re-regulating the Retail Energy Market

Mantzari, D; Ioannidou, M; (2019) The UK Domestic Gas Electricity (Tariff Cap) Act: Re-regulating the Retail Energy Market. Modern Law Review (In press).

https://ift.tt/2pp5ur8

Trends in Hospital Admissions for Nonfatal Adversity-Related Injury Among Youths in England, 2002-2016

Blackburn, RM; Herbert, A; Wijlaars, L; Gilbert, R; (2018) Trends in Hospital Admissions for Nonfatal Adversity-Related Injury Among Youths in England, 2002-2016. JAMA Pediatrics E1-E3. 10.1001/jamapediatrics.2018.2516 . (In press).

https://ift.tt/2MNFeQz

Global Determinants of Navigation Ability

Coutrot, A; Silva, R; Manley, E; de Cothi, W; Sami, S; Bohbot, VD; Wiener, JM; ... Spiers, HJ; + view all Coutrot, A; Silva, R; Manley, E; de Cothi, W; Sami, S; Bohbot, VD; Wiener, JM; Hölscher, C; Dalton, RC; Hornberger, M; Spiers, HJ; - view fewer (2018) Global Determinants of Navigation Ability. Current Biology , 28 (17) 10.1016/j.cub.2018.06.009 .

https://ift.tt/2pmvjIv

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition

Latif-Hernandez, A; Shah, D; Craessaerts, K; Saido, T; Saito, T; De Strooper, B; Van der Linden, A; Latif-Hernandez, A; Shah, D; Craessaerts, K; Saido, T; Saito, T; De Strooper, B; Van der Linden, A; D'Hooge, R; - view fewer (2017) Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition. Behavioural Brain Research 10.1016/j.bbr.2017.11.017 . (In press).

https://ift.tt/2MNFyif

Nanoparticles Encapsulated in Porous Carbon Matrix Coated on Carbon Fibers: An Ultrastable Cathode for Li-Ion Batteries

Zou, R; Liu, Q; He, G; Yuen, MF; Xu, K; Hu, J; Parkin, IP; ... Zhang, W; + view all Zou, R; Liu, Q; He, G; Yuen, MF; Xu, K; Hu, J; Parkin, IP; Lee, C-S; Zhang, W; - view fewer (2017) Nanoparticles Encapsulated in Porous Carbon Matrix Coated on Carbon Fibers: An Ultrastable Cathode for Li-Ion Batteries. Advanced Energy Materials , 7 (2) , Article 1601363. 10.1002/aenm.201601363 . Green open access

https://ift.tt/2pnlTwc

Solid solution nitride/carbon nanotube hybrids enhance electrocatalysis of oxygen in zinc-air batteries

He, G; Han, X; Moss, B; Weng, Z; Gadipelli, S; Lai, F; Kafizas, AG; ... Parkin, IP; + view all He, G; Han, X; Moss, B; Weng, Z; Gadipelli, S; Lai, F; Kafizas, AG; Brett, DJL; Guo, ZX; Wang, H; Parkin, IP; - view fewer (2018) Solid solution nitride/carbon nanotube hybrids enhance electrocatalysis of oxygen in zinc-air batteries. Energy Storage Materials 10.1016/j.ensm.2018.08.020 . (In press). Green open access

https://ift.tt/2MNF0ZJ

Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

Economides, G; Falk, S; Mercer, A; (2018) Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons. Journal of Visualized Experiments (In press).

https://ift.tt/2pom0YH

Automated quantification of nonperfusion areas in 3 vascular plexuses with optical coherence tomography angiography in eyes of patients with diabetes

Hwang, TS; Hagag, AM; Wang, J; Zhang, M; Smith, A; Wilson, DJ; Huang, D; Hwang, TS; Hagag, AM; Wang, J; Zhang, M; Smith, A; Wilson, DJ; Huang, D; Jia, Y; - view fewer (2018) Automated quantification of nonperfusion areas in 3 vascular plexuses with optical coherence tomography angiography in eyes of patients with diabetes. JAMA Ophthalmology , 136 (8) pp. 929-936. 10.1001/jamaophthalmol.2018.2257 .

https://ift.tt/2MNEFpV

Effect of copolymer composition on particle morphology and release behavior in vitro using progesterone

Zhang, Y; Shams, T; Harker, AH; Parhizkar, M; Edirisinghe, M; (2018) Effect of copolymer composition on particle morphology and release behavior in vitro using progesterone. Materials & Design , 159 pp. 57-67. 10.1016/j.matdes.2018.08.024 . Green open access

https://ift.tt/2puyttX

‘Death is not the answer’: the challenge of measuring the impact of early warning systems

Chapman, S; Wray, J; Oulton, K; Peters, M; (2018) 'Death is not the answer': the challenge of measuring the impact of early warning systems. [Editorial comment]. Archives of Disease in Childhood 10.1136/archdischild-2018-315392 . (In press). Green open access

https://ift.tt/2MN3n9Z

Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial

O'Callaghan, FJK; Edwards, SW; Dietrich Alber, F; Cortina Borja, M; Hancock, E; Johnson, AL; Kennedy, CR; ... Osborne, JP; + view all O'Callaghan, FJK; Edwards, SW; Dietrich Alber, F; Cortina Borja, M; Hancock, E; Johnson, AL; Kennedy, CR; Likeman, M; Lux, AL; Mackay, MT; Mallick, AA; Newton, RW; Nolan, M; Pressler, R; Rating, D; Schmitt, B; Verity, CM; Osborne, JP; - view fewer (2018) Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial. The Lancet Child and Adolescent Health , 2 (10) pp. 715-725. 10.1016/S2352-4642(18)30244-X . (In press).

https://ift.tt/2poE4C0