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- Single nucleotide polymorphisms in renal transplan...
- Genotypic variants influencing acute allograft rej...
- Gender Inequality in Anesthesiology Research: An O...
- Transient Tachypnea of Newborns Is Associated With...
- Consensus Statement of the Malignant Hyperthermia ...
- In Response
- Perioperative Epidural Use and Risk of Delirium in...
- Proposal for a Revised Classification of the Depth...
- Clot Retraction: Lost in Interpretation?
- American Society for Enhanced Recovery and Periope...
- Randomized Trial Comparing Early and Late Administ...
- Managing Complications in Paediatric Anaesthesia
- Drug Calculation Errors in Anesthesiology Resident...
- Fluorescence‐Advanced Videodermatoscopy: A promisi...
- A 14‐year review of a UK teledermatology service: ...
- Acral angioma serpiginosum: Clinicopathologic and ...
- Bacteriotherapy with Streptococcus salivarius 24SM...
- Age-Related Patterns of DNA Detection and Specific...
- Mujer y ciencia
- Desarrollo de lenguaje en niños con implante cocle...
- Calidad de vida en pacientes con implante coclear ...
- Momento de inicio de radioterapia posoperatoria co...
- Rinosinusitis crónica: Una revisión de su etiopato...
- Evaluación de procesamiento auditivo y percepción ...
- Influencia de las zonas cocleares muertas sobre la...
- Influencia auditiva de la pared posterosuperior de...
- Tumores de glándula parótida: Experiencia quirúrgi...
- Tumores de glándula submandibular: Experiencia clí...
- Influencia del exceso de peso en el éxito de la ad...
- Carcinoma adenoideo quístico pulmonar primario con...
- Plenitud ótica como primer síntoma en patología de...
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Ετικέτες
Πέμπτη 14 Φεβρουαρίου 2019
Transient Tachypnea of Newborns Is Associated With Maternal Spinal Hypotension During Elective Cesarean Delivery: A Retrospective Cohort Study
http://bit.ly/2GrRU0Y
Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia
http://bit.ly/2Ii8YIm
Perioperative Epidural Use and Risk of Delirium in Surgical Patients: A Secondary Analysis of the PODCAST Trial
http://bit.ly/2IdBE56
Proposal for a Revised Classification of the Depth of Neuromuscular Block and Suggestions for Further Development in Neuromuscular Monitoring
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Perioperative Management of Patients on Preoperative Opioid Therapy
http://bit.ly/2Ig8DWu
Randomized Trial Comparing Early and Late Administration of Rocuronium Before and After Checking Mask Ventilation in Patients With Normal Airways
http://bit.ly/2IcWEcw
Drug Calculation Errors in Anesthesiology Residents and Faculty: An Analysis of Contributing Factors
http://bit.ly/2Ig8xhA
Fluorescence‐Advanced Videodermatoscopy: A promising and potential technique for the in vivo evaluation of vitiligo
http://bit.ly/2TR5FsP
A 14‐year review of a UK teledermatology service: experience of over 40 000 teleconsultations
Summary
Background
There is a paucity of published evidence of established teledermatology (TD) services in the UK. An in‐house TD service using store‐and‐forward technology was set up at a large regional dermatology department in 2004.
Aim
To review the TD service at our centre, including teleconsultation numbers, coding of diagnoses and patient outcomes.
Methods
Retrospective data were retrieved using the electronic patient database, from 31 July 2004 to 31 July 2018. More detailed information on patient outcomes was obtained from patient notes and histology records. A paper questionnaire was distributed to 100 patients to obtain patient feedback.
Results
In total, 40 201 teleconsultations were made over 14 years, and 64% of cases were coded (n = 25 555), of which 77% were lesions. The most common coded lesions were benign naevus (25%), seborrhoeic keratosis (22%) and basal cell carcinoma (19%). Of the total number of cases, 50% were discharged to their general practitioner with advice, 34% were booked for surgery and 16% were booked for a face‐to‐face appointment. In the survey, 82% of patients surveyed felt that the service was 'good' or 'very good'. A detailed study between 1 January 2015 and 1 January 2016 showed that there were 383 patients (10%) with no diagnosis made following teleconsultation, suggesting diagnostic uncertainty. Reasons for this included lack of diagnostic features, possibility of malignancy and service factors. Within this cohort, there was 68% diagnostic concordance.
Conclusions
We have set up a successful TD service at a UK centre, which has prevented 16 282 face‐to‐face appointments over 14 years. Patient feedback has been very good. Review of cases with diagnostic uncertainty provides important information for service improvement and has not previously been documented.
http://bit.ly/2SRmabe
Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a oral spray for children with recurrent streptococcal pharyngotonsillitis: a randomized placebo-controlled clinical study
Abstract
Purpose
Group A beta-hemolytic Streptococcus (GABHS) causes a recurrent acute pharyngotonsillitis (RAPT) in children. Moreover, the repeated use of antibiotics contributes to its resistance. However, S. Salivarius 24SMB and S. oralis 89a were effective probiotics in other infections. Thus, we decided to evaluate this combination efficacy compared to placebo in RAPT.
Methods
Patients with microbiologically confirmed GABHS were enrolled in this randomized, placebo-controlled trial. They received the aforementioned combination or placebo as an oral spray. We investigated episodes of frequency and duration, need for antibiotics, school days lost, the treatment impact on life quality, treatment compliance and side effects during a 90-day treatment and a 6-month follow-up.
Results
We included 41 patients in each group. The mean number of GABHS infection was significantly lower during both study periods for the two groups. However, our treatment group showed a lower rate. Moreover, the probiotic group had a lower mean number and a shorter median duration of GABHS episodes during both study periods than controls. Furthermore, the mean duration of antibiotic treatment was lower in the probiotic group during the 90-day and 6-month follow-up periods. Similarly, patients in the probiotic group showed a significantly lower mean number of absence days from school but higher EQ-VAS score. Indeed, all patients included were compliant to treatment.
Conclusions
We identified potential probiotics, possessing desirable features against GABHS pharyngotonsillitis. Our findings represent the first evidence which throws the light on using these probiotics that can reduce antibiotics use which did not have efficient results regarding recurrence.
http://bit.ly/2SNa42X
Age-Related Patterns of DNA Detection and Specific IgG Subclasses in Healthy HHV-6- and HHV-7-Infected Individuals
Viral Immunology, Ahead of Print.
http://bit.ly/2TOyA0F
Mujer y ciencia
http://bit.ly/2GsHMET
Desarrollo de lenguaje en niños con implante coclear en centro terciario de salud: Serie clínica
ABSTRACT Introduction: Since the 90s, cochlear implantation has progressed from experimental to standard clinical practice for children with severe and profound hearing loss. Research has produced changes in implant technology and has led to the expansion of implant candidacy to include children younger than 2 years of age. The primary goal of pediatric cochlear implantation is to facilitate spoken language development. Despite the advances in implant technology and the changes to the management of hearing loss, language outcomes for children are still highly variable, participating in this process both timely treatment, the family network and socio economic level among others. Aim: describe outcomes of patients younger than 6 years undergoing cochlear implant surgery in a tertiary care center. Material and method: retrospective longitudinal cohort study, 99 patients implanted in a tertiary health center since the program's inception in 1994 to 2015 was analyzed. Results: 99 patients, 57 % men 43 % women, average age of implantation 16.3 months. 54.8 % of cases were congenital or prematurity. In 74.4 % they had auditory verbal language. Socioeconomic status (SES) showed association with the lack of language development (p =0.009) demonstrating that low SES patients (20%) do not develop language. The disability associated variable (p <0.001) and the SES variable (p =0.036) were independently associated with sign language or no oral language development. Conclusions: Cochlear implants offer an option for hearing rehabilitation in profound hearing loss, for candidates of all ages, however the results depend largely on the environment in which cochlear implants are used.
http://bit.ly/2Idi9tq
Calidad de vida en pacientes con implante coclear en Hospital Barros Luco Trudeau
Abstract Introduction: Quality of life has become very important, and nowadays all health interventions are valued for the impact they can have on it. Profound bilateral hearing loss produces major consequences such as delaying the acquisition of language, which results in a significant decrease in learning and creates difficulties in how the individual develops in their environment. The cochlear implant is the treatment of choice in this pathology, and it is imperative to know the real impact it has on the quality of life of those subjected to this intervention. Aim: To know the overall quality of life of the patients implanted in the Barros Luco Trudeau Hospital between 2015 and 2016, using the KINDL quality of life measurement instrument. Material and method: Prospective analytical cohort study, to measure the quality of life, the KINDL instrument was used. The instrument was applied to implanted minors and their parents through a direct interview in pre-implantation periods at six months and after one year of implantation. The data and statistics tests were made with SPSS 13 software. Results: 16 pediatric patients implanted in the Barros Luco Trudeau Hospital were studied. There were changes in the global quality of life and the subscales of emotional well-being, such as the patient's self-esteem, education, relationships with friends and family, as well as the perception of illness. Conclusions: The cochlear implant in our series demonstrated a positive change in the global quality of life for both patients and their family environments.
http://bit.ly/2GsJ17g
Momento de inicio de radioterapia posoperatoria como factor pronóstico en pacientes con cáncer de laringe avanzado
ABSTRACT Introduction: Among the factors that play a role in the survival and recurrence of disease of patients with operated squamous laryngeal cancer is the time to initiation of postoperative radiotherapy (RT). Aim: To determine the impact of delayed onset of postoperative RT on survival and disease recurrence in patients with advanced operated squamous laryngeal cancer. Material and Method: Retrospective cohort study. Collection of data through review of clinical records. Analysis of survival and disease recurrence using the Kaplan-Meier method, comparison of curves with Log-Rank test and Cox regression model for analysis of prognostic factors. Results: The waiting time between surgery and the initiation of RT in our hospital realities was 11 weeks. The 5-year specific survival in patients who start RT ≤ 6 weeks after surgery is 33.3% and decreases to 20% in those who start > 6 weeks (p = 0.20). Conclusion: Patients who start RT in more than 6 weeks after surgery do not present a statistically significant difference in prognosis.
http://bit.ly/2IfEHKp
Rinosinusitis crónica: Una revisión de su etiopatogenia
RESUMEN La rinosinusitis crónica (RSC) se define como una inflamación sintomática de las cavidades nasales y paranasales. Es una enfermedad altamente prevalente, que conlleva una gran carga económica asociada y cuyo tratamiento médico actual consigue un alivio sintomático en aproximadamente 50% de los pacientes. Tradicionalmente se ha clasificado de acuerdo a la presencia o ausencia de pólipos nasales, sin embargo, no se conoce con total claridad los mecanismos que llevan a la diferenciación de ambos fenotipos. Se estima que existirían tanto factores exógenos como endógenos involucrados que configurarían un origen multifactorial de la enfermedad. La RSC es motivo de intensa investigación científica actual dado su impacto y prevalencia, de manera de determinar con mejor precisión los objetivos de un eventual tratamiento de mayor efectividad. Es por ello que presentamos una revisión actualizada en relación a los mecanismos fisiopatológicos subyacentes en RSC.
ABSTRACT Chronic rhinosinusitis (CRS) is defined as a symptomatic inflammation of the nasal and paranasal cavities. It is a highly prevalent disease carrying a large associated economic burden, and its current medical treatment achieves symptomatic relief in approximately 50% of patients. Traditionally, it has been classified according to the presence or absence of nasal polyps. However, the mechanisms that lead to the differentiation of both phenotypes are not fully understood. It has been estimated that there are both exogenous and endogenous factors involved that would configure a multifactorial origin of the disease. Given its impact and prevalence, CRS is currently a subject of intense scientific research, in order to accurately determine the targets for a more effective treatment. For this reason, we present an updated review in relation to the underlying pathophysiological mechanisms in CRS.
http://bit.ly/2GqBc1S
Evaluación de procesamiento auditivo y percepción sonora en sujetos con presbiacusia
RESUMEN Introducción: Pacientes portadores de hipoacusia simétrica en la audiometría pueden percibir su déficit como asimétrico. La explicación de este fenómeno podría tener su origen en variaciones en la conducción del estimulo hablado hacia la corteza auditiva, o procesamiento auditivo. Objetivo: Evaluar el procesamiento auditivo en pacientes que refieren escuchar mejor por un oído en presencia de umbrales audiométricos simétricos. Material y método: Pacientes mayores de 65 años. Criterios de exclusión: patología otológica, deterioro cognitivo (Mini Mental test <21 puntos), usuario de audífono, hipoacusia asimétrica. La batería de procesamiento auditivo incluyó evaluación de comprensión del habla en competencia (habla en ruido), pruebas dicóticas (dígitos dicóticos y la versión en español de Staggered spondaic words, SSW), y evaluación temporal (patrón de frecuencia y discriminación de silencio). Todas estas pruebas estaban previamente validadas en población chilena. Análisis estadístico mediante programa SPSS. Se utilizaron estadísticos descriptivos y pruebas no paramétricas (Kruskal Wallis y Mann Whitney). p <.05. Protocolo aprobado por comité de ética de Investigación, pacientes consienten. Trabajo financiado por Concurso de Proyectos de Investigación de la SOCHIORL y Proyecto Anillo ACT1403. Resultados: 49 pacientes cumplen criterios de ingreso, 37 son de sexo femenino. Se identifican tres grupos: escuchan mejor por oído derecho (n: 19), por oído izquierdo (n: 14), o sin diferencia entre ambos oídos (n: 16). El grupo de pacientes con audición simétrica tenia PTP significativamente menor que los otros dos grupos. Al analizar los distintos tests de procesamiento auditivo no hay diferencia entre los grupos. Al evaluar habla dicótica se observó que el oído derecho tuvo un significativo mejor rendimiento que el oído izquierdo para dígitos dicóticos y SSW (p .000 y .007 respectivamente, test de Mann Whitney) en todo el grupo de pacientes evaluados, sin diferencia al agrupar por percepción auditiva (p .835, test de Kruskal Wallis). Conclusión: Para el grupo de pacientes evaluados no se pudo demostrar una relación entre procesamiento auditivo y percepción asimétrica de la palabra.
Abstract Introduction: Presbycusis corresponds to a symmetrical loss in the audiogram. Nevertheless, some patients complaint that they hear better in one ear. Aim: The purpose of this work is to analyze if this asymmetrical perception relates with auditory processing. Material and method: Subjects older than 65 years of age. Exclusion criteria: ear pathology, cognitive decline (Mini Mental test with score <21 points), previous use of hearing aid, asymmetrical thresholds in audiometry. Auditory processing was evaluated with speech in noise test, dichotic tests (dichotic digits and the Spanish version of Staggered spondaic words, SSW), and temporal resolution (frequency pattern and gap in noise). Statistical analysis with SPSS. Descriptive tests, Kruskal Wallis and Mann Whitney, p <.05. Protocol approved by the local ethics committee. Subjects consented. Financial support by the Chilean Society of Otorhinolaryngology and Proyecto Anillo ACT1403. Results: 49 subjects were recruited, 37 female. 19 of them reported better hearing with the right ear, 14 with the left ear, and 16 no difference among ears. Those subjects with symmetrical perception had better PTP than the other two groups. The three groups had no difference in auditory processing evaluation. In the dichotic hearing assessment most patients had a significant better performance for the right ear both for dichotic digits and SSW, independent of the better ear. Conclusions: For the cases included there was no relation between speech perception and auditory processing. In dichotic tests the right ear had a significant better performance.
http://bit.ly/2IcGcsM
Influencia de las zonas cocleares muertas sobre la autopercepción de las habilidades auditivas en adultos con hipoacusia sensorioneural bilateral
ABSTRACT Introduction: Cochlear dead regions are areas of the basilar membrane where the hair cells and/or auditory nerve fibers are not functional, which can alter the temporal analysis of an acoustic signal. The functional effects that could generate still are not entirely clear, and set through the use of self-perception questionnaires, provide useful information for audiological management of patients. Aim: To investigate the relationship between the presence of cochlear dead regions and the self-reported of listening difficulties of adults with bilateral sensorineural hearing loss. Material and Method: Twenty adults with symmetric bilateral sensorineural hearing loss, aged 51 to 75 years were tested, without previous story of use of hearing aids. Cochlear dead regions were tested using the TEN test at 1, 2, 3 and 4 kHz. The questionnaire of twelve questions, IROS12, was applied to the participants. Results: Cochlear dead regions were present in 10 participants. No significant differences were observed between groups, however lower IROS12 scores were observed in those who had present of dead regions. Conclusion: The perception of hearing difficulties in individuals with bilateral sensorineural hearing loss with cochlear dead regions did not differ significantly from those individuals without cochlear dead regions.
http://bit.ly/2GwsPlB
Influencia auditiva de la pared posterosuperior del conducto auditivo externo, en la hipoacusia de conducción postimpanomastoidectomía
ABSTRACT Introduction: Cholesteatomas treatment is surgical and the goals are complete resection of it, to prevent complications and recurrences. The gold standard operative technique is canal wall down tympanomastoidectomy (CWDT), which reduces the recurrence rate lower than 2%. Studies on human temporal bones have defined that CWDT causes a decrease of 1 to 5 dB at frequencies below 1000 Hz and 0 to 10 dB between 1000 and 3000 Hz. Aim: To determine how many decibels the hearing is improved by reconstituting the posterior wall of the ear canal (EC) in patients after CWDT. Material and method: Experimental study. In patients after CWDT, the posterior wall of EC was reconstructed temporarily. Audiometry was performed before and after the procedure. Results: 23 patients were enrolled (25 ears evaluated). Average age 48.8 years (range 18 to 72 years). In 96% of the ears there was a difference after the procedure with a hearing improvement of 4.2 ± 2.8dB. In frequencies below 1000 Hz, hearing improvement was 6.0 dB (p<0.001), between 1000-3000 Hz, the improvement was 2.6 dB (p<0.001) and >3000 Hz there was no difference. When considering the airway-conduction pure tone average (PTA), the difference was a 4.6 dB improvement (p<0.001). Conclusions: Our study shows that there is a hearing improvement in the vast majority of ears that were evaluated by reconstituting the posterior wall of the EC, reaching a gain of 6 dB at frequencies <1000 Hz and 2,6 dB at mid frequencies. Considering the airway PTA, the improvement is 4.6 dB in the presence of posterior canal wall.
http://bit.ly/2IeUJ7h
Tumores de glándula parótida: Experiencia quirúrgica Hospital Guillermo Grant Benavente
Abstract Introduction: Parotid gland is the most common site of salivary gland tumors, corresponding to 75-85% of these and 3% of all head and neck tumors. 80% of them correspond to benign tumors. Aim: To analyze the surgical experience in parotid tumors operated in the Guillermo Grant Benavente Hospital. Material and Method: Review of all patients with parotid tumors operated in the Otorhinolaryngology and Head and Neck Surgery Unit of Hospital Guillermo Grant Benavente between January 2011 and April 2016. All surgeries were performed by the same surgical team. Demographic, clinical, surgical, histological and postoperative results were recorded. Results: In the period described, a total of 94 patients were operated on. 84.3% corresponded to benign tumors and 15.7% to malignant tumors. 62.9% corresponds to female patients and 37.1% male, representing a ratio of 1.69:1. The incidence of transient facial paralysis was 16.1%, and of these, only one patient maintained permanent paralysis. Conclusions: Malignant tumors represented 15.7% of cases, being less than reported in the literature. This article presents a large series of parotid tumors treated surgically in our country, with a low associated complication rate.
http://bit.ly/2GrCXMo
Tumores de glándula submandibular: Experiencia clínica del Hospital Guillermo Grant Benavente
ABSTRACT Introduction: Submandibular gland tumors are rare. They represent less than 1% of all head and neck tumors. They correspond to 10% of the tumors of the salivary glands. Approximately 50% are malignant. Aim: To analyze the clinical experience with the submandibulectomies performed in the Otorhinolaryngology and Head and Neck Surgery Service of the Guillermo Grant Benavente Hospital. Material and Method: Retrospective descriptive study. Review of clinical records of patients treated with a submandibulectomy between January 1,2011 and December 31, 2016 in our service. Results: 28 submandibulectomies were performed due to tumor pathology. The average age was 54 years, being 71% female. 21 tumors were benign (75%), being the most frequent the pleomorphic adenoma (14 cases), and 7 malignant tumors (25%), being the most frequent the adenoidequistic carcinoma. Two transient complications (7%) were reported, a paresis of the marginal branch of the facial nerve and a paresis of the hypoglossal nerve. 42% of malignant tumors presented recurrence. Conclusion: Our series presents results according to the literature regarding age of presentation, distribution by sex, histological types, complication rate and recurrence; however, it differs in the lower frequency of malignant tumors, being in our series of 25%. Uncommon pathology. The presence of a submandibular painless mass must be referred to the reference centers for study and possible surgical resolution due to the risk of malignancy.
http://bit.ly/2IdIGH3
Influencia del exceso de peso en el éxito de la adenoamigdalectomía en pacientes con hiperplasia adenoamigdalina sintomática
Resumen Introducción: En población pediátrica con malnutrición por exceso, existe controversia respecto al rol de la hiperplasia adenoamigdalina en la etiología de los trastornos del sueño y de la efectividad de la adenoamigdalectomía sobre dicha sintomatología. Objetivo: Comparar la efectividad de la adenoamigdalectomía entre pacientes pediátricos eutróficos y con malnutrición por exceso sometidos a adenoamigdalectomía por hiperplasia adenoamigdalina, en relación a la disminución de la sintomatología. Materiales y método: Estudio retrospectivo mediante revisión de fichas clínicas entre junio de 2016 y enero de 2017 de pacientes operados de adenoamigdalectomía por hiperplasia adenoamigdalina sintomática. Se clasificaron los pacientes de acuerdo a edad y estado nutricional en 4 grupos y se evaluó la resolución de la sintomatologia mediante interrogación a padres/tutores. Resultados: Se incluyeron 98 pacientes, con una edad media de 6,3 años. 44,9% de los pacientes fueron eutróficos y 55,1% con malnutrición por exceso. El análisis estadístico entre pacientes eutróficos y aquellos con malnutrición no demostró diferencias significativas en relación a la resolución de la sintomatología. Conclusión: La adenoamigdalectomía por hiperplasia adenoamigdalina sintomática se asocia a una reducción de la frecuencia de roncopatía con pausas en pacientes pediátricos, independientemente del estado nutricional.
Abstract Introduction: In pediatric population with malnutrition by excess, the role of the adenotonsillar hyperplasia in the etiology of breathing-related sleep disorders, and the effectivity of the adenotonsillectomy for reducing symptoms remains controversial. Aim: To compare and evaluate the effectiveness of the adenotonsillectomy between eutrophic and malnutrition by excess pediatric patients submitted to adenotonsillectomy by adenotonsillar hyperplasia, regarding to symptoms resolution. Material and method: A retrospective study was performed collecting data from clinical records between June 2016 and January 2017 of patients submitted to adenotonsillectomy by symptomatic adenotonsillar hyperplasia. Patients were assigned to 4 groups according to age and nutrional status and the rate of symptoms resolution was evaluated through interrogation to parents/guardians. Results: We included 98 patients, with an average age of 6.3 years. A 44.9% of patients were eutrophic and 55.1% had malnutrition by excess. Comparing eutrophic and malnutrition by excess patients, no significant differences were observed regarding to symptoms resolution. Conclusion: The adenotonsillectomy by symptomatic adenotonsillar hyperplasia was associated to an amelioration of the rate of snoring and respiratory pauses during sleeping in pediatric patients, independently of the nutritional status.
http://bit.ly/2GsHrC7
Carcinoma adenoideo quístico pulmonar primario con metástasis precoces exclusivas hepáticas, un caso inusual
ABSTRACT Adenoid cystic carcinoma (ACC) is a pathology of the salivary glands, exceptional cases have been described as primary of the bronchus. This is a case of primary adenoid cystic carcinoma of the tracheobronchial tree (PACCTBT), with partial response to radiation therapy, in addition, presents liver metastases, without evidence of metastasis injuries in other parts of the body. Such characteristics mean that we should pay attention to the atypical forms of ACC, especially PACCTBT and its unpredictable behavior.
http://bit.ly/2GrXP67
Plenitud ótica como primer síntoma en patología del espacio parafaríngeo
ABSTRACT Parapharyngeal space (PPS) tumors are infrequent and account for 0.5%-1% of head and neck neoplasms. Therefore, they represent a diagnostic challenge. The distribution of PPS tumors is as follows: 40% salivary tumors, followed by neurogenic tumors and adenopathies. We report a case of a 50 year old woman that presented with a 3-month history of otic fullness and pharyngeal disturbances. The otolaryngological examination showed PPS pathology that was confirmed by radiological images. Surgical excision by transcervical-transparotid approach was performed followed by uncomplicated healing with no recurrence in one year. The histological examination reported a pleomorphic parotid adenoma. The authors provide a discussion of the etiopathogenesis, diagnosis and treatment of this type of lesions. This clinical manuscript may shed light on the importance of a complete otolaryngological examination in a patient with unspecific symptoms considering that the PPS is a complex anatomic region and its pathology can easily go unnoticed.
http://bit.ly/2InkzpM
Hiperparatiroidismo persistente debido a paratiromatosis
ABSTRACT Parathyromatosis is described as a condition in which there are multiple nodules of hyperfunctioning parathyroid tissue disseminated by the neck and mediastinum. Imaging tests are not effective in locating the parathyroid glands and requires the combination of medical and surgical treatment that sometimes is challenging. We describe the case of a 61-year-old woman with recurrent primary hyperparathyroidism. A total of 9 parathyroid glands where removed in 3 different surgeries. We also reviewed the literature.
http://bit.ly/2GsHqhx
Enfermedad de Rosai-Dorfman con compromiso laríngeo: A propósito de un caso
RESUMEN La enfermedad de Rosai-Dorfman (ERD) o histiocitosis sinusal con linfadenopatía masiva es una enfermedad infrecuente, de etiología desconocida caracterizada por linfadenopatías cervicales masivas bilaterales. El compromiso extraganglionar puede ocurrir en diferentes sitios, incluida la vía aérea, en la cual la localización nasosinusal es la más frecuente, pero puede comprometer también otros sitios de la vía aérea superior. Dentro de éstos, el compromiso laríngeo es muy poco frecuente. Se presenta el caso de una paciente de 82 años con antecedentes de ERD localizada en los ganglios linfáticos cervicales en remisión espontánea, que desarrolló posteriormente una obstrucción subaguda de las vías respiratorias. La tomografía computarizada y la nasofaringolaringoscopía mostraron lesiones subglóticas que obstruían severamente las vías respiratorias. Se realizó una traqueostomía de emergencia y biopsia de las lesiones, confirmando el diagnóstico de ERD extranodal.
ABSTRACT Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare disease of unknown etiology characterized by bilateral massive cervical lymphadenopathy. Extranodal involvement can occur in different sites including airway where nasosinusal involvement is common but this disease may occur in other sites of the upper airway. Laryngeal involvement is rare. We present the case of an 82-year-old female patient with a history of Rosai-Dorfman disease located in cervical lymph nodes in spontaneous remission that subsequently develops airway obstruction. Computed tomographic scan and nasopharyngolaryngoscopy showed subglottic lessons that severely obstructed the airway. Emergency tracheotomy and biopsy were performed, confirming the diagnosis of extranodal RDD. Patient was observed and tracheostomy was maintained with good tolerance.
http://bit.ly/2Ig06TH
Técnica de embalsamiento de cadáver según Thiel. Un método valioso para entrenar y mejorar las destrezas quirúrgicas en el campo de la otorrinolaringología
RESUMEN Los tiempos modernos nos obligan a que la formación de un médico cirujano no se base sólo en conocimientos teóricos, sino que adquiera las mayores habilidades quirúrgicas para así evitar riesgos innecesarios en una sociedad altamente exigente. La disección y el entrenamiento de los procedimientos quirúrgicos juegan un papel primordial para cumplir este objetivo, por lo que recientemente se ha promovido una forma de preservación cadavérica que permite realizar mediante situaciones bastantes realistas dichos adiestramientos. Se realizó una búsqueda bibliográfica electrónica, restringida al idioma inglés en Pubmed, Scopus y WOS donde se pretende describir y analizar las aplicaciones de esta técnica. La revisión ofreció artículos de relevancia que demuestran la aplicación de esta técnica novedosa en la preservación de cadáveres y sus posibles aplicaciones en el campo de otorrinolaringología.
ABSTRACT Nowadays, it is not possible to train a healthcare professional only based on theoretical knowledge, but acquiring the highest surgical skills to avoid unnecessary risks in a highly demanding society, therefore dissection and training of surgical procedures play a key role in fulfilling this objective, which is why a form of cadaveric preservation has recently been promoted, which allows realizing such training through realistic situations. An electronic literature search was carried out, restricted to the English language in MEDLINE, where it is intended to describe and analyze the applications of this technique. The review offered articles of relevance that demonstrate the application of this novel technique in the preservation of corpses and their possible applications in the field of otorhinolaryngology.
http://bit.ly/2GpoqRf
Reconstrucción en cabeza y cuello: Un desafío en oncología
RESUMEN Considerando los avances en las modalidades de tratamiento para el cáncer de cabeza y cuello, el manejo quirúrgico de los defectos ha cambiado significativamente en las últimas décadas. Con la mejoría del manejo previo a la cirugía en la década de los 40s-50s, la cirugía ablativa o resectiva se convirtió en el pilar del tratamiento de los tumores avanzados en esta región, lo cual rutinariamente era seguido de tratamiento con radioterapia. Desafortunadamente, la cirugía reconstructiva no avanzó de la misma forma, no existiendo previamente opciones confiables de rehabilitación de estos pacientes. Además, los cirujanos de cabeza y cuello como otorrinolaringólogos de la época no consideraban la reconstrucción como parte importante del tratamiento quirúrgico. Sin embargo, en las últimas décadas, la cirugía reconstructiva ha presentado distintos avances que han permitido complementar el manejo de estas patologías, entregando una terapia oncológica con menos morbilidad cosmética y funcional. Esta revisión pretende de forma general dar a conocer los distintos tipos de colgajo, sus indicaciones y opciones en cirugía reconstructiva de cabeza y cuello, lo cual es de suma importancia para los servicios que manejen patología oncológica de esta región anatómica.
ABSTRACT Encompassing with the advances in the preferred treatment modalities for head and neck cancer, the management of surgical defects has changed significantly over the last decades. With the advent of improved perioperative management in the 1940-50s, radical ablative surgery became the mainstay for treatment of advanced tumors in this region, which was routinely followed by radiation therapy. Unfortunately, reconstructive surgery did not advance at the same pace, and there were no reliable reconstructive options to rehabilitate these patients. Furthermore, head and neck surgeons and otolaryngologists of the time did not consider reconstruction as an important part of the surgical treatment. However, in the last decades, reconstructive surgery has presented different advances that have made it possible to complement the management of these pathologies, delivering an oncological therapy with less cosmetic and functional morbidity. This review aims in general to make known the different types of flap, its indications and options in reconstructive surgery of the head and neck, of utmost importance for the services that handle oncological pathology of this anatomical region.
http://bit.ly/2IbAoj7
Carta al Editor
RESUMEN La rinosinusitis crónica (RSC) se define como una inflamación sintomática de las cavidades nasales y paranasales. Es una enfermedad altamente prevalente, que conlleva una gran carga económica asociada y cuyo tratamiento médico actual consigue un alivio sintomático en aproximadamente 50% de los pacientes. Tradicionalmente se ha clasificado de acuerdo a la presencia o ausencia de pólipos nasales, sin embargo, no se conoce con total claridad los mecanismos que llevan a la diferenciación de ambos fenotipos. Se estima que existirían tanto factores exógenos como endógenos involucrados que configurarían un origen multifactorial de la enfermedad. La RSC es motivo de intensa investigación científica actual dado su impacto y prevalencia, de manera de determinar con mejor precisión los objetivos de un eventual tratamiento de mayor efectividad. Es por ello que presentamos una revisión actualizada en relación a los mecanismos fisiopatológicos subyacentes en RSC.
ABSTRACT Chronic rhinosinusitis (CRS) is defined as a symptomatic inflammation of the nasal and paranasal cavities. It is a highly prevalent disease carrying a large associated economic burden, and its current medical treatment achieves symptomatic relief in approximately 50% of patients. Traditionally, it has been classified according to the presence or absence of nasal polyps. However, the mechanisms that lead to the differentiation of both phenotypes are not fully understood. It has been estimated that there are both exogenous and endogenous factors involved that would configure a multifactorial origin of the disease. Given its impact and prevalence, CRS is currently a subject of intense scientific research, in order to accurately determine the targets for a more effective treatment. For this reason, we present an updated review in relation to the underlying pathophysiological mechanisms in CRS.
http://bit.ly/2IoEXqa
Fe de errata/Errata
ABSTRACT Chronic rhinosinusitis (CRS) is defined as a symptomatic inflammation of the nasal and paranasal cavities. It is a highly prevalent disease carrying a large associated economic burden, and its current medical treatment achieves symptomatic relief in approximately 50% of patients. Traditionally, it has been classified according to the presence or absence of nasal polyps. However, the mechanisms that lead to the differentiation of both phenotypes are not fully understood. It has been estimated that there are both exogenous and endogenous factors involved that would configure a multifactorial origin of the disease. Given its impact and prevalence, CRS is currently a subject of intense scientific research, in order to accurately determine the targets for a more effective treatment. For this reason, we present an updated review in relation to the underlying pathophysiological mechanisms in CRS.
http://bit.ly/2GrskZM
Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer
Abstract
Metastatic lung cancers from the colon and rectum (MLCR) frequently have necrotic components. The aim of this study is to elucidate clinicopathological factors associated with the amount of necrosis in MLCR. Ninety patients who underwent the first pulmonary metastasectomy for MLCR with a tumor diameter ≦ 3.0 cm and without chemotherapy were enrolled in this study. Analyzing digitally scanned pathological slides, we calculated the necrosis percentage (NP, the necrosis area divided by the tumor area). The relationship between NP and clinicopathological factors was analyzed. Moreover, to determine whether NP was affected by tissue hypoxia, vascularization, or tumor cell proliferation, tissues were analyzed by immunohistochemical staining using carbonic anhydrase IX (CAIX), CD34 antibodies, and Ki-67 antibodies, respectively. Median tumor area and NP were 0.69 cm2 (0.11–3.01) and 13.1% (0–71.6), respectively. Although NP was not associated with the tumor area, it was significantly higher in the patients with a positive smoking history (8.14% vs 17.1%, p = 0.045). Other clinicopathological factors were not correlated with NP. Immunohistochemical analysis revealed that CA IX expression on tumor cells, CD34 micro-vessel density, CD34 micro-vessel area, and Ki-67 index were not significantly associated with NP. NP in the primary site was not associated with NP in the pulmonary metastasis. NP was not determined by tumor size, tissue hypoxia, vascularization, or tumor cell proliferation. Positive correlation of NP with smoking history suggests a unique lung microenvironment in smokers which makes necrosis of MLCR more likely to occur.
http://bit.ly/2DJ2pct
A reliable method to avoid contamination during cartilage graft preparation in septorhinoplasty
Abstract
Purpose
The aim of the study is to determine the risk of contamination in the cartilage graft materials prepared on the swester table and those prepared in a sterile package, and to reveal a more reliable method by performing the microbiological examination of these materials.
Methods
Cartilages removed from the nasal septum were divided into four pieces. The first part (Sample A) was directly placed into the medium. Sample B was prepared by being crushed in a sterile package. Sample C was prepared on the auxiliary swester table, and Sample D was prepared on the main swester table actively used by surgery team. All samples were transferred in a 1 ml brain heart(BH) liquid medium. From each BH medium, 100 µl culture was performed on blood agar, eosin–methylene blue–lactose–sucrose agar and chocolate agar.
Results
Bacterial growth was detected in 2 of the samples A, in 4 of the samples B, in 24 of the samples C, and in 36 of the samples D. The number of patients with bacterial growth in the samples C and/or D despite no growth in the sample B was 35. When the samples A/B and C/D were compared in terms of bacterial growth, a significant difference was found in all matchings (p < 0.001 for all comparisons).
Conclusion
These findings showed that preparation of the cartilage grafts on the swester table was extremely risky for microbiological contamination. Arslan and his colleagues suggest that preparing a graft material in a sterile package is extremely simple, cheap, and it also reduces contamination risk significantly.
http://bit.ly/2IcBZFu
African American Ancestry Contribution to Asthma and Atopic Dermatitis
Despite advances in therapeutics and a better understanding of environmental risk factors, racial disparities in both asthma and atopic dermatitis (AD) are profound, and cannot be explained by non-genetic factors alone1,2. Disparities are compounded by a disproportionate under-representation of minority populations in genetic and pharmacogenetic studies of asthma and AD. As a result, genetic risk factors for these clinical conditions are much less well understood in African ancestry populations compared to European populations.
http://bit.ly/2GIqfId
Con: OIT is safe/better than food avoidance
Food allergy (FA) is well-recognized as a major public health problem, affecting 8% of children and 5% of adults in the industrialized countries.1 Despite the relatively high prevalence of this disorder, there is unfortunately no definitive cure. For a long time, the classical approach for the management of IgE-mediated FA has been strict food avoidance and the prescription of epinephrine auto-injector in case of accidental reaction. Regular oral food challenges (OFC) are performed in order to assess spontaneous tolerance acquisition.
http://bit.ly/2GI4GaW
From the pages of AllergyWatch May 2019
Head and Neck, MOC:
http://bit.ly/2toJQFs
Drug Hypersensitivity Reactions in the Americas: Similarities and Differences
Drugs are the most frequent cause of fatal anaphylaxis worldwide(1). The prevalence of adverse drug reactions (ADRs), including allergy, is known to be related to drug exposure frequency, gender, age, ethnicity and genetic factors, and it varies according to the classes of drugs, definitions of hypersensitivity reactions (HRs) and study design. Drug usage patterns vary significantly with time and geography, both across large countries and around the world(1-3).
http://bit.ly/2tm1c5N
Pro-Con Debate: Component resolved diagnostic testing is not useful for making food allergy diagnoses
Funding: none
http://bit.ly/2GG3GEa
Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness
Drug induced enterocolitis syndrome (DIES) is a rare, non-IgE mediated hypersensitivity reaction provoked by drugs which can be severe and lead to shock. Despite the potential severity of the reactions, awareness of DIES is low. In contrast, enterocolitis syndrome induced by food proteins (FPIES) has been better documented. Previous studies have reported the occurrence of hypovolemic shock in approximately 15% of reactions, which indicates that FPIES is a potentially life threating disease.(1) To increase clinical awareness on DIES we here report a case of a child who was referred to our pediatric allergy clinic and was diagnosed with DIES by amoxicillin.
http://bit.ly/2tkIX0G
Clinical Thyroidology®High-Impact Articles
FREE ACCESS through February 28, 2019
Read Now:
Greetings From the Editor of Clinical Thyroidology
Angela M. Leung
Treatment of Hyperthyroidism Decreases but Does Not Completely Abolish the Increased Risk of Cardiovascular-Related Hospitalization
Natalia Genere and Marius N. Stan
Iodine Content Is Low or Absent in Some U.S. Multivitamin and Prenatal Vitamin Brands
Charles H. Emerson
Is It Time to Update the Classification for Radioiodine-Refractory Differentiated Thyroid Cancer?
Edward B. Silberstein, Guest Associate Editor
Patients with Advanced Thyroid Cancer Containing TRK Fusions May Benefit from Recently FDA-Approved Larotrectinib
Brian W. Kim
The post Clinical Thyroidology<sup>®</sup>High-Impact Articles appeared first on American Thyroid Association.
http://bit.ly/2N8dcRB
Stratifying clinical complexity of dermatology outpatient visits: validation of a pilot instrument
The United States population is aging and increasing in comorbidity, and patient care is accordingly growing increasingly complex. Complexity impacts patterns of resource consumption, adverse event and medical error rates, health-related quality of life, physician burnout, and more. Tools capturing complexity can be of benefit in the modern value-based reimbursement landscape and have been well-studied in specialties other than dermatology. In this paper, we describe the validation of a tool specific to outpatient dermatologic care that captures the complexity of clinical visit medical decision-making.
http://bit.ly/2GJlQol
Reevaluating a Standardized Sedation Weaning Protocol for Pediatric Laryngotracheal Reconstruction
http://bit.ly/2DGf0wY
Emergence of Cheyne-Stokes Breathing after Hypoglossal Nerve Stimulator Implant in a Patient with Mixed Sleep Apnea
http://bit.ly/2Sy5pm2
Reassessing the Safety of Bicycle Helmets
http://bit.ly/2DEALNv
Negative Auswirkungen der Streifenconchotomie auf die intranasale Klimatisierung
Zusammenfassung
Ziel
Die partielle Resektion des kaudalen Anteils der unteren Nasenmuschel einschließlich des Nasenmuschelkopfs ist ein nach wie vor anzutreffendes Verfahren in der Rhinochirurgie („Streifenconchotomie"). Ausgedehnte Resektionen der Nasenmuschel beeinträchtigen allerdings den nasalen Luftstrom und die intranasale Klimatisierung. Das Ziel dieser Studie war es, den Effekt einer partiellen Resektion der unteren Nasenmuschel inklusive des Nasenmuschelkopfs auf die intranasale Luftströmung sowie Erwärmung und Befeuchtung der einströmenden Luft mit Computational Fluid Dynamics zu bestimmen.
Material und Methoden
Basierend auf dem computertomographischen Datensatz eines Patienten wurde ein bilaterales realistisches Nasenmodell erstellt. Eine einseitige Teilresektion der unteren Nasenmuschel auf der rechten Seite war bei erhaltener unterer Muschel links extern erfolgt. Zur Analyse der intranasalen Luftströmungsmuster, der Temperatur der eingeatmeten Luft und der Feuchtigkeitsverteilung wurde eine numerische Simulation durchgeführt.
Ergebnisse
Aufgrund der partiellen Resektion der unteren Nasenmuschel auf der rechten Seite einschließlich des Nasenmuschelkopfs war das Strömungsmuster im Vergleich zur Gegenseite deutlich verändert. Die Resektion führt zu einer zentrierten und höheren Geschwindigkeit im unteren Nasengang sowie zu einer reduzierten Erwärmung und Befeuchtung der eingeatmeten Luft im Vergleich zur nichtoperierten linken Nasenhöhle.
Schlussfolgerung
Die häufig durchgeführte Teilresektion des kaudalen Anteils der unteren Nasenmuschel kann bei extensiver Resektion zu einer gestörten intranasalen Klimatisierung führen. Daher sollte dieses Verfahren, wenn möglich, in der Rhinochirurgie vermieden und stattdessen ein schleimhautschonenderes Verfahren gewählt werden.
http://bit.ly/2N6tIlb
Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema
Hereditary angioedema (HAE) is a life-threatening disease characterized by recurrent episodes of subcutaneous and mucosal swellings and abdominal cramping. Corticosteroids and antihistamines, which are usually...
http://bit.ly/2V35c7n
Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement
Abstract
Background
Parotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien.
Methods
In total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed.
Results
Lymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Eight of the 10 parotid‐positive patients developed a recurrence vs 17 of the 30 parotid‐negative patients (P = 0.28). There were no differences in overall survival, melanoma‐specific survival, and disease‐free survival between the parotid‐positive and parotid‐negative patients.
Conclusion
Although in this series no survival differences were found, parotidectomy still merits a sustained role in therapeutic neck dissection procedures to improve regional control and to prevent facial nerve damage after surgery for a second relapse from occult metastases in the parotid.
http://bit.ly/2N5cCE3
Acknowledgment of Reviewers 2018
Violence and Gender, Ahead of Print.
http://bit.ly/2S1rDrt
Decreased ciliary beat responsiveness to acetylcholine in the nasal polyp epithelium
Abstract
Objective
We investigated the difference in ciliary beat responsiveness to acetylcholine in ex vivo and the difference in the expressions of associated molecules (M1/M3 muscarinic receptors, pannexin‐1 and P2X7 purinergic receptor) between the nasal polyp and turbinate mucosa.
Study Design
Laboratorial study.
Participants
Nasal polyp and inferior turbinate were collected from patients with hypertrophic rhinitis and/or nasal polyp during endoscopic sinonasal surgery.
Main outcome measures
The mucosa was cut into thin strips, and ciliary movement was observed under a phase‐contrast light microscope equipped with a high‐speed digital video camera. The samples were also examined by scanning electron microscopy, fluorescence immunohistochemistry, and quantitative reverse transcription‐polymerase chain reaction.
Results
Cilia were well preserved in both tissues at the ultrastructural level. The baseline ciliary beat frequency (CBF) was not different between the two tissues. The CBF of the turbinate was significantly increased by stimulation with acetylcholine (P<0.001), but that of the polyp was not. The ratio of the acetylcholine‐stimulated CBF to the baseline CBF was significantly lower in the polyp than in the turbinate (P<0.001). Immunohistochemical study revealed that immunoreactivities for M3, pannexin‐1 and P2X7 were weaker in the polyp than in the turbinate. The mRNA expressions of M1, M3 and P2X7 were significantly lower and that of pannexin‐1 tended to be lower in the polyp than in the turbinate.
Conclusions
These results indicate that ciliary beat responsiveness to acetylcholine is decreased in the nasal polyp. This may be explained by the decreased expressions of M3, P2X7 and probably pannexin‐1 in this tissue.
Keywords
Nasal polyp, ciliary beat frequency, acetylcholine, muscarinic receptor, pannexin‐1 channel, P2X7 purinergic receptor
This article is protected by copyright. All rights reserved.
http://bit.ly/2N70jan
How to Comfort Your Child’s Broken Heart
How can you, as a parent, help comfort your child's broken heart after they go through a breakup? Few experiences are as emotionally intense for teens as a broken heart. Teen breakups can be difficult to navigate for children, and also their parents. As a parent, it's important to know how to respond. In this video, Dr. Sarah Garwood provides specific advice on what to do, and what not to do, when your child is going through their first heartbreak. Learn some tips for having supportive conversations about teens and dating, breakups, healthy coping and appropriate social media use. Finally, find out what some warning signs are that your teen isn't coping well and might need additional help.
The post How to Comfort Your Child's Broken Heart appeared first on ChildrensMD.
http://bit.ly/2tm442L
Hearing interventions to prevent dementia
Abstract
Hearing loss is a marker of risk for cognitive decline and dementia. Controlled hearing intervention studies of long-term cognitive outcomes are challenging, and thus the evidence for the impact of hearing interventions is primarily from observational studies and will likely continue to be from studies other than randomised controlled trials. Seven studies of hearing interventions with cognitive outcomes assessed over longer than 3 years are reviewed. Most were of low-to-moderate quality. One cochlear implant study had indeterminate findings. Of six hearing aid studies, three reported a positive impact of hearing aid use while three reported no impact of hearing aid use on cognitive decline or incident cognitive impairment. Further studies are required to elucidate the benefit of hearing interventions on long-term cognitive outcomes. Research should include objectively ascertained hearing data, theoretically motivated cognitive outcomes including dementia subtypes, characterisation, and control for confounds and application of advanced statistical modelling to test causal hypotheses.
http://bit.ly/2N4ZHlG
Vulnerabilità sismica di classi di edifici a telaio in C.A.: sensibilità della probabilità di superamento dello SLV ai dettagli costruttivi e ai materiali adottati
Gentile, R; Fondi, L; Pampanin, S; (2017) Vulnerabilità sismica di classi di edifici a telaio in C.A.: sensibilità della probabilità di superamento dello SLV ai dettagli costruttivi e ai materiali adottati. In: Proceedings of the XVII National Conference ANIDIS, 17–21 September 2017. (pp. SG03-416-SG03-426). Green open access
http://bit.ly/2tk5E5j
Antibiotic Prophylaxis at Dental Implant Placement: Which is the Best Protocol? A Systematic Review and Network Meta-Analysis
Romandini, M; De Tullio, I; Congedi, F; Kalemaj, Z; D'Ambrosio, M; Laforí, A; Quaranta, C; ... Perfetti, G; + view all Romandini, M; De Tullio, I; Congedi, F; Kalemaj, Z; D'Ambrosio, M; Laforí, A; Quaranta, C; Buti, J; Perfetti, G; - view fewer (2019) Antibiotic Prophylaxis at Dental Implant Placement: Which is the Best Protocol? A Systematic Review and Network Meta-Analysis. Journal of Clinical Periodontology 10.1111/jcpe.13080 . (In press).
http://bit.ly/2GN5sU9
Simplified polynomial formulation for the calculation of the Moment-Curvature diagram of RC rectangular sections
Gentile, R; Raffaele, D; Uva, G; (2017) Simplified polynomial formulation for the calculation of the Moment-Curvature diagram of RC rectangular sections. In: Proceedings of the XVII National Conference ANIDIS, 17–21 September 2017. (pp. SG11-19-SG11-26). Green open access
http://bit.ly/2tjMigD
A Polya Tree Based Model for Unmarked Individuals in an Open Wildlife Population
Diana, A; Griffin, J; Matechou, E; (2019) A Polya Tree Based Model for Unmarked Individuals in an Open Wildlife Population. In: Wade, Sara, (ed.) Proceedings of Bayesian Young Statisticians Meeting 2018 - BAYSM2018. Springer: University of Warwick, UK. (In press).
http://bit.ly/2GJcMji
“The people that no-one notices”? – The power of building control inspectors in sustainable construction
Murtagh, NM; Achkar, L; Roberts, A; (2016) "The people that no-one notices"? – The power of building control inspectors in sustainable construction. In: (Proceedings) 32nd Annual ARCOM Conference, 5-7 September 2016, Manchester, UK. (In press).
http://bit.ly/2to7UZf
Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation
Srinivasan, NT; Orini, M; Providencia, R; Dhinoja, MB; Lowe, MD; Ahsan, SY; Chow, AW; ... Lambiase, PD; + view all Srinivasan, NT; Orini, M; Providencia, R; Dhinoja, MB; Lowe, MD; Ahsan, SY; Chow, AW; Hunter, RJ; Schilling, RJ; Taggart, P; Lambiase, PD; - view fewer (2018) Prolonged action potential duration and dynamic transmural action potential duration heterogeneity underlie vulnerability to ventricular tachycardia in patients undergoing ventricular tachycardia ablation. Europace 10.1093/europace/euy260 . (In press). Green open access
http://bit.ly/2GKWuGL
“To encourage people to think” – The power of building control inspectors in sustainable construction
Murtagh, NM; Achkar, L; Roberts, A; (2016) "To encourage people to think" – The power of building control inspectors in sustainable construction. In: (Proceedings) International Sustainable Ecological Engineering Design for Society (SEEDS). (In press).
http://bit.ly/2tlQCfb
Do More Recent Born Generations of Older Adults Have Stronger Grip? A Comparison of Three Cohorts of 66- to 84-Year-Olds in the Tromsø Study
Strand, BH; Bergland, A; Jørgensen, L; Schirmer, H; Emaus, N; Cooper, R; (2018) Do More Recent Born Generations of Older Adults Have Stronger Grip? A Comparison of Three Cohorts of 66- to 84-Year-Olds in the Tromsø Study. J Gerontol A Biol Sci Med Sci 10.1093/gerona/gly234 . (In press). Green open access
http://bit.ly/2GKWuqf
Peptide-biofunctionalization of biomaterials for osteochondral tissue regeneration in early stage osteoarthritis: challenges and opportunities
Bicho, D; Ajami, S; Liu, C; Reis, R; Oliveira, J; (2019) Peptide-biofunctionalization of biomaterials for osteochondral tissue regeneration in early stage osteoarthritis: challenges and opportunities. Journal of Materials Chemistry B , 7 (7) 10.1039/C8TB03173H .
http://bit.ly/2tiGGTQ
Householders as actors for urban resilience: What influences the intentions of English householders to take precautionary action against overheating?
Murtagh, NM; Gatersleben, B; Fife-Schaw, C; (2017) Householders as actors for urban resilience: What influences the intentions of English householders to take precautionary action against overheating? In: (Proceedings) IAPS2017. International Association of People-Environment Studies (In press).
http://bit.ly/2GJcIjy
Precautionary action against overheating in English homes: What influences householders’ intentions?
Murtagh, NM; Gatersleben, B; FIfe-Schaw, C; (2017) Precautionary action against overheating in English homes: What influences householders' intentions? In: Chan, PW and Neilson, CJ, (eds.) Association of Researchers in Construction Management (ARCOM): PROCEEDINGS OF THE 33rd ANNUAL CONFERENCE. Association of Researchers in Construction Management: Manchester, UK.
http://bit.ly/2to1ysG
Resilience to overheating in homes in southern England: Householders’ awareness and preparedness.
Murtagh, NM; Gatersleben, B; Fife-Schaw, C; (2017) Resilience to overheating in homes in southern England: Householders' awareness and preparedness. In: (Proceedings) SEEDS2017. (In press).
http://bit.ly/2GGviJj
Calderwood, L. and Sanchez, C. (2016). Next Steps (formerly known as the Longitudinal Study of Young People in England). Journal of Open Health Data, 4
Calderwood, L; Sanchez, C; (2016) Calderwood, L. and Sanchez, C. (2016). Next Steps (formerly known as the Longitudinal Study of Young People in England). Journal of Open Health Data, 4. Open Health Data , Article e2. 10.5334/ohd.16 . Green open access
http://bit.ly/2tntXiM
Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls
De Francesco, D; Underwood, J; Bagkeris, E; Boffito, M; Post, FA; Mallon, P; Vera, JH; ... Pharmacokinetic and Clinical Observations in People over Fifty (, .; + view all De Francesco, D; Underwood, J; Bagkeris, E; Boffito, M; Post, FA; Mallon, P; Vera, JH; Williams, I; Anderson, J; Johnson, M; Sabin, CA; Winston, A; Pharmacokinetic and Clinical Observations in People over Fifty (, .; - view fewer (2019) Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls. HIV Medicine 10.1111/hiv.12714 . (In press). Green open access
http://bit.ly/2GJcjxy
Improving X-ray CT Dimensional Metrology with Simple Holeplates
Corcoran, Hannah Clare; (2018) Improving X-ray CT Dimensional Metrology with Simple Holeplates. Doctoral thesis (Eng.D), UCL (University College London). Green open access
http://bit.ly/2tmNCzq
New insight from CryoSat-2 sea ice thickness for sea ice modelling
Schroeder, D; Feltham, DL; Tsamados, M; Ridout, A; Tilling, R; (2019) New insight from CryoSat-2 sea ice thickness for sea ice modelling. The Cryosphere , 13 (1) pp. 125-139. 10.5194/tc-13-125-2019 . Green open access
http://bit.ly/2GFDOIm
On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation
Ramezani, R; Liu, Y; Dehkhoda, F; Soltan, A; Haci, D; Zhao, H; Firfilionis, D; ... Degenaar, P; + view all Ramezani, R; Liu, Y; Dehkhoda, F; Soltan, A; Haci, D; Zhao, H; Firfilionis, D; Hazra, A; Cunningham, MO; Jackson, A; Constandinou, TG; Degenaar, P; - view fewer (2018) On-Probe Neural Interface ASIC for Combined Electrical Recording and Optogenetic Stimulation. IEEE Transactions on Biomedical Circuits and Systems , 12 (3) pp. 576-588. 10.1109/TBCAS.2018.2818818 . Green open access
http://bit.ly/2tocLcJ
Promising Under Duress
Saprai, P; (2019) Promising Under Duress. Law and Philosophy (In press).
http://bit.ly/2GHAoVz
The Dialectics of Urban Water Poverty Trajectories: Policy-driven and Everyday Practices in Dar es Salaam
Hofmann, Pascale; (2018) The Dialectics of Urban Water Poverty Trajectories: Policy-driven and Everyday Practices in Dar es Salaam. Doctoral thesis (Eng.D), UCL (University College London).
http://bit.ly/2tlOtA8
Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge
Dun, X-P; Carr, L; Woodley, PK; Barry, RW; Drake, LK; Mindos, T; Roberts, SL; ... Parkinson, DB; + view all Dun, X-P; Carr, L; Woodley, PK; Barry, RW; Drake, LK; Mindos, T; Roberts, SL; Lloyd, AC; Parkinson, DB; - view fewer (2019) Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge. Cell Reports , 26 (6) 1458-1472.e4. 10.1016/j.celrep.2018.12.081 . Green open access
http://bit.ly/2GOFTCb
A rare anal mass: anal leiomyoma presented as perianal fistula
http://bit.ly/2BCgfgj
Anterior mediastinal tumor as a solitary lymph node metastasis of occult thyroid carcinoma
http://bit.ly/2TPzeuQ
Hysteroscopic guided, laparoscopic excision of caesarean scar defect: video presentation of a combined technique
http://bit.ly/2TPzaLC
Circulating CD14+CD163+CD209+ M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients
Publication date: April 2019
Source: Molecular Immunology, Volume 108
Author(s): Jie Hou, Xinrui Wang, Manli Zhang, Min Wang, Pujun Gao, Yanfang Jiang
Abstract
Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. pylori infection in 35 H. pylori-associated gastritis patients and 14 healthy controls. We found that the numbers of CD14+CD163−CD64+ M1-like monocytes as well as CD14+CD163+CD206+, CD14+CD163+CD209+, and CD14+CD163+IL-10+ M2-like monocytes were significantly increased in H. pylori-infected patients in comparison with the controls, accompanied by higher levels of plasma IL-10. In addition, IL-10 production was significantly higher in the stimulated M2-like cells from patients with H. pylori infection compared with controls. Moreover, the H. pylori-infected patients with CagA- or VacA-positive strains had a significantly higher number of CD14+CD163+CD206+, CD14+CD163+CD209+, CD14+CD163+IL-10+ monocytes compared to those with CagA- or VacA-negative strains. Furthermore, patients suffering from H. pylori-positive peptic ulcers had a greater number of CD14+CD163+CD209+ monocytes than H. pylori-positive nonatrophic or atrophic gastritis patients, with the numbers of CD14+CD163+CD209+ monocytes positively correlated with the extent of H. pylori infection. Notably, the triple anti-H. pylori therapy significantly reduced the numbers of CD14+CD163+CD206+ and CD14+CD163+CD209+ monocyte subsets. In conclusion, CD14+CD163+CD209+ M2-like monocyte subsets are increased in H. pylori infection, especially in patients with peptic ulcers. CD14+CD163+CD209+ M2-like monocytes are positively associated with the severity of H. pylori infection.
http://bit.ly/2GrJu9M
Retrospective analysis of aeroallergen’s sensitization patterns in Edmonton, Canada
Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensiti...
http://bit.ly/2BzoCcu
STING-associated lung disease in mice relies on T cells but not type I interferon
Publication date: Available online 14 February 2019
Source: Journal of Allergy and Clinical Immunology
Author(s): Hella Luksch, W.Alexander Stinson, Derek J. Platt, Wei Qian, Gowri Kalugotla, Cathrine A. Miner, Brock G. Bennion, Alexander Gerbaulet, Angela Rösen-Wolff, Jonathan J. Miner
Abstract
Background
Monogenic interferonopathies are thought to be mediated by type I interferon (IFN). For example, a gain-of-function mutation in STING (STING N153S) up-regulates type I IFN-stimulated genes (ISGs) and causes perivascular inflammatory lung disease in mice. The equivalent mutation in humans also causes lung disease, which is thought to require signaling through the cGAS-STING pathway and subsequent activation of IFN regulatory factors (IRF) 3/7, type I IFN, and ISGs.
Objective
We set out to define the roles of cGAS, IRF3, IRF7, the type I IFN receptor (IFNAR1), T cells, and B cells in spontaneous lung disease in STING N153S mice.
Methods
STING N153S mice were crossed to animals lacking cGAS, IRF3/IRF7, IFNAR1, adaptive immunity, αβ T cells, and mature B cells. Mice were evaluated for spontaneous lung disease. Additionally, bone marrow chimeric mice were assessed for lung disease severity and survival.
Results
Lung disease in STING N153S mice developed independently of cGAS, IRF3/IRF7, and IFNAR1. Bone marrow transplantation revealed that certain features of STING N153S-associated disease are intrinsic to the hematopoietic compartment. Rag1-/- STING N153S mice that lack adaptive immunity had no lung disease, and Tcrβ-/- STING N153S animals only developed mild disease. STING N153S led to a reduction in percent and number of naive and regulatory T cells, as well as an increased frequency of cytokine-producing effector T cells.
Conclusion
Spontaneous lung disease in STING N153S mice develops independently of type I IFN signaling and cGAS. STING N153S relies primarily on T cells to promote lung disease in mice.
Graphical abstract
http://bit.ly/2BAIkVb
A combined immunodeficiency with severe infections, inflammation and allergy caused by ARPC1B deficiency
Publication date: Available online 13 February 2019
Source: Journal of Allergy and Clinical Immunology
Author(s): Stefano Volpi, Maria Pia Cicalese, Paul Tuijnenburg, Anton T.J. Tool, Eloy Cuadrado, Hamid Ahanchian, Raed Alzyoud, Zeynep Coban Akdemir, Federica Barzaghi, Alexander Blank, Bertrand Boisson, Cristina Bottino, Roberta Caorsi, Jean-Laurent Casanova, Sabrina Chiesa, Ivan Kingyue Chinn, Gregor Dückers, Anselm Enders, Hans Christian Erichsen, Lisa R. Forbes
http://bit.ly/2TQ1qOj
Human papillomavirus detection in matched oral rinses, oropharyngeal and oral brushings of cancer-free high-risk individuals
Publication date: April 2019
Source: Oral Oncology, Volume 91
Author(s): Maria Gabriella Donà, Barbara Pichi, Francesca Rollo, Maria Benevolo, Alessandra Latini, Valentina Laquintana, Raul Pellini, Manuela Colafigli, Mirko Frasca, Massimo Giuliani, Antonio Cristaudo
Abstract
Objectives
The detection of oral Human Papillomavirus (HPV) may be of clinical utility because of the major role HPV plays in the etiology of oropharyngeal cancer. However, oral HPV testing is not standardized and the best sampling method has yet to be identified. We aimed to compare HPV findings in matched oral rinse-and-gargles (rinses), oropharyngeal brushings and oral brushings.
Materials and methods
HPV-DNA was investigated using Linear Array in samples collected from cancer-free individuals at increased risk for oral HPV.
Results
163 oral rinses already tested for HPV were selected. The matched oropharyngeal (n = 163) and oral brushings (n = 100) were analyzed. The detection rate for any HPV, high-risk (HR)-HPVs and HPV16 was significantly higher in rinses than brushings. The overall agreement for any HPV between rinses and oropharyngeal brushings was 51.2% (Cohen K: 0.14, 95% CI: 0.07–0.21). The proportion of positive agreement was 16.8%. The overall agreement for HR-HPVs was 74.1% (Cohen K: 0.20, 95% CI: 0.07–0.33). The genotype-specific profile of rinses and brushings which were concomitantly HPV-positive only partially overlapped in cases with multiple infections, with more genotypes detected in the rinse, which were not isolated in the corresponding brushings.
Conclusion
The agreement for HPV status between rinses and brushings is poor, particularly for the HPV-positive findings. Despite the fact that the origin of the HPV-infected cells present in the oral rinse is unclear, since they could not be traced back to the oropharynx or oral cavity, oral rinses provided the highest detection rate for HR-HPVs and HPV16.
http://bit.ly/2to2ihr