Complex regional pain syndrome type II arising from a gunshot wound (GSW) associated with infective endocarditis and aortic valve replacement

A 34-year-old man with a history of gunshot wound (GSW) to the right upper chest developed secondary aortic valve endocarditis (AVE) and was treated with an artificial valve placement (AVP). Three months after, he presented to an outpatient pain management clinic right arm pain and was diagnosed with complex regional pain syndrome type II (CRPS II). The patient underwent a diagnostic sympathetic ganglion block, before undergoing endoscopic thoracic sympathectomy surgery. Successful outcomes revealed decreased pain, opioid utilisation and improved tolerance to therapy and activities of daily living. To our knowledge, this is the first case reporting CRPS II arising from a GSW complicated by AVE followed by AVP, which emphasises how unforeseen syndromes can arise from the management of seemingly unrelated pathology. This case demonstrates the importance of timely and proper diagnosis of uncharacterised residual pain status post-trauma and differential diagnosis and management of chronic pain syndromes.

https://ift.tt/2AdXaAI

Metropolitan W135 meningococcal compressive pericarditis treated with intrapericardial fibrinolysis

Meningococcal pericarditis is a rare but severe form of acute purulent pericarditis. It is a classic complication of Neisseria meningitidis of serotype W135, usually occurring in pilgrims to Mecca and their household contacts. This severe form of meningococcaemia is difficult to diagnose and evolves frequently and gradually towards a tamponade, requiring emergency drainage. We report a case of meningococcal pericarditis caused by N. meningitidis W135 in an immunocompetent patient, without any other organ involvement especially meningeal, requiring pericardium drainage in emergency and then intrapericardial fibrinolysis.

https://ift.tt/2QU39jO

Rare origin of left main coronary artery from non-coronary sinus with aortic coarctation

Anomalous origin of left main coronary artery from non-coronary sinus (LCANCS) is an extremely rare anomaly. Aortic coarctation in association with LCANCS has not been previously described in literature.

https://ift.tt/2AfiMgm

Fits, feet and HIV: lessons from a case of coexisting epilepsy and neuropathy in a patient with perinatally acquired HIV-1 infection

An 18-year-old black African man with well-controlled perinatally acquired HIV-1 was diagnosed in late adolescence with the unrelated diagnoses of Charcot-Marie-Tooth type 1A (CMT1A), epilepsy due to polymicrogyria and subsequently developed severe depression. The CMT1A diagnosis occurred after transfer of care from a local paediatric HIV service to a tertiary paediatric referral centre and was precipitated by recognition of a history and neurological signs not typically associated with perinatal HIV. The case resulted in the establishment of a quarterly combined paediatric HIV and paediatric neurology multidisciplinary team clinic to assess children and adolescents living with HIV with neurological symptoms.

https://ift.tt/2QUJQ9Z

A Rare case of recurrent Guillain-Barre syndrome without albuminocytological dissociation

Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy, often preceded by an illness. It is a self-limiting illness in most of the cases, but recurrence is rare and can be seen in about 1%–6% of patients. GBS is characterised by progressive, symmetrical, proximal and distal weakness. Areflexia and sensory disturbances are also common. Patients with GBS usually have albuminocytological dissociation on cerebrospinal fluid (CSF) analysis. This is a case of a 69-year-old woman with recurrent GBS and normal CSF findings.

https://ift.tt/2Aet3sS

Sinus arrest with prolonged asystole due to the trigeminocardiac reflex during application of local anaesthetic in the nasal mucosa

The trigeminocardiac reflex (TCR) is defined as a sudden onset of parasympathetic dysrhythmias during stimulation of the trigeminal nerve. We describe a peripheral variation of TCR during manipulation of the nasal mucosa. A 42-year-old patient suffering from severe obstructive sleep apnoea was scheduled for surgical treatment. After inducted anaesthesia, the surgeon infiltrated the nasal mucosa with a local anaesthetic. The patient immediately showed an asystole and was treated with ephedrine and five chest compressions, despite spontaneous sinus rhythm return after ceasing of manipulation. Treatment with atropine established this TCR episode and ensured an event-free surgery.

The authors present here, for the first time, a prolonged asystole caused by the TCR, triggered by minimal manipulation of the nasal mucosa. This severe manifestation of peripheral TCR demonstrates its importance in daily clinical business. This case was treated according to a modified treatment algorithm for all subtypes of TCR which is presented here.

https://ift.tt/2QXlf4w

Friedreichs sign

Description  

An 82-year-old man with chronic atrial fibrillation treated with anticoagulation was admitted to the hospital for subacute progressive exertional dyspnoea. On examination, the jugular venous waveform was elevated to the mandibular angle with the patient sitting upright. Heart sounds were muffled. Transthoracic echocardiography (TTE) revealed a large circumferential pericardial effusion with early tamponade physiology. Pericardiocentesis yielded a large volume of sanguineous fluid. Following the procedure, there was improvement in jugular venous pressure to 14 cm H₂O. The height of the waveform increased with inspiration (Kussmaul's sign) and there was a prominent y descent, known as Friedreich's sign (see video 1). Repeat TTE revealed thickened pericardium, early diastolic septal bounce and respirophasic changes in early diastolic filling consistent with constrictive pericardial physiology. Friedreich's sign is a physical finding of constrictive pericarditis. The normal jugular venous waveform contains two descents, x and y. The x descent, which corresponds...

https://ift.tt/2Aero6G

Fungal thyroiditis in a lung transplant recipient

Description  

A 59-year-old man was admitted with 3 weeks of worsening shortness of breath 18 months after receiving a bilateral lung transplant for idiopathic pulmonary fibrosis. His immunosuppression included tacrolimus, everolimus and low-dose prednisone with no antifungal prophylaxis at the time of admission. CT chest revealed multiple, bilateral pulmonary nodules (figure 1—red arrows). CT-guided biopsy revealed fungal hyphae (figure 2). The initial CT and ultrasound of the neck at the onset of sore throat was negative; however, repeat CT neck for evolving neck pain and dysphasia during hospital course showed a mass-like lesion in the right thyroid lobe with extensive surrounding inflammatory changes (figure 3—green arrow). The lesion was also visualised on ultrasound, where it appeared as a hypoechoic solitary nodule (figure 4). Laboratory evaluation revealed hyperthyroidism, with a Thyroid Stimulating Hormone (TSH) of <0.01 µIU/mL (normal: 0.35–4.94 µIU/mL) and a...

https://ift.tt/2CPWJ2b

Eurasian Steppe Chariots and Social Complexity During the Bronze Age

Abstract

This paper aims to examine some societal principles that underlie the development of horse-drawn chariots in Inner Eurasia during the Middle and Late Bronze Age (cal. 2050–1750 BC). Analysis is based on an evaluation and re-examination of the archaeological evidence for horse-drawn chariots, and the social constructs they entail. Chariots were developed in the zone of the Northern Eurasian steppes before c. 2000 BC in the context of complex but stateless societies. Because chariots depend on a set of developed skills, valuable resources, and complicated technologies, which involve several outstanding improvements to previously known solutions, they require specific conditions for their development and maintenance in social life. Most fundamentally, they require a group of people with an interest in this complex technology: a class of military elites characterized by aggrandizing behavior. The competition between collectives of military elites for resources, power and prestige brought into life the earliest chariot complex in the world.

https://ift.tt/2ykUZdx

Staphylococcus aureus from patients with chronic rhinosinusitis show minimal genetic association between polyp and non-polyp phenotypes

Abstract

Background

Staphylococcus aureus has a high prevalence in chronic rhinosinusitis (CRS) patients and is suggested to play a more etiopathogenic role in CRS patients with nasal polyps (CRSwNP), a severe form of the CRS spectrum with poorer surgical outcomes. We performed a microbial genome-wide association study (mGWAS) to investigate whether S. aureus isolates from CRS patients have particular genetic markers associated with CRS with nasal polyps (CRSwNP) or CRS without nasal polyps (CRSsNP).

Methods

Whole genome sequencing was performed on S. aureus isolates collected from 28 CRSsNP and 30 CRSwNP patients. A mGWAS approach was employed using large-scale comparative genomics to identify genetic variation within our dataset.

Results

Considerable genetic variation was observed, with > 90,000 single nucleotide polymorphisms (SNPs) sites identified. There was little correlation with CRS subtype based on SNPs and Insertion/Delection (Indels). One indel was found to significantly correlate with CRSwNP and occurred in the promoter region of a bacitracin transport system ATP-binding protein. Additionally, two variants of the highly variable superantigen-like (SSL) proteins were found to significantly correlate with each CRS phenotype. No significant association with other virulence or antibiotic resistance genes were observed, consistent with previous studies.

Conclusion

To our knowledge this study is the first to use mGWAS to investigate the contribution of microbial genetic variation to CRS presentations. Utilising the most comprehensive genome-wide analysis methods available, our results suggest that CRS phenotype may be influenced by genetic factors other than specific virulence mechanisms within the S. aureus genome.

https://ift.tt/2ClnsTc

Ipilimumab/Nivolumab-related Opsoclonus-Myoclonus-Ataxia Syndrome Variant in a Patient with Malignant Pleural Mesothelioma

Introduction: Ipilimumab and nivolumab are immune-checkpoint inhibitors commonly used for melanoma. The combination is being investigated for its efficacy against several types of cancer, including malignant pleural mesothelioma. Although immune-related adverse events have been reported in patients receiving immune-checkpoint inhibitors, opsoclonus-myoclonus-ataxia syndrome has never been previously described. Case Presentation: We describe a 74-year-old male with malignant pleural mesothelioma who presented with opsoclonus and marked truncal ataxia ∼10 weeks following immunotherapy with ipilimumab and nivolumab. No myoclonus was present. Oligoclonal bands were detected in cerebrospinal fluid. Treatment with methylprednisolone and intravenous immunoglobulin along with clonazepam and valproic acid resulted in a rapid clinical improvement. A follow-up visit 2 months afterward showed a resolution of opsoclonus and he was able to walk with cane. Conclusions: A variant of opsoclonus-myoclonus-ataxia syndrome may occur following treatment with ipilimumab and nivolumab.

https://ift.tt/2Eo5eD1

Utilizing T-cell Activation Signals 1, 2, and 3 for Tumor-infiltrating Lymphocytes (TIL) Expansion: The Advantage Over the Sole Use of Interleukin-2 in Cutaneous and Uveal Melanoma

In this study, we address one of the major critiques for tumor-infiltrating lymphocyte (TIL) therapy—the time needed for proper expansion of a suitable product. We postulated that T-cell receptor activation in the first phase of expansion combined with an agonistic stimulation of CD137/4-1BB and interleukin-2 would favor preferential expansion of CD8+ TIL. Indeed, this novel 3-signal approach for optimal T-cell activation resulted in faster and more consistent expansion of CD8+CD3+ TIL. This new method allowed for successful expansion of TIL from cutaneous and uveal melanoma tumors in 100% of the cultures in

https://ift.tt/2RSHRV3

The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell–mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells

CD40 ligand (TNFSF5/CD154/CD40L), a member of the tumor necrosis factor (TNF) superfamily is a key regulator of the immune system. The cognate receptor CD40 (TNFRSF5) is expressed broadly on antigen-presenting cells and many tumor types, and has emerged as an attractive target for immunologic cancer treatment. Most of the CD40 targeting drugs in clinical development are antibodies which display some disadvantages: their activity typically depends on Fcγ receptor–mediated crosslinking, and depletion of CD40-expressing immune cells by antibody-dependent cellular cytotoxicity compromises an efficient antitumor response. To overcome the inadequacies of antibodies, we have developed the hexavalent receptor agonist (HERA) Technology. HERA compounds are fusion proteins composed of 3 receptor binding domains in a single chain arrangement, linked to an Fc-silenced human IgG1 thereby generating a hexavalent molecule. HERA-CD40L provides efficient receptor agonism on CD40-expressing cells and, importantly, does not require FcγR-mediated crosslinking. Strong activation of NFκB signaling was observed upon treatment of B cells with HERA-CD40L. Monocyte treatment with HERA-CD40L promoted differentiation towards the M1 spectrum and repolarization of M2 spectrum macrophages towards the M1 spectrum phenotype. Treatment of in vitro co-cultures of T and B cells with HERA-CD40L–triggered robust antitumor activation of T cells, which depended upon direct interaction with B cells. In contrast, bivalent anti-CD40 antibodies and trivalent soluble CD40L displayed weak activity which critically depended on crosslinking. In vivo, a murine surrogate of HERA-CD40L–stimulated clonal expansion of OT-I–specific murine CD8+ T cells and showed single agent antitumor activity in the CD40− syngeneic MC38-CEA mouse model of colorectal cancer, suggesting an involvement of the immune system in controlling tumor growth. We conclude that HERA-CD40L is able to establish robust antitumor immune responses both in vitro and in vivo.

https://ift.tt/2EoTtMT

Hemofiltration Successfully Eliminates Severe Cytokine Release Syndrome Following CD19 CAR-T-Cell Therapy

Cytokine release syndrome (CRS) remains to be a major adverse effect of chimeric antigen receptor T (CAR-T) cell therapy in B-cell acute lymphoblastic leukemia (B-ALL) and lymphoma. It was urgent to explore novel strategy for managing severe CRS. We conducted a clinical trial to assess the safety and efficacy of CD19-targeting CAR-T-cells in the treatment of relapsed and chemotherapy-refractory B-ALL and lymphoma. A 10-year-old boy with B-ALL who never achieved minimal residual disease (MRD) negative status after 5 courses of chemotherapy was enrolled into our study and received a total of 3.19×106/kg autologous CD19 CAR-T-cells. Before CAR-T-cell infusion, naive lymphocytes made up 41.8% of bone marrow cells, which were reduced to 1% at the 14th day after transfusion, with MRD

https://ift.tt/2RUoDyf

Treatment With Tumor-infiltrating Lymphocytes in Advanced Melanoma: Evaluation of Early Clinical Implementation of an Advanced Therapy Medicinal Product

Tumor-infiltrating lymphocytes (TIL)-therapy in advanced melanoma is an advanced therapy medicinal product (ATMP) which, despite promising results, has not been implemented widely. In a European setting, TIL-therapy has been in use since 2011 and is currently being evaluated in a randomized controlled trial. As clinical implementation of ATMPs is challenging, this study aims to evaluate early application of TIL-therapy, through the application of a constructive technology assessment (CTA). First the literature on ATMP barriers and facilitators in clinical translation was summarized. Subsequently, application of TIL-therapy was evaluated through semistructured interviews with 26 stakeholders according to 6 CTA domains: clinical, economic, patient-related, organizational, technical, and future. In addition, treatment costs were estimated. A number of barriers to clinical translation were identified in the literature, including: inadequate financial support, lack of regulatory knowledge, risks in using live tissues, and the complex path to market approval. Innovative reimbursement procedures could particularly facilitate translation. The CTA survey of TIL-therapy acknowledged these barriers, and revealed the following facilitators: the expected effectiveness resulting in institutional support for an internal pilot, the results of which led to the inclusion of TIL-therapy in a national coverage with evidence development program, the availability of an in-house pharmacist, quality assurance expertise and a TIL-skilled technician. Institutional and national implementation of TIL-therapy remains complex. The promising clinical effectiveness is expected to facilitate the adoption of TIL-therapy, especially when validated through a randomized controlled trial. Innovative and conditional reimbursement procedures, together with the organization of knowledge transfer, could support and improve clinical translation of TIL and ATMPs.

https://ift.tt/2Esw2SO

Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2EqYJ2y

Acute Physical Effort Increases Sympathovagal Balance Responses to Autonomic Stimulation in Metabolic Syndrome

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2RUhSwv

c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer

Thyroid, Ahead of Print.


https://ift.tt/2P7XYPQ

Persistent/Recurrent Differentiated Thyroid Cancer: Clinical and Radiological Characteristics of Persistent Disease and Clinical Recurrence Based on Computed Tomography Analysis

Thyroid, Ahead of Print.


https://ift.tt/2PDo4qW

Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential

Thyroid, Ahead of Print.


https://ift.tt/2P22Xl3

Gasless Transaxillary Endoscopic Thyroidectomy with Robotic Assistance: A High-Volume Experience in North America

Thyroid, Ahead of Print.


https://ift.tt/2PDnXM2

Response to Lenvatinib in Children with Papillary Thyroid Carcinoma

Thyroid, Ahead of Print.


https://ift.tt/2P1b15F

Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma

Thyroid, Ahead of Print.


https://ift.tt/2PDnTMi

Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation

Thyroid, Ahead of Print.


https://ift.tt/2P7XXeK

Staphylococcus aureus from patients with chronic rhinosinusitis show minimal genetic association between polyp and non-polyp phenotypes

Staphylococcus aureus has a high prevalence in chronic rhinosinusitis (CRS) patients and is suggested to play a more etiopathogenic role in CRS patients with nasal polyps (CRSwNP), a severe form of the CRS spectr...

https://ift.tt/2P14CYi

Current approaches to instrumental assessment of swallowing in children

Purpose of the review This article reviews recent developments in the instrumental assessment of swallowing in children with a specific focus on research published between January 2017 and June 2018. Recent findings Instrumental swallowing assessments reported in the time period included: videofluoroscopic study of swallowing, digital cervical auscultation, dynamic ultrasound, high-resolution impedance manometry, nasal airflow thermistry and respiratory inductance plethysmography. Several studies were found exploring tools to objectively quantify videofluoroscopic study of swallowing data; swallowing from the mouth through to stomach was addressed including approaches to analysing mastication as well as evaluating oesophageal motility disorders. Summary Even though a vast range of instrumentation were studied, lack of clarity on clinical feasibility and objective measures that facilitate medical decision-making in practice mean further research is required to provide guidance on implementation. Promising novel approaches to aid the quantification of swallowing physiology from the mouth, pharynx and through to the oesophagus are emerging. Correspondence to Isuru Dharmarathna, BSc, Speech Science, School of Psychology, Tamaki Campus, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Tel: +64 9 923 8177; fax: +64 9 373 7902; e-mail: pdha800@aucklanduni.ac.nz Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2Afqnvh

Current approaches to instrumental assessment of swallowing in children

Purpose of the review This article reviews recent developments in the instrumental assessment of swallowing in children with a specific focus on research published between January 2017 and June 2018. Recent findings Instrumental swallowing assessments reported in the time period included: videofluoroscopic study of swallowing, digital cervical auscultation, dynamic ultrasound, high-resolution impedance manometry, nasal airflow thermistry and respiratory inductance plethysmography. Several studies were found exploring tools to objectively quantify videofluoroscopic study of swallowing data; swallowing from the mouth through to stomach was addressed including approaches to analysing mastication as well as evaluating oesophageal motility disorders. Summary Even though a vast range of instrumentation were studied, lack of clarity on clinical feasibility and objective measures that facilitate medical decision-making in practice mean further research is required to provide guidance on implementation. Promising novel approaches to aid the quantification of swallowing physiology from the mouth, pharynx and through to the oesophagus are emerging. Correspondence to Isuru Dharmarathna, BSc, Speech Science, School of Psychology, Tamaki Campus, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Tel: +64 9 923 8177; fax: +64 9 373 7902; e-mail: pdha800@aucklanduni.ac.nz Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

https://ift.tt/2Afqnvh

The speech perception after cochlear implantation: The hearing gain difference according to the implant systems is important?

The outcome of cochlear implantation (CI) is affected by various factors, including the manufacturer of the device. We validated the factors contributing to postoperative performance and evaluated the influence of different company devices on pure tone thresholds and postoperative performance.

https://ift.tt/2P7IYl0

Pleuroparenchymal fibroelastosis as a histological background of autoimmune diseases

Abstract

Patients with autoimmune disease–related interstitial lung disease (AID-ILD) occasionally develop radiologic pleuroparenchymal fibroelastosis (PPFE)–like lesions. However, the significance of AID as an etiology of PPFE has not been fully elucidated. The aim of this study is to verify the increase of elastic fibers in AID-ILD patients and evaluate the prevalence of histological PPFE in patients with AID-ILD. We selected cases of clinically diagnosed AID-ILD and idiopathic pulmonary fibrosis (IPF), in which an autopsy had been performed or in which the patient had undergone pneumonectomy for lung transplantation. We quantified the collagen fibers and elastic fibers in each lobe as the percentage of the non-aerated lung area (collagen fiber score and elastic fiber score, respectively) in histological specimens from a total of 73 patients (AID-ILD, n = 24; IPF, n = 49). There were no significant differences in the collagen fiber scores of the AID-ILD and IPF groups. Meanwhile, the elastic fiber scores of the AID-ILD group were significantly greater than those of the IPF group in the whole lung (17.3 ± 7.70 vs 11.6 ± 4.55), and the upper (16.6 ± 8.11 vs 11.2 ± 5.18), and lower (18.0 ± 9.68 vs 12.0 ± 5.55) lobes (all p < 0.01). Histological PPFE pattern was found in 12 of 24 AID-ILD patients (50%), and histological PPFE pattern as a dominant pattern of fibrosis was found in 2 of the 24 patients (8%). Thus, PPFE can be a manifestation of AID-ILD.

https://ift.tt/2yGMqcc

Correction for Lee et al., Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models [Correction]

APPLIED BIOLOGICAL SCIENCES Correction for "Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models," by Kyu-Sun Lee, Sungun Huh, Seongsoo Lee, Zhihao Wu, Ae-Kyeong Kim, Ha-Young Kang, and Bingwei Lu, which was first published September 5, 2018; 10.1073/pnas.1721136115 (Proc Natl Acad Sci USA...

https://ift.tt/2QUU9Lj

Correction for Sanchez et al., Near-term deployment of carbon capture and sequestration from biorefineries in the United States [Correction]

SUSTAINABILITY SCIENCE Correction for "Near-term deployment of carbon capture and sequestration from biorefineries in the United States," by Daniel L. Sanchez, Nils Johnson, Sean T. McCoy, Peter A. Turner, and Katharine J. Mach, which was first published April 23, 2018; 10.1073/pnas.1719695115 (Proc Natl Acad Sci USA 115:4875–4880). The authors note...

https://ift.tt/2Af1RKG

Correction for CaraDonna et al., Shifts in flowering phenology reshape a subalpine plant community [Correction]

ECOLOGY Correction for "Shifts in flowering phenology reshape a subalpine plant community," by Paul J. CaraDonna, Amy M. Iler, and David W. Inouye, which was first published March 17, 2014; 10.1073/pnas.1323073111 (Proc Natl Acad Sci USA 111:4916–4921). The authors note that Fig. 3 appeared incorrectly. The corrected figure and its...

https://ift.tt/2AdUFOV

Converging evidence for functional and structural segregation within the left ventral occipitotemporal cortex in reading [Psychological and Cognitive Sciences]

The ventral occipitotemporal cortex (vOTC) is crucial for recognizing visual patterns, and previous evidence suggests that there may be different subregions within the vOTC involved in the rapid identification of word forms. Here, we characterize vOTC reading circuitry using a multimodal approach combining functional, structural, and quantitative MRI and behavioral...

https://ift.tt/2QUUaPn

Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase [Plant Biology]

Stomatal pore apertures are narrowing globally due to the continuing rise in atmospheric [CO2]. CO2 elevation and the plant hormone abscisic acid (ABA) both induce rapid stomatal closure. However, the underlying signal transduction mechanisms for CO2/ABA interaction remain unclear. Two models have been considered: (i) CO2 elevation enhances ABA concentrations...

https://ift.tt/2IYDXps

DNA demethylase ROS1 negatively regulates the imprinting of DOGL4 and seed dormancy in Arabidopsis thaliana [Plant Biology]

Genomic imprinting is a form of epigenetic regulation resulting in differential gene expression that reflects the parent of origin. In plants, imprinted gene expression predominantly occurs in the seed endosperm. Maternal-specific DNA demethylation by the DNA demethylase DME frequently underlies genomic imprinting in endosperm. Whether other more ubiquitously expressed DNA...

https://ift.tt/2Ou4S2n

Changes in resource partitioning between and within organs support growth adjustment to neighbor proximity in Brassicaceae seedlings [Plant Biology]

In shade-intolerant plants, the perception of proximate neighbors rapidly induces architectural changes resulting in elongated stems and reduced leaf size. Sensing and signaling steps triggering this modified growth program have been identified. However, the underlying changes in resource allocation that fuel stem growth remain poorly understood. Through 14CO2 pulse labeling...

https://ift.tt/2IZWqSK

High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing [Pharmacology]

Dysfunctional endothelium causes more disease than any other cell type. Systemically administered RNA delivery to nonliver tissues remains challenging, in large part because there is no high-throughput method to identify nanoparticles that deliver functional mRNA to cells in vivo. Here we report a system capable of simultaneously quantifying how >100...

https://ift.tt/2OrLcw5

Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice [Neuroscience]

The tight balance between synaptic excitation and inhibition (E/I) within neocortical circuits in the mammalian brain is important for complex behavior. Many loss-of-function studies have demonstrated that brain-derived neurotrophic factor (BDNF) and its cognate receptor tropomyosin receptor kinase B (TrkB) are essential for the development of inhibitory GABAergic neurons. However,...

https://ift.tt/2OtGIW0

Natural molecules induce and synergize to boost expression of the human antimicrobial peptide {beta}-defensin-3 [Immunology and Inflammation]

Antimicrobial peptides (AMPs) are mucosal defense effectors of the human innate immune response. In the intestine, AMPs are produced and secreted by epithelial cells to protect the host against pathogens and to support homeostasis with commensals. The inducible nature of AMPs suggests that potent inducers could be used to increase...

https://ift.tt/2OrBU3f

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers [Biochemistry]

Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem proteinopathy. Mutation of aspartic acid...

https://ift.tt/2IZWy4G

CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth [Immunology and Inflammation]

Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5–producing CXCR6+ST2+CD44+ mTh2 cells play...

https://ift.tt/2OwZ7B5

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex [Biochemistry]

Autophagy is an enigmatic cellular process in which double-membrane compartments, called "autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and package cytoplasmic contents for delivery to lysosomes. Expansion of the precursor membrane phagophore requires autophagy-related 2 (ATG2), which localizes to the PI3P-enriched ER–phagophore junction. We combined single-particle electron...

https://ift.tt/2OuhYwO

Role of PDGF receptor-{alpha} during human cytomegalovirus entry into fibroblasts [Microbiology]

Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in fibroblasts and a pentameric complex (gH/gL/pUL128-pUL130-pUL131A) that mediates infection in epithelial and endothelial cells. We performed genome-wide CRISPR screens in which the PDGF receptor-α (PDGFRα)...

https://ift.tt/2OusTGL

Long noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2 [Cell Biology]

Although many long noncoding RNAs (lncRNAs) have been identified in muscle, their physiological function and regulatory mechanisms remain largely unexplored. In this study, we systematically characterized the expression profiles of lncRNAs during C2C12 myoblast differentiation and identified an intronic lncRNA, SYISL (SYNPO2 intron sense-overlapping lncRNA), that is highly expressed in...

https://ift.tt/2J24bY6

Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion [Neuroscience]

A particularly essential determinant of a neuron's functionality is its neurotransmitter phenotype. While the prevailing view is that neurotransmitter phenotypes are fixed and determined early during development, a growing body of evidence suggests that neurons retain the ability to switch between different neurotransmitters. However, such changes are considered unlikely in...

https://ift.tt/2OwZ7kz

Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells [Developmental Biology]

The ability of cells to collectively interpret surrounding environmental signals underpins their capacity to coordinate their migration in various contexts, including embryonic development and cancer metastasis. One tractable model for studying collective migration is the parapineal, a left-sided group of neurons that arises from bilaterally positioned precursors that undergo a...

https://ift.tt/2OtaJVO

Raf kinase inhibitor protein negatively regulates FcϵRI-mediated mast cell activation and allergic response [Immunology and Inflammation]

The signaling cascades triggered by the cross-linkage of immunoglobulin E (IgE) with its high-affinity receptor (FcεRI) on mast cells contribute to multiple allergic disorders, such as asthma, rhinitis, and atopic dermatitis. Restraint of intracellular signals for mast cell activation is essential to restore homeostasis. In this study, we found that...

https://ift.tt/2J0QKHT

Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti [Developmental Biology]

Disease-transmitting female mosquitoes require a vertebrate blood meal to produce their eggs. An obligatory hematophagous lifestyle, rapid reproduction, and existence of a large number of transmittable diseases make mosquitoes the world's deadliest animals. Attaining optimal body size and nutritional status is critical for mosquitoes to become reproductively competent and effective...

https://ift.tt/2J248LU

Integrative genomic analysis of mouse and human hepatocellular carcinoma [Medical Sciences]

Cancer genomics has enabled the exhaustive molecular characterization of tumors and exposed hepatocellular carcinoma (HCC) as among the most complex cancers. This complexity is paralleled by dozens of mouse models that generate histologically similar tumors but have not been systematically validated at the molecular level. Accurate models of the molecular...

https://ift.tt/2IYEQ1j

The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: a case series

The purpose of this study was to evaluate the benefit of induction chemotherapy followed by surgery in locally advanced unresectable stage IVb laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).

https://ift.tt/2J3lgRq

EPSA17: Selected papers from the biannual conference in Exeter

https://ift.tt/2CKAZF3

The role of induction chemotherapy followed by surgery in unresectable stage IVb laryngeal and hypopharyngeal cancers: a case series

Abstract

Background

The purpose of this study was to evaluate the benefit of induction chemotherapy followed by surgery in locally advanced unresectable stage IVb laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC).

Methods

Data of patients with stage IVb LHSCC who received induction chemotherapy for the purpose of tumor resection between January 2007 and January 2016 were retrospectively collected. Definitive surgery with postoperative adjuvant therapy was performed in patients whose tumors became resectable (resectable group). Chemoradiotherapy, radiotherapy, or supportive care was considered in patients whose tumors remained unresectable (unresectable group).

Results

Thirty-two patients were identified; the tumor resectability rate after induction chemotherapy was approximately 56%. The median overall survival (OS) rates of the resectable and unresectable groups were 20.0 months (range, 16.0–35.5 months) and 9.5 months (range, 6.0–15.0 months), respectively (p = 0.008). The estimated 2-year OS rates of the resectable and unresectable groups were 59.5% (95% confidence interval [CI], 33.2–78.3%) and 10.7% (95% CI, 1.1–35.4%), respectively (p = 0.008). The estimated 2-year disease-free survival (DFS) rates of the resectable and unresectable groups were 53.5% (95% CI, 27.9–73.6%), and 14.3% (95% CI, 2.3–36.6%), respectively (p = 0.009). On multivariate analysis, factors positively impacting OS and DFS in all patients were surgical resection, a laryngeal primary site, and induction chemotherapy with docetaxel, cisplatin, and fluorouracil.

Conclusions

In advanced unresectable stage IVb LHSCC patients, surgical resection following induction chemotherapy appears to improve survival outcomes.

https://ift.tt/2Ad4kFw

Radiation Oncology Mobile Application

Conditions:   Head and Neck Cancer;   Radiation Toxicity
Intervention:  
Sponsor:   King Hussein Cancer Center
Not yet recruiting

https://ift.tt/2RUVnro

Phase III Study of Camrelizumab in Combination With Chemotherapy in Recurrent/Metastatic Nasopharyngeal Carcinoma

Condition:   Nasopharyngeal Carcinoma
Interventions:   Drug: Camrelizumab;   Drug: Placebos;   Drug: Gemcitabine;   Drug: Cisplatin
Sponsor:   Jiangsu HengRui Medicine Co., Ltd.
Not yet recruiting

https://ift.tt/2EmUpBn

The Effect of Functional Exercises on Balance With Postural Thoracic Kyphosis

Conditions:   Postural Kyphosis;   Balance
Interventions:   Behavioral: The Group I Postural Exercise;   Behavioral: The Group II Three-dimensional Exercise Therapy Program
Sponsor:   Istanbul Medipol University Hospital
Recruiting

https://ift.tt/2RMKS9r

Genetic Analysis of Blood and Tissue Samples From Participants With Advanced Cancer

Conditions:   Advanced Melanoma;   Advanced Renal Cell Carcinoma;   Anatomic Stage III Breast Cancer AJCC v8;   Anatomic Stage IIIA Breast Cancer AJCC v8;   Anatomic Stage IIIB Breast Cancer AJCC v8;   Anatomic Stage IIIC Breast Cancer AJCC v8;   Anatomic Stage IV Breast Cancer AJCC v8;   Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IIIA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IIIB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8;   Pathologic Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8;   Prognostic Stage III Breast Cancer AJCC v8;   Prognostic Stage IIIA Breast Cancer AJCC v8;   Prognostic Stage IIIB Breast Cancer AJCC v8;   Prognostic Stage IIIC Breast Cancer AJCC v8;   Prognostic Stage IV Breast Cancer AJCC v8;   Stage III Colorectal Cancer AJCC v8;   Stage III Lung Cancer AJCC v8;   Stage III Ovarian Cancer AJCC v8;   Stage III Prostate Cancer AJCC v8;   Stage IIIA Colorectal Cancer AJCC v8;   Stage IIIA Lung Cancer AJCC v8;   Stage IIIA Ovarian Cancer AJCC v8;   Stage IIIA Prostate Cancer AJCC v8;   Stage IIIA1 Ovarian Cancer AJCC v8;   Stage IIIA2 Ovarian Cancer AJCC v8;   Stage IIIB Colorectal Cancer AJCC v8;   Stage IIIB Lung Cancer AJCC v8;   Stage IIIB Ovarian Cancer AJCC v8;   Stage IIIB Prostate Cancer AJCC v8;   Stage IIIC Colorectal Cancer AJCC v8;   Stage IIIC Lung Cancer AJCC v8;   Stage IIIC Ovarian Cancer AJCC v8;   Stage IIIC Prostate Cancer AJCC v8;   Stage IV Colorectal Cancer AJCC v8;   Stage IV Lung Cancer AJCC v8;   Stage IV Ovarian Cancer AJCC v8;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Colorectal Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVA Ovarian Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Colorectal Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8;   Stage IVB Ovarian Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8;   Stage IVC Colorectal Cancer AJCC v8
Intervention:   Procedure: Biospecimen Collection
Sponsor:   National Cancer Institute (NCI)
Not yet recruiting

https://ift.tt/2EnJmYH

Safety, Tolerability and Efficacy Profile of Rivoceranib With Paclitaxel in Advanced GC or GEJ Cancer.

Conditions:   Gastric Cancer;   Gastroesophageal Junction Adenocarcinoma
Interventions:   Drug: Rivoceranib;   Drug: Paclitaxel
Sponsor:   LSK BioPartners Inc.
Not yet recruiting

https://ift.tt/2RW9Sez

Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica

Condition:   Back Pain
Intervention:   Other: Spine Exercise Program
Sponsor:   The University of The West Indies
Not yet recruiting

https://ift.tt/2EkHuQi

CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer

Condition:   Advanced Esophageal Cancer
Interventions:   Biological: Anti-MUC1 CAR-T cells;   Biological: PD-1 knockout Engineered T cells;   Combination Product: CAR-T combined with PD-1 Knockout T cells
Sponsors:   The First Affiliated Hospital of Guangdong Pharmaceutical University;   Guangzhou Anjie Biomedical Technology Co;LTD
Recruiting

https://ift.tt/2RUNxxD

A Study to Compare Efficacy and Safety of DRT VS CRT Plus Surgery in Patients Who Achieved CCR for Esophageal Cancer

Conditions:   Stage II Esophageal Cancer;   Stage III Esophageal Cancer
Interventions:   Combination Product: Definitive Radiochemotherapy;   Combination Product: Neoadjuvant Radiochemotherapy
Sponsors:   Tianjin Medical University Cancer Institute and Hospital;   Cancer Institute and Hospital, Chinese Academy of Medical Sciences;   Sun Yat-sen University;   Beijing Cancer Hospital
Not yet recruiting

https://ift.tt/2EmU0yR

Environmental and Life-Style Related Risk Factors for Sinonasal and Nasopharyngeal Malignancies among a Prospective Cohort in Jos, Nigeria

Background. Worldwide evidence indicates that environmental and life-style related factors are associated with increased risk for cancers in the head and neck region. We aim to study the association between these risk factors and cancers in the sinonasal and nasopharyngeal regions in our environment. Methods. Longitudinal prospective cohort study at the Jos University Teaching Hospital, Jos, Nigeria. Risk exposures were classified based on the International Agency for the Research on Cancer (IARC) classification of suspected carcinogens. Associations between variables were analyzed using logistic regression. Results. We studied 44 patients with malignancies in nasopharynx (n= 24; 54.5%) and sinonasal regions (n= 20; 45.5%). Male to female ratio is 1.9:1 and mean age is 45.2 years. Alcohol was the commonest risk factor in males (n= 19; 43.2%) while cooking wood fumes were the commonest in females (n= 14; 31.8%) which was associated with increased risk for malignancies for all sites, showing ten times risk in nasal cancers (OR= 9.67; 95% CI 1.87- 9.88; p= 0.01). Tobacco was associated with elevated risk of malignancies in the nasomaxillary and nasal regions. Other risks were herbicides, pesticides, and chemical fertilizers in farmers. Conclusion. The significant risk exposures in females were cooking wood fumes and alcohol, tobacco, and exposure to agricultural chemicals in males. Life-style modification and environmental changes to ensure clean air in Nigeria are essential to reduce risks.

https://ift.tt/2EqmZlr

Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process

Goldrick, S; Lovett, D; Montague, G; Lennox, B; (2018) Influence of Incident Wavelength and Detector Material Selection on Fluorescence in the Application of Raman Spectroscopy to a Fungal Fermentation Process. Bioengineering , 5 (4) , Article 79. 10.3390/bioengineering5040079 . Green open access

https://ift.tt/2pT6tAd

The Experience of Improvising in Organizations: A Creative Process Perspective

Fisher, CM; Barrett, FJ; (2018) The Experience of Improvising in Organizations: A Creative Process Perspective. Academy of Management Perspectives 10.5465/amp.2017.0100 . (In press). Green open access

https://ift.tt/2NKmAcX

Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data

Macdougall, IC; White, C; Anker, SD; Bhandari, S; Farrington, K; Kalra, PA; McMurray, JJV; ... PIVOTAL Trial investigators, .; + view all Macdougall, IC; White, C; Anker, SD; Bhandari, S; Farrington, K; Kalra, PA; McMurray, JJV; Murray, H; Steenkamp, R; Tomson, CRV; Wheeler, DC; Winearls, CG; Ford, I; PIVOTAL Trial investigators, .; - view fewer (2018) Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data. American Journal of Nephrology , 48 (4) pp. 260-298. 10.1159/000493551 . Green open access

https://ift.tt/2pVJXH3

Subjective Evaluation of the Environmental Quality in China's Industrial Corridors

Xu, J; Zhang, M; Shao, L; Kang, J; (2016) Subjective Evaluation of the Environmental Quality in China's Industrial Corridors. Journal of Environmental Engineering & Landscape Management , 24 (1) pp. 21-36. 10.3846/16486897.2015.1100997 . Green open access

https://ift.tt/2NH6noF

Resistant Hypertension Trials and Tribulations

George, MJ; Marks, DJB; Rezk, T; Breckenridge, R; Sofat, R; Martin, J; MacAllister, R; ... Hingorani, A; + view all George, MJ; Marks, DJB; Rezk, T; Breckenridge, R; Sofat, R; Martin, J; MacAllister, R; Touyz, RM; Staessen, JA; Bursztyn, M; Lappin, D; Barigou, M; Hingorani, A; - view fewer (2018) Resistant Hypertension Trials and Tribulations. Hypertension , 71 (5) pp. 772-780. 10.1161/HYPERTENSIONAHA.118.10864 .

https://ift.tt/2pU5e3B

Potential risks of iatrogenic complications of nerve conduction studies (NCS) and electromyography (EMG)

Gechev, A; Kane, NM; Koltzenburg, M; Rao, DG; van der Star, R; (2016) Potential risks of iatrogenic complications of nerve conduction studies (NCS) and electromyography (EMG). Clinical Neurophysiology Practice , 1 pp. 62-66. 10.1016/j.cnp.2016.09.003 . Green open access

https://ift.tt/2NKmwtJ

Identifying diagnostic test accuracy publications using a deep model

Singh, G; Marshall, I; Thomas, J; Wallace, B; (2017) Identifying diagnostic test accuracy publications using a deep model. In: Cappellato, L and Ferro, N and Goeuriot, L and Mandl, T, (eds.) CLEF 2017 Working Notes: Working Notes of CLEF 2017 - Conference and Labs of the Evaluation Forum. CEUR Workshop Proceedings: Dublin, Ireland. Green open access

https://ift.tt/2q3eXVH

Quantitative MRI in post-operative paediatric cerebellar mutism syndrome

Toescu, SM; Hales, PW; Aquilina, K; Clark, CA; (2018) Quantitative MRI in post-operative paediatric cerebellar mutism syndrome. European Journal of Radiology , 108 pp. 43-51. 10.1016/j.ejrad.2018.09.007 .

https://ift.tt/2NHWZ4g

Search for annual and diurnal rate modulations in the LUX experiment

Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Balajthy, J; Beltrame, P; Bernard, EP; ... Zhang, C; + view all Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Balajthy, J; Beltrame, P; Bernard, EP; Bernstein, A; Biesiadzinski, TP; Boulton, EM; Boxer, B; Bras, P; Burdin, S; Byram, D; Carmona-Benitez, MC; Chan, C; Cutter, JE; Davison, TJR; Druszkiewicz, E; Fallon, SR; Fan, A; Fiorucci, S; Gaitskell, RJ; Genovesi, J; Ghag, C; Gilchriese, MGD; Gwilliam, C; Hall, CR; Haselschwardt, SJ; Hertel, SA; Hogan, DP; Horn, M; Huang, DQ; Ignarra, CM; Jacobsen, RG; Ji, W; Kamdin, K; Kazkaz, K; Khaitan, D; Knoche, R; Korolkova, EV; Kravitz, S; Kudryavtsev, VA; Lenardo, BG; Lesko, KT; Liao, J; Lin, J; Lindote, A; Lopes, MI; Manalaysay, A; Mannino, RL; Marangou, N; Marzioni, MF; McKinsey, DN; Mei, D-M; Moongweluwan, M; Morad, JA; Murphy, ASJ; Nehrkorn, C; Nelson, HN; Neves, F; Oliver-Mallory, KC; Palladino, KJ; Pease, EK; Rischbieter, GRC; Rhyne, C; Rossiter, P; Shaw, S; Shutt, TA; Silva, C; Solmaz, M; Solovov, VN; Sorensen, P; Sumner, TJ; Szydagis, M; Taylor, DJ; Taylor, WC; Tennyson, BP; Terman, PA; Tiedt, DR; To, WH; Tripathi, M; Tvrznikova, L; Utku, U; Uvarov, S; Velan, V; Verbus, JR; Webb, RC; White, JT; Whitis, TJ; Witherell, MS; Wolfs, FLH; Woodward, D; Xu, J; Yazdani, K; Zhang, C; - view fewer (2018) Search for annual and diurnal rate modulations in the LUX experiment. Physical Review D , 98 (6) 10.1103/PhysRevD.98.062005 . Green open access

https://ift.tt/2pTh664

Polycentric Competition Law

Lianos, I; (2019) Polycentric Competition Law. Current Legal Problems (In press).

https://ift.tt/2NKqHWc

What does the financial market pricing do? A simulation analysis with a view to systemic volatility, exuberance and vagary

Biondi, Y; Righi, S; (2016) What does the financial market pricing do? A simulation analysis with a view to systemic volatility, exuberance and vagary. Journal of Economic Interaction and Coordination , 11 (2) pp. 175-203. 10.1007/s11403-015-0159-3 . Green open access

https://ift.tt/2pWH74g

Won’t somebody please think of the children? Hate speech, harm, and childhood

Simpson, RM; (2019) Won't somebody please think of the children? Hate speech, harm, and childhood. Law and Philosophy (In press).

https://ift.tt/2NKqClm

The impact of hunting on tropical mammal and bird populations

Benítez-López, A; Alkemade, R; Schipper, AM; Ingram, DJ; Verweij, PA; Eikelboom, JAJ; Huijbregts, MAJ; (2017) The impact of hunting on tropical mammal and bird populations. Science , 356 (6334) pp. 180-183. 10.1126/science.aaj1891 . Green open access

https://ift.tt/2pWH5JG

Distinct TDP-43 aggregate features and toxicity stratify FTD patients

Laferriere, F; Maniecja, Z; Perez-Berlanga, M; Hruska-Plochan, M; Larissa, G; Hock, E-M; Wagner, U; ... Polymenidou, M; + view all Laferriere, F; Maniecja, Z; Perez-Berlanga, M; Hruska-Plochan, M; Larissa, G; Hock, E-M; Wagner, U; Afroz, T; Boersema, PJ; Barmettler, G; Foti, S; Asi, Y; Isaacs, A; Al-Amoudi, A; Lewis, A; Henning, S; Ravits, J; De Giorgi, F; Ichas, F; Erwan, B; Paola, P; Lashley, TC; Polymenidou, M; - view fewer (2019) Distinct TDP-43 aggregate features and toxicity stratify FTD patients. Nature Neuroscience (In press).

https://ift.tt/2NL1Kdd

A viewpoint from the Foothills: Making Sepik Valley images as containers

Coupaye, L; (2018) A viewpoint from the Foothills: Making Sepik Valley images as containers. Journal de la Société des océanistes , 146 pp. 227-238. 10.4000/jso.8024 .

https://ift.tt/2pXfZCy

Root coverage procedures for treating localised and multiple recession-type defects

Chambrone, L; Salinas Ortega, MA; Sukekava, F; Rotundo, R; Zamira, K; Buti, J; Pini Prato, GP; (2018) Root coverage procedures for treating localised and multiple recession-type defects. Cochrane Database of Systematic Reviews , 10 , Article CD007161. 10.1002/14651858.CD007161.pub3 .

https://ift.tt/2NIBlgf

Reconciling Regulation with Scientific Autonomy in Dual-use Research

Evans, N; Selgelid, M; Simpson, RM; (2019) Reconciling Regulation with Scientific Autonomy in Dual-use Research. Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine (In press).

https://ift.tt/2pXfRmy

A road less travelled: early childhood evidence to investment

Britto, PR; Sherr, L; (2016) A road less travelled: early childhood evidence to investment. Vulnerable Children and Youth Studies , 11 (3) pp. 193-210. 10.1080/17450128.2016.1220659 . Green open access

https://ift.tt/2NIBal5

Understanding mothers' decision-making needs for autopsy consent after stillbirth: Framework analysis of a large survey

Schirmann, A; Boyle, FM; Horey, D; Siassakos, D; Ellwood, D; Rowlands, I; Flenady, V; (2018) Understanding mothers' decision-making needs for autopsy consent after stillbirth: Framework analysis of a large survey. Birth , 45 (3) pp. 255-262. 10.1111/birt.12344 .

https://ift.tt/2q3eT8p

Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate

Magdalinou, NK; Golden, HL; Nicholas, JM; Witoonpanich, P; Mummery, CJ; Morris, HR; Djamshidian, A; ... Warren, JD; + view all Magdalinou, NK; Golden, HL; Nicholas, JM; Witoonpanich, P; Mummery, CJ; Morris, HR; Djamshidian, A; Warner, TT; Warrington, EK; Lees, AJ; Warren, JD; - view fewer (2018) Verbal adynamia in parkinsonian syndromes: behavioral correlates and neuroanatomical substrate. Neurocase 10.1080/13554794.2018.1527368 . (In press). Green open access

https://ift.tt/2NK9nRs

Bilateral subdural empyemas with meningitis secondary to acute barosinusitis

Publication date: Available online 15 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): J. Sung, O. Kwon, D. Kim, K. Kim

Abstract

Introduction

Intracranial complications of acute rhinosinusitis are rare, but may turn life-threatening.

Case summary

We report a healthy 30-year-old male who complained of frontal headache, which developed while on a plane. A brain CT showed a low-density lesion on the left frontal convexity with right maxillary and ethmoid sinusitis. Despite receiving intravenous antibiotics, a follow-up brain CT showed two lesions with adjacent dural and leptomeningeal enhancement. A paranasal sinus CT revealed aggravated left frontal sinusitis and right maxillary sinusitis. The patient underwent craniotomy and brain abscess removal along with endoscopic sinus surgery. Seventeen days after the surgery, the patient was discharged with no neurological sequelae.

Conclusion

To the best of our knowledge, this case is the first report regarding the association between barotrauma and intracranial complications of acute rhinosinusitis. A high index of suspicion and well-timed surgical evacuation may ensure a full recovery.

https://ift.tt/2yGll9c

Congenital bilateral dacryocystocele

Publication date: Available online 15 October 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): Pedro Carneiro de Sousa, Marta Neves, Delfim Duarte, Paula Azevedo

Abstract

Introduction

Newborns are obligatory nasal breathers. Therefore, nasal obstruction can lead to cyanosis and desaturation. In spite of being very rare, congenital bilateral dacryocystocele is a possible etiology for neonatal respiratory distress.

Case summary

Case report of a male newborn with respiratory distress caused by a bilateral polypoid and bluish lesion occupying almost the entire inferior nasal meatus. Imaging confirmed bilateral dacryocystocele. Treatment was conservative. There was spontaneous drainage, with relief of respiratory distress. Discussion The diagnosis of congenital dacryocystocele is clinical, although imaging exams may be requested to confirm it. Treatment is controversial, because the natural history is variable. An initial conservative management may be recommended, but, if there is a permanent respiratory obstruction without improvement, surgical management is mandatory.

https://ift.tt/2yl6stA

Rekonstruktive Orbitachirurgie

Zusammenfassung

Hintergrund

Komplexe Orbitarekonstruktionen erfordern die korrekte und sorgfältige Wiederherstellung der Hart- und Weichgewebe als Voraussetzung für ein ästhetisches und funktionelles Resultat. Der Einsatz der computerassistierten Chirurgie („computer-assisted surgery", CAS) kann den Operateur vor und während der Rekonstruktion sowie im Rahmen der Qualitätskontrolle maßgeblich unterstützen. Dies soll allgemein sowie mithilfe von 3 klinischen Beispielen erläutert werden.

Material und Methoden

Anhand eines 3D-Datensatzes werden die zu rekonstruierenden Strukturen und deren Umgebung erfasst. Einen Anhalt für die erwünschte Rekonstruktion bietet meist die nichtbetroffene Gegenseite durch Spiegelung. Das erzeugte virtuelle Modell kann nun zur Herstellung patientenspezifischer Modelle und Implantate, intraoperativ per Navigation oder zur direkten Qualitätskontrolle mithilfe des intraoperativen Röntgens genutzt werden.

Ergebnisse

Zur Rekonstruktion primärer und sekundärer traumatologischer Defekte sowie im Rahmen angeborener Fehlbildungen oder neoplastischer Erkrankungen kann der beschriebene Arbeitsablauf zum Einsatz kommen. Virtuelle Visualisierung, patientenspezifische Rekonstruktionen und direkte Qualitätskontrolle mithilfe des intraoperativen Röntgens erzielen ein planungskonformes Ergebnis. Unter Einhaltung des Wechselspiels von Hart- und Weichgewebe werden bestmögliche Rekonstruktionen erreicht.

Schlussfolgerung

Die CAS hat sich in den letzten Jahren stetig weiterentwickelt und ist im klinischen Alltag im Einsatz. Patientenspezifische Implantate in Kombination mit der direkten intraoperativen Qualitätskontrolle erleichtern die Rekonstruktion komplexer Orbitaverletzungen und -defekte und ermöglichen die ideale Rekonstruktion sowohl aus ästhetischen als auch funktionellen Aspekten.

https://ift.tt/2ynXdsm

Treatment of early-stage laryngeal cancer: A comparison of treatment options

Publication date: December 2018

Source: Oral Oncology, Volume 87

Author(s): Brandon Jackson Baird, C. Kwang Sung, Beth M. Beadle, Vasu Divi

Abstract

Over the course of the last several decades, the treatment options for early laryngeal cancers (T1 and T2) have evolved; however, simultaneously the mortality rate has increased. As larynx preservation approaches have become the standard of care, the selection of the proper treatment modality has become paramount. Radiation therapy or transoral laser microsurgery are the most common options for treatment of these early lesions. Oncologic and functional outcomes are considered equivalent between the two modalities for early glottic cancers; however, no direct comparisons exist for robust analysis. In terms of larynx preservation, there also is not compelling data favoring one treatment option or another. For early stage lesions, the goal for any larynx-sparing technique, either radiation or surgery, should be the intent to cure with single modality treatment and minimal short- and long-term toxicity. This article is designed to create a frame of reference for managing early stage disease with respect to lesions of the glottis and supraglottis while weighing treatment implications from an oncologic, functional, and cost perspective.

https://ift.tt/2IYduZ5

Endoscopic Management of Subperiosteal Orbital Abscesses

Publication date: Available online 16 October 2018

Source: Operative Techniques in Otolaryngology-Head and Neck Surgery

Author(s): Christopher Pool, Johnathan McGinn

Abstract

While the progression of acute rhinosinusitis to orbital infections has decreased in the modern antibiotic era, they still occur, particularly in the pediatric population. Infection may spread from the nasal cavity and sinuses via direct extension into the orbit through the thin lamina papyracea or through the valveless veins in the bony orbital wall.¹ Congenital dehiscence and trauma also allow for direct extension of the infection to the orbit.¹ Most of these orbital infections originate in the ethmoid sinuses and subperiosteal abscesses most commonly occur along the medial orbital wall. However, the frontal sinus is implicated in superior abscesses in older children and adults. Postseptal orbital infections require prompt diagnosis and treatment as they may impact vision and progress centrally, manifesting as cavernous sinus and intracranial infections associated with significant morbidity and mortality.2, 3

https://ift.tt/2AcQzXg

Intracranial Neoplasms in the First Year of Life: Results of a Third Cohort of Patients From a Single Institution

Toescu, SM; James, G; Phipps, K; Jeelani, O; Thompson, D; Hayward, R; Aquilina, K; (2018) Intracranial Neoplasms in the First Year of Life: Results of a Third Cohort of Patients From a Single Institution. Neurosurgery 10.1093/neuros/nyy081 . (In press).

https://ift.tt/2yI02UI

Towards a Middle Pleistocene Terrestrial Climate Reconstruction Based on Herpetofaunal Assemblages From the Iberian Peninsula: State of the Art and Perspectives

Blain, H-A; Cruz Silva, JA; Jimenez Arenas, JM; Margari, V; Roucoux, K; (2018) Towards a Middle Pleistocene Terrestrial Climate Reconstruction Based on Herpetofaunal Assemblages From the Iberian Peninsula: State of the Art and Perspectives. Quaternary Science Reviews , 191 pp. 167-188. 10.1016/j.quascirev.2018.04.019 .

https://ift.tt/2yjd7nN

Quantitative assessment of myocardial scar heterogeneity using cardiovascular magnetic resonance texture analysis to risk stratify patients post-myocardial infarction

Gibbs, T; Villa, ADM; Sammut, E; Jeyabraba, S; Carr-White, G; Ismail, TF; Mullen, G; ... Chiribiri, A; + view all Gibbs, T; Villa, ADM; Sammut, E; Jeyabraba, S; Carr-White, G; Ismail, TF; Mullen, G; Ganeshan, B; Chiribiri, A; - view fewer (2018) Quantitative assessment of myocardial scar heterogeneity using cardiovascular magnetic resonance texture analysis to risk stratify patients post-myocardial infarction. Clinical Radiology 10.1016/j.crad.2018.08.012 . (In press).

https://ift.tt/2yHNCfz

Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution

Larson, SD; Gleeson, P; Brown, AEX; (2018) Connectome to behaviour: modelling Caenorhabditis elegans at cellular resolution. Philosophical Transactions B: Biological Sciences , 373 (1758) 10.1098/rstb.2017.0366 . Green open access

https://ift.tt/2ykVC6D

Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees

ASiT/BOTA Lost Tribe Study Group, .; (2018) Early years postgraduate surgical training programmes in the UK are failing to meet national quality standards: An analysis from the ASiT/BOTA Lost Tribe prospective cohort study of 2,569 surgical trainees. International Journal of Surgery , 52 pp. 376-382. 10.1016/j.ijsu.2017.09.074 . Green open access

https://ift.tt/2yEbHDW

Time-resolved Tomographic Quantification of the Microstructural Evolution of Ice Cream

Lee, PD; (2018) Time-resolved Tomographic Quantification of the Microstructural Evolution of Ice Cream. Materials (In press).

https://ift.tt/2yl7ntX

Characterizing the skull base in craniofacial microsomia using principal component analysis

Schaal, SC; Ruff, C; Pluijmers, BI; Pauws, E; Looman, CWN; Koudstaall, MJ; Dunaway, DJ; (2017) Characterizing the skull base in craniofacial microsomia using principal component analysis. International Journal of Oral and Maxillofacial Surgery , 46 (12) pp. 1656-1663. 10.1016/j.ijom.2017.07.008 . Green open access

https://ift.tt/2yHysa3

Re: Ellipsoid zone change according to glaucoma-stage advancement

Mahroo, OAR; Khawaja, A; Keane, P; (2018) Re: Ellipsoid zone change according to glaucoma-stage advancement. American Journal of Ophthalmology 10.1016/j.ajo.2018.08.048 . (In press).

https://ift.tt/2yigXOc

Development of an Opsonophagocytic Killing Assay for Group A Streptococcus

Jones, S; Moreland, NJ; Zancolli, M; Raynes, J; Loh, JMS; Smeesters, PR; Sriskandan, S; ... Goldblatt, D; + view all Jones, S; Moreland, NJ; Zancolli, M; Raynes, J; Loh, JMS; Smeesters, PR; Sriskandan, S; Carapetis, JR; Fraser, JD; Goldblatt, D; - view fewer (2018) Development of an Opsonophagocytic Killing Assay for Group A Streptococcus. Vaccine , 36 (26) pp. 3756-3763. 10.1016/j.vaccine.2018.05.056 .

https://ift.tt/2yCN1LS

Cardiovascular Disease and COPD: Dangerous Liaisons

Rabe, KF; Hurst, JR; Suissa, S; (2018) Cardiovascular Disease and COPD: Dangerous Liaisons. European Respiratory Review , 27 (149) , Article 180057. 10.1183/16000617.0057-2018 . Green open access

https://ift.tt/2yjGS86

Interventions in randomised controlled trials in surgery: issues to consider during trial design

Blencowe, NS; Brown, JM; Cook, JA; Metcalfe, C; Morton, DG; Nicholl, J; Sharples, LD; ... Members of the MRC Hub for Trials Methodology Research Network W, ; + view all Blencowe, NS; Brown, JM; Cook, JA; Metcalfe, C; Morton, DG; Nicholl, J; Sharples, LD; Treweek, S; Blazeby, JM; Members of the MRC Hub for Trials Methodology Research Network W, ; - view fewer (2015) Interventions in randomised controlled trials in surgery: issues to consider during trial design. Trials , 16 , Article 392. 10.1186/s13063-015-0918-4 . Green open access

https://ift.tt/2yIb2kX

Photography's Jewish Affinities: Unintended Benefits and Squandered Opportunities for Zionism and Israel

Berkowitz, M; (2019) Photography's Jewish Affinities: Unintended Benefits and Squandered Opportunities for Zionism and Israel. Journal of Israeli History (In press).

https://ift.tt/2yk80DQ

Automated specification of steel reinforcement to support the optimisation of RC floors

Eleftheriadis, E; Duffour, P; Stephenson, B; Mumovic, D; (2018) Automated specification of steel reinforcement to support the optimisation of RC floors. Automation in Construction , 96 pp. 366-377. 10.1016/j.autcon.2018.10.005 . Green open access

https://ift.tt/2yGesES

Winston Churchill's cerebrovascular disease: small vessels with big implications

Werring, DJ; (2018) Winston Churchill's cerebrovascular disease: small vessels with big implications. Journal of the Royal Society of Medicine , 111 (9) pp. 314-315. 10.1177/0141076818796194 . Green open access

https://ift.tt/2yjGSF8

Exploring hybrid parallel systems for probabilistic record linkage

Boratto, M; Alonso, P; Pinto, C; Melo, P; Barreto, M; Denaxas, S; (2018) Exploring hybrid parallel systems for probabilistic record linkage. The Journal of Supercomputing 10.1007/s11227-018-2328-3 . (In press).

https://ift.tt/2yIDSS7

Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report

Toescu, SM; Alalade, AF; Steele, L; Bhargava, D; Hunter, R; (2017) Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. Acta Neurochirurgica , 159 (2) pp. 393-396. 10.1007/s00701-016-3024-9 . Green open access

https://ift.tt/2ymI62y

Local transformations of the hippocampal cognitive map

Krupic, J; Bauza, M; Burton, S; O'Keefe, J; (2018) Local transformations of the hippocampal cognitive map. Science , 359 (6380) pp. 1143-1145. 10.1126/science.aao4960 . Green open access

https://ift.tt/2yIDvab

Trustees' Indemnities - Is Timing Everything?

Agnew, SC; Purkis, K; (2018) Trustees' Indemnities - Is Timing Everything? Trusts and Trustees (In press).

https://ift.tt/2yl48Tb

Implementing the Creating Learning Environments for Compassionate Care (CLECC) programme in acute hospital settings: a pilot RCT and feasibility study

Bridges, J; Pickering, RM; Barker, H; Chable, R; Fuller, A; Gould, L; Libberton, P; ... Griffiths, P; + view all Bridges, J; Pickering, RM; Barker, H; Chable, R; Fuller, A; Gould, L; Libberton, P; Mesa-Eguiagaray, I; Raftery, J; Aihie Sayer, A; Westwood, G; Yao, G; Zhu, S; Griffiths, P; - view fewer (2018) Implementing the Creating Learning Environments for Compassionate Care (CLECC) programme in acute hospital settings: a pilot RCT and feasibility study. Health Services and Delivery Research , 6 (33) pp. 1-166. 10.3310/hsdr06330 . Green open access

https://ift.tt/2yGvVge

Personality Traits Do Not Predict How We Look at Faces

Harrison, C; Binetti, N; Coutrot, A; Johnston, A; Mareschal, I; (2018) Personality Traits Do Not Predict How We Look at Faces. Perception , 47 (9) pp. 976-984. 10.1177/0301006618788754 . Green open access

https://ift.tt/2yjGQNw

Does endoscopic stapedotomy increase hearing restoration rates comparing to microscopic? A systematic review and meta-analysis

Abstract

Objective

To assess all available data regarding the comparative success rates of endoscopic and microscopic stapes surgery.

Methods

MEDLINE, the Cochrane Library and Web of Science databases as well as other sources were searched by two independent reviewers. Controlled studies comparing endoscopic and microscopic stapedotomy in patients with otosclerosis or congenital stapedial fixation were included. Achievement of a postoperative air-bone gap ≤ 10 decibel was the primary outcome. Secondary outcomes were postoperative dysgeusia, scutum drilling and operation time. In case of homogenous, processable data (I² < 60%) a meta-analysis was performed. Odds ratio (OR) and Chi-square test were used to compare the two methods.

Results

Seven studies met the inclusion criteria. The OR analysis showed no significant differences between the two methods (OR 1.41, 95%CI [0.84, 2.38]), but goodness-of-fit analysis showed a correlation of endoscopic stapedotomy with normal hearing restoration (p = 0.00). Dysgeusia and scutum drilling took place significantly less often in the endoscopy group (OR 0.31, 95%CI [0.14, 0.69], p = 0.00 and OR 0.01, 95%CI [0.00, 0.07], p = 0.00 respectively).

Conclusion

As of yet, endoscopic surgery does not seem to confer benefit on audiological improvement comparing to conventional microscopic, however, it leads to less scutum drilling and fewer postoperative dysgeusia cases. High-quality, large-sample studies need to be performed in the future.

https://ift.tt/2J0AMxF

The 8th edition AJCC/UICC TNM staging for p16-positive oropharyngeal carcinoma: is there space for improvement?

Abstract

The 8th edition of the AJCC/UICC TNM-staging system for p16[HPV]-positive OPSCC manages to improve prediction of prognosis and will essentially influence choice of therapy in future. Nonetheless, adjustments of the current version are needed. The surrogate marker p16 alone is inadequate for HPV detection, the role of ECS in HPV-positive OPSCC is not fully understood, and the patient's characteristics as well as molecular signatures and genetics have not been taken into consideration yet.

https://ift.tt/2OqlWGw

Retrospective Comparison of Velcro® and Twill Tie Outcomes Following Pediatric Tracheotomy

Publication date: Available online 16 October 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Anna C. Bitners, William B. Burton, Christina J. Yang

Abstract

Objectives

To compare the rates of skin-related complications and accidental decannulation in pediatric patients who received Velcro^® ties versus twill ties during the early postoperative period following tracheotomy. The rates of skin-related complications and accidental decannulation in patients with Velcro^® ties was hypothesized to differ from those in patients with twill ties.

Methods

Medical records of 109 patients ≤18 years old who underwent elective tracheotomy were reviewed: 70 received twill ties and 39 received Velcro^® ties. Patients were followed for the first seven postoperative days. The primary outcome was skin-related complications, which were further categorized into mild (irritation) and severe (breakdown). The secondary outcome was accidental decannulation. Rates of skin-related complication and accidental decannulation were compared across the two groups using chi-square analysis.

Results

Skin irritation occurred in 32 patients (45.7%) with twill ties and 10 patients (25.6%) with Velcro^®. Skin breakdown occurred in 20 patients (28.6%) with twill ties and 6 patients (15.4%) with Velcro^®. There were no accidental decannulation events. The use of Velcro^® ties was associated with a decreased rate of skin irritation (OR: 0.41; 95% CI: 0.17 – 0.97; P = 0.039).

Conclusions

The use of Velcro^® ties was associated with a decrease in the rate of skin irritation. There were no accidental decannulation events. These findings support the use of Velcro^® ties at the time of pediatric tracheotomy placement.

https://ift.tt/2OYhj6h

Non-atopic eczema in elderly women – Impact of air pollution and genes

Publication date: Available online 16 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Anke Hüls, Michael J. Abramson, Dorothea Sugiri, Kateryna Fuks, Ursula Krämer, Jean Krutmann, Tamara Schikowski

Abstract

Background

Whilst many risk factors have been described for atopic eczema in children, little is known about the eczema phenotype in middle aged or elderly adults.

Objective

To examine the association between air pollution, atopy and eczema in adulthood.

Methods

This analysis was based on 834 women from the Study on the influence of Air pollution on Lung Function, Inflammation and Ageing (SALIA) cohort in Germany. Incident symptoms of eczema after the age of 55 years and prevalent symptoms of eczema ≤12 months before investigation were assessed by questionnaire at second follow-up (2007-2010). Total serum Immunoglobulin E (IgE) was measured at baseline (1985-1994) and in 2007-2010. Exposure to air pollution was assessed using land use regression. Adjusted logistic regression models were applied to estimate the association between air pollution and incident and prevalent symptoms of eczema. Weighted genetic risk scores were used to investigate the impact of atopic eczema related risk alleles on this association.

Results

Exposures to oxides of nitrogen (NO₂ and NO_x) and particulate matter (PM_2.5 and PM₁₀) were significantly associated with increased odds of incident eczema (e.g. with PM_2.5 per 4.7μg/m³: OR=1.45, 95%CI: 1.06,1.99). These associations were slightly more pronounced with non-atopic eczema (e.g. with PM_2.5 OR=1.65, 95%CI: 1.15, 2.34 for participants without hay fever or elevated IgE levels). Associations with air pollution were stronger in carriers of fewer risk alleles for atopic eczema.

Conclusion

Non-atopic eczema in the elderly is associated with traffic related air pollutants and this phenotype differs from genetically driven atopic eczema.

https://ift.tt/2Adxdl7

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant

Publication date: Available online 16 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Sarah Beaussant Cohen, Wayne Bainter, Jared L. Johnson, Ting-Yu Lin, Jenny C.Y. Wong, Jacqueline Wallace, Jennifer Jones, Fatima Mir, Farah Qamar, Lewis C. Cantley, Raif S. Geha, Janet Chou

https://ift.tt/2OXbPsr

Imatinib stimulates PGE2 and attenuates cytokine release via EP4 receptor activation

Publication date: Available online 16 October 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Thomas Bärnthaler, Katharina Jandl, Heinz Sill, Barbara Uhl, Yannick Schreiber, Magdalena Grill, Dominique Thomas, Rudolf Schicho, Gunther Marsche, Saša Frank, Akos Heinemann, Rufina Schuligoi

https://ift.tt/2yQk5R1

Unilateral and Bilateral PNIF in Quality Control of Nasal Septal Surgery

The aim of this study was to explore the usefulness of unilateral, combined unilateral (left + right), and bilateral peak nasal inspiratory flow (PNIF) measurements in assessing the results of nasal septal surgery. Nasal obstruction was recorded subjectively and objectively before and 4 months after nasal septoplasty using a visual analogue scale (VAS) and a PNIF meter. Nasal septoplasty (58 patients) and septoplasty with turbinoplasty (68 patients) were performed on 126 patients (85 males; 41 females) with a mean age of 32.8 years. The results showed a significant improvement in VAS scores, as well as unilateral, combined unilateral, and bilateral PNIF values after both septoplasty and septoplasty with turbinoplasty. Septoplasty with turbinoplasty showed better improvement in VAS and PNIF scores than septoplasty alone and this was significant for bilateral PNIF scores. The best unilateral pre- and postoperative correlations between VAS and PNIF measurements were found using the lower of the two unilateral PNIF scores, irrespective of side. In the total material, VAS/PNIF correlations were mostly significant, but weak (all r

https://ift.tt/2pU820L

Dynamics of antimicrobial resistance of Helicobacter pylori isolates in the Smolensk region of Russian Federation

Helicobacter, EarlyView.


https://ift.tt/2CMRCjs

Successful Helicobacter pylori eradication therapy improves symptoms of chronic constipation

Helicobacter, EarlyView.


https://ift.tt/2Cl344r

Normative data for static balance testing in healthy individuals using open source computerized posturography

Abstract

Purpose

Computerized posturography is the gold standard for balance assessment. Because of the great cost and dimensions of commercial equipments, low-cost and portable devices have been developed and validated, such as RombergLab, a software in open source term which works connected with a low-cost force platform. The objective of this study was to obtain normative posturography data using this software.

Methods

A multicentric prospective and descriptive study, with 350 healthy participants, was designed. Static postural stability (measured using the modified clinical test of sensory interaction on balance) was evaluated using the software connected to the force platform. Using the confidence ellipse area (CEA) in each condition, global equilibrium score (GES) was calculated and adjusted for significant variable factors using cluster analysis.

Results

Mean (SD) GES was 0.72 (0.22). Age (p < 0.01), height (p < 0.01) and recruitment center (p < 0.05) were found as influence factors for GES. Cluster analysis obtained 16 groups stratified by age and height. GES decreases with age and height (p < 0.005). No significant interaction of age nor height was found with GES in these clusters (p > 0.05). After correction for height and age, GES was no longer influenced by the recruitment center (p > 0.05).

Conclusions

With the introduction of the global equilibrium score values of the present study into the software, we consider RombergLab v1.3 a reference posturography tool for healthy individuals. Further studies are needed for validating it as a suitable instrumented test for screening between healthy and pathologic subjects and its reliability over time for the follow-up of patients.

https://ift.tt/2IYfctC

Neuromuscular blocking agents induced anaphylaxis: Results and trends of a French pharmacovigilance survey from 2000 to 2012

Allergy, EarlyView.


https://ift.tt/2ROcRW6

Issue Information

Dermatologic Therapy, Volume 31, Issue 5, September/October 2018.


https://ift.tt/2EqwUrf

Infantile hemangiomas with minimal or arrested growth: A retrospective case series

Pediatric Dermatology, EarlyView.


https://ift.tt/2Ow0oID

Allergic contact dermatitis to slime: The epidemic of isothiazolinone allergy encompasses school glue

Pediatric Dermatology, EarlyView.


https://ift.tt/2J0nOzZ

Multifocal congenital pyogenic granuloma successfully treated with oral propranolol

Pediatric Dermatology, EarlyView.


https://ift.tt/2OvDAch

Solitary plaque on the leg of a child: A report of two cases and a brief review of acral pseudolymphomatous angiokeratoma of children and unilesional mycosis fungoides

Pediatric Dermatology, EarlyView.


https://ift.tt/2IZCOhj

Prescribing isotretinoin for transgender youth: A pledge for more inclusive care

Pediatric Dermatology, EarlyView.


https://ift.tt/2IZ6cEB

The readability, suitability, and content features of eczema action plans in the United States

Pediatric Dermatology, EarlyView.


https://ift.tt/2Oqec7q

Congenital tufted angioma: A multicenter retrospective study of 30 cases

Pediatric Dermatology, EarlyView.


https://ift.tt/2IZDKTc

Pediatric dermatology workforce in the United States

Pediatric Dermatology, EarlyView.


https://ift.tt/2OoBDhs

Recalcitrant alopecia areata responsive to leflunomide and anthralin—Potentially undiscovered JAK/STAT inhibitors?

Pediatric Dermatology, EarlyView.


https://ift.tt/2J0nKQL

Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)

The Journal of Dermatology, EarlyView.


https://ift.tt/2yG9Cr0

Sinonasal cancer in The Netherlands: Follow‐up of a population‐based study 1989‐2014 and incidence of occupation‐related adenocarcinoma

Head &Neck, EarlyView.


https://ift.tt/2Enfo6Z

Scabies herpeticum, an emerging clinical form of crusted scabies in AIDS patient: case report and literature review

International Journal of Dermatology, EarlyView.


https://ift.tt/2CMGtz8

Engineering cities of the future

Parikh, PH; Bouillard, P; (2018) Engineering cities of the future. Proceedings of the Institution of Civil Engineers - Civil Engineering , 171 (6) p. 2. 10.1680/jcien.2018.171.6.2 .

https://ift.tt/2NJ0Qhi

Is detecting oral cancer in general dental practices a realistic expectation? A population-based study using population linked data in Scotland

Purkayastha, M; McMahon, AD; Gibson, J; Conway, DI; (2018) Is detecting oral cancer in general dental practices a realistic expectation? A population-based study using population linked data in Scotland. British Dental Journal , 225 (3) pp. 241-246. 10.1038/sj.bdj.2018.544 .

https://ift.tt/2pVYsuf

Quantitative magnetic resonance imaging has potential for assessment of spondyloarthritis; the arguments for its exploration and use

Hall-Craggs, M; Bray, T; Ciurtin, C; Bainbridge, A; (2019) Quantitative magnetic resonance imaging has potential for assessment of spondyloarthritis; the arguments for its exploration and use. [Letter]. The Journal of Rheumatology (In press).

https://ift.tt/2NL4szA

Medicines reconciliation in primary care: a study evaluating the quality of medication-related information provided on discharge from secondary care

Shah, C; Hough, J; Jani, Y; (2018) Medicines reconciliation in primary care: a study evaluating the quality of medication-related information provided on discharge from secondary care. European Journal of Hospital Pharmacy 10.1136/ejhpharm-2018-001613 . (In press). Green open access

https://ift.tt/2pQW08u

Synthesis of novel thieno[3,2-b]thienobis(silolothiophene) based low bandgap polymers for organic photovoltaics

Schroeder, BC; Ashraf, RS; Thomas, S; White, AJP; Biniek, L; Nielsen, CB; Zhang, W; ... McCulloch, I; + view all Schroeder, BC; Ashraf, RS; Thomas, S; White, AJP; Biniek, L; Nielsen, CB; Zhang, W; Huang, Z; Tuladhar, PS; Watkins, SE; Anthopoulos, TD; Durrant, JR; McCulloch, I; - view fewer (2012) Synthesis of novel thieno[3,2-b]thienobis(silolothiophene) based low bandgap polymers for organic photovoltaics. Chemical Communications , 48 (62) pp. 7699-7701. 10.1039/c2cc33718e . Green open access

https://ift.tt/2NL4mbc

Making academia more accessible

Brown, N; Thompson, P; Leigh, J; (2018) Making academia more accessible. Journal of Perspectives in Applied Academic Practice , 6 (2) (In press).

https://ift.tt/2pSpv9T

Silberraffinations-Schlacken der Insula 39, Colonia Ulpia Traiana, Xanten: Ihre mineralogische Untersuchung und archäometallurgische Interpretation

Rehren, THH; Hauptmann, A; (1995) Silberraffinations-Schlacken der Insula 39, Colonia Ulpia Traiana, Xanten: Ihre mineralogische Untersuchung und archäometallurgische Interpretation. Xantener Berichte , 6 pp. 119-137.

https://ift.tt/2NJReTH

Early childhood investment impacts social decision-making four decades later

Luo, Y; Hétu, S; Lohrenz, T; Hula, A; Dayan, P; Ramey, SL; Sonnier-Netto, L; ... Ramey, C; + view all Luo, Y; Hétu, S; Lohrenz, T; Hula, A; Dayan, P; Ramey, SL; Sonnier-Netto, L; Lisinki, J; LaConte, S; Nolte, T; Fonagy, P; Rahmani, E; Montague, PR; Ramey, C; - view fewer (2018) Early childhood investment impacts social decision-making four decades later. Nature Communications (In press).

https://ift.tt/2pWCQOu

Substantial Heterogeneity in Progress Toward Reaching the 90-90-90 HIV Target in the WHO European Region

Porter, K; Gourlay, A; Attawell, K; Hales, D; Supervie, V; Touloumi, G; Rosinska, M; ... Noori, T; + view all Porter, K; Gourlay, A; Attawell, K; Hales, D; Supervie, V; Touloumi, G; Rosinska, M; Vourli, G; van Sighem, A; Pharris, A; Noori, T; - view fewer (2018) Substantial Heterogeneity in Progress Toward Reaching the 90-90-90 HIV Target in the WHO European Region. JAIDS Journal of Acquired Immune Deficiency Syndromes , 79 (1) pp. 28-37. 10.1097/QAI.0000000000001761 . Green open access

https://ift.tt/2NJAFan

Improving patient experience in primary care: a multimethod programme of research on the measurement and improvement of patient experience

Burt, J; Campbell, J; Abel, G; Aboulghate, A; Ahmed, F; Asprey, A; Barry, H; ... Roland, M; + view all Burt, J; Campbell, J; Abel, G; Aboulghate, A; Ahmed, F; Asprey, A; Barry, H; Beckwith, J; Benson, J; Boiko, O; Bower, P; Calitri, R; Carter, M; Davey, A; Elliott, MN; Elmore, N; Farrington, C; Haque, HW; Henley, W; Lattimer, V; Llanwarne, N; Lloyd, C; Lyratzopoulos, G; Maramba, I; Mounce, L; Newbould, J; Paddison, C; Parker, R; Richards, S; Roberts, M; Setodji, C; Silverman, J; Warren, F; Wilson, E; Wright, C; Roland, M; - view fewer (2017) Improving patient experience in primary care: a multimethod programme of research on the measurement and improvement of patient experience. Programme Grants for Applied Research , 5 (9) 10.3310/pgfar05090 . Green open access

https://ift.tt/2pUNm8Q

An overview of major microsociological contributions in the field of sociology of communication

Sharlamanov, K; Tomičić, A; (2018) An overview of major microsociological contributions in the field of sociology of communication. Sociologija , 60 (3) pp. 583-594. 10.2298/SOC1803583K . Green open access

https://ift.tt/2NJ4tE4

Is R2P Still Controversial? Continuity and Change in the Debate on 'Humanitarian Intervention'

Crossley, NK; (2018) Is R2P Still Controversial? Continuity and Change in the Debate on 'Humanitarian Intervention'. Cambridge Review of International Affairs (In press).

https://ift.tt/2pVGvMD

Associations of transcranial doppler velocity, age, and gender with cognitive function in children with sickle cell anemia in Nigeria

Prussien, KV; Salihu, A; Abdullahi, SU; Galadanci, NA; Bulama, K; Belonwu, RO; Kirkham, FJ; ... Compas, BE; + view all Prussien, KV; Salihu, A; Abdullahi, SU; Galadanci, NA; Bulama, K; Belonwu, RO; Kirkham, FJ; Yarboi, J; Bemis, H; DeBaun, MR; Compas, BE; - view fewer (2018) Associations of transcranial doppler velocity, age, and gender with cognitive function in children with sickle cell anemia in Nigeria. Child Neuropsychology 10.1080/09297049.2018.1526272 . (In press).

https://ift.tt/2NJLTfd

Optimality of the Friedman rule in economies with distorting taxes

Chari, VV; Christiano, LJ; Kehoe, PJ; (1993) Optimality of the Friedman rule in economies with distorting taxes. (NBER Working Paper 4443). National Bureau of Economic Research: Cambridge, Massachusetts, USA. Green open access

https://ift.tt/2pSCOXS

Who are the male sexual partners of adolescent girls and young women? Comparative analysis of population data in three settings prior to DREAMS roll-out

Doyle, AM; Floyd, S; Baisley, K; Orindi, B; Kwaro, D; Mthiyane, TN; Muuo, S; ... Birdthistle, I; + view all Doyle, AM; Floyd, S; Baisley, K; Orindi, B; Kwaro, D; Mthiyane, TN; Muuo, S; Shahmanesh, M; Ziraba, A; Birdthistle, I; - view fewer (2018) Who are the male sexual partners of adolescent girls and young women? Comparative analysis of population data in three settings prior to DREAMS roll-out. PLoS One , 13 (9) , Article e0198783. 10.1371/journal.pone.0198783 . Green open access

https://ift.tt/2NO6Aqs

Prevalence, predictive factors, and clinical course of persistent pain associated with teeth displaying periapical healing following non-surgical root canal treatment: a prospective study

Philpott, R; Gulabivala, K; Leeson, R; Ng, YL; (2018) Prevalence, predictive factors, and clinical course of persistent pain associated with teeth displaying periapical healing following non-surgical root canal treatment: a prospective study. International Endodontic Journal (In press).

https://ift.tt/2pWV4PW

Visualizing the Carbon Binder Phase of Battery Electrodes in Three Dimensions

Daemi, SR; Tan, C; Volkenandt, T; Cooper, SJ; Palacios-Padros, A; Cookson, J; Brett, DJL; Daemi, SR; Tan, C; Volkenandt, T; Cooper, SJ; Palacios-Padros, A; Cookson, J; Brett, DJL; Shearing, PR; - view fewer (2018) Visualizing the Carbon Binder Phase of Battery Electrodes in Three Dimensions. ACS Applied Energy Materials , 1 (8) pp. 3702-3710. 10.1021/acsaem.8b00501 . Green open access

https://ift.tt/2NK6qQy

Attention or salience?

Parr, T; Friston, KJ; (2018) Attention or salience? Current Opinion in Psychology (In press).

https://ift.tt/2pWyW8q

United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services

Denniston, AK; Lee, AY; Lee, CS; Crabb, DP; Bailey, C; Lip, P-L; Taylor, P; ... Egan, CA; + view all Denniston, AK; Lee, AY; Lee, CS; Crabb, DP; Bailey, C; Lip, P-L; Taylor, P; Pikoula, M; Cook, E; Akerele, T; Antcliff, R; Brand, C; Chakravarthy, U; Chavan, R; Dhingra, N; Downey, L; Eleftheriadis, H; Ghanchi, F; Khan, R; Kumar, V; Lobo, A; Lotery, A; Menon, G; Mukherjee, R; Palmer, H; Patra, S; Paul, B; Sim, DA; Talks, JS; Wilkinson, E; Tufail, A; Egan, CA; - view fewer (2018) United Kingdom Diabetic Retinopathy Electronic Medical Record (UK DR EMR) Users Group: report 4, real-world data on the impact of deprivation on the presentation of diabetic eye disease at hospital services. British Journal of Ophthalmology 10.1136/bjophthalmol-2018-312568 . (In press). Green open access

https://ift.tt/2NK6mAi

Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017

Panicker, JN; Anding, R; Arlandis, S; Blok, B; Dorrepaal, C; Harding, C; Marcelissen, T; ... Apostolidis, A; + view all Panicker, JN; Anding, R; Arlandis, S; Blok, B; Dorrepaal, C; Harding, C; Marcelissen, T; Rademakers, K; Abrams, P; Apostolidis, A; - view fewer (2018) Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017. Neurourology and Urodynamics , 37 (S4) S75-S85. 10.1002/nau.23709 .

https://ift.tt/2pVX2zO