Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma with Unique HPV type 52 Association: A Case Report with Review of Literature

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently described distinctive clinicopathologic entity defined by association to high risk HPV, localization to sinonasal tract and close histologic resemblance to salivary gland tumors. Lack of awareness of its pathologic features and biology among pathologists and oncologists make this entity susceptible to misdiagnosis and erroneous management. Herein, we illustrate a case of HMSC of the nasal cavity associated with heretofore unreported subtype HPV-52 and discuss the challenges associated with diagnosis and management of this rare tumor. A 48-year-old woman with intermittent epistaxis for 6 months presented with a nasal mass and underwent middle turbinectomy. Histology showed a tumor with features typical of adenoid cystic carcinoma (ACC) in the form of basaloid cells and cribriform architecture. However, careful inspection revealed findings uncommon in ACC; such as surface pagetoid tumor spread, areas of solid sheets of myoepithelial cells accompanied by increased mitotic figures which prompted immunohistochemistry. Multidirectional differentiation into ductal (CK7, AE1/AE3) and myoepithelial (p63, p40, S100, calponin) lineage together with strong and diffuse immunopositivity for p16 distinguished this tumor from ACC. HPV genotyping was positive for high risk HPV subtype HPV52, which confirmed the diagnosis of HMSC. HPV-related multiphenotypic sinonasal carcinoma is an under-recognized unique clinicopathologic entity that needs awareness to avoid mistaking it for commoner salivary gland tumors. Making accurate diagnosis of this newly-described tumor is imperative in order to understand its biology and to develop optimal therapeutic strategies.

https://ift.tt/2NDfJqm

Post-traumatic bilateral vesicocutaneous fistula of thighs treated with buccal mucosa graft urethroplasty and cyanoacrylate glue instillation: a novel treatment for management of a complicated fistula

Post-traumatic vesicocutaneous fistula (VCF) is a rare variant of urinary fistulas. These fistulas may externally communicate to abdomen, perineum, buttocks, scrotum or very rarely thigh. These fistulas usually develop at a variable time duration after trauma and are usually preceded with thigh swelling or abscess formation followed by spontaneous rupture. We, hereby, report a case of VCF of bilateral thighs with associated penobulbar urethral stricture after road traffic accident which was managed with dual modality of buccal mucosa graft urethroplasty surgery and cyanoacrylate glue injection in the fistulous tracts. To the best of our knowledge, this is first report of bilateral VCFs communicating externally to thighs. In literature, very few cases of VCFs of thigh are reported and are rarely managed with adhesive glue application.

https://ift.tt/2xFonL8

Cushings reflex secondary to neck haematoma following thyroidectomy

Neck haematoma following thyroid surgery can present with respiratory distress which is generally attributed to airway obstruction. We recently had a 63-year-old female patient who underwent total thyroidectomy for toxic nodular goitre. However, within 4 hours of surgery, she developed sudden respiratory distress which was managed by prompt evacuation of the neck haematoma. Just before the haematoma evacuation, the patient had hypertension and bradycardia along with the distress. The arterial blood gas analysis sampled at that time was normal. Intraoperatively, the tracheal framework was found rigid and non-pliable. Considering the various clinical–biochemical findings observed, we think that the cause of the respiratory distress in the index case was transiently elevated intracranial pressure, secondary to bilateral internal jugular veins' compression. We hypothesise that in many patients with immediate postoperative neck haematoma, the Cushing's reflex would at least contribute partly, if not solely to the respiratory distress.

https://ift.tt/2DwRF3T

Three differently timed presentations of dermatomyositis associated with advanced ovarian cancer

Each of the three patients reported in this article presented with dermatomyositis at various stages of their advanced ovarian cancer. Dermatomyositis was the presenting feature and preceded the diagnosis of ovarian cancer by several months in one patient. In another patient, dermatomyositis occurred just prior to the scheduled third cycle of palliative chemotherapy after surgical debulking for stage 4 disease. The third patient presented with pathognomonic diagnostic features of dermatomyositis after ovarian cancer recurrence. Diagnosis was delayed in at least two of these patients; however, once appropriately diagnosed, each patient responded well to immunomodulatory treatment. In one patient, initiation of oral prednisolone seemed to correlate with a steady improvement in her proximal myopathy. A pulsed methylprednisolone approach was used in another patient with conversion to a tapering dose of oral prednisolone to good effect. In the patient in whom the most severe myopathy affecting bulbar muscle groups was demonstrated, an infusion of 5 days of intravenous immunoglobulin produced an eventual improvement in her steroid-refractory myopathy.

https://ift.tt/2xBDS6M

DNA as a self-antigen: nature and regulation

Chetna Soni | Boris Reizis

https://ift.tt/2Q8eQ5R

Macrophage Activation Syndrome, Glomerulonephritis, Pericarditis, and Retinal Vasculitis as Initial Presentation of Systemic Lupus Erythematosus

Macrophage activation syndrome (MAS) is a rare manifestation of systemic lupus erythematosus (SLE) with potentially life-threatening consequences. To the best of our knowledge, this is the first case reported in literature for a constellation of MAS, glomerulonephritis, pericarditis, and retinal vasculitis as initial presentation of SLE. Despite extensive multisystem involvement of his disease, the patient responded well to initial steroid treatment, with mycophenolate mofetil successfully added as a steroid-sparing agent. Our case highlights the importance of multispecialty collaboration in the diagnosis and management of SLE with multisystem involvement.

https://ift.tt/2Q8i6OR

An international survey-based study on colorectal cancer pathology reporting—guidelines versus local practice

Abstract

Different guidelines for colorectal cancer (CRC) pathology reporting have been published. We aimed to identify differences between publicly available CRC reporting guidelines and to survey pathologists from different countries to establish the degree of guideline implementation in local routine practice. We compared all core and non-core items of CRC reporting guidelines to identify discrepancies. We then created a survey, which was sent out to 782 pathologists practicing in 30 different countries. It included questions on the demographics of the reporting pathologist as well as resection specimen handling and microscopic evaluation, grading, staging, and additional techniques, such as immunohistochemistry or molecular pathology. First, core and non-core items of five national CRC reporting guidelines were compared and 12 items were found to differ. Different items are considered core or non-core by different guidelines and more than one TNM staging edition was applied across guidelines. The survey was completed by 143 pathologists from 30 countries. We identified differences between local practice and guidelines with potential clinical impact, e.g., tumor budding was never reported by 28.7% of responders, although it has prognostic value for survival in stage II CRC. This is the first international study comparing CRC pathology reporting guidelines with real-world local practices. There are differences in CRC pathology reporting guidelines and in guideline implementation into local practice, both with potential impact on patient care. Harmonization of datasets, use of templates, and audits of local pathology practice are needed to ensure best possible quality of CRC pathology reporting.

https://ift.tt/2N3yxtE

Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma

Condition:   Melanoma
Interventions:   Procedure: SLNE with preoperative hybrid SPECT/CT;   Procedure: Standard SLNE
Sponsor:   University Hospital, Essen
Not yet recruiting

https://ift.tt/2N3M44C

The glomus tumor resorbed bone and teeth in the mandible: a case report

Abstract

Background

A glomus tumor is a rare neoplasm usually found in the dermis or subcutaneous tissue of the extremities. It is rare for the glomus tumor to occur on the head and face. Only 26 glomus tumors of the oral region and affected bone have been reported in the English-language literature (Table 1). We report a case of a glomus tumor at the mandible. As a new point, the glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible.

Case presentation

The patient was a 44-year-old Japanese man who complained swelling of the right mandible. Radiographic examination showed a multilocular radiolucency area in the left mandible. Radiographic findings on our case resembled those of a common benign tumor. The lesion occupied to the premolar and molar area and revealed that the tumor resorbed the roots of the teeth. The lesion was removed surgically with the buccal cortical bone and buccal mucosa in contact with the mass of the tumor. The mass fully excised intraorally under general anesthesia, and the inferior alveolar nerve in contact with the mass was preserved.

The specimen was pathologically diagnosed as a glomus tumor. Immunohistochemical staining was positive for vimentin, muscle-specific actin/HHF35, and calponin. A hairline-shaped area of positive staining for type IV collagen surrounding the tumor cells was also observed. In contrast, staining for alpha-SMA, cytokeratin (AE1/AE3), cytokeratin (CAM5.2), CK19, CD31, CD34, CD68, p63, S-100, Factor VIII, and desmin was all negative. The Ki-67 labeling index was almost 1%.

A recurrent tumor was again detected in the site below the primary tumor at an 8-year follow-up, and it was surgically removed. The patient has had no symptoms of recurrence in 2 years after the second operation.

Conclusion

The glomus tumor resorbed a bone and teeth roots when the tumor progressed into the mandible. The immunohistochemical features of the tumor were consistent with those described in previous reports. It is important to completely remove the Glomus tumor.

https://ift.tt/2Q1Uzz5

Insulin allergy can be successfully managed by a systematic approach

Type I insulin allergy can be a challenging condition, and there is no international consensus on how to establish the diagnosis. Measurement of specific IgE and skin testing have been cornerstones in the diag...

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Bronchial Blocker Use in the Difficult Airway Patient Requiring Lung Isolation: Clarification as to What Blockers Are Actually Available

No abstract available

https://ift.tt/2DuByE4

Intraoperative Considerations for Transgender Patients

No abstract available

https://ift.tt/2QXTfOL

In Response

No abstract available

https://ift.tt/2Dt9VeD

In Response

No abstract available

https://ift.tt/2QYBE9r

Programmed Intermittent Bolus Regimen for Erector Spinae Plane Blocks in Children: A Retrospective Review of a Single-Institution Experience

With few published reports on erector spinae plane block use in children, limited guidance on perioperative local anesthetic dosing exists. We present a series of 22 patients who received erector spinae plane catheters with programmed intermittent bolus for various surgeries. Median loading dose of 0.4 mL/kg (interquartile range [IQR], 0.1 mL/kg) ropivacaine 0.5%, intraoperative bolus of 0.3 mL/kg/h (IQR, 0.1 mL/kg) ropivacaine 0.2%, and a postoperative programmed intermittent bolus regimen of maximum 0.6 mg/kg/h resulted in highest pain scores on postoperative day 1 with a median score of 1.7 of 10 (IQR, 1.8) and highest morphine equivalents consumed on postoperative day 2 with a median score of 0.16 mg/kg up to 120 hours after surgery. Accepted for publication August 22, 2018. Funding: None. Conflicts of Interest: See Disclosures at the end of the article. Reprints will not be available from the authors. Address correspondence to Ban C. H. Tsui, MD, FRCPC, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford, 300 Pasteur Dr, 3rd Floor, Room H3584, MC 5640, Stanford, CA 94305. Address e-mail to bantsui@stanford.edu. © 2018 International Anesthesia Research Society

https://ift.tt/2Dw32Ji

Acute Stroke Management in the First 24 Hours: A Practical Guide for Clinicians

No abstract available

https://ift.tt/2QYBvmp

Obstetric Anesthesiology in the United States: Current and Future Demand for Fellowship-Trained Subspecialists

No abstract available

https://ift.tt/2Dwkcqq

Lack of Bias Evaluation and Inadequate Study Selection May Produce Misleading Results

No abstract available

https://ift.tt/2QYBgrv

Should We Always Continue β-Blocking Agents Preoperatively?

No abstract available

https://ift.tt/2DGm1RN

Is Tube Thermosoftening Helpful for Videolaryngoscope-Guided Nasotracheal Intubation?: A Randomized Controlled Trial

BACKGROUND: Thermosoftening of the endotracheal tube (ETT) and telescoping the ETT into a rubber catheter have been suggested as a method for reducing epistaxis during nasotracheal intubation (NTI). However, thermosoftening technique is known to make it difficult to navigate the ETT into trachea without the use of Magill forceps during NTI. The cuff inflation technique has been suggested as an effective alternative to the use of Magill forceps to improve the oropharyngeal navigation of the ETT, irrespective of their stiffness, during direct laryngoscope-guided NTI. We evaluated whether thermosoftening of the ETT telescoped into rubber catheters has an additional benefit in reducing nasal injury. Simultaneously, we also evaluated whether thermosoftening of the ETT worsened orotracheal navigability during cuff inflation-supplemented videolaryngoscope-guided NTI. METHODS: One hundred forty patients were randomly assigned to 1 of the 2 groups depending on whether the ETT was softened by warming or not. The primary outcome was the incidence of epistaxis during NTI. The secondary outcome was nasotracheal navigability of the ETT, assessed by navigation grade and time required for insertion of ETT in each phase (from nose to oropharynx, from oropharynx to glottic inlet aided by cuff inflation if needed, and from glottic inlet to trachea). RESULTS: The ETTs were successfully inserted through the selected nostril of all 140 patients. In the thermosoftening group, the incidence and severity of epistaxis was significantly lower (7% vs 51%; difference of 44.2%; 95% confidence interval, 29.9%–56.2%; P .99 and P = .054, respectively) and from the glottic inlet to the trachea (P > .99 and P = .750, respectively) between the 2 groups. In both groups, all ETTs could be navigated into the trachea without the use of Magill forceps. CONCLUSIONS: Supplemented with cuff inflation during videolaryngoscope-guided NTI, thermosoftening of the ETT telescoped into rubber catheters has a substantial benefit because it significantly reduces the incidence of epistaxis without worsening the oropharyngeal navigability of the ETT. Accepted for publication August 17, 2018. Funding: None. The authors declare no conflicts of interest. This study was approved by the Institutional Ethics Committee (institutional review board [IRB] approval number 2017-03-020, IRB contact information: Institutional Review Board, Hallym University Kangnam Sacred Heart Hospital, B1, 12, Siheung-daero 187-gil, Yeongdeungpo-gu, Seoul 07441, Republic of Korea. E-mail: dandelionc@hallym.or.kr. Reprints will not be available from the authors. Address correspondence to Joo Hyun Jun, MD, PhD, Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul 07441, Republic of Korea. Address e-mail to ilpleut@naver.com. © 2018 International Anesthesia Research Society

https://ift.tt/2QRHvxv

Multimodal General Anesthesia: Theory and Practice

Balanced general anesthesia, the most common management strategy used in anesthesia care, entails the administration of different drugs together to create the anesthetic state. Anesthesiologists developed this approach to avoid sole reliance on ether for general anesthesia maintenance. Balanced general anesthesia uses less of each drug than if the drug were administered alone, thereby increasing the likelihood of its desired effects and reducing the likelihood of its side effects. To manage nociception intraoperatively and pain postoperatively, the current practice of balanced general anesthesia relies almost exclusively on opioids. While opioids are the most effective antinociceptive agents, they have undesirable side effects. Moreover, overreliance on opioids has contributed to the opioid epidemic in the United States. Spurred by concern of opioid overuse, balanced general anesthesia strategies are now using more agents to create the anesthetic state. Under these approaches, called "multimodal general anesthesia," the additional drugs may include agents with specific central nervous system targets such as dexmedetomidine and ones with less specific targets, such as magnesium. It is postulated that use of more agents at smaller doses further maximizes desired effects while minimizing side effects. Although this approach appears to maximize the benefit-to-side effect ratio, no rational strategy has been provided for choosing the drug combinations. Nociception induced by surgery is the primary reason for placing a patient in a state of general anesthesia. Hence, any rational strategy should focus on nociception control intraoperatively and pain control postoperatively. In this Special Article, we review the anatomy and physiology of the nociceptive and arousal circuits, and the mechanisms through which commonly used anesthetics and anesthetic adjuncts act in these systems. We propose a rational strategy for multimodal general anesthesia predicated on choosing a combination of agents that act at different targets in the nociceptive system to control nociception intraoperatively and pain postoperatively. Because these agents also decrease arousal, the doses of hypnotics and/or inhaled ethers needed to control unconsciousness are reduced. Effective use of this strategy requires simultaneous monitoring of antinociception and level of unconsciousness. We illustrate the application of this strategy by summarizing anesthetic management for 4 representative surgeries. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Accepted for publication June 11, 2018. Funding: This work was supported by the National Institutes of Health (Bethesda, MD): R01 GM104948 (to E.N.B.) and P01GM118269 (to E.N.B.); and by the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA. Conflicts of Interest: See Disclosures at the end of the article. A glossary of terms is available in the Appendix. Reprints will not be available from the authors. Address correspondence to Emery N. Brown, MD, PhD, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St, Grey-Jackson 444, Boston, MA 02114. Address e-mail to enb@neurostat.mit.edu. © 2018 International Anesthesia Research Society

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Performance of Air Seal of Flexible Reinforced Laryngeal Mask Airway in Thyroid Surgery Compared With Endotracheal Tube: A Randomized Controlled Trial

BACKGROUND: Flexible reinforced laryngeal mask airway (FLMA®) has gained popularity in thyroid surgery, but air leak and displacement are still concerns. METHODS: In this randomized, single-blinded, noninferiority, controlled trial, we randomized patients scheduled for elective radical thyroidectomy to an endotracheal tube (ETT) group or a FLMA group. The primary outcomes were ventilation leak volume, peak airway pressure, and partial pressure of end-tidal carbon dioxide (PetCO2). Data for primary outcomes were collected after insertion of ETT/FLMA, at incision, and at 10-minute intervals during surgery. Ten milliliters, 5 cm H2O, and 10 mm Hg were used as the noninferiority deltas for ventilation leak volume, peak airway pressure, and PetCO2, respectively. We assessed noninferiority of FLMA to ETT on the primary outcomes over time using the results of a linear mixed-effects model. The position of FLMA mask was evaluated before and after surgery, and the airway complications were recorded. RESULTS: A total of 132 patients were included: 65 in ETT group and 67 in FLMA group. Differences (FLMA group minus ETT group) of ventilation leak volume, peak airway pressure, and PetCO2 from the mixed-effects models were 2.09 mL (98.3% confidence interval [CI], –6.46 to 10.64), −0.60 cm H2O (98.3% CI, –2.15 to 0.96), and 1.02 mm Hg (98.3% CI, 0.04–1.99), respectively. Score of fiber-optic position of FLMA was significantly higher after surgery than before. There was no severe shift, loss of the mask seal, regurgitation, or aspiration in the FLMA group. One patient in the FLMA group experienced brief and easily controlled laryngospasm. CONCLUSIONS: In thyroid surgery, FLMA is noninferior to ETT in the peak airway pressure and PetCO2 although mild to moderate mask shift could occur during surgical manipulation. There is no evidence for a higher complication rate when FLMA is used. Accepted for publication July 27, 2018. Funding: None. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Clinical Trial Number: ChiCTR-IOR-15006602. LMA Flexible and LMA Classic are registered trademarks of Teleflex Incorporated or its affiliates. Reprints will not be available from the authors. Address correspondence to Jie Yi, MD, Department of Anesthesiology, Peking Union Medical College Hospital, Beijing 100730, China. Address e-mail to easyue@163.com. © 2018 International Anesthesia Research Society

https://ift.tt/2R0ndlB

AP2 transcription factor CBX1 with a specific function in symbiotic exchange of nutrients in mycorrhizal Lotus japonicus [Plant Biology]

The arbuscular mycorrhizal (AM) symbiosis, a widespread mutualistic association between land plants and fungi, depends on reciprocal exchange of phosphorus driven by proton-coupled phosphate uptake into host plants and carbon supplied to AM fungi by host-dependent sugar and lipid biosynthesis. The molecular mechanisms and cis-regulatory modules underlying the control of...

https://ift.tt/2zsMbmw

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury [Neuroscience]

Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in...

https://ift.tt/2ORSbun

Correction for Loyer et al., Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth [Correction]

DEVELOPMENTAL BIOLOGY Correction for "Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth," by Nicolas Loyer, Irina Kolotuev, Mathieu Pinot, and Roland Le Borgne, which was first published September 30, 2015; 10.1073/pnas.1504455112 (Proc Natl Acad Sci USA 112:12717–12722). The authors note that Fig....

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Correction for Schickinger et al., Tethered multifluorophore motion reveals equilibrium transition kinetics of single DNA double helices [Correction]

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for "Tethered multifluorophore motion reveals equilibrium transition kinetics of single DNA double helices," by Matthias Schickinger, Martin Zacharias, and Hendrik Dietz, which was first published July 23, 2018; 10.1073/pnas.1800585115 (Proc Natl Acad Sci USA 115:E7512–E7521). The authors note that, due to a printer's error, some...

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Correction for Pereyaslavets et al., On the importance of accounting for nuclear quantum effects in ab initio calibrated force fields in biological simulations [Correction]

CHEMISTRY, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for "On the importance of accounting for nuclear quantum effects in ab initio calibrated force fields in biological simulations," by Leonid Pereyaslavets, Igor Kurnikov, Ganesh Kamath, Oleg Butin, Alexey Illarionov, Igor Leontyev, Michael Olevanov, Michael Levitt, Roger D. Kornberg, and Boris Fain, which was...

https://ift.tt/2OOeukF

Correction for Sharp et al., Psychological targeting [Correction]

LETTER Correction for "Psychological targeting," by Byron Sharp, Nick Danenberg, and Steven Bellman, which was first published August 3, 2018; 10.1073/pnas.1810436115 (Proc Natl Acad Sci USA 115:E7890). The authors note that their conflict of interest statement was omitted during publication. The authors declare the following: B.S., N.D., and S.B. are...

https://ift.tt/2ztuPq0

Cortical circuit activity underlying sleep slow oscillations and spindles [Neuroscience]

Slow oscillations and sleep spindles are hallmarks of the EEG during slow-wave sleep (SWS). Both oscillatory events, especially when co-occurring in the constellation of spindles nesting in the slow oscillation upstate, are considered to support memory formation and underlying synaptic plasticity. The regulatory mechanisms of this function at the circuit...

https://ift.tt/2zsMcXC

Homologous recombination is an intrinsic defense against antiviral RNA interference [Microbiology]

RNA interference (RNAi) is the major antiviral defense mechanism of plants and invertebrates, rendering the capacity to evade it a defining factor in shaping the viral landscape. Here we sought to determine whether different virus replication strategies provided any inherent capacity to evade RNAi in the absence of an antagonist....

https://ift.tt/2OaGYbr

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor [Microbiology]

Murine norovirus (MNoV) is closely related to human norovirus (HNoV), an infectious agent responsible for acute gastroenteritis worldwide. Here we report the X-ray crystal structure of the dimeric MNoV VP1 protruding (P) domain in complex with its cellular receptor CD300lf. CD300lf binds the P domain with a 2:2 stoichiometry, engaging...

https://ift.tt/2Q7Ig4p

Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy [Medical Sciences]

In gene therapy for Duchenne muscular dystrophy there are two potential immunological obstacles. An individual with Duchenne muscular dystrophy has a genetic mutation in dystrophin, and therefore the wild-type protein is "foreign," and thus potentially immunogenic. The adeno-associated virus serotype-6 (AAV6) vector for delivery of dystrophin is a viral-derived vector...

https://ift.tt/2zsZaET

Macrocycle ring deformation as the secondary design principle for light-harvesting complexes [Chemistry]

Natural light-harvesting is performed by pigment–protein complexes, which collect and funnel the solar energy at the start of photosynthesis. The identity and arrangement of pigments largely define the absorption spectrum of the antenna complex, which is further regulated by a palette of structural factors. Small alterations are induced by pigment–protein...

https://ift.tt/2zszQPw

Partial maintenance of organ-specific epigenetic marks during plant asexual reproduction leads to heritable phenotypic variation [Genetics]

Plants differ from animals in their capability to easily regenerate fertile adult individuals from terminally differentiated cells. This unique developmental plasticity is commonly observed in nature, where many species can reproduce asexually through the ectopic initiation of organogenic or embryogenic developmental programs. While organ-specific epigenetic marks are not passed on...

https://ift.tt/2DsaIfG

Pendular alignment and strong chemical binding are induced in helium dimer molecules by intense laser fields [Chemistry]

Intense pulsed-laser fields have provided means to both induce spatial alignment of molecules and enhance strength of chemical bonds. The duration of the laser field typically ranges from hundreds of picoseconds to a few femtoseconds. Accordingly, the induced "laser-dressed" properties can be adiabatic, existing only during the pulse, or nonadiabatic,...

https://ift.tt/2OQoABI

Mutually inhibitory Ras-PI(3,4)P2 feedback loops mediate cell migration [Cell Biology]

Signal transduction and cytoskeleton networks in a wide variety of cells display excitability, but the mechanisms are poorly understood. Here, we show that during random migration and in response to chemoattractants, cells maintain complementary spatial and temporal distributions of Ras activity and phosphatidylinositol (3,4)-bisphosphate [PI(3,4)P2]. In addition, depletion of PI(3,4)P2...

https://ift.tt/2OQovxU

The culture of social comparison [Psychological and Cognitive Sciences]

Social comparison is one of the most ubiquitous features of human social life. This fundamental human tendency to look to others for information about how to think, feel, and behave has provided us with the ability to thrive in a highly complex and interconnected modern social world. Despite its prominent...

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Interferon stimulation creates chromatin marks and establishes transcriptional memory [Immunology and Inflammation]

Epigenetic memory for signal-dependent transcription has remained elusive. So far, the concept of epigenetic memory has been largely limited to cell-autonomous, preprogrammed processes such as development and metabolism. Here we show that IFNβ stimulation creates transcriptional memory in fibroblasts, conferring faster and greater transcription upon restimulation. The memory was inherited...

https://ift.tt/2zsMg9O

Structure-specific DNA replication-fork recognition directs helicase and replication restart activities of the PriA helicase [Biochemistry]

DNA replication restart, the essential process that reinitiates prematurely terminated genome replication reactions, relies on exquisitely specific recognition of abandoned DNA replication-fork structures. The PriA DNA helicase mediates this process in bacteria through mechanisms that remain poorly defined. We report the crystal structure of a PriA/replication-fork complex, which resolves leading-strand...

https://ift.tt/2zsMr4Y

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis [Cell Biology]

Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human diseases, including Parkinson's disease and Crohn's disease, whereas LRRK2 deficiency leads to accumulation of abnormal lysosomes in aged animals. However, the cellular roles and mechanisms of LRRK2-mediated lysosomal regulation have remained elusive. Here, we reveal a mechanism...

https://ift.tt/2zsMo9i

Function and crystal structure of the dimeric P-loop ATPase CFD1 coordinating an exposed [4Fe-4S] cluster for transfer to apoproteins [Biochemistry]

Maturation of iron-sulfur (Fe-S) proteins in eukaryotes requires complex machineries in mitochondria and cytosol. Initially, Fe-S clusters are assembled on dedicated scaffold proteins and then are trafficked to target apoproteins. Within the cytosolic Fe-S protein assembly (CIA) machinery, the conserved P-loop nucleoside triphosphatase Nbp35 performs a scaffold function. In yeast,...

https://ift.tt/2ORdxs3

Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis [Developmental Biology]

The Xenopus laevis embryo has been subjected to almost saturating screens for molecules specifically expressed in dorsal Spemann organizer tissue. In this study, we performed high-throughput RNA sequencing of ectodermal explants, called animal caps, which normally give rise to epidermis. We analyzed dissociated animal cap cells that, through sustained activation...

https://ift.tt/2zszE2K

Newborn hearing screening protocols and their outcomes: A systematic review

Publication date: Available online 25 September 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Amisha Kanji, Katijah Khoza-Shangase, Nomfundo Moroe

Abstract

Objective

To conduct a review of the most current research in objective measures used within newborn hearing screening protocols with the aim of exploring the actual protocols in terms of the types of measures used and their frequency of use within a protocol, as well as their outcomes in terms of sensitivity, specificity, false positives, and false negatives in different countries worldwide.

Methods

A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Electronic databases such as PubMed, Google Scholar and Science Direct were used for the literature search. A total of 422 articles were identified, of which only 15 formed part of the current study. The 15 articles that met the study's criteria were reviewed. Pertinent data and findings from the review were tabulated and qualitatively analysed under the following headings: country; objective screening and/or diagnostic measures; details of screening protocol; results (including false positive and negative findings, sensitivity and/or specificity), conclusion and/or recommendations. These tabulated findings were then discussed with conclusions and recommendations offered.

Results

Findings reported in this paper are based on a qualitative rather than a quantitative analysis of the reviewed data. Generally, findings in this review revealed firstly, that there is a lack of uniformity in protocols adopted within newborn hearing screening. Secondly, many of the screening protocols reviewed consist of two or more tiers or stages, with transient evoked otoacoustic emissions (TEOAEs) and automated auditory brainstem response (AABR) being most commonly used. Thirdly, DPOAEs appear to be less commonly used when compared to TEOAEs. Lastly, a question around routine inclusion of AABR as part of the NHS protocol remains inconclusively answered.

Conclusions

There is sufficient evidence to suggest that the inclusion of AABR within a NHS programme is effective in achieving better hearing screening outcomes. The use of AABR in combination with OAEs within a test-battery approach or cross-check principle to screening is appropriate, but the inclusion of AABR to facilitate appropriate referral for diagnostic assessment needs to be systematically studied.

https://ift.tt/2NF8QVq

Onkologie und Versorgung in Fach- und Publikumsmedien

https://ift.tt/2Q5wnM1

Stress Fracture Prevention | A Guide for Parents and Athletes

We are right in the middle of the fall season of sports. Athletes started hard in August and have been continuing to give it their all week in and week out. The middle of the season is usually when overuse injuries start to creep up. One overuse injury that an athlete never wants to hear about is a stress fracture.  This means no more playing and rest that may keep them out for the rest of the fall.  Why do these injuries happen? What can be done to prevent them?

Why do Stress Fractures Occur?

Stress fractures can happen for a number of reasons. Overuse is one of the main reasons. A bone gets overloaded over and over leading to a small crack that causes pain. Eventually, the pain becomes enough that an athlete's performance goes down and they seek treatment. These fractures can happen in many different bones and this usually depends on the type of sports that they play. Most stress fractures occur in the foot or lower leg.

Other reasons for stress fractures include poor footwear, hard running surfaces, and increasing activities too quickly.

Identifying Stress Fractures

How do you know if your child may have a stress fracture? They will complain of pain that is usually over one specific area. They may have some swelling in that area as well. If you are concerned, your child should see their pediatrician or an orthopedist. They can do an x-ray (or occasionally an MRI) to see if a stress fracture is there. If they find something, they will have your child rest from activities and usually will give them a walking boot or cast (if the injury is in the foot or lower leg). Rest can take anywhere from 4-8 weeks.

Preventing Stress Fractures

Now that we know what to look for, can these injuries be prevented? Below is a list of things that can be helpful in preventing a stress injury in your young athlete.

• Change activities gradually! When starting a new season or getting into a new sport, start slow. Build up activities over a period of weeks, not days.
• Add cross-training into your workout. Doing the same thing over and over puts you at risk for a stress injury. Mixing it up and adding different things helps prevent this.
• Keep an eye on your equipment. Make sure to change out running shoes and cleats often. Poor padding in old shoes can contribute to increased stress and injuries
• Get enough calcium and Vitamin Although not proven to prevent stress fractures, getting enough calcium and Vitamin D is always important for bone health. Follow the daily Recommended Dietary Allowance (RDA) for your child's age group.

If you are ever concerned about a stress fracture, call your child's pediatrician or sports medicine doctor for an evaluation.

The post Stress Fracture Prevention | A Guide for Parents and Athletes appeared first on ChildrensMD.

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Detection of Tannerella forsythia bspA and prtH genotypes among periodontitis patients and healthy subjects – a case - control study

Publication date: Available online 24 September 2018

Source: Archives of Oral Biology

Author(s): Krishnan Mahalakshmi, Padma Krishnan, S.C. Chandrasekaran

Abstract

Background

T. forsythia a gram negative, anaerobe inhabits the mature biofilm present at sites expressing progressive periodontitis. It is a part of "red complex" group which contributes to the pathogenesis of periodontitis. The BspA protein and prtH gene encoded cysteine protease play a vital role in the virulence of T. forsythia. The present study aims to detect the two genotypes (bspA and prtH) in periodontitis and healthy subjects.

Materials & Method

Subgingival plaque samples were collected from periodontitis patients and healthy subjects (Chronic Periodontitis n = 128, Aggressive Periodontitis n = 72, healthy subjects n = 200). The samples were screened for the presence of T. forsythia 16S rRNA, bspA and prtH genotypes by Polymerase Chain Reaction. The prevalence of the genotypes between periodontitis patients and healthy subjects was compared with Pearson's Chi-square test. A P value of < 0.05 was considered to be statistically significant.

Results

The prevalence for T. forsythia in Chronic Periodontitis (n = 128), Aggressive Periodontitis (n = 72) and health (n = 200) was 73.4%, 59.7% and 10.5% respectively. The prevalence of T.forsythia bspA/prtH genotypes was 81.90%/43.60%, 88.40%/53.50% and 33.30%/14.3% in Chronic Periodontitis, aggressive Periodontitis and health respectively. Compared to healthy subjects, the odds of detecting T.forsythia 16S rRNA was 18.53 times high in individuals with periodontitis (P = 0.0001).

Conclusion

The high odds ratio of T.forsythia 16S rRNA among periodontitis strongly suggests its role in periodontitis. In addition, the high prevalence of T. forsythia bspA genotype among Chronic Periodontitis signifies it as a useful marker for chronic periodontitis.

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Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB

Johnson, B; Leek, AN; Sole, L; Maverick, EE; Levine, TP; Tamkun, MM; (2018) Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB. Proceedings of the National Academy of Sciences of the United States of America , 115 (31) E7331-E7340. 10.1073/pnas.1805757115 .

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Investigation of broadband terahertz generation from metasurface

Fang, M; Niu, K; Huang, Z; Sha, WEI; Wu, X; Koschny, T; Soukoulis, CM; (2018) Investigation of broadband terahertz generation from metasurface. Optics Express , 26 (11) pp. 14241-14250. 10.1364/OE.26.014241 . Green open access

https://ift.tt/2ONS7fb

Global urban policy and the geopolitics of urban data

Robin, E; Acuto, M; (2018) Global urban policy and the geopolitics of urban data. Political Geography , 66 pp. 76-87. 10.1016/j.polgeo.2018.08.013 . Green open access

https://ift.tt/2ztbiGc

Variability and reliability of effective connectivity within the core default mode network: A multi-site longitudinal spectral DCM study

Almgren, H; Van de Steen, F; Kühn, S; Razi, A; Friston, K; Marinazzo, D; (2018) Variability and reliability of effective connectivity within the core default mode network: A multi-site longitudinal spectral DCM study. NeuroImage , 183 pp. 757-768. 10.1016/j.neuroimage.2018.08.053 . Green open access

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Improving implementation of evidence based practice for people with psychosis through training the wider workforce: Results of the GOALS feasibility randomised controlled trial

Waller, H; Landau, S; Fornells-Ambrojo, M; Jolley, S; McCrone, P; Halkoree, R; Basit, N; ... Garety, P; + view all Waller, H; Landau, S; Fornells-Ambrojo, M; Jolley, S; McCrone, P; Halkoree, R; Basit, N; Iredale, C; Tunnard, C; Zala, D; Craig, TJK; Garety, P; - view fewer (2017) Improving implementation of evidence based practice for people with psychosis through training the wider workforce: Results of the GOALS feasibility randomised controlled trial. Journal of Behavior Therapy and Experimental Psychiatry , 59 pp. 121-128. 10.1016/j.jbtep.2017.12.004 .

https://ift.tt/2ztb5mo

Treating the Eyes to Help the Brain: The Association Between Visual and Cognitive Function

Foster, PJ; Chua, SYL; Petzold, A; (2018) Treating the Eyes to Help the Brain: The Association Between Visual and Cognitive Function. JAMA Ophthalmology , 136 (9) pp. 996-997. 10.1001/jamaophthalmol.2018.2491 .

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A standardized protocol for quantification of saccadic eye movements: DEMoNS

Nij Bijvank, JA; Petzold, A; Balk, LJ; Tan, HS; Uitdehaag, BMJ; Theodorou, M; van Rijn, LJ; (2018) A standardized protocol for quantification of saccadic eye movements: DEMoNS. PLoS One , 13 (7) , Article e0200695. 10.1371/journal.pone.0200695 . Green open access

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3D-Printed Structural Pseudocapacitors

Liu, X; Jervis, R; Maher, RC; Villar-Garcia, IJ; Naylor-Marlow, M; Shearing, PR; Ouyang, M; ... Wu, B; + view all Liu, X; Jervis, R; Maher, RC; Villar-Garcia, IJ; Naylor-Marlow, M; Shearing, PR; Ouyang, M; Cohen, L; Brandon, NP; Wu, B; - view fewer (2016) 3D-Printed Structural Pseudocapacitors. Advanced Materials Technologies , 1 (9) , Article 1600167. 10.1002/admt.201600167 . Green open access

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Let's make private data into a public good

Mazzucato, M; (2018) Let's make private data into a public good. MIT Technology Review , 121 (4) pp. 74-75.

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Isolating the chiral contribution in optical two-dimensional chiral spectroscopy using linearly polarized light

Holdaway, DIH; Collini, E; Olaya-Castro, A; (2017) Isolating the chiral contribution in optical two-dimensional chiral spectroscopy using linearly polarized light. Optics Express , 25 (6) pp. 6383-6401. 10.1364/OE.25.006383 . Green open access

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E-cigarette use in England 2014-2017 as a function of socioeconomic profile

Kock, L; Shahab, L; West, R; Brown, J; (2018) E-cigarette use in England 2014-2017 as a function of socioeconomic profile. Addiction (In press).

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Is psychotherapy effective? A re-analysis of treatments for depression

Munder, T; Flückiger, C; Leichsenring, F; Abbass, AA; Hilsenroth, MJ; Luyten, P; Rabung, S; ... Wampold, BE; + view all Munder, T; Flückiger, C; Leichsenring, F; Abbass, AA; Hilsenroth, MJ; Luyten, P; Rabung, S; Steinert, C; Wampold, BE; - view fewer (2018) Is psychotherapy effective? A re-analysis of treatments for depression. Epidemiology and Psychiatric Sciences 10.1017/S2045796018000355 . (In press).

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Sex differences in fitness to practise test scores: Cohort study of GPs

Unwin, E; Woolf, K; Dacre, J; Potts, HWW; (2018) Sex differences in fitness to practise test scores: Cohort study of GPs. British Journal of General Practice (In press).

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Harvesting the promise of AOPs: An assessment and recommendations

Carusi, A; Davies, M; De Grandis, G; Escher, B; Hodges, G; Leung, K; Whelan, M; ... Ankley, G; + view all Carusi, A; Davies, M; De Grandis, G; Escher, B; Hodges, G; Leung, K; Whelan, M; Willet, C; Ankley, G; - view fewer (2018) Harvesting the promise of AOPs: An assessment and recommendations. Science of the Total Environment , 628-9 pp. 1542-1556. 10.1016/j.scitotenv.2018.02.015 . Green open access

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Impact of Financial Incentives on Alcohol Consumption Recording in Primary Health Care Among Adults with Schizophrenia and Other Psychoses: A Cross-Sectional and Retrospective Cohort Study

Khadjesari, Z; Hardoon, SL; Petersen, I; Hamilton, FL; Nazareth, I; (2016) Impact of Financial Incentives on Alcohol Consumption Recording in Primary Health Care Among Adults with Schizophrenia and Other Psychoses: A Cross-Sectional and Retrospective Cohort Study. Alcohol and Alcoholism , 52 (2) pp. 197-205. 10.1093/alcalc/agw076 . Green open access

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A comparative study on different Descemet membrane endothelial keratoplasty graft preparation techniques

Parekh, M; Borroni, D; Ruzza, A; Levis, HJ; Ferrari, S; Ponzin, D; Romano, V; (2018) A comparative study on different Descemet membrane endothelial keratoplasty graft preparation techniques. Acta Ophthalmol 10.1111/aos.13746 . (In press).

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Multiple ionization of argon via multi-XUV-photon absorption induced by 20-GW high-order harmonic laser pulses

Nayak, A; Orfanos, I; Makos, I; Dumergue, M; Kühn, S; Skantzakis, E; Bodi, B; ... Tzallas, P; + view all Nayak, A; Orfanos, I; Makos, I; Dumergue, M; Kühn, S; Skantzakis, E; Bodi, B; Varju, K; Kalpouzos, C; Banks, HIB; Emmanouilidou, A; Charalambidis, D; Tzallas, P; - view fewer (2018) Multiple ionization of argon via multi-XUV-photon absorption induced by 20-GW high-order harmonic laser pulses. Physical Review A , 98 (2) , Article 023426. 10.1103/PhysRevA.98.023426 . Green open access

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Recombinant human serum albumin for corneal preservation

Parekh, M; Elbadawy, H; Salvalaio, G; Amoureux, M-C; Di Iorio, E; Fortier, D; Ponzin, D; ... Ruzza, A; + view all Parekh, M; Elbadawy, H; Salvalaio, G; Amoureux, M-C; Di Iorio, E; Fortier, D; Ponzin, D; Ferrari, S; Ruzza, A; - view fewer (2018) Recombinant human serum albumin for corneal preservation. Acta Ophthalmol , 96 (1) e79-e86. 10.1111/aos.13498 .

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Can the NHS be a learning healthcare system in the age of digital technology?

Banerjee, A; Drumright, LN; Mitchell, ARJ; (2018) Can the NHS be a learning healthcare system in the age of digital technology? BMJ Evidence-Based Medicine 10.1136/bmjebm-2018-110953 . (In press). Green open access

https://ift.tt/2zrVVxF

Physical Layer Security Over Correlated Log-Normal Cooperative Power Line Communication Channels

Salem, A; Hamdi, KA; Alsusa, E; (2017) Physical Layer Security Over Correlated Log-Normal Cooperative Power Line Communication Channels. IEEE Access , 5 pp. 13909-13921. 10.1109/ACCESS.2017.2729784 . Green open access

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In This Issue

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The anaphylatoxin C3a primes model colonic epithelial cells for expression of inflammatory mediators through Gαi

Publication date: November 2018

Source: Molecular Immunology, Volume 103

Author(s): Justin D. McCarthy, Qi Cao, Nathaniel Winsor, Johan Van Limbergen, Andrew W. Stadnyk

Abstract

Multiple studies have identified that complement becomes activated during inflammation of the intestines yet it is unclear what roles the split complement molecules play. The epithelium, in particular, may be impacted and accordingly, we first discovered that colonic cell lines indeed possess the C5aR. Here we examined whether these cells also possess the C3aR. We determined that T84, HT-29 and Caco2 all possess C3aR mRNA and protein; T84 and HT29 were used to further explore the consequence of C3a binding the C3aR. C3a led to increased mRNA for CXCL2, CXCL8 and CXCL11. Polarized T84 monolayers responded to apically applied C3a with increased CXCL8 mRNA more rapidly than if the C3a was applied basolaterally. Polarized monolayers also increased permeability when treated with C3a. ERK1/2 was activated by C3a and the increase in CXCL8 mRNA was ERK-dependent in both T84 and HT-29. C3a resulted in activation of Gαi, determined by the ERK1/2 signal showing sensitivity to pertussis toxin. The transmembrane signal was further mapped to include Ras and c-Raf. Finally, we show that the C3aR is expressed by primary cells in mouse enteroids. We conclude that complement activation will contribute to the epithelial response during inflammation through C3a binding to the C3aR including by priming the cells to upregulate mRNA for selected chemokines.

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Analytic and clinical validity of thyroid nodule mutational profiling using droplet digital polymerase chain reaction

Recent guidelines for the management of thyroid nodules incorporate mutation testing as an adjunct for surgical decision-making, however current tests are costly with limited accuracy. Droplet digital PCR (ddP...

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Systematic review and meta-analysis of risk-reductive dental strategies for medication related osteonecrosis of the jaw among cancer patients: Approaches and strategies

Publication date: Available online 24 September 2018

Source: Oral Oncology

Author(s): Rama Jayaraj, Chellan Kumarasamy, Suja Ramalingam, Arikketh Devi

https://ift.tt/2OKfy97

Fast adaptive optics scanning light ophthalmoscope retinal montaging

Davidson, B; Kalitzeos, A; Carroll, J; Dubra, A; Ourselin, S; Michaelides, M; Bergeles, C; (2018) Fast adaptive optics scanning light ophthalmoscope retinal montaging. Biomedical Optics Express , 9 (9) pp. 4317-4328. 10.1364/BOE.9.004317 . Green open access

https://ift.tt/2O8GgeG

Pharmacogenomic Inequalities: Strategies for Justice in Biomedical Research and Healthcare

De Grandis, G; (2017) Pharmacogenomic Inequalities: Strategies for Justice in Biomedical Research and Healthcare. Diametros : an Online Journal of Philosophy , 51 pp. 153-172. 10.13153/diam.51.2017.1036 . Green open access

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Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X-Ray Tomography

Kok, MDR; Jervis, R; Brett, D; Shearing, PR; Gostick, JT; (2018) Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X-Ray Tomography. Small , 14 (9) , Article 1703616. 10.1002/smll.201703616 .

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Reversibility and quantum coherence in one-dimensional quantum cellular automata

Centrone, F; Tassi, C; Barbieri, M; Serafini, A; (2018) Reversibility and quantum coherence in one-dimensional quantum cellular automata. Physical Review A , 98 (1) 10.1103/PhysRevA.98.012105 . Green open access

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Quantitative bioluminescence tomography using spectral derivative data

Dehghani, H; Guggenheim, JA; Taylor, SL; Xu, X; Wang, KK-H; (2018) Quantitative bioluminescence tomography using spectral derivative data. Biomedical Optics Express , 9 (9) pp. 4163-4174. 10.1364/BOE.9.004163 . Green open access

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Recommendations for clinical translation of nanoparticle-enhanced radiotherapy

Ricketts, K; Ahmad, R; Beaton, L; Cousins, B; Critchley, K; Davies, M; Evans, S; ... Royle, G; + view all Ricketts, K; Ahmad, R; Beaton, L; Cousins, B; Critchley, K; Davies, M; Evans, S; Fenuyi, I; Gavriilidis, A; Harmer, QJ; Jayne, D; Jefford, M; Loizidou, M; Macrobert, A; Moorcroft, S; Naasani, I; Ong, ZY; Prise, KM; Rannard, S; Richards, T; Schettino, G; Sharma, RA; Tillement, O; Wakefield, G; Williams, NR; Yaghini, E; Royle, G; - view fewer (2018) Recommendations for clinical translation of nanoparticle-enhanced radiotherapy. British Journal of Radiology 10.1259/bjr.20180325 . (In press).

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Cerebellar Processing Common to Delay and Trace Eyelid Conditioning

Halverson, HE; Khilkevich, A; Mauk, MD; (2018) Cerebellar Processing Common to Delay and Trace Eyelid Conditioning. The Journal of Neuroscience , 38 (33) pp. 7221-7236. 10.1523/JNEUROSCI.0430-18.2018 .

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Review of Particle Physics: Particle Data Group

Tanabashi, M; Grp, PD; Hagiwara, K; Hikasa, K; Nakamura, K; Sumino, Y; Takahashi, F; ... Schaffner, P; + view all Tanabashi, M; Grp, PD; Hagiwara, K; Hikasa, K; Nakamura, K; Sumino, Y; Takahashi, F; Tanaka, J; Agashe, K; Aielli, G; Amsler, C; Antonelli, M; Asner, DM; Baer, H; Banerjee, S; Barnett, RM; Basaglia, T; Bauer, CW; Beatty, JJ; Belousov, VI; Beringer, J; Bethke, S; Bettini, A; Bichsel, H; Biebel, O; Black, KM; Blucher, E; Buchmuller, O; Burkert, V; Bychkov, MA; Cahn, RN; Carena, M; Ceccucci, A; Cerri, A; Chakraborty, D; Chen, M-C; Chivukula, RS; Cowan, G; Dahl, O; D'Ambrosio, G; Damour, T; de Florian, D; de Gouvea, A; DeGrand, T; de Jong, P; Dissertori, G; Dobrescu, BA; D'Onofrio, M; Doser, M; Drees, M; Dreiner, HK; Dwyer, DA; Eerola, P; Eidelman, S; Ellis, J; Erler, J; Ezhela, VV; Fetscher, W; Fields, BD; Firestone, R; Foster, B; Freitas, A; Gallagher, H; Garren, L; Gerber, H-J; Gerbier, G; Gershon, T; Gershtein, Y; Gherghetta, T; Godizov, AA; Goodman, M; Grab, C; Gritsan, AV; Grojean, C; Groom, DE; Grunewald, M; Gurtu, A; Gutsche, T; Haber, HE; Hanhart, C; Hashimoto, S; Hayato, Y; Hayes, KG; Hebecker, A; Heinemeyer, S; Heltsley, B; Hernandez-Rey, JJ; Hisano, J; Hocker, A; Holder, J; Holtkamp, A; Hyodo, T; Irwin, KD; Johnson, KF; Kado, M; Karliner, M; Katz, UF; Klein, SR; Klempt, E; Kowalewski, RV; Krauss, F; Kreps, M; Krusche, B; Kuyanov, YV; Kwon, Y; Lahav, O; Laiho, J; Lesgourgues, J; Liddle, A; Ligeti, Z; Lin, C-J; Lippmann, C; Liss, TM; Littenberg, L; Lugovsky, KS; Lugovsky, SB; Lusiani, A; Makida, Y; Maltoni, F; Mannel, T; Manohar, AV; Marciano, WJ; Martin, AD; Masoni, A; Matthews, J; Meissner, U-G; Milstead, D; Mitche, RE; Moenig, K; Molaro, P; Moortgat, F; Moskovic, M; Murayama, H; Narain, M; Nason, P; Navas, S; Neubert, M; Nevski, P; Nir, Y; Olive, KA; Griso, SP; Parsons, J; Patrignani, C; Peacock, JA; Pennington, M; Petcov, ST; Petrov, VA; Pianori, E; Piepke, A; Pomarol, A; Quadt, A; Rademacker, J; Raffelt, G; Ratcliff, BN; Richardson, P; Ringwald, A; Roesler, S; Rolli, S; Romaniouk, A; Rosenberg, LJ; Rosner, JL; Rybka, G; Ryutin, RA; Sachrajda, CT; Sakai, Y; Salam, GP; Sarkar, S; Sauli, F; Schneider, O; Scholberg, K; Schwartz, AJ; Scott, D; Sharma, V; Sharpe, SR; Shutt, T; Silari, M; Sjostrand, T; Skands, P; Skwarnicki, T; Smith, JG; Smoot, GF; Spanier, S; Spieler, H; Spiering, C; Stah, A; Stone, SL; Sumiyoshi, T; Syphers, MJ; Terashi, K; Terning, J; Thoma, U; Thorne, RS; Tiator, L; Titov, M; Tkachenko, NP; Tornqvist, NA; Tovey, DR; Valencia, G; Van de Water, R; Varelas, N; Venanzoni, G; Verde, L; Vincter, MG; Voge, P; Vogt, A; Wakely, SP; Walkowiak, W; Walter, CW; Wands, D; Ward, DR; Wascko, MO; Weiglein, G; Weinberg, DH; Weinberg, EJ; White, M; Wiencke, LR; Willocq, S; Woh, CC; Womersley, J; Woody, CL; Workman, RL; Yao, W-M; Zeller, GP; Zenin, OV; Zhu, R-Y; Zhu, S-L; Zimmermann, F; Zyla, PA; Anderson, J; Fuller, L; Lugovsky, VS; Schaffner, P; - view fewer (2018) Review of Particle Physics: Particle Data Group. Physical Review D , 98 (3) 10.1103/PhysRevD.98.030001 . Green open access

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The EUI flight instrument of Solar Orbiter: from optical alignment to end-to-end calibration

Halain, JP; Renotte, E; Auchère, F; Berghmans, D; Delmotte, F; Harra, L; Schmutz, W; ... Rochus, P; + view all Halain, JP; Renotte, E; Auchère, F; Berghmans, D; Delmotte, F; Harra, L; Schmutz, W; Schühle, U; Aznar Cuadrado, R; Dumesnil, C; Gyo, M; Kennedy, T; Verbeeck, C; Barbay, J; Giordanengo, B; Gissot, S; Gottwald, A; Heerlein, K; Hellin, M-L; Hermans, A; Hervier, V; Jacques, L; Laubis, C; Mazzoli, A; Meining, S; Mercier, R; Philippon, A; Roose, S; Rossi, L; Scholze, F; Smith, P; Teriaca, L; Zhang, X; Rochus, P; - view fewer (2018) The EUI flight instrument of Solar Orbiter: from optical alignment to end-to-end calibration. In: den Herder, Jan-Willem A and Nikzad, Shouleh and Nakazawa, Kazuhiro, (eds.) Proceedings of SPIE - Space Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray. Society of Photo-optical Instrumentation Engineers: Bellingham (WA), USA. Green open access

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A chemical survey of exoplanets with ARIEL

Tinetti, G; (2018) A chemical survey of exoplanets with ARIEL. Experimental Astronomy pp. 1-75. 10.1007/s10686-018-9598-x . (In press). Green open access

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Search for resonances in the mass distribution of jet pairs with one or two jets identified as b-jets in proton-proton collisions at root s=13 TeV with the ATLAS detector

Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; ... Zwalinski, L; + view all Aaboud, M; Aad, G; Abbott, B; Abdinov, O; Abeloos, B; Abhayasinghe, DK; Abidi, SH; AbouZeid, OS; Abraham, NL; Abramowicz, H; Abreu, H; Abulaiti, Y; Acharya, BS; Adachi, S; Adamczyk, L; Adelman, J; Adersberger, M; Adiguzel, A; Adye, T; Affolder, AA; Afik, Y; Agheorghiesei, C; Aguilar-Saavedra, JA; Ahmadov, F; Aielli, G; Akatsuka, S; Akesson, TPA; Akilli, E; Akimov, AV; Alberghi, GL; Albert, J; Albicocco, P; Verzini, MJA; Alderweireldt, S; Aleksa, M; Aleksandrov, IN; Alexa, C; Alexopoulos, T; Alhroob, M; Ali, B; Alimonti, G; Alison, J; Alkire, SP; Allaire, C; Allbrooke, BMM; Allen, BW; Allport, PP; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Alshehri, AA; Alstaty, MI; Gonzalez, BA; Alvarez Piqueras, D; Alviggi, MG; Amadio, BT; Coutinho, YA; Ambroz, L; Amelung, C; Amidei, D; Dos Santos, SPA; Amoroso, S; Amrouche, CS; Anastopoulos, C; Ancu, LS; Andari, N; Andeen, T; Anders, CF; Anders, JK; Anderson, KJ; Andreazza, A; Andrei, V; Anelli, CR; Angelidakis, S; Angelozzi, I; Angerami, A; Anisenkov, AV; Annovi, A; Antel, C; Anthony, MT; Antonelli, M; Antrim, DJA; Anulli, F; Aoki, M; Bella, LA; Arabidze, G; Arai, Y; Araque, JP; Araujo Ferraz, V; Araujo Pereira, R; Arce, ATH; Ardell, RE; Arduh, FA; Arguin, J-F; Argyropoulos, S; Armbruster, AJ; Armitage, LJ; Armstrong, A; Arnaez, O; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Artz, S; Asai, S; Asbah, N; Ashkenazi, A; Asimakopoulou, EM; Asquith, L; Assamagan, K; Astalos, R; Atkin, RJ; Atkinson, M; Atlay, NB; Augsten, K; Avolio, G; Avramidou, R; Axen, B; Ayoub, MK; Azuelos, G; Baas, AE; Baca, MJ; Bachacou, H; Bachas, K; Backes, M; Bagnaia, P; Bahmani, M; Bahrasemani, H; Bailey, AJ; Baines, JT; Bajic, M; Bakalis, C; Baker, OK; Bakker, PJ; Gupta, DB; Baldin, EM; Balek, P; Balli, F; Balunas, WK; Balz, J; Banas, E; Bandyopadhyay, A; Banerjee, S; Bannoura, AAE; Barak, L; Barbe, WM; Barberio, EL; Barberis, D; Barbero, M; Barillari, T; Barisits, M-S; Barkeloo, J; Barklow, T; Barlow, N; Barnea, R; Barnes, SL; Barnett, BM; Barnett, RM; Barnovska-Blenessy, Z; Baroncelli, A; Barone, G; Barr, AJ; Barranco Navarro, L; Barreiro, F; Barreiro Guimaraes da Costa, J; Bartoldus, R; Barton, AE; Bartos, P; Basalaev, A; Bassalat, A; Bates, RL; Batista, SJ; Batlamous, S; Batley, JR; Battaglia, M; Bauce, M; Bauer, F; Bauer, KT; Bawa, HS; Beacham, JB; Beattie, MD; Beau, T; Beauchemin, PH; Bechtle, P; Beck, HC; Beck, HP; Becker, K; Becker, M; Becot, C; Beddall, A; Beddall, AJ; Bednyakov, VA; Bedognetti, M; Bee, CP; Beermann, TA; Begalli, M; Begel, M; Behera, A; Behr, JK; Bell, AS; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Bellos, P; Belotskiy, K; Belyaev, NL; Benary, O; Benchekroun, D; Bender, M; Benekos, N; Benhammou, Y; Noccioli, EB; Benitez, J; Benjamin, DP; Benoit, M; Bensinger, JR; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, EB; Berger, N; Bergsten, LJ; Beringer, J; Berlendis, S; Bernard, NR; Bernardi, G; Bernius, C; Bernlochner, FU; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertram, IA; Besjes, GJ; Bylund, OB; Bessner, M; Besson, N; Bethani, A; Bethke, S; Betti, A; Bevan, AJ; Beyer, J; Bianchi, RMB; Biebel, O; Biedermann, D; Bielski, R; Bierwagen, K; Biesuz, NV; Biglietti, M; Billoud, TRV; Bindi, M; Bingul, A; Bini, C; Biondi, S; Bisanz, T; Biswal, JP; Bittrich, C; Bjergaard, DM; Black, JE; Black, KM; Blair, RE; Blazek, T; Bloch, I; Blocker, C; Blue, A; Blumenschein, U; Blunier, D; Bobbink, GJ; Bobrovnikov, VS; Bocchetta, SS; Bocci, A; Boerner, D; Bogavac, D; Bogdanchikov, AG; Bohm, C; Boisvert, V; Bokan, P; Bold, T; Boldyrev, AS; Bolz, AE; Bomben, M; Bona, M; Bonilla, JS; Boonekamp, M; Borisov, A; Borissov, G; Bortfeldt, J; Bortoletto, D; Bortolotto, V; Boscherini, D; Bosman, M; Sola, JDB; Bouaouda, K; Boudreau, J; Bouhova-Thacker, EV; Boumediene, D; Bourdarios, C; Boutle, SK; Boveia, A; Boyd, J; Boyko, IR; Bozson, AJ; Bracinik, J; Brahimi, N; Brandt, A; Brandt, G; Brandt, O; Braren, F; Bratzler, U; Brau, B; Brau, JE; Madden, WDB; Brendlinger, K; Brennan, AJ; Brenner, L; Brenner, R; Bressler, S; Brickwedde, B; Briglin, DL; Britton, D; Britzger, D; Brock, I; Brock, R; Brooijmans, G; Brooks, T; Brooks, WK; Brost, E; Broughton, JH; de Renstrom, PAB; Bruncko, D; Bruni, A; Bruni, G; Bruni, LS; Bruno, S; Brunt, BH; Bruschi, M; Bruscino, N; Bryant, P; Bryngemark, L; Buanes, T; Buat, Q; Buchholz, P; Buckley, AG; Budagov, IA; Buehrer, F; Bugge, MK; Bulekov, O; Bullock, D; Burch, TJ; Burdin, S; Burgard, CD; Burger, AM; Burghgrave, B; Burka, K; Burke, S; Burmeister, I; Burr, JTP; Buescher, D; Buescher, V; Buschmann, E; Bussey, P; Butler, JM; Buttar, CM; Butterworth, JM; Butti, P; Buttinger, W; Buzatu, A; Buzykaev, AR; Cabras, G; Urban, SC; Caforio, D; Cai, H; Cairo, VMM; Cakir, O; Calace, N; Calafiura, P; Calandri, A; Calderini, G; Calfayan, P; Callea, G; Caloba, LP; Lopez, SC; Calvet, D; Calvet, S; Calvet, TP; Calvetti, M; Toro, RC; Camarda, S; Camarri, P; Cameron, D; Armadans, RC; Camincher, C; Campana, S; Campanelli, M; Camplani, A; Campoverde, A; 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Chiarella, V; Chiarelli, G; Chiodini, G; Chisholm, AS; Chitan, A; Chiu, I; Chiu, YH; Chizhov, MV; Choi, K; Chomont, AR; Chouridou, S; Chow, YS; Christodoulou, V; Chu, MC; Chudoba, J; Chuinard, AJ; Chwastowski, JJ; Chytka, L; Cinca, D; Cindro, V; Cioara, IA; Ciocio, A; Cirotto, F; Citron, ZH; Citterio, M; Clark, A; Clark, MR; Clark, PJ; Clement, C; Coadou, Y; Cobal, M; Coccaro, A; Cochran, J; Coimbra, AEC; Colasurdo, L; Cole, B; Colijn, AP; Collot, J; Muino, PC; Coniavitis, E; Connell, SH; Connelly, IA; Constantinescu, S; Conventi, F; Cooper-Sarkar, AM; Cormier, F; Cormier, KJR; Corradi, M; Corrigan, EE; Corriveau, F; Cortes-Gonzalez, A; Costa, MJ; Costanzo, D; Cottin, G; Cowan, G; Cox, BE; Crane, J; Cranmer, K; Crawley, SJ; Creager, RA; Cree, G; Crepe-Renaudin, S; Crescioli, F; Cristinziani, M; Croft, V; Crosetti, G; Cueto, A; Donszelmann, TC; Cukierman, AR; Curatolo, M; Cuth, J; Czekierda, S; Czodrowski, P; Da Cunha Sargedas De Sousa, MJ; Da Via, C; Dabrowski, W; Dado, T; Dahbi, S; Dai, T; Dallaire, F; Dallapiccola, C; Dam, M; D'amen, G; Damp, J; Dandoy, JR; Daneri, MF; Dang, NP; Dann, ND; Danninger, M; Dao, V; Darbo, G; Darmora, S; Dartsi, O; Dattagupta, A; Daubney, T; D'Auria, S; Davey, W; David, C; Davidek, T; Davis, DR; Dawe, E; Dawson, I; De, K; De Asmundis, R; De Benedetti, A; De Castro, S; De Cecco, S; De Groot, N; De Jong, P; De la Torre, H; De Lorenzi, F; De Maria, A; De Pedis, D; De Salvo, A; De Sanctis, U; De Santo, A; Corga, KDV; De Regie, JBDV; Debenedetti, C; Dedovich, DV; Dehghanian, N; Del Gaudio, M; Del Peso, J; Delgove, D; Deliot, F; Delitzsch, CM; Della Pietra, M; Della Volpe, D; Dell'Acqua, A; Dell'Asta, L; Delmastro, M; Delporte, C; Delsart, PA; DeMarco, DA; Demers, S; Demichev, M; Denisov, SP; Denysiuk, D; D'Eramo, L; Derendarz, D; Derkaoui, JE; Derue, F; Dervan, P; Desch, K; Deterre, C; Dette, K; Devesa, MR; Deviveiros, PO; Dewhurst, A; Dhaliwal, S; Di Bello, FA; Di Ciaccio, A; Di Ciaccio, L; Di Clemente, WK; Di Donato, C; Di Girolamo, A; Di Micco, B; Di Nardo, R; Di Petrillo, KF; Di Simone, A; Di Sipio, R; Di Valentino, D; Diaconu, C; Diamond, M; Dias, FA; Do Vale, TD; Diaz, MA; Dickinson, J; Diehl, EB; Dietrich, J; Cornell, SD; Dimitrievska, A; Dingfelder, J; Dittus, F; Djama, F; Djobava, T; Djuvsland, JI; Do Vale, MAB; Dobre, M; Dodsworth, D; Doglioni, C; Dolejsi, J; Dolezal, Z; Donadelli, M; Donini, J; D'onofrio, A; D'Onofrio, M; Dopke, J; Doria, A; Dova, MT; Doyle, AT; Drechsler, E; Dreyer, E; Dreyer, T; Dris, M; Du, Y; Duarte-Campderros, J; Dubinin, F; Dubovsky, M; Dubreuil, A; Duchovni, E; Duckeck, G; Ducourthial, A; Ducu, OA; Duda, D; Dudarev, A; Dudder, AC; Duffield, EM; Duflot, L; Duhrssen, M; Dulsen, C; Dumancic, M; Dumitriu, AE; Duncan, AK; Dunford, M; Duperrin, A; Yildiz, HD; Duren, M; Durglishvili, A; Duschinger, D; Dutta, B; Duvnjak, D; Dyndal, M; Dysch, S; Dziedzic, BS; Eckardt, C; Ecker, KM; Edgar, RC; Eifert, T; Eigen, G; Einsweiler, K; Ekelof, T; El Kacimi, M; El Kosseifi, R; Ellajosyula, V; Ellert, M; Ellinghaus, F; 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Zeissner, SV; Zeitnitz, C; Zemaityte, G; Zeng, JC; Zeng, Q; Zenin, O; Zerwas, D; Zgubic, M; Zhang, DF; Zhang, D; Zhang, F; Zhang, G; Zhang, H; Zhang, J; Zhang, L; Zhang, L; Zhang, M; Zhang, P; Zhang, R; Zhang, R; Zhang, X; Zhang, Y; Zhang, Z; Zhao, X; Zhao, Y; Zhao, Z; Zhemchugov, A; Zhou, B; Zhou, C; Zhou, L; Zhou, MS; Zhou, M; Zhou, N; Zhou, Y; Zhu, CG; Zhu, HL; Zhu, H; Zhu, J; Zhu, Y; Zhuang, X; Zhukov, K; Zhulanov, V; Zibell, A; Zieminska, D; Zimine, NI; Zimmermann, S; Zinonos, Z; Zinser, M; Ziolkowski, M; Zobernig, G; Zoccoli, A; Zoch, K; Zorbas, TG; Zou, R; Zur Nedden, M; Zwalinski, L; - view fewer (2018) Search for resonances in the mass distribution of jet pairs with one or two jets identified as b-jets in proton-proton collisions at root s=13 TeV with the ATLAS detector. Physical Review D , 98 (3) , Article 032016-24. 10.1103/PhysRevD.98.032016 . Green open access

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The Promise and Perils of Biotech in Personalised Healthcare. Can New Regulatory Pathways Protect the Vulnerable?

De Grandis, G; Brass, I; Petersen, A; (2018) The Promise and Perils of Biotech in Personalised Healthcare. Can New Regulatory Pathways Protect the Vulnerable? Risk and Regulation magazine (In press).

https://ift.tt/2Q4CwZ8

Selective serotonin reuptake inhibitor use and mortality, postoperative complications, and quality of care in hip fracture patients: a Danish nationwide cohort study

Bruun, SB; Petersen, I; Kristensen, NR; Cronin-Fenton, D; Pedersen, AB; (2018) Selective serotonin reuptake inhibitor use and mortality, postoperative complications, and quality of care in hip fracture patients: a Danish nationwide cohort study. Clinical Epidemiology , 10 pp. 1053-1071. 10.2147/CLEP.S166309 . Green open access

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1986, The Michael Faraday prize and the promotion of science in the nineteenth century

James, FAJL; (2018) 1986, The Michael Faraday prize and the promotion of science in the nineteenth century. Public Understanding of Science , 27 (3) pp. 382-388. 10.1177/0963662517746006 . Green open access

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On the feasibility of automated mechanical ventilation control through EIT

Tregidgo, H; Crabb, MG; Hazel, A; Lionheart, W; (2018) On the feasibility of automated mechanical ventilation control through EIT. IEEE Transactions on Biomedical Engineering 10.1109/TBME.2018.2798812 . (In press). Green open access

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Defending broad neutrality

Howard, JW; (2018) Defending broad neutrality. Critical Review of International Social and Political Philosophy 10.1080/13698230.2018.1487232 . (In press).

https://ift.tt/2Q5oAOq

Eine Tragödie in drei Akten - Casa Sperimentale in Fregene (I)

Weber, PM; Storp, S; (2018) Eine Tragödie in drei Akten - Casa Sperimentale in Fregene (I). Deutsche Bauzeitung , 2018 (09) pp. 128-129. (In press).

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Introduction: Laborde, liberalism, and religion

Bardon, A; Howard, JW; (2018) Introduction: Laborde, liberalism, and religion. Critical Review of International Social and Political Philosophy pp. 1-8. 10.1080/13698230.2018.1487229 . (In press).

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Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial

Masi, S; Orlandi, M; Parkar, M; Bhowruth, D; Kingston, I; O'Rourke, C; Virdis, A; ... Deanfield, J; + view all Masi, S; Orlandi, M; Parkar, M; Bhowruth, D; Kingston, I; O'Rourke, C; Virdis, A; Hingorani, A; Hurel, SJ; Donos, N; D'Aiuto, F; Deanfield, J; - view fewer (2018) Mitochondrial oxidative stress, endothelial function and metabolic control in patients with type II diabetes and periodontitis: A randomised controlled clinical trial. International Journal of Cardiology , 271 pp. 263-268. 10.1016/j.ijcard.2018.05.019 . Green open access

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The labors of justice: democracy, respect, and judicial review

Howard, JW; (2017) The labors of justice: democracy, respect, and judicial review. Critical Review of International Social and Political Philosophy pp. 1-24. 10.1080/13698230.2017.1334437 . (In press).

https://ift.tt/2Q2HSnK

Prediction of tongue obstruction observed from drug induced sleep computed tomography by cephalometric parameters

Publication date: Available online 24 September 2018

Source: Auris Nasus Larynx

Author(s): Rashu Mittal, Li-Ang Lee, Cheng Hui Lin, Li-Jen Hsin, Navdeep Bhusri, Hsueh-Yu Li

Abstract

Objective

To elucidate potential role of cephalometric measurements to predict tongue base obstruction as observed on drug Induced Sleep Computed Tomography (DIS-CT).

Methods

Study included 35 patients with moderate to severe sleep apnea who underwent DIS-CT & cephalometric examination to assess tongue base obstruction.

Results

Statistically significant difference was noted for SNA angle & Mandibular posterior airway space (PAS) among groups with total tongue obstruction versus Non-total tongue obstruction identified on DIS-CT.

Conclusion

Lateral cephalogram can be used as a standard screening tool with commonly used skeletal and soft tissue parameters to predict the possibility of tongue collapse/obstruction during sleep in patient with moderate to severe OSAS.

https://ift.tt/2OPAsnt

Efficacy and safety assessment of expiratory positive airway pressure (EPAP) mask for OSAHS therapy

Publication date: Available online 24 September 2018

Source: Auris Nasus Larynx

Author(s): Yaxuan Liu, Yangyang Ying, Jaffar S. Pandu, Yan Wang, Shuang Dou, Yanzhong Li, Dedong Ma

Abstract

Objective

We have designed the expiratory positive airway pressure (EPAP) mask to provide a new sort of therapeutic strategies for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS). And this study aims to assess the safety, efficacy and compliance of the EPAP therapy.

Methods

40 healthy volunteers were enrolled to measure the end-tidal carbon dioxide pressure (PETCO₂) while being treated by EPAP mask. 40 symptomatic moderate or severe OSAHS patients (AHI ≥ 15/h) recruited were equally divided into two groups randomly and treated with CPAP or mask for a week respectively. After a week of washing out, the patients were applied with exchanged therapeutic methods for another week. The PSG was performed at the end of each week of treatment with device-on.

Results

There were no significant differences of PETCO₂ under different exhaled positive pressure level between CPAP, EPAP therapies and non-therapy for the healthy volunteers (P > 0.05). After being treated, among the OSAHS patients in the two groups, the ESS scores and AHI decreased, and minimum SaO₂ and mean SaO₂ increased significantly (all P > 0.05). There was no significant differences of the efficacy between EPAP and CPAP therapy.

Conclusions

EPAP mask therapy was safe and reliable with significant efficacy for selected OSAHS patients. However, the compliance needs further improvement.

https://ift.tt/2zsxRL6

Exercise-Induced Anaphylaxis Associated With the Use of Bee Pollen

Publication date: Available online 25 September 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Kara B. McNamara, Lily Pien

https://ift.tt/2IdbDPJ

Morphea/lokalisierte Sklerodermie und extragenitaler Lichen sclerosus

Zusammenfassung

Die lokalisierte Sklerodermie (LoS) ist eine sehr heterogene Bindegewebserkrankung, die durch eine progrediente Sklerosierung der Haut mit möglicher Beteiligung extrakutaner Strukturen gekennzeichnet ist. Sowohl Kinder als auch Erwachsene können betroffen sein, zeigen aber unterschiedliche Häufigkeiten in den einzelnen Subtypen der Erkrankung. Die Erkrankung kann sich klinisch an der Haut je nach Subtyp sehr unterschiedlich darstellen. Aus diesem Grund wurden bereits eine Reihe von Klassifikationen entwickelt und in der Literatur beschrieben. Im Wesentlichen werden 5 Subgruppen differenziert, die durch horizontale bzw. vertikale Ausdehnung der Gewebsschädigung definiert sind und die je nach Ausprägung der kutanen und der subkutanen Beteiligung die Lebensqualität der betroffenen Patienten massiv einschränken können. Eine kausale Therapie existiert bisher nicht, trotzdem sollten die zur Verfügung stehenden Medikamenten bei progressiven Subtypen früh eingesetzt werden, um schwerwiegende funktionelle und kosmetische Beeinträchtigungen zu verringern bzw. zu vermeiden. Lichen sclerosus (LS) tritt genital und extragenital, ebenfalls sowohl bei Kindern als auch bei Erwachsenen, auf. Die extragenitale Form, auf die der vorliegende Beitrag fokussiert, kommt häufiger bei Erwachsenen vor. Auch hier ist die Genese der Erkrankung noch nicht aufgedeckt, und kausale Therapieformen stehen ebenfalls noch nicht zur Verfügung. Die Therapie orientiert sich an LoS.

https://ift.tt/2xNEPbw