Thyroid, Ahead of Print.
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- Levothyroxine Replacement Therapy and Overuse: A T...
- Distinct transcriptomic profiles of early-onset at...
- Neutrophil to lymphocyte ratio is a novel independ...
- Foreign bodies in the ear, nose, and throat in Jap...
- Winter Coats & Car Seats | Safety Tips
- In Response to Accuracy and Reliability of the Flo...
- IFAR 2018 Reviewers
- Changes in the clinical and histological character...
- Optic neuritis following diphtheria, tetanus, pert...
- Efficacy and Safety of a Water-Based Head Lice Lot...
- A rare presentation of a paediatric sinonasal inve...
- Brunner’s gland hyperplasia: an unusual duodenal s...
- Minimally invasive drainage of a giant ovarian muc...
- Embodied precision: Intranasal oxytocin modulates ...
- Euphony: Harmonious Unification of Cacophonous Ant...
- Practical challenges for biomedical modeling using...
- Henry James on the Bench
- Developmental Trajectories of Conduct Problems and...
- Optimization of extrusion based ceramic 3D printin...
- Power applied to purpose : environmental control a...
- The Archaeobotany of Khao Sam Kaeo and Phu Khao Th...
- Predicting serum ferritin levels in patients with ...
- Slice-illuminated optical projection tomography
- Comparison of gefitinib, erlotinib and afatinib in...
- Online support vector regression for network trave...
- Fertility histories and chronic conditions later i...
- Whole rat stomach decellularisation using a deterg...
- Devolving healthcare services redesign to local cl...
- Examining second language vocabulary growth: Repli...
- Learning from failure: exploring the psychodynamic...
- Poverty and Family Troubles: Mothers, Children, an...
- Simulation: the power of what hurts
- The evolving role of automation in process develop...
- Salvage laryngectomy following organ-preservation ...
- Magnetic resonance-based volumetric measurement of...
- Role of phosphorylcholine in Streptococcus pneumon...
- Corrigendum to “Environmental factors associated w...
- Klassifikation und Pathophysiologie von Angioödemen
- Large-Scale Otoscopic and Audiometric Population A...
- Dog Bite Injuries to the Face: Is there Risk with ...
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- The arts and dementia: Emerging directions for the...
- OpenWorm: overview and recent advances in integrat...
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- Digest: Evolution of sperm size and number in exte...
- Dark Energy Survey Year 1 Results: A Precise H-0 E...
- Regional variability in the atmospheric nitrogen d...
- Soliton solutions in geometrically nonlinear Cosse...
- Changes In LXRα Phosphorylation Promote A Novel Di...
- Review of Particle Physics: Particle Data Group
- Die Konzentration überschreitend
- Erratum
- Anti-microbial Resistance In Atopic Dermatitis: Ne...
- Challenges in allergy immunology practice: Solutio...
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- Increased IRF4 expression in isolated B cells from...
- Development of a tool for screening adverse food r...
- Changes in the prevalence of asthma and related ri...
- Self-reported hypersensitivity and allergy to food...
- Plasma CXCL13 is a predictive factor for HBsAg los...
- Studies into the insecticidal activity and mode of...
- The impact of Vitamin D supplementation on musculo...
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- Distance-decay effect in stone tool transport by w...
- Creative Challenge and Cognitive Constraint: Stude...
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Ετικέτες
Παρασκευή 30 Νοεμβρίου 2018
Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach
Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. The pipeline of novel targeted treatments for AD is expanding, largely based on our growing knowledge of disease mechanisms, with new therapeutics particularly focused on immune modulation.1 Most of our understanding of AD is derived from profiling tissues and blood of longstanding AD in adults, due to the difficulty of obtaining samples from infants and young children. However, initiation of AD typically happens very early in life, and the disease is already chronically established in the majority of patients by 5yrs of age.
https://ift.tt/2KKrFC9
Neutrophil to lymphocyte ratio is a novel independent predictor of severe exacerbation in asthma patients
Severe exacerbations are well-known complications of asthma, which increase the total and asthma-related health care costs1 and decrease the quality of life of patients2. Although some exacerbation predictors have been reported3,4, it is difficult to predict and prevent severe exacerbations in a large percentage of patients affected by asthma.
https://ift.tt/2BI6IVo
Foreign bodies in the ear, nose, and throat in Japan: association with sociocultural and geographical conditions
Foreign bodies (FBs) in ear, nose, and throat (ENT) are common ENT emergencies but are sometimes life-threatening. However, FBs could be avoidable by the efficient announcement about the risk of these occurrence to the public. Fish bones are commonly found as throat FBs, and small toys are commonly found as pediatric ear and nose FBs. We hypothesized that there were relationships between the occurrence of FBs and sociocultural/geographical conditions. The purpose of this study is to clarify the risk factors of FBs in ENT regions related to eating customs and weather conditions.
https://ift.tt/2QqiM5Y
Winter Coats & Car Seats | Safety Tips
Did you know babies & small children should never wear coats while in their car seats? Our Safety Stop team demonstrates how coats prevent children from getting a snug fit in the car seat. We'll share our favorite alternatives to keep your child safe and warm in the car this winter.
Learn more about the Safety Stop team and how to book an appointment at one of our area locations: https://ift.tt/1GMzn80
The post Winter Coats & Car Seats | Safety Tips appeared first on ChildrensMD.
https://ift.tt/2Q8s5Z7
In Response to Accuracy and Reliability of the Flow Coupler in Postoperative Monitoring of Head and Neck Free Flaps
https://ift.tt/2DTr1Rd
IFAR 2018 Reviewers
https://ift.tt/2E8AhlJ
Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years
Background
Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China.
Methods
A total of 115 consecutive CRSwNP patients from 2003 to 2005 and 114 consecutive CRSwNP patients from 2014 to 2016 were enrolled in this retrospective study. The clinical and histological data were compared between patients from the 2 time periods.
Results
The percentage of eosinophils in nasal polyp tissue increased, and the percentage of neutrophils and total inflammatory cell count decreased, over 11 years. The proportion of eosinophilic CRSwNP significantly increased from 59.1% to 73.7% over 11 years. The proportion of neutrophils and the total inflammatory cell count in nasal polyps decreased, and the proportion of eosinophilic CRSwNP patients using intranasal corticosteroids 1 month before surgery increased remarkably over 11 years. Moreover, eosinophilic CRSwNP patients had better compliance with intranasal corticosteroid use than non‐eosinophilic CRSwNP patients, and patients with comorbid allergic rhinitis and asthma had better compliance with intranasal corticosteroid use than patients without those conditions.
Conclusion
Eosinophilic CRSwNP, which was previously a minor subtype in East Asians, has increased remarkably in incidence to become the predominant CRSwNP subtype in Beijing, China, indicating that rhinologists should place greater emphasis on its diagnosis and treatment.
https://ift.tt/2SkgySU
Optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination: a case report
Diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccine is widely used in young children as part of a series of immunizations before they start attending school. Case studies of demyelinati...
https://ift.tt/2FPpDSh
Efficacy and Safety of a Water-Based Head Lice Lotion: A Randomized, Controlled, Investigator-Blinded, Comparative, Bicentric Study
Abstract
Introduction
Silicones (e.g., dimethicone) are effective and safe alternatives to insecticides for the treatment of head lice. However, silicones are lipophilic substances and do not only leave the hair greasy but they are also difficult to wash out. We have evaluated the efficacy and safety of a potential solution to this problem: an aqueous dispersion of a novel silylated polyol that has the same mode of action as dimethicone (suffocation) without its negative impact on hair characteristics.
Methods
This was a randomized, controlled, investigator-blinded, bicentric study that was conducted at two locations in the state of Florida (USA) to compare the test product (medical device) to a pyrethrum-based pediculicide that is a first-line, prescription-free treatment against head lice in the USA. The subjects (n = 70) were randomly divided into two groups of 35 persons (test product group and reference product group), with each participant receiving two applications (day 0 and 7) of the product to be tested, according to the instructions for use. Efficacy and safety was evaluated at distinct time points. The primary objective was to establish a cure rate for the test product that was better than 70% at study end (day 10). Esthetic effects of the test product versus dimethicone were evaluated in a blinded, cross-over consumer study (n = 100).
Results
At study end, the cure rate (corrected for re-infestation) of 88.2% with the test product significantly surpassed the pre-defined target of 70%, and thus the superiority of the test product versus the reference product was confirmed. The number of subjects cured (free of head lice) after the first treatment was remarkably higher with the test product than with the reference product (57.1 vs. 2.9%, respectively). Both products were safe and well tolerated and both showed beneficial esthetical effects. The consumer test demonstrated that the test product had better washing-out properties than dimethicone, as reflected by a significantly lower average rinsing time and number of washings required to restore the visual aspect of the hair, especially in terms of greasiness.
Conclusion
Aqueous dispersions of silylated polyols are a promising new class of pediculicides that combine high cure rates with optimal user convenience (short treatment period, easy wash-out with positive effect on hair quality).
Trial Registration
ClinicalTrials.gov identifier, NCT03617926.
Funding
Oystershell Laboratories.
https://ift.tt/2E9WorM
A rare presentation of a paediatric sinonasal inverted papilloma
https://ift.tt/2DUXRS1
Brunner’s gland hyperplasia: an unusual duodenal submucosal lesion seen in four patients
https://ift.tt/2Qv60TE
Minimally invasive drainage of a giant ovarian mucinous cystadenoma associated with a mature cystic teratoma
https://ift.tt/2DQ62yG
Embodied precision: Intranasal oxytocin modulates multisensory integration
Crucianelli, L; Paloyelis, Y; Ricciardi, L; Jenkinson, P; Fotopoulou, A; (2019) Embodied precision: Intranasal oxytocin modulates multisensory integration. Journal of Cognitive Neuroscience (In press).
https://ift.tt/2P7RdcY
Euphony: Harmonious Unification of Cacophonous Anti-Virus Vendor Labels for Android Malware
Hurier, M; Suarez-Tangil, G; Dash, SK; Bissyande, TF; Le Traon, Y; Klein, J; Cavallaro, L; (2017) Euphony: Harmonious Unification of Cacophonous Anti-Virus Vendor Labels for Android Malware. In: Proceedings of the 2017 IEEE/ACM 14th International Conference on Mining Software Repositories (MSR). (pp. pp. 425-435). IEEE: Buenos Aires, Argentina. Green open access
https://ift.tt/2zB6r5d
Practical challenges for biomedical modeling using HPC
Wright, D; Richardson, R; Coveney, P; (2018) Practical challenges for biomedical modeling using HPC. peerj.com: London, UK. Green open access
https://ift.tt/2P5DyDf
Henry James on the Bench
Horne, FP; (2019) Henry James on the Bench. Henry James Review (In press).
https://ift.tt/2zBshFE
Developmental Trajectories of Conduct Problems and Cumulative Risk from Early Childhood to Adolescence
Gutman, LM; Joshi, H; Schoon, I; (2019) Developmental Trajectories of Conduct Problems and Cumulative Risk from Early Childhood to Adolescence. Journal of Youth and Adolescence (In press).
https://ift.tt/2Pc8oKf
Optimization of extrusion based ceramic 3D printing process for complex bony designs
Roopavath, U; Malferrari, S; Haver, AV; Rath, SN; verstreken, F; Kalaskar, DM; (2018) Optimization of extrusion based ceramic 3D printing process for complex bony designs. Materials and Design 10.1016/j.matdes.2018.11.054 . (In press). Green open access
https://ift.tt/2ztWoyQ
Power applied to purpose : environmental control and the shape of modern architecture
Lord, David Allan; (1987) Power applied to purpose : environmental control and the shape of modern architecture. Doctoral thesis (Ph.D), UCL (University College London). Green open access
https://ift.tt/2P7QR68
The Archaeobotany of Khao Sam Kaeo and Phu Khao Thong: The Agriculture of Late Prehistoric Southern Thailand
Castillo, C; (2013) The Archaeobotany of Khao Sam Kaeo and Phu Khao Thong: The Agriculture of Late Prehistoric Southern Thailand. Doctoral thesis (PhD), UCL (University College London). Green open access
https://ift.tt/2zxy2V8
Predicting serum ferritin levels in patients with iron overload treated with the film-coated tablet of deferasirox during the ECLIPSE study
Taher, AT; Weber, S; Han, J; Bruederle, A; Porter, JB; (2018) Predicting serum ferritin levels in patients with iron overload treated with the film-coated tablet of deferasirox during the ECLIPSE study. American Journal of Hematology 10.1002/ajh.25322 . (In press). Green open access
https://ift.tt/2PaXuVp
Slice-illuminated optical projection tomography
Davis, SPX; Wisniewski, L; Kumar, S; Correia, T; Arridge, SR; Frankel, P; McGinty, J; Davis, SPX; Wisniewski, L; Kumar, S; Correia, T; Arridge, SR; Frankel, P; McGinty, J; French, PMW; - view fewer (2018) Slice-illuminated optical projection tomography. Optics Letters , 43 (22) pp. 5555-5558. 10.1364/OL.43.005555 . Green open access
https://ift.tt/2zxdkEM
Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis
Yang, Z; Hackshaw, A; Feng, Q; Fu, X; Zhang, Y; Mao, C; Tang, J; (2017) Comparison of gefitinib, erlotinib and afatinib in non-small cell lung cancer: A meta-analysis. International Journal of Cancer , 140 (12) pp. 2805-2819. 10.1002/ijc.30691 . Green open access
https://ift.tt/2Pc8hyj
Online support vector regression for network travel time prediction
Sari Aslam, Nilufer; (2013) Online support vector regression for network travel time prediction. Masters thesis (M.Sc), UCL (University College London). Green open access
https://ift.tt/2zxh8FY
Fertility histories and chronic conditions later in life in Europe
Sironi, M; (2019) Fertility histories and chronic conditions later in life in Europe. European Journal of Ageing 10.1007/s10433-018-0494-z . (In press). Green open access
https://ift.tt/2Pc8667
Whole rat stomach decellularisation using a detergent-enzymatic protocol
Zambaiti, E; Scottoni, F; Rizzi, E; Russo, S; Deguchi, K; Eaton, S; Pellegata, AF; Zambaiti, E; Scottoni, F; Rizzi, E; Russo, S; Deguchi, K; Eaton, S; Pellegata, AF; De Coppi, P; - view fewer (2018) Whole rat stomach decellularisation using a detergent-enzymatic protocol. Pediatric Surgery International 10.1007/s00383-018-4372-8 . (In press). Green open access
https://ift.tt/2zBDjuF
Devolving healthcare services redesign to local clinical leaders: Does it work in practice
Marshall, MN; Storey, J; Holti, R; Hartley, J; (2018) Devolving healthcare services redesign to local clinical leaders: Does it work in practice. Journal of Health Organization and Management 10.1108/JHOM-05-2018-0144 . (In press).
https://ift.tt/2Pc7VHZ
Examining second language vocabulary growth: Replications of Schmitt (1998) and Webb & Chang (2012)
Pellicer Sanchez, A; (2018) Examining second language vocabulary growth: Replications of Schmitt (1998) and Webb & Chang (2012). Language Teaching 10.1017/S026144481800037X . (In press). Green open access
https://ift.tt/2zBsdFU
Learning from failure: exploring the psychodynamics of work in a clinical simulation centre
Pelletier, C; Buchan, K; Hall-Jackson, M; (2019) Learning from failure: exploring the psychodynamics of work in a clinical simulation centre. Psychoanalysis, Culture and Society (In press).
https://ift.tt/2Pc7QnF
Poverty and Family Troubles: Mothers, Children, and Neoliberal “Antipoverty” Initiatives
Rosen, R; (2018) Poverty and Family Troubles: Mothers, Children, and Neoliberal "Antipoverty" Initiatives. Journal of Family Issues 10.1177/0192513X18809745 . (In press). Green open access
https://ift.tt/2zyF6k5
Simulation: the power of what hurts
Turton, D; Buchan, K; Hall-Jackson, M; Pelletier, C; (2018) Simulation: the power of what hurts. Medical Education 10.1111/medu.13788 . (In press).
https://ift.tt/2Pc7JbJ
The evolving role of automation in process development & manufacture of cell & gene-based therapies
Rafiq, QA; Thomas, RJ; (2016) The evolving role of automation in process development & manufacture of cell & gene-based therapies. Cell and Gene Therapy Insights , 2 (4) pp. 473-479. 10.18609/cgti.2016.058 .
https://ift.tt/2zyqam9
Salvage laryngectomy following organ-preservation therapy – An evidence-based review
Publication date: January 2019
Source: Oral Oncology, Volume 88
Author(s): Dustin A. Silverman, Sidharth V. Puram, James W. Rocco, Matthew O. Old, Stephen Y. Kang
Abstract
Salvage total laryngectomy is often indicated in patients with recurrent or persistent laryngeal cancer after radiation or chemoradiation treatment. This article reviews and discusses key considerations regarding salvage laryngectomy. Within this article, a review of the salvage laryngectomy incidence in the major organ preservation trials, survival rates, predictors of outcomes, complication rates, and the roles of elective neck dissection and free tissue transfer for reconstruction in patients undergoing salvage laryngectomy is provided.
https://ift.tt/2AFEybN
Magnetic resonance-based volumetric measurement of the endolymphatic space in patients with Meniere’s disease and other endolymphatic hydrops-related diseases
Publication date: Available online 30 November 2018
Source: Auris Nasus Larynx
Author(s): Hiroshi Inui, Tsuyoshi Sakamoto, Taeko Ito, Tadashi Kitahara
Abstract
Objective
To employ magnetic resonance imaging (MRI) to measure the volume of the inner ear endolymphatic space (ELS) in patients with acute low-tone sensorineural hearing loss (ALHL), sudden deafness (SD), cochlear Meniere's disease (cMD), and unilateral MD (uMD) compared with control subjects (CS) with chronic rhinosinusitis.
Methods
Forty-one patients with ALHL, 82 with SD, 48 with cMD, 72 with uMD, and 47 CS participated in the study. With the exception of all uMD patients, none of the subjects had vertigo. Images of the inner ear fluid space, positive perilymph signal, and positive endolymph signal were acquired using a 3-T MRI scanner. Three-dimensional images were reconstructed semi-automatically by using anatomical and tissue information to fuse the inner ear fluid space images and the ELS images.
Results
The cochlear ELS/total fluid space (TFS) volume ratio was 10.2 ± 6.7% (mean ± standard deviation) in the CS group, 12.1 ± 5.7% in ALHL patients, 15.2 ± 8.7% in SD patients, 18.1 ± 8.2% in cMD patients, and 21.9 ± 16.4% in uMD patients. The vestibular ELS/TFS volume ratio was 17.7 ± 10.2% in the CS group, 18.9 ± 8.3% in ALHL patients, 19.9 ± 11.3% in SD patients, 22.5 ± 13.7% in cMD patients, and 35.7 ± 24.1% in uMD patients. The cochlear ELS/TFS volume ratio in patients with uMD was similar to that in the cMD group and significantly higher than that in the CS, ALHL, and SD groups (CS = ALHL < SD < cMD = uMD: p < 0.05 for CS vs. SD and p < 0.01 for CS vs. cMD). The vestibular ELS/TFS volume ratio in patients with uMD was significantly higher than that in the CS and all other patient groups (CS = ALHL = SD = cMD < uMD: p < 0.01 for uMD vs. all other groups).
Conclusion
The cochlear ELS volume of patients with MD and other endolymphatic hydrops-related diseases differed from that of CS. Our results suggest that ALHL may not be caused by endolymphatic hydrops. We confirmed the presence of extended ELS in patients with SD.
https://ift.tt/2Rl6fOp
Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells
Publication date: Available online 29 November 2018
Source: Auris Nasus Larynx
Author(s): Hiroyuki Iuchi, Junichiro Ohori, Takayuki Kyutoku, Kotoko Ito, Yuichi Kurono
Abstract
Objective
Phosphorylcholine (PC) is a structural component of Streptococcus pneumoniae (Spn) and nontypeable Haemophilus influenzae (NTHi), and is known to be associated with adherence through the platelet activating factor receptor (PAF-R). Furthermore, high PC expression is considered to be involved in Spn and NTHi virulence. In this study, we examined the influence of PC expression on the adherence of Spn and NTHi to epithelial cells in order to clarify the potential effectiveness of a vaccine targeting PC.
Methods
Twenty-seven strains of Spn and twenty-two strains of NTHi were used, cultured overnight, and PC expression was evaluated by fluorescence activated cell sorting; the strains were divided into two groups: PC low expression (PC-low) and PC high expression (PC-high) groups. Bacterial adherence was then examined using Detroit 562 cells and BALB/c mice. Bacterial invasion was then examined in Detroit 562 cells.
Results
The adherence of Spn and NTHi and invasion of NTHi in the PC-high group was significantly reduced by pretreatment with a monoclonal anti-PC antibody (TEPC-15), PAF-R antagonist (ABT-491), and PC-keyhole limpet hemocyanin (PC-KLH). However, such findings were not observed in the PC-low group.
Conclusion
The present study suggests that PC is involved in the mucosal adhesion of Spn and NTHi, and the mucosal invasion of NTHi with PC-high strains, but not PC-low strains. These results suggest that a PC-targeting mucosal vaccine only affects PC-high Spn and NTHi strains and does not disturb commensal bacterial flora in the upper respiratory tract, which comprises nonpathogenic PC-low bacteria.
https://ift.tt/2Q0IH4G
Corrigendum to “Environmental factors associated with allergic rhinitis symptoms in Japanese university students: A cross-sectional study” [Auris Nasus Larynx 45 (2018) 1006–1013]
Publication date: Available online 29 November 2018
Source: Auris Nasus Larynx
Author(s): Hironobu Nishijima, Sayaka Suzuki, Kenji Kondo, Tatsuya Yamasoba, Shintaro Yanagimoto
https://ift.tt/2RuSehm
Klassifikation und Pathophysiologie von Angioödemen
Zusammenfassung
Hintergrund
Die differenzialdiagnostische Einordung von Angioödemen kann im klinischen Alltag eine Herausforderung darstellen.
Ziel der Arbeit
Ziel ist es, eine Übersicht über die aktuelle Klassifikation von Angioödemen zu geben und deren zugrunde liegende Pathophysiologie zu erläutern.
Material und Methoden
Es erfolgte die Auswertung aktueller Leitlinien und Forschungsarbeiten zur Pathophysiologie und Klassifikation von Angioödemen.
Ergebnisse
Angioödeme werden grundlegend in Mastzellmediator-induziert und Bradykinin-vermittelt unterschieden. Akute Angioödeme durch allergische Reaktionen oder im Rahmen einer akuten Urtikaria bzw. rezidivierende Angioödeme bei Patienten mit chronischer Urtikaria sind klassische Beispiele für Mastzellmediator-induzierte Angioödeme. Zu den Bradykinin-vermittelten Angioödemformen gehören das hereditäre Angioödem und das ACE(„angiotensin-converting enzyme")-Hemmer-induzierte Angioödem. Bradykinin-vermittelte Angioödeme kommen deutlich seltener vor als Mastzellmediator-induzierte Angioödeme und verlaufen of schwerer. Die Basis zur klinischen Unterscheidung beider Formen von Angioödemen ist die gezielte Anamneseerhebung und laborchemische Diagnostik.
Schlussfolgerungen
In den meisten Fällen lassen sich Angioödeme in Zusammenschau von Klinik und Diagnostik als Mastzellmediator-induziert oder Bradykinin-vermittelt unterscheiden. In sehr seltenen Fällen bleiben die Ursache und die verantwortlichen Mediatoren unklar.
https://ift.tt/2Q1GfLk
Large-Scale Otoscopic and Audiometric Population Assessment: A Pilot Study
Publication date: Available online 30 November 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Kenny H. Chan, Susan Dreith, Kristin M. Uhler, Veronica Tallo, Marilla Lucero, Joanne De Jesus, Eric AF. Simões
ABSTRACT
Objective
Large-scale otoscopic and audiometric assessment of populations is difficult due to logistic impracticalities, particularly in low- and middle-income countries (LMIC). We report a novel assessment methodology based on training local field workers, advances in audiometric testing equipment and cloud-based technology.
Methods
Prospective observational study in Bohol, Philippines. A U.S. otolaryngologist/audiologist team trained 5 local nurses on all procedures in a didactic and hands-on process. An operating otoscope (Welch-AllynR) was used to clear cerumen and view the tympanic membrane, images of which were recorded using a video otoscope (JedMedR). Subjects underwent tympanometry and distortion product otoacoustic emission (DPOAE) (Path SentieroR), and underwent screening audiometry using noise cancelling headphones and a handheld Android device (HearScreenR). Sound-booth audiometry was reserved for failed subjects. Data were uploaded to a REDCap database. Teenage children previously enrolled in a 2000-2004 Phase 3 pneumococcal conjugate vaccine trial, were the subjects of the trainees.
Results
During 4 days of training, 47 Filipino children (M/F = 28/19; mean/median age = 14.6/14.6 years) were the subjects of the trainee nurses. After the training, all nurses could perform all procedures independently. Otoscopic findings by ears included: normal (N=77), otitis media with effusion (N=2), myringosclerosis (N=5), healed perforation (N=6), perforation (N=2) and retraction pocket/cholesteatoma (N=2). Abnormal audiometric findings included: tympanogram (N=4), DPOAE (N=4) and screening audiometry (N=0).
Conclusion
Training of local nurses has been shown to be robust and this methodology overcomes challenges of distant large-scale population otologic/audiometric assessment.
https://ift.tt/2BHfVgO
Dog Bite Injuries to the Face: Is there Risk with Breed Ownership? A Systematic Review with Meta-Analysis
Publication date: Available online 29 November 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Garth Essig, Cameron Sheehan, Shefali Rikhi, Charles Elmaraghy, J. Jared Christophel
Abstract
Introduction
Dog bite injuries to the face are a serious, yet modifiable public health concern. This study explores the relationship between dog breed and the risk of biting and injury. The objective of this study is to determine the relative risk and severity of dog bite injuries to the face by breed.
Methods
Retrospective chart review of facial dog bite injuries presenting to the University of Virginia Health System and Nationwide Children's Hospital. Additionally, descriptive data was collected from 240 patients over the last 15 years. Bite risk by breed was assessed by a literature search from 1970 to current. A composite measure was used to determine the severity of injury, and characterize each patient into an ordinal scale of bite severity. An average of each breed bite rate within each study was calculated and combined to create an empiric bite risk by breed. Dog breeds were also further characterized morphologically.
Results
Bite risk by breed from the literature review and bite severity by breed from our case series were combined to create a total bite risk plot. Injuries from Pitbull's and mixed breed dogs were both more frequent and more severe. This data is well-suited for a bubble plot showing bite risk on the x-axis, bite severity on the y-axis, and size of the bubble by number of cases. This creates a "risk to own" graphic for potential dog owners.
Conclusions
Breeds vary in both rates of biting and severity. The highest risk breeds had both a high rate of biting and caused significant tissue injury. Physical characteristics can also help determine risk for unknown or mixed dog breeds. Potential dog owners can utilize this data when assessing which breed to own.
https://ift.tt/2KHFKjy
Surgical ablation of lingual tonsils in the treatment of obstructive sleep apnea
Publication date: Available online 30 November 2018
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): C. Mure, M. Blumen, A. Alali, L. Page, F. Chabolle
Abstract
Objectives/Hypothesis
The retrolingual space is one of the potential sites of obstruction identified in patients with obstructive sleep apnea syndrome (OSAS). Hypertrophied lingual tonsils (LT) can obstruct the airway at this level. The goal of this study was to measure the tolerance and efficacy of lingual tonsillectomy in patients with OSAS.
Study design
A retrospective chart review was conducted recruiting all patients with OSAS confirmed on sleep recording, who either had failed or refused medical treatment and who underwent lingual tonsillectomy.
Materials and methods
Diagnosis of LT hypertrophy was made by full ENT clinical examination using a flexible endoscopy, completed by MRI and followed by drug-induced sleep endoscopy. The surgical intervention was carried out endoscopically by diode laser or coblation. The primary endpoint to measure efficacy was drop in apnea-hypopnea index (AHI) on sleep recording at 6 months. Secondary endpoints comprised reduced snoring and Epworth Sleepiness Scale (ESS) and postoperative symptom tolerance.
Results
Eleven patients aged 44.3 ± 12.6 years were included. AHI dropped from 29.5 ± 21.7/h to 11.6 ± 9.6/h: i.e., by 60% (P = 0.005). Five patients had AHI < 10/h: i.e., cure rate of 45%. ESS dropped from 13 ± 3.4 to 8.1 ± 4.9 (P = 0.012). No complications were observed.
Conclusions
LT ablation seemed effective in OSAS with retrolingual obstruction in failure of medical treatment.
Level of evidence
4.
https://ift.tt/2BHd0EK
Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy
Publication date: Available online 29 November 2018
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): E. Moreddu, E. Lambert, D. Kacmarynski, R. Nicollas, J.-M. Triglia, R.J. Smith
Abstract
Objective
The study objective was to determine risk factors for severity of juvenile-onset recurrent respiratory papillomatosis (RRP) at first endoscopic evaluation.
Methods
Based on a review of all cases undergoing surgery for juvenile-onset RRP in two pediatric otolaryngology departments in the USA and France, the following severity risk factors were analyzed: number of laryngeal levels involved, extension to the subglottis, and bilateral involvement.
Results
Thirty-two patients were included, with 571 endoscopic procedures. Number of endoscopies per patient varied according to initial extension: 30.67 procedures when all three levels were involved, 15.57 procedures when two and 14.08 procedures when only one (P = 0.03). The odds ratio for risk of > 14 procedures in 3-level involvement was 20.43 (P = 0.047). Initial subglottic extension tended to be associated with more endoscopic procedures (23.67 vs 15.56, P = 0.16).
Conclusions
RRP severity correlated with initial laryngeal extension of papillomatous lesions at first endoscopy. This finding allowed a short 3-item assessment scale to be created for routine use, complementary to Derkay's assessment scale.
https://ift.tt/2KJ9wVf
The Trauma and Life Events (TALE) checklist: development of a tool for improving routine screening in people with psychosis
Carr, S; Hardy, A; Fornells-Ambrojo, M; (2018) The Trauma and Life Events (TALE) checklist: development of a tool for improving routine screening in people with psychosis. European Journal of Psychotraumatology , 9 (1) , Article 1512265. 10.1080/20008198.2018.1512265 . Green open access
https://ift.tt/2TWuJzc
Helping babies breathe can reduce deaths with the right combination oftraining and expertise
Enweronu-Laryea, C; Robertson, NJ; (2017) Helping babies breathe can reduce deaths with the right combination oftraining and expertise. Acta Pædiatrica , 106 (10) pp. 1552-1553. 10.1111/apa.13988 . Green open access
https://ift.tt/2AFirCj
A Dedicated Prostate MRI Teaching Course Improves the Ability of the Urologist to Interpret Clinically Significant Prostate Cancer on Multiparametric MRI
Kasivisvanathan, V; Ambrosi, A; Giganti, F; Chau, E; Kirkham, A; Punwani, S; Allen, C; ... Moore, CM; + view all Kasivisvanathan, V; Ambrosi, A; Giganti, F; Chau, E; Kirkham, A; Punwani, S; Allen, C; Emberton, M; Moore, CM; - view fewer (2018) A Dedicated Prostate MRI Teaching Course Improves the Ability of the Urologist to Interpret Clinically Significant Prostate Cancer on Multiparametric MRI. European Urology 10.1016/j.eururo.2018.09.033 . (In press).
https://ift.tt/2U0qUco
A Systemic Framework for Infrastructure Need Assessment
Dolan, TE; (2019) A Systemic Framework for Infrastructure Need Assessment. Proceedings of the Institution of Civil Engineers - Smart Infrastructure and Construction 10.1680/jsmic.18.00006 . (In press).
https://ift.tt/2AxQY5u
Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient
Lingam, I; Robertson, NJ; (2018) Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient. Developmental Neuroscience , 40 (1) pp. 1-12. 10.1159/000484891 .
https://ift.tt/2U1wESY
Assessing Quasi-Periodicities in Jovian X-Ray Emissions: Techniques and Heritage Survey
Jackman, CM; Knigge, C; Altamirano, D; Gladstone, R; Dunn, W; Elsner, R; Kraft, R; ... Ford, P; + view all Jackman, CM; Knigge, C; Altamirano, D; Gladstone, R; Dunn, W; Elsner, R; Kraft, R; Branduardi-Raymont, G; Ford, P; - view fewer (2018) Assessing Quasi-Periodicities in Jovian X-Ray Emissions: Techniques and Heritage Survey. Journal of Geophysical Research: Space Physics , 123 10.1029/2018JA025490 . (In press). Green open access
https://ift.tt/2AFiqi6
The fetus at the tipping point: modifying the outcome of fetal asphyxia
Dhillon, SK; Lear, CA; Galinsky, R; Wassink, G; Davidson, JO; Juul, S; Robertson, NJ; ... Bennet, L; + view all Dhillon, SK; Lear, CA; Galinsky, R; Wassink, G; Davidson, JO; Juul, S; Robertson, NJ; Gunn, AJ; Bennet, L; - view fewer (2018) The fetus at the tipping point: modifying the outcome of fetal asphyxia. Journal of Physiology , 596 (23) pp. 5571-5592. 10.1113/JP274949 .
https://ift.tt/2TZ1ZG7
Behavior of 1-bits near the many-body localization transition
Kulshreshtha, AK; Pal, A; Wahl, TB; Simon, SH; (2018) Behavior of 1-bits near the many-body localization transition. Physical Review B , 98 (18) , Article 184201. 10.1103/PhysRevB.98.184201 . Green open access
https://ift.tt/2ABtaOp
Bringing pupils into the ORBYTS of research
McKemmish, LK; Chubb, KL; Rivlin, T; Baker, JS; Gorman, MN; Heward, A; Dunn, W; McKemmish, LK; Chubb, KL; Rivlin, T; Baker, JS; Gorman, MN; Heward, A; Dunn, W; Tessenyi, M; - view fewer (2017) Bringing pupils into the ORBYTS of research. Astronomy and Geophysics , 58 (5) 5.11. 10.1093/astrogeo/atx169 . Green open access
https://ift.tt/2TWuAf8
Beyond basic resuscitation: What are the next steps to improve the outcomes of resuscitation at birth when resources are limited?
Niermeyer, S; Robertson, NJ; Ersdal, HL; (2018) Beyond basic resuscitation: What are the next steps to improve the outcomes of resuscitation at birth when resources are limited? Seminars in Fetal and Neonatal Medicine , 23 (5) pp. 361-368. 10.1016/j.siny.2018.06.002 .
https://ift.tt/2ABsVCZ
3D-printed Franz type diffusion cells
Sil, BC; Alvarez, MP; Zhang, Y; Kung, C-P; Hossain, M; Iliopoulos, F; Luo, L; ... Hilton, ST; + view all Sil, BC; Alvarez, MP; Zhang, Y; Kung, C-P; Hossain, M; Iliopoulos, F; Luo, L; Crowther, JM; Moore, DJ; Hadgraft, J; Hilton, ST; - view fewer (2018) 3D-printed Franz type diffusion cells. International Journal of Cosmetic Science 10.1111/ics.12504 . (In press).
https://ift.tt/2TWubcC
The arts and dementia: Emerging directions for theory, research and practice
Camic, PM; Zeilig, H; Crutch, SJ; (2018) The arts and dementia: Emerging directions for theory, research and practice. [Editorial comment]. Dementia , 17 (6) pp. 641-644. 10.1177/1471301218772972 . Green open access
https://ift.tt/2ABsJDL
OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans
Sarma, GP; Lee, CW; Portegys, T; Ghayoomie, V; Jacobs, T; Alicea, B; Cantarelli, M; ... Larson, SD; + view all Sarma, GP; Lee, CW; Portegys, T; Ghayoomie, V; Jacobs, T; Alicea, B; Cantarelli, M; Currie, M; Gerkin, RC; Gingell, S; Gleeson, P; Gordon, R; Hasani, RM; Idili, G; Khayrulin, S; Lung, D; Palyanov, A; Watts, M; Larson, SD; - view fewer (2018) OpenWorm: overview and recent advances in integrative biological simulation of Caenorhabditis elegans. Philosophical Transactions of the Royal Society B:Biological Sciences , 373 (1758) 10.1098/rstb.2017.0382 . Green open access
https://ift.tt/2TUqLae
International Perspectives: Birth-Associated Neonatal Encephalopathy: Postresuscitation Care in West African Newborns
Enweronu-Laryea, CC; Adedemy, JD; Okonkwo, IR; Lee, ACC; Robertson, NJ; (2018) International Perspectives: Birth-Associated Neonatal Encephalopathy: Postresuscitation Care in West African Newborns. NeoReviews , 19 (9) e507-e515. 10.1542/neo.19-9-e507 .
https://ift.tt/2ABrUe9
Digest: Evolution of sperm size and number in external fertilizers
Samani, P; (2017) Digest: Evolution of sperm size and number in external fertilizers. Evolution , 72 (1) pp. 211-212. 10.1111/evo.13400 . Green open access
https://ift.tt/2TYD4SZ
Dark Energy Survey Year 1 Results: A Precise H-0 Estimate from DES Y1, BAO, and D/H Data
Abbott, TMC; Abdalla, FB; Annis, J; Bechtol, K; Blazek, J; Benson, BA; Bernstein, RA; ... Zuntz, J; + view all Abbott, TMC; Abdalla, FB; Annis, J; Bechtol, K; Blazek, J; Benson, BA; Bernstein, RA; Bernstein, GM; Bertin, E; Brooks, D; Burke, DL; Carnero Rosell, A; Carrasco Kind, M; Carretero, J; Castander, FJ; Chang, CL; Crawford, TM; Cunha, CE; D'Andrea, CB; da Costa, LN; Davis, C; DeRose, J; Desai, S; Diehl, HT; Dietrich, JP; Doel, P; Drlica-Wagner, A; Evrard, AE; Fernandez, E; Flaugher, B; Fosalba, P; Frieman, J; Garcia-Bellido, J; Gaztanaga, E; Gerdes, DW; Giannantonio, T; Gruen, D; Gruendl, RA; Gschwend, J; Gutierrez, G; Hartley, WG; Henning, JW; Honscheid, K; Hoyle, B; Huterer, D; Jain, B; James, DJ; Jarvis, M; Jeltema, T; Johnson, MD; Johnson, MWG; Krause, E; Kuehn, K; Kuhlmann, S; Kuropatkin, N; Lahav, O; Liddle, AR; Lima, M; Lin, H; MacCrann, N; Maia, MAG; Manzotti, A; March, M; Marshall, JL; Miquel, R; Mohr, JJ; Natoli, T; Nugent, P; Ogando, RLC; Park, Y; Plazas, AA; Reichardt, CL; Reil, K; Roodman, A; Ross, AJ; Rozo, E; Rykoff, ES; Sanchez, E; Scarpine, V; Schubnell, M; Scolnic, D; Sevilla-Noarbe, I; Sheldon, E; Smith, M; Smith, RC; Soares-Santos, M; Sobreira, F; Suchyta, E; Tarle, G; Thomas, D; Troxel, MA; Walker, AR; Wechsler, RH; Weller, J; Wester, W; Wu, WLK; Zuntz, J; - view fewer (2018) Dark Energy Survey Year 1 Results: A Precise H-0 Estimate from DES Y1, BAO, and D/H Data. Monthly Notices of the Royal Astronomical Society , 480 (3) pp. 3879-3888. 10.1093/mnras/sty1939 . Green open access
https://ift.tt/2ADDUMb
Regional variability in the atmospheric nitrogen deposition signal and its transfer to the sediment record in Greenland lakes
Anderson, NJ; Curtis, CJ; Whiteford, EJ; Jones, VJ; McGowan, S; Simpson, GL; Kaiser, J; (2018) Regional variability in the atmospheric nitrogen deposition signal and its transfer to the sediment record in Greenland lakes. Limnology and Oceanography , 63 (5) pp. 2250-2265. 10.1002/lno.10936 . Green open access
https://ift.tt/2TZ1cVF
Soliton solutions in geometrically nonlinear Cosserat micropolar elasticity with large deformations
Böhmer, CG; Lee, Y; Neff, P; (2019) Soliton solutions in geometrically nonlinear Cosserat micropolar elasticity with large deformations. Wave Motion , 84 pp. 110-124. 10.1016/j.wavemoti.2018.10.005 . (In press). Green open access
https://ift.tt/2ACuhxi
Changes In LXRα Phosphorylation Promote A Novel Diet-Induced Transcriptome That Alters The Transition From Fatty Liver To Steatohepatitis
Becares, N; Gage, M; Martin-Gutierrez, L; Pourcet, B; Louie, R; Pello, O; Luong, TV; ... Pineda Torra, I; + view all Becares, N; Gage, M; Martin-Gutierrez, L; Pourcet, B; Louie, R; Pello, O; Luong, TV; Goni, S; Liang, N; Pichardo, C; Shrestha, E; Roberg-Larsen, H; Diaz, V; Steffensen, K; Garabedian, M; Rombouts, K; Treuter, E; Pineda Torra, I; - view fewer (2017) Changes In LXRα Phosphorylation Promote A Novel Diet-Induced Transcriptome That Alters The Transition From Fatty Liver To Steatohepatitis. BioRxiv: Cold Spring Harbor, NY, USA. Green open access
https://ift.tt/2U0qCSQ
Review of Particle Physics: Particle Data Group
Patrignani, C; Agashe, K; Aielli, G; Amsler, C; Antonelli, M; Asner, DM; Baer, H; ... Schaffner, P; + view all Patrignani, C; Agashe, K; Aielli, G; Amsler, C; Antonelli, M; Asner, DM; Baer, H; Banerjee, S; Barnett, RM; Basaglia, T; Bauer, CW; Beatty, JJ; Belousov, VI; Beringer, J; Bethke, S; Bichsel, H; Biebel, O; Blucher, E; Brooijmans, G; Buchmueller, O; Burkert, V; Bychkov, MA; Cahn, RN; Carena, M; Ceccucci, A; Cerri, A; Chakraborty, D; Chen, M-C; Chivukula, RS; Copic, K; Cowan, G; Dahl, O; D'Ambrosio, G; Damour, T; de Florian, D; de Gouvea, A; DeGrand, T; de Jong, P; Dissertori, G; Dobrescu, BA; D'Onofrio, M; Doser, M; Drees, M; Dreiner, HK; Dwyer, DA; Eerola, P; Eidelman, S; Ellis, J; Erler, J; Ezhela, VV; Fetscher, W; Fields, BD; Foster, B; Freitas, A; Gallagher, H; Garren, L; Gerber, H-J; Gerbier, G; Gershon, T; Gherghetta, T; Godizov, AA; Goodman, M; Grab, C; Gritsan, AV; Grojean, C; Groom, DE; Gruenewald, M; Gurtu, A; Gutsche, T; Haber, HE; Hagiwara, K; Hanhart, C; Hashimoto, S; Hayato, Y; Hayes, KG; Hebecker, A; Heltsley, B; Hernandez-Rey, JJ; Hikasa, K; Hisano, J; Hoecker, A; Holder, J; Holtkamp, A; Huston, J; Hyodo, T; Irwin, K; Jackson, JD; Johnson, KF; Kado, M; Karliner, M; Katz, UF; Klein, SR; Klempt, E; Kowalewski, RV; Krauss, F; Kreps, M; Krusche, B; Kuyanov, YV; Kwon, Y; Lahav, O; Laiho, J; Langacker, P; Liddle, A; Ligeti, Z; Lin, C-J; Lippmann, C; Liss, TM; Littenberg, L; Lugovsky, KS; Lugovsky, SB; Lusiani, A; Makida, Y; Maltoni, F; Mannel, T; Manohar, AV; Marciano, WJ; Martin, AD; Masoni, A; Matthews, J; Meissner, U-G; Milstead, D; Mitchell, RE; Molaro, P; Monig, K; Moortgat, F; Mortonson, MJ; Murayama, H; Nakamura, K; Narain, M; Nason, P; Navas, S; Neubert, M; Nevski, P; Nir, Y; Olive, KA; Griso, SP; Parsons, J; Peacock, JA; Pennington, M; Petcov, ST; Petrov, VA; Piepke, A; Pomarol, A; Quadt, A; Raby, S; Rademacker, J; Raffelt, G; Ratcliff, BN; Richardson, P; Ringwald, A; Roesler, S; Rolli, S; Romaniouk, A; Rosenberg, LJ; Rosner, JL; Rybka, G; Ryutin, RA; Sachrajda, CT; Sakai, Y; Salam, GP; Sarkar, S; Sauli, F; Schneider, O; Scholberg, K; Schwartz, AJ; Scott, D; Sharma, V; Sharpe, SR; Shutt, T; Silari, M; Sjostrand, T; Skands, P; Skwarnicki, T; Smith, JG; Smoot, GF; Spanier, S; Spieler, H; Spiering, C; Stahl, A; Stone, SL; Sumino, Y; Sumiyoshi, T; Syphers, MJ; Takahashi, F; Tanabashi, M; Terashi, K; Terning, J; Thorne, RS; Tiator, L; Titov, M; Tkachenko, NP; Tornqvist, NA; Tovey, D; Valencia, G; Van de Water, R; Varelas, N; Venanzoni, G; Vincter, MG; Vogel, P; Vogt, A; Wakely, SP; Walkowiak, W; Walter, CW; Wands, D; Ward, DR; Wascko, MO; Weiglein, G; Weinberg, DH; Weinberg, EJ; White, M; Wiencke, LR; Wiliocq, S; Wohl, CC; Wolfenstein, L; Womersley, J; Woody, CL; Workman, RL; Yao, W-M; Zeller, GP; Zenin, OV; Zhu, R-Y; Zimmermann, F; Zyla, PA; Anderson, J; Harper, G; Lugovsky, VS; Schaffner, P; - view fewer (2016) Review of Particle Physics: Particle Data Group. [Review]. Chinese Physics C , 40 (10) , Article 100001. 10.1088/1674-1137/40/10/100001 .
https://ift.tt/2AAktnm
Erratum
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s):
https://ift.tt/2KLOQvC
Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink
Publication date: Available online 29 November 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): C.P. Harkins, M.T.G. Holden, A.D. Irvine
https://ift.tt/2BJbyBW
Challenges in allergy immunology practice: Solutions needed for persistent patient problems
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s): Gailen D. Marshall
https://ift.tt/2So2d89
Author Index
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s):
https://ift.tt/2E5OVdl
A new acronym for PPI-REE?
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s): Russell Hopp
https://ift.tt/2SmBYil
Editorial Board
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s):
https://ift.tt/2E6hdUR
Information for Authors
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s):
https://ift.tt/2SmBRTX
Table of Contents
Publication date: December 2018
Source: Annals of Allergy, Asthma & Immunology, Volume 121, Issue 6
Author(s):
https://ift.tt/2E44KkB
Increased IRF4 expression in isolated B cells from common variable immunodeficiency (CVID) patients
Publication date: Available online 30 November 2018
Source: Allergologia et Immunopathologia
Author(s): S. Afshar-Ghasemlou, N. Esmaeil, R. Sherkat, R. Yazdani, F. Abbasi-Rad, M. Ganjalikhani-Hakemi, A. Rezaei
Abstract
Background
Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by low serum levels of immunoglobulins (Igs) and recurrent infection. In most CVID patients, a defect in the differentiation of B cells into plasma cells has been observed. Several factors play an important role in the proliferation and differentiation of B cells, including IRF4 and XBP1 transcription factors.
Methods
In the present study we investigated the expression of IRF4 and XBP1 in the B-cells of CVID and healthy controls (HCs). For this purpose, we assessed the expression of IRF4 and XBP1 at both mRNA and protein levels by real time-PCR and flow cytometry, respectively.
Results
We found that IRF4 expression was significantly increased in CVID patients compared with controls. Although the XBP1 protein level was lower in patients in comparison to controls, this difference was not significant.
Conclusion
Taken together, increased IRF4 expression could be involved in defective functions of B cells in CVID patients.
https://ift.tt/2SfHIKK
Development of a tool for screening adverse food reactions and food allergy in Portuguese children
Publication date: Available online 30 November 2018
Source: Allergologia et Immunopathologia
Author(s): A. Jorge, M. Santos Silva, C. Lozoya-Ibánez, F. Lorente, E. Sarinho, R.M. Afonso, H. Pereira, L. Taborda-Barata
Abstract
Introduction and objectives
A standardised questionnaire may be an excellent tool for epidemiological studies aiming at screening children with suspected food allergies. Thus, the aim of the present study was to develop a screening questionnaire for assessing children with suspected food allergy and to analyse its reproducibility.
Materials and methods
A questionnaire of adverse food reactions was developed by literary review of similar questionnaires validated in other countries as well as less well defined, non-validated Portuguese questionnaires. Peer review of the questionnaire by a panel of specialists and subsequent exploratory analysis was carried out by applying the questionnaire in children with confirmed food allergy. Test–retest analysis was performed by giving a face-to-face questionnaire to 159 children with suspected adverse food reactions, aged between three and 11 years. Temporal stability using Spearman Rho correlation test and reproducibility was studied using Cohen's Kappa index.
Results
115 children confirmed adverse food reactions that occurred with one or more foods. Retest was given about three weeks after the test, to 50 of these children who were randomly selected. The questionnaire showed good temporal stability (Spearman correlation coefficient of 0.834), and good reproducibility (only two of the 27 items had a Kappa index <0.60).
Conclusions
This questionnaire showed good temporal stability and reproducibility. Its validation for screening children with suspected food allergy will allow a standardised approach to diagnosis and comparison of results obtained in different centres.
https://ift.tt/2E3Si4z
Changes in the prevalence of asthma and related risk factors in adolescents: Three surveys between 1994 and 2015
Publication date: Available online 30 November 2018
Source: Allergologia et Immunopathologia
Author(s): J. Mallol, V. Aguirre, M. Mallol-Simmonds, A. Matamala- Bezmalinovic, L. Calderón-Rodriguez, F. Osses-Vergara
Abstract
Methods
This study assesses the temporal trend of current asthma symptoms prevalence and associated factors in Chilean adolescents from South-Santiago, considering surveys performed in 1994, 2002 and 2015.
Results
The prevalence of current asthma symptoms showed a trend to increase from 11.1% in 1994 to 13.4% in 2015 (p < 0.001); physician-diagnosed asthma increased from 11.5% to 13.8%, (p < 0.001) whereas severe asthma and asthma with exercise decreased (p < 0.001). Female adolescents had a higher prevalence of current asthma in the three surveys (p < 0.001), and was a risk factor for asthma in the three surveys. In 2002, frequent consumption of meat and potatoes were associated with current asthma while frequent vigorous exercise was protective. Frequent exercise and parental tobacco smoking were risk for asthma in 2015 (p < 0.001). Current active tobacco smoking showed a trend to increase reaching a prevalence of 28.9% in 2015 (p < 0.001). There was a consistently low proportion of adolescents with current wheezing and asthma diagnosis (32.1% in 2015) and 37.6% of them had no asthma treatment.
Conclusion
The prevalence of current asthma in adolescents from the studied area would be still increasing. As in other studies, female adolescents had a higher prevalence of current asthma. Current active tobacco smoking has strikingly increased in the studied children while indoor passive tobacco exposure remains inadmissibly high. Our findings suggest that asthma in children is underdiagnosed and undertreated. More attention should be given to female gender, tobacco exposure, air pollution and local diagnostic preferences when studying and interpreting trends of asthma prevalence in adolescents from developing localities.
https://ift.tt/2SfHGCC
Self-reported hypersensitivity and allergy to foods amongst Mexican adolescents: Prevalence and associated factors
Publication date: Available online 30 November 2018
Source: Allergologia et Immunopathologia
Author(s): T.R. Bedolla-Pulido, M. Bedolla-Barajas, J. Morales-Romero, T.I. Bedolla-Pulido, M.V. Domínguez-García, D.D. Hernández-Colín, M.V. Flores-Merino
Abstract
Background
The prevalence of food allergy is on the rise on a global scale.
Objective
To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences.
Methods
A cross-sectional study was carried out among 1992 adolescents (aged 15–18 years). Each adolescent answered a structured questionnaire. A multivariate analysis was used to identify the association between the variables.
Results
The prevalence of FHS was 10.6% (the most commonly associated foods were shrimp, cow's milk and avocado) and the PFA was 7.8% (shrimp, cow's milk and pecan). The prevalences of oral allergy syndrome, food-associated urticaria and systemic reaction were 4.9%, 3.6% and 1.5%, respectively. The following factors were associated with FHS: personal history of asthma (OR 1.63; 95% CI: 1.11–2.41), allergic rhinitis (OR 2.60; 95% CI: 1.75–3.87), atopic dermatitis (OR 2.07; 95% CI: 1.25–3.43), maternal history of asthma (OR 1.80; 95% CI: 1.02–3.16), atopic dermatitis (OR 6.11; 95% CI: 2.45–15.29), and female sex (OR 1.89; 95% CI: 1.38–2.59). PFA was associated with a personal history of asthma (OR 1.65; 95% CI: 1.06–2.56), allergic rhinitis (OR 2.46; 95% CI: 1.56–3.88), atopic dermatitis (OR 2.02; 95% CI: 1.15–3.54), paternal allergic rhinitis (OR 2.52; 95% CI: 1.15–5.51), maternal atopic dermatitis (OR 7.46; 95% CI: 2.93–19.00), and female sex (OR 1.89; 95% CI: 1.31–2.72).
Conclusion
The adverse reactions associated with foods among late adolescents are a frequent occurrence, and the most commonly associated factor is atopy.
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Plasma CXCL13 is a predictive factor for HBsAg loss and clinical relapse after discontinuation of nucleos(t)ide analogue treatment
Publication date: Available online 30 November 2018
Source: Clinical Immunology
Author(s): Muye Xia, Guichan Liao, Hongjie Chen, Yin Wu, Rong Fan, Xiaoyong Zhang, Jie Peng
Abstract
In this study, we investigated whether plasma cytokine/chemokine levels could predict HBsAg loss or clinical relapse (CR) after stopping nucleos(t)ides analogue (NA) treatment. Theplasma cytokines/chemokines levels were measured at 0, 4, 8, 12, 24 and 48 weeks after NA discontinuation by using the enzyme-linked immunoassay (ELISA) kit. Cox regression analysis revealed that CXCL13 level at the end of treatment (EOT) was an independent predictor for CR (HR 0.26, p < 0.001) and HBsAg loss (HR 3.01, p = 0.008) after treatment cessation. Among the patients with EOT CXCL13 level < 80 pg/ml, the cumulative incidences of CR and HBsAg loss were 65% and 0% at 4 years, respectively. As for the patients with EOT CXCL13 level ≥ 1000 pg/ml, 47.5% cases had HBsAg loss. Our study showed that EOT CXCL13 level was associated with off-treatment response, which may be used to guide cessation of NA treatment in clinical practice.
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Studies into the insecticidal activity and mode of action of monoterpenoid constituents of essential oils against the human louse, Pediculus humanus
Priestley, CM; (2002) Studies into the insecticidal activity and mode of action of monoterpenoid constituents of essential oils against the human louse, Pediculus humanus. Doctoral thesis (PhD), University of London. Green open access
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The impact of Vitamin D supplementation on musculoskeletal health outcomes in children, adolescents, and young adults living with HIV: A systematic review
Penner, J; Ferrand, RA; Richards, C; Ward, KA; Burns, JE; Gregson, CL; (2018) The impact of Vitamin D supplementation on musculoskeletal health outcomes in children, adolescents, and young adults living with HIV: A systematic review. [Review]. PLoS ONE , 13 (11) , Article e0207022. 10.1371/journal.pone.0207022 . Green open access
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5D operando tomographic diffraction imaging of a catalyst bed
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Distance-decay effect in stone tool transport by wild chimpanzees
Luncz, LV; Proffitt, T; Kulik, L; Haslam, M; Wittig, RM; (2016) Distance-decay effect in stone tool transport by wild chimpanzees. Proceedings of the Royal Society B: Biological Sciences , 283 (1845) 10.1098/rspb.2016.1607 . Green open access
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Creative Challenge and Cognitive Constraint: Students' Use of A Pattern Language for Complex Design
Marshall, S; (2016) Creative Challenge and Cognitive Constraint: Students' Use of A Pattern Language for Complex Design. In: Portugali, J and Stolk, E, (eds.) Complexity, Cognition, Urban Planning and Design: Post-Proceedings of the 2nd Delft International Conference. (pp. pp. 251-269). Springer: Cham, Switzerland. Green open access
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Pili mediated intercellular forces shape heterogeneous bacterial microcolonies prior to multicellular differentiation
Pönisch, W; Eckenrode, KB; Alzurqa, K; Nasrollahi, H; Weber, C; Zaburdaev, V; Biais, N; (2018) Pili mediated intercellular forces shape heterogeneous bacterial microcolonies prior to multicellular differentiation. Scientific Reports , 8 , Article 16567. 10.1038/s41598-018-34754-4 . Green open access
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A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection
Evans, D; Papadimitriou, KI; Vasilakis, N; Pantelidis, P; Kelleher, P; Morgan, H; Prodromakis, T; (2018) A Novel Microfluidic Point-of-Care Biosensor System on Printed Circuit Board for Cytokine Detection. Sensors , 18 (11) 10.3390/s18114011 . Green open access
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An Informal Internet Survey on the Current State of Consciousness Science
Michel, M; Fleming, SM; Lau, H; Lee, ALF; Martinez-Conde, S; Passingham, RE; Peters, MAK; ... Liu, K; + view all Michel, M; Fleming, SM; Lau, H; Lee, ALF; Martinez-Conde, S; Passingham, RE; Peters, MAK; Rahnev, D; Sergent, C; Liu, K; - view fewer (2018) An Informal Internet Survey on the Current State of Consciousness Science. Frontiers in Psychology , 9 , Article 2134. 10.3389/fpsyg.2018.02134 . Green open access
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Austrian Studies at Twenty-Five: A Generation of Scholarship
Deborah Holmes, ; Florian Krobb, ; Edward Timms, ; Judith Beniston, ; (2017) Austrian Studies at Twenty-Five: A Generation of Scholarship. Austrian Studies , 25 (Celebrat) pp. 1-14. 10.5699/austrianstudies.25.2017.0001 . Green open access
https://ift.tt/2Sg9SVQ
BACE2 distribution in major brain cell types and identification of novel substrates
Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; Voytyuk, I; Mueller, SA; Herber, J; Snellinx, A; Moechars, D; van Loo, G; Lichtenthaler, SF; De Strooper, B; - view fewer (2018) BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance , 1 (1) , Article e201800026. 10.26508/lsa.201800026 . Green open access
https://ift.tt/2E6EGVU
Paternal anxiety and satisfaction in elective caesarean section
Oliver, CM; (2011) Paternal anxiety and satisfaction in elective caesarean section. Presented at: AAGBI Annual Congress,, Edinburgh, UK. Green open access
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‘What support would you find helpful?’ The relationship between treatment expectations, therapeutic engagement and clinical outcomes in parent-infant psychotherapy
Ransley, R; Sleed, M; Baradon, T; Fonagy, P; (2019) 'What support would you find helpful?' The relationship between treatment expectations, therapeutic engagement and clinical outcomes in parent-infant psychotherapy. Infant Mental Health Journal (In press).
https://ift.tt/2E7GwGr
The global teaching profession: how treating teachers as knowledge workers improves the esteem of the teaching profession
Price, HE; Weatherby, K; (2018) The global teaching profession: how treating teachers as knowledge workers improves the esteem of the teaching profession. School Effectiveness and School Improvement , 29 (1) pp. 113-149. 10.1080/09243453.2017.1394882 .
https://ift.tt/2SiWxfr
Molecular Genetic Insights Into Varicella Zoster Virus (VZV), the vOka Vaccine Strain, and the Pathogenesis of Latency and Reactivation
Breuer, J; (2018) Molecular Genetic Insights Into Varicella Zoster Virus (VZV), the vOka Vaccine Strain, and the Pathogenesis of Latency and Reactivation. The Journal of Infectious Diseases , 218 (suppl_2) S75-S80. 10.1093/infdis/jiy279 .
https://ift.tt/2E4I17Z
Holy Cows or Cash Cows? The Economic Return to Livestock in Rural India
Attanasio, O; Augsburg, B; (2018) Holy Cows or Cash Cows? The Economic Return to Livestock in Rural India. Economic Development and Cultural Change , 66 (2) pp. 307-330. 10.1086/695138 . Green open access
https://ift.tt/2SlvaRU
Synthesis and bioluminescence of electronically modified and rotationally restricted colour-shifting infraluciferin analogues
Anderson, JC; Jathoul, AP; Syed, AJ; (2019) Synthesis and bioluminescence of electronically modified and rotationally restricted colour-shifting infraluciferin analogues. Tetrahedron (In press).
https://ift.tt/2E5iJH4
Estimation of Oil, Gas and Water Fluid Flow Velocities in Active Wells From Acoustic Measurements Using Fibre Optic Distributed Acoustic Sensors
Vahabi, N; Willman, E; Wang, K; Baghsiahi, H; Selviah, D; (2019) Estimation of Oil, Gas and Water Fluid Flow Velocities in Active Wells From Acoustic Measurements Using Fibre Optic Distributed Acoustic Sensors. IEEE Transactions on Industrial Electronics (In press).
https://ift.tt/2Sj1IMr
A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex
Marzi, SJ; Leung, SK; Ribarska, T; Hannon, E; Smith, AR; Pishva, E; Poschmann, J; ... Mill, J; + view all Marzi, SJ; Leung, SK; Ribarska, T; Hannon, E; Smith, AR; Pishva, E; Poschmann, J; Moore, K; Troakes, C; Al-Sarraj, S; Beck, S; Newman, S; Lunnon, K; Schalkwyk, LC; Mill, J; - view fewer (2018) A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience , 21 pp. 1618-1627. 10.1038/s41593-018-0253-7 .
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Measurement of dijet azimuthal decorrelations in pp collisions at root s=8 TeV with the ATLAS detector and determination of the strong coupling
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Physical Review D , 98 , Article 092004. 10.1103/PhysRevD.98.092004 . Green open access
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The Naked Prompt: A Semiotic Study of Pirandello's Plays
Stone, Jennifer; (1982) The Naked Prompt: A Semiotic Study of Pirandello's Plays. Doctoral thesis (Ph.D), UCL (University College London). Green open access
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