Long-term efficacy follow-up on two cryolipolysis case studies: 6 and 9 years post-treatment

Summary

Cryolipolysis is a noninvasive esthetic procedure that utilizes controlled cooling to reduce subcutaneous fat. Clinical studies have established its safety, efficacy, and tolerability for fat reduction in a variety of areas including the abdomen, flanks, thighs, submental area, arms, back, and chest. Because of obvious esthetic concerns, long-term unilateral studies leaving an untreated flank, thigh, or arm are not performed, but serve as ideal controls for weight gain or loss or re-distribution of fat for other reasons. This article follows two patients previously documented in a case report to demonstrate their ongoing treatment efficacy at 6 and 9 years after treatment. Clinical photographs of the treated flanks and untreated contralateral controls demonstrate long-term durability in these two subjects.

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Recent Advances in Template-directed Synthesis of Porphyrin Nanorings

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC04556A, Feature Article

Shu-Ping Wang, Yan-Feng Shen, Ben-Yue Zhu, Jing Wu, Shijun Li
Template-directed strategy is a powerful method to construct porphyrin nanorings with high complexities, wherein metalloporphyrin precursors pre-organize via supramolecular interactions of the porphyrin or its central metal with a carefully...
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Organic Photoredox Catalysis for the Oxidation of Silicates: Applications in Radical Synthesis and Dual Catalysis

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC04636C, Communication

Louis Fensterbank, Christophe Leveque, Ludwig Chenneberg, Vincent Corce, Cyril Ollivier
Metal free photooxidation of alkyl bis(catecholato)silicates with the organic dye, 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyano-benzene (4CzIPN), allows the smooth formation of alkyl radicals. The latter can be efficiently engaged either with radical acceptors to...
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Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

Chem. Commun., 2016, Accepted Manuscript
DOI: 10.1039/C6CC04813G, Communication

Erin Wachter, Ana Maria Zamoria, David K Heidary, Jose Ruiz, Edith Glazer
Two thermally activated ruthenium(II) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to...
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Systemic inflammatory response syndrome in a patient diagnosed with high grade inflammatory triple negative breast cancer: a case report of a potentially rare paraneoplastic syndrome

Abstract

Background

Inflammatory breast cancer is a complex pathological entity associated with poor outcomes. This loco-regional disease is characterised by a rapid clinical course in the presence breast erythema and infiltration of dermal lymphatics by tumours cells. Herein we describe a case of inflammatory breast cancer with a rare presentation and disease course defined by a profound systemic inflammatory response in the absence of an infective cause.

Case presentation

The patient presented with pyrexia and malaise following a recent tissue diagnosis of inflammatory breast cancer. At the time of admission the patient demonstrated clinical features of the systemic inflammatory response syndrome (SIRS) in the presence of a negative septic screen. Her condition deteriorated despite systemic broad spectrum intravenous antibiotics and she underwent surgical debulking of a 180 × 135 × 100 mm (821 g) primary tumour composed of oedematous, friable and haemorrhagic tissue (pT4,N1a,M0; oestrogen/progesterone/HER-2 receptor negative). Following surgery, the clinical picture dramatically improved with cessation of SIRS and normalisation of inflammatory markers. After 4 weeks the patient required readmission to hospital due to recurrent SIRS and negative septic screen. The patient received treatment with systemic chemotherapy showing transient clinical improvement and suppression of SIRS. Despite on going chemotherapy, systemic antibiotics and a trial of steroid therapy the patient died 5 months after her initial presentation to hospital. At the time of death she demonstrated persistent SIRS with elevated inflammatory markers.

Conclusion

This is the first case report of inflammatory breath cancer associated with SIRS in the absence of clinically confirmed infection. Important learning points highlighted by this case are: (a) recognition of the diagnostic and therapeutic uncertainties that still exist in the context of inflammatory breast cancer; (b) appreciation of the potential paraneoplastic systemic inflammatory manifestations of this disease, and finally; (c) the importance a multidisciplinary and multimodal approach to treatment.

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Advances in hormonal therapies for hormone naïve and castration-resistant prostate cancers with or without previous chemotherapy

Abstract

Hormonal manipulation plays a significant role in the treatment of advanced hormone naïve prostate cancer and castration-resistant prostate cancer (CRPC) with or without previous chemotherapy. Combination of gonadotropin releasing hormone (GnRH) agonists and androgen receptor (AR) antagonists (combined androgen blockade; CAB) is the first line therapy for advanced hormone naïve prostate cancer, but current strategies are developing novel GnRH antagonists to overcome disadvantages associated with GnRH agonist monotherapy and CAB in the clinical setting. Abiraterone acetate and enzalutamide are hormonal agents currently available for patients with CRPC and are both shown to improve overall survival versus placebo. Recently, in clinical trials, testosterone has been administered in cycles with existing surgical and chemical androgen deprivation therapies (ADT) (intermittent therapy) to CRPC patients of different stages (low risk, metastatic) to abate symptoms of testosterone deficiency and reduce cost of treatment from current hormonal therapies for patients with CRPC. This review will provide an overview on the therapeutic roles of hormonal manipulation in advanced hormone naïve and castration-resistant prostate cancers, as well as the development of novel hormonal therapies currently in preclinical and clinical trials.

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Surgeons' assessment of internal anal sphincter nerve supply during TaTME - inbetween expectations and reality.

Surgeons' assessment of internal anal sphincter nerve supply during TaTME - inbetween expectations and reality.

Minim Invasive Ther Allied Technol. 2016 Jun 22;:1-6

Authors: Kneist W, Hanke L, Kauff DW, Lang H

Abstract
BACKGROUND: Intraoperative identification of nerve fibers heading from the inferior rectal plexus (IRP) to the internal anal sphincter (IAS) is challenging. The transanal total mesorectal excision (TaTME) is said to better preserve pelvic autonomic nerves. The aim of this study was to investigate the nerve identification rates during TaTME by transanal visual and electrophysiological assessment.
MATERIAL AND METHODS: A total of 52 patients underwent TaTME for malignant conditions. The IRP with its posterior branches to the IAS and the pelvic splanchnic nerves (PSN) were visually assessed in 20 patients (v-TaTME). Electrophysiological nerve identification was performed in 32 patients using electric stimulation under processed electromyography of IAS (e-TaTME).
RESULTS: The indication profile for TaTME was comparable between the v-TaTME and the e-TaTME group. The identification of IRP was more meaningful under electrophysiological assessment than under visual assessment for the left pelvic side (81% vs. 45%, p = 0.008) as well as the right pelvic side (78% vs. 45%, p = 0.016). The identification rates for PSN did not significantly differ between both groups, respectively (81% vs. 75%, p = 0.420 and 84% vs. 70%, p = 0.187).
CONCLUSIONS: The transanal approach facilitated visual identification of IAS nerve supply. In combination with electrophysiological nerve assessment the identification rate almost doubled. For further insights functional data are needed.

PMID: 27333465 [PubMed - as supplied by publisher]

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Endovascular placement of an extraluminal arterial bypass graft - in vitro feasibility study.

Endovascular placement of an extraluminal arterial bypass graft - in vitro feasibility study.

Minim Invasive Ther Allied Technol. 2016 Jun 22;:1-6

Authors: Zimmermann M, Pfeffer J, Na HS, Liebl M, Schulze-Hagen M, Kuhl CK, Isfort P, Bruners P

Abstract
PURPOSE: A novel approach for arterial bypass grafting using exclusively endovascular techniques was established in-vitro in a phantom model.
MATERIAL AND METHODS: The experimental setting consisted of a gel-wax phantom with two embedded parallel fluid-filled silicon tubes simulating the superficial femoral vessels. Through an 8-French sheath, a re-entry catheter (OUTBACK(®), Cordis) was placed in the simulated artery and used to puncture the vascular wall. Then a 0.014-inch guide wire was advanced into the extravascular space. With the curved needle of the re-entry catheter, the guide wire was steered on a course parallel to the vessel wall in the extravascular space for 5-10 cm. At the desired reentry site, the re-entry catheter was used to puncture the vascular wall again in order to regain access to the endovascular space. Once the tip of the guide wire had safely been placed in the vascular lumen, a self-expandable stent graft (VIABAHN(®) GORE(®)) was deployed to complete the extraluminal bypass.
RESULTS: Endovascular placement of an extraluminal bypass was successfully achieved in 20 attempts. The mean duration of the procedure amounted to 14:58 (minutes: seconds) (SD ± 3:56).
CONCLUSIONS: This in-vitro study suggests that endovascular placement of an extraluminal arterial bypass graft is technically feasible.

PMID: 27333262 [PubMed - as supplied by publisher]

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Safety and economical innovations regarding surgical treatment of fibroids.

Safety and economical innovations regarding surgical treatment of fibroids.

Minim Invasive Ther Allied Technol. 2016 Jun 22;:1-13

Authors: Alkatout I, Mettler L, Günther V, Maass N, Eckmann-Scholz C, Elessawy M, Anapolski M

Abstract
Uterine leiomyomas are the most frequent benign tumors of the female genital tract. Fibroids are associated with a variety of clinical problems, e.g. bleeding disorders, bulk-related symptoms or infertility. For women wishing to preserve their uterus, fibroids can be surgically removed by hysteroscopy, laparoscopy or laparotomy. The purpose of our review is to show that hysterectomy offers the only definitive solution. The indication for treatment has to be taken carefully after weighing up alternative treatment methods, such as expectant management, medical treatment or interventional radiologic methods, and after obtaining informed consent. The optimal method of treatment takes into account the patient's interests and wishes and the practical feasibility in the clinical setup. Surgical skills and experience play an important role as surgical procedures on the uterus are not without risk and can lead to severe complications. The decision to operate anticipates an improvement of the initial situation; therefore, the ideal surgical approach is of utmost importance.

PMID: 27331342 [PubMed - as supplied by publisher]

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Effect of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin maintenance dose in children aged less than 18 years: a protocol for systematic review and meta-analysis

Despite its shortcomings, warfarin is still the most commonly prescribed anticoagulant to prevent thromboembolism in children. In adults, numerous studies confirmed the robust relationship between warfarin mai...

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Myxoma of the nasal bone.

Myxoma of the nasal bone.

Auris Nasus Larynx. 2016 Jun 18;

Authors: Al-Qahtani K, Islam T, AlOulah M, Bafaqeeh S, Faqeeh Y

Abstract
Myxoma is a benign tumor that arises from mesenchymal tissue, and found in the soft tissue and less commonly in the bone. The majority of bony myxomas of the head and neck occur in the jaws and maxilla. We report an extremely rare case of nasal bone myxoma in a 52-year-old man. The diagnosis was confirmed by biopsy. Due to the aggressive nature of the lesion the nasal bone was eroded by the disease. The patient underwent resection of the mass with reconstruction of the defect by septal cartilage. The patient remains tumor free after 5 years.

PMID: 27328895 [PubMed - as supplied by publisher]

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A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms.

Related Articles

A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms.

Mol Med Rep. 2015 Oct;12(4):5058-64

Authors: Jia J, Dai S, Sun X, Sang Y, Xu Z, Zhang J, Cui X, Song J, Guo X

Abstract
Human esophageal cancer‑related gene 4 (ECRG4) is a potential tumor suppressor gene isolated from human esophageal epithelial cells. Studies have shown that ECRG4 effectively inhibits the proliferation of tumor cells and induces apoptosis. However, the role of ECRG4 in laryngeal cancer has not yet been clearly defined. In this study, a human laryngeal cancer cell line stably overexpressing ECRG4 was established. The effect of ECRG4 on the proliferation and apoptosis of laryngeal cancer cells and the associated mechanisms were investigated. The Hep‑2 human laryngeal carcinoma cell line exhibited a low basal level of ECRG4 expression and was selected for the present study. The eukaryotic expression plasmid pcDNA3.1‑ECRG4 was constructed and introduced into Hep‑2 cells by transfection reagents. Western blot analysis, reverse transcription-quantitative polymerase chain reaction and immunofluorescence staining confirmed high‑level expression of ECRG4. The 3‑(4, 5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay and colony formation assay showed that ECRG4 overexpression suppressed the proliferative capacity of laryngeal cancer cells in vitro. Cell cycle analysis showed that ECRG4 induced cell cycle arrest at the G0/G1 phase. Flow cytometric analysis and Hoechst staining demonstrated that overexpression of ECRG4 significantly induced apoptosis. Western blot analysis confirmed that Bcl‑2‑associated X protein, cleaved‑caspase‑3 and cleaved‑poly (ADP‑ribose) polymerase were upregulated in the apoptotic process, whereas B‑cell lymphoma 2 was downregulated. In conclusion, overexpression of ECRG4 inhibited laryngeal cancer cell proliferation and induced cancer cell apoptosis. Therefore, ECRG4 exhibits potential as an effective target in gene therapy for laryngeal cancer.

PMID: 26165988 [PubMed - indexed for MEDLINE]

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Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study.

Related Articles

Signs and Symptoms of Dry Eye in Keratoconus Patients: A Pilot Study.

Curr Eye Res. 2015;40(11):1088-94

Authors: Carracedo G, Recchioni A, Alejandre-Alba N, Martin-Gil A, Crooke A, Morote IJ, Pintor J

Abstract
PURPOSE: To compare signs and symptoms of dry eye in keratoconus (KC) patients versus healthy subjects.
METHODS: A total of 15 KC patients (KC group, n = 15 eyes) and 16 healthy subjects (control group, 16 eyes) were enrolled in this study. The Schirmer I test with no anesthetic, tear break-up time (TBUT), corneal staining characteristics, and ocular surface disease index (OSDI) scores were evaluated for both groups. Impression cytology, combined with/scanning laser confocal microscopy (LCM), was performed to evaluate goblet cell density, mucin cloud height (MCH), and goblet cell layer thickness (CLT). Finally, tear concentrations of di-adenosine tetraphosphate (Ap4A) were assessed. Results were statistically analyzed using Shapiro-Wilk and non-parametric Wilcoxon rank sum tests. Statistical significance was set at p < 0.05.
RESULTS: KC patients had lower tear volumes and greater corneal staining than did healthy subjects (p < 0.05). OSDI scores were 44.96 ± 8.65 and 17.78 ± 6.50 for the KC and control groups, respectively (p < 0.05). We found no statistically significant differences in TBUT between groups. Impression cytology revealed lower goblet cell densities in KC group patients versus control group subjects (84.88 ± 32.98 and 128.88 ± 50.60 cells/mm,(2) respectively, p < 0.05). There was a statistically significant reduction in MCH and CLT in KC group patients compared with control group subjects. Ap4A tear concentrations were higher in KC group patients than in control group subjects (2.56 ± 1.10 and 0.15 ± 0.12 µM, respectively, p < 0.05).
CONCLUSIONS: The parameters evaluated in this study indicate that KC patients suffer greater symptoms of dry eye and greater tear instability, primarily due to the decreased mucin production in their tears, than do healthy patients with no KC.

PMID: 25495191 [PubMed - indexed for MEDLINE]

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Audiology patient fall statistics and risk factors compared to non-audiology patients.

Audiology patient fall statistics and risk factors compared to non-audiology patients.

Int J Audiol. 2016 Jun 22;:1-7

Authors: Criter RE, Honaker JA

Abstract
OBJECTIVE: To compare fall statistics (e.g. incidence, prevalence), fall risks, and characteristics of patients who seek hearing healthcare from an audiologist to individuals who have not sought such services.
DESIGN: Case-control study.
STUDY SAMPLE: Two groups of community-dwelling older adult patients: 25 audiology patients aged 60 years or older (M age: 69.2 years, SD: 4.5, range: 61-77) and a control group (gender- and age-matched ±2 years) of 25 non-audiology patients (M age: 69.6, SD: 4.7, range: 60-77).
RESULTS: Annual incidence of falls (most recent 12 months) was higher in audiology patients (68.0%) than non-audiology patients (28.0%; p = .005). Audiology patients reported a higher incidence of multiple recent falls (p =.025) and more chronic health conditions (p = .028) than non-audiology patients.
CONCLUSIONS: Significantly more audiology patients fall on an annual basis than non-audiology patients, suggesting that falls are a pervasive issue in general hearing clinics. Further action on the part of healthcare professionals providing audiologic services may be necessary to identify individuals at risk for falling.

PMID: 27329486 [PubMed - as supplied by publisher]

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Cochlear implantation: Optimizing outcomes through evidence-based clinical decisions.

Cochlear implantation: Optimizing outcomes through evidence-based clinical decisions.

Int J Audiol. 2016;55 Suppl 2:S1-2

Authors: Dowell R, Galvin K, Cowan R

PMID: 27329573 [PubMed - in process]

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Audiology patient fall statistics and risk factors compared to non-audiology patients.

Audiology patient fall statistics and risk factors compared to non-audiology patients.

Int J Audiol. 2016 Jun 22;:1-7

Authors: Criter RE, Honaker JA

Abstract
OBJECTIVE: To compare fall statistics (e.g. incidence, prevalence), fall risks, and characteristics of patients who seek hearing healthcare from an audiologist to individuals who have not sought such services.
DESIGN: Case-control study.
STUDY SAMPLE: Two groups of community-dwelling older adult patients: 25 audiology patients aged 60 years or older (M age: 69.2 years, SD: 4.5, range: 61-77) and a control group (gender- and age-matched ±2 years) of 25 non-audiology patients (M age: 69.6, SD: 4.7, range: 60-77).
RESULTS: Annual incidence of falls (most recent 12 months) was higher in audiology patients (68.0%) than non-audiology patients (28.0%; p = .005). Audiology patients reported a higher incidence of multiple recent falls (p =.025) and more chronic health conditions (p = .028) than non-audiology patients.
CONCLUSIONS: Significantly more audiology patients fall on an annual basis than non-audiology patients, suggesting that falls are a pervasive issue in general hearing clinics. Further action on the part of healthcare professionals providing audiologic services may be necessary to identify individuals at risk for falling.

PMID: 27329486 [PubMed - as supplied by publisher]

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Hearing thresholds, tinnitus, and headphone listening habits in nine-year-old children.

Hearing thresholds, tinnitus, and headphone listening habits in nine-year-old children.

Int J Audiol. 2016 Jun 22;:1-10

Authors: Båsjö S, Möller C, Widén S, Jutengren G, Kähäri K

Abstract
OBJECTIVE: Investigate hearing function and headphone listening habits in nine-year-old Swedish children.
DESIGN: A cross-sectional study was conducted and included otoscopy, tympanometry, pure-tone audiometry, and spontaneous otoacoustic emissions (SOAE). A questionnaire was used to evaluate headphone listening habits, tinnitus, and hyperacusis.
STUDY SAMPLE: A total of 415 children aged nine years.
RESULTS: The prevalence of a hearing threshold ≥20 dB HL at one or several frequencies was 53%, and the hearing thresholds at 6 and 8 kHz were higher than those at the low and mid frequencies. SOAEs were observed in 35% of the children, and the prevalence of tinnitus was 5.3%. No significant relationship between SOAE and tinnitus was found. Pure-tone audiometry showed poorer hearing thresholds in children with tinnitus and in children who regularly listened with headphones.
CONCLUSION: The present study of hearing, listening habits, and tinnitus in nine-year old children is, to our knowledge, the largest study so far. The main findings were that hearing thresholds in the right ear were poorer in children who used headphones than in children not using them, which could be interpreted as headphone listening may have negative consequences to children's hearing. Children with tinnitus showed poorer hearing thresholds compared to children without tinnitus.

PMID: 27329351 [PubMed - as supplied by publisher]

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Sudden sensorineural hearing loss with positional vertigo: Initial findings of positional nystagmus and hearing outcomes.

Sudden sensorineural hearing loss with positional vertigo: Initial findings of positional nystagmus and hearing outcomes.

Int J Audiol. 2016 Jun 22;:1-6

Authors: Kim CH, Shin JE, Yang YS, Im D

Abstract
OBJECTIVES: To investigate the initial findings of positional nystagmus in patients with sudden sensorineural hearing loss (SSNHL) and positional vertigo, and to compare hearing improvement among patients with different types of positional nystagmus.
DESIGN: The characteristics of positional nystagmus upon initial examination were analysed, and the initial mean pure-tone audiometry (PTA) threshold was compared with that at three months after treatment.
STUDY SAMPLE: Forty-four SSNHL patients with concomitant positional vertigo were included.
RESULTS: Positional nystagmus was classified into five subgroups; persistent geotropic direction-changing positional nystagmus (DCPN) in head-roll test (HRT) and negative Dix-Hallpike test (DHT), persistent apogeotropic DCPN in HRT and negative DHT, positive DHT and negative HRT, persistent geotropic DCPN in HRT and positive DHT, and persistent apogeotropic DCPN in HRT and positive DHT. PTA threshold improvement was significantly greater in SSNHL patients with negative DHT than with positive DHT (p = 0.027).
CONCLUSIONS: When geotropic DCPN was elicited by HRT, the nystagmus was persistent, which suggests that alteration of specific gravity of the endolymph, rather than the lateral canal canalolithiasis, may be a cause of this characteristic positional nystagmus. Positive DTH may be a prognostic factor for worse hearing recovery among patients with SSNHL and positional vertigo.

PMID: 27329283 [PubMed - as supplied by publisher]

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Results using the OPAL strategy in Mandarin speaking cochlear implant recipients.

Results using the OPAL strategy in Mandarin speaking cochlear implant recipients.

Int J Audiol. 2016 Jun 22;:1-12

Authors: Vandali AE, Dawson PW, Arora K

Abstract
OBJECTIVE: To evaluate the effectiveness of an experimental pitch-coding strategy for improving recognition of Mandarin lexical tone in cochlear implant (CI) recipients.
DESIGN: Adult CI recipients were tested on recognition of Mandarin tones in quiet and speech-shaped noise at a signal-to-noise ratio of +10 dB; Mandarin sentence speech-reception threshold (SRT) in speech-shaped noise; and pitch discrimination of synthetic complex-harmonic tones in quiet. Two versions of the experimental strategy were examined: (OPAL) linear (1:1) mapping of fundamental frequency (F0) to the coded modulation rate; and (OPAL+) transposed mapping of high F0s to a lower coded rate. Outcomes were compared to results using the clinical ACE™ strategy.
STUDY SAMPLE: Five Mandarin speaking users of Nucleus® cochlear implants.
RESULTS: A small but significant benefit in recognition of lexical tones was observed using OPAL compared to ACE in noise, but not in quiet, and not for OPAL+ compared to ACE or OPAL in quiet or noise. Sentence SRTs were significantly better using OPAL+ and comparable using OPAL to those using ACE. No differences in pitch discrimination thresholds were observed across strategies.
CONCLUSIONS: OPAL can provide benefits to Mandarin lexical tone recognition in moderately noisy conditions and preserve perception of Mandarin sentences in challenging noise conditions.

PMID: 27329178 [PubMed - as supplied by publisher]

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Development of a Multimedia Dysphagia Assessment Learning System Using Responsive Web Design: From e-Learning to m-Learning.

Development of a Multimedia Dysphagia Assessment Learning System Using Responsive Web Design: From e-Learning to m-Learning.

Stud Health Technol Inform. 2016;225:619-620

Authors: Huang HC, Guo SH

Abstract
Swallowing problems have significant affect the health outcome of some residents in long-term care facilities. Nursing staff who care these residents should have the ability of assessing dysphagia. However, nursing continued education to improve the performance of dysphagia assessment is still challenged. To enhance nurses' capability of dysphagia assessment, a Multimedia Dysphagia Assessment learning System was developed for nursing staff in long-term care institutions. This system was evaluated by performing a user usability test.

PMID: 27332279 [PubMed - as supplied by publisher]

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Achalasia: From Bench to Peroral Endoscopic Myotomy.

Achalasia: From Bench to Peroral Endoscopic Myotomy.

Dig Dis. 2016 Jun 22;34(5):476-482

Authors: Boeckxstaens GE

Abstract
Achalasia is a primary esophageal motility disorder with an estimated annual incidence of 1 per 100,000 persons. It is characterized by the absence of esophageal peristalsis and failure of the lower esophageal sphincter (LES) to relax upon swallowing, resulting in progressively severe dysphagia for solids and liquids, regurgitation, aspiration, chest pain and weight loss. Achalasia results from a loss of enteric neurons, most likely due to an autoimmune reaction in patients with a particular immunogenetic background. To date, 3 manometric subtypes have been identified based on high resolution manometry. To what extent these subtypes also indicate differences in underlying pathophysiological mechanisms is however unclear. As achalasia cannot be cured, treatment is confined to disruption of the LES to improve bolus passage and thereby relieving symptoms. The 2 most commonly used treatment modalities available for this purpose include pneumodilation and laparoscopic Heller myotomy. Both treatments have been shown repeatedly to be successful; however, success rates decline in time, most likely due to progression of the disease. A recent European randomized trial provides objective data indicating that both treatments are equally effective. In view of these data and the low incidence of the disease, the choice between these 2 treatments should be based on the expertise and experience available. Recently, excellent short-term success rates have been reported with a new endoscopic technique, that is, peroral endoscopic myotomy. However, longer follow-up data are absolutely needed before accepting this technique as a new treatment option for achalasia in clinical practice.

PMID: 27331393 [PubMed - as supplied by publisher]

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Nonthyroid Metastasis to the Thyroid Gland: Case Series and Review with Observations by Primary Pathology.

Nonthyroid Metastasis to the Thyroid Gland: Case Series and Review with Observations by Primary Pathology.

Otolaryngol Head Neck Surg. 2016 Jun 21;

Authors: Russell JO, Yan K, Burkey B, Scharpf J

Abstract
OBJECTIVE: Nonthyroid metastases to the thyroid gland can cause morbidity, including dysphagia, dysphonia, and airway compromise. Because metastatic malignancies portend a poor prognosis, obtaining equipoise between treatment morbidity and local disease progression is paramount. We reviewed cases of nonthyroid metastases to determine treatment and prognostic recommendations.
STUDY DESIGN: Case series with chart review.
SETTING: Tertiary care hospital.
SUBJECTS AND METHODS: We searched PubMed for reported cases between 1994 and September 2013 using search terms as follows: any combination of primary tumor locations and thyroid, as well as the terms thyroid and metastasis. Only unique cases of nonthyroid metastases were included. Combined with 17 additional tumors at our own institution, we found 818 unique nonthyroid metastases, of which 384 had management and survival data available.
RESULTS: Renal cell carcinoma was most common, presenting in 293 (35.8%) patients, followed by lung and gastrointestinal malignancies. Patients were treated with total thyroidectomy (34.0%), subtotal thyroidectomy including lobectomy (32.6%), and no surgery (33.5%). Surgical management was associated with improved survival duration (P < .01). Locoregional recurrence was less likely in patients treated with total versus partial thyroidectomy (4.8% vs 13%). Extent of surgical management did not have a significant effect on patient survival. Delayed presentation was associated with improved survival duration (P = .01).
CONCLUSIONS: Nonthyroid metastases to the thyroid gland are unusual tumors. Surgical intervention is associated with improved survival, but expected morbidity of untreated tumors is difficult to assess. Site of origin, time to diagnosis, and surgical approach are related to survival and recurrence rates.

PMID: 27329421 [PubMed - as supplied by publisher]

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Clinical Reasoning: An 11-year-old boy with language disorder and epilepsy.

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Clinical Reasoning: An 11-year-old boy with language disorder and epilepsy.

Neurology. 2016 Feb 2;86(5):e48-53

Authors: Dong L, Zhou XQ

PMID: 26833943 [PubMed - indexed for MEDLINE]

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Gastroesophageal Reflux Disease and Sleeve Gastrectomy.

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Gastroesophageal Reflux Disease and Sleeve Gastrectomy.

Obes Surg. 2015 Dec;25(12):2430-5

Authors: Melissas J, Braghetto I, Molina JC, Silecchia G, Iossa A, Iannelli A, Foletto M

Abstract
Gastroesophageal reflux disease (GERD) and/or hiatus hernia (HH) are one of the most common disorders of the upper gastrointestinal tract. Despite the positive effect of sleeve gastrectomy (SG) regarding weight loss and improvement in obesity co-morbidities, there are concerns about the development of de novo gastroesophageal reflux disease or worsening the existing GERD after this bariatric operation. Furthermore, controversy exists on the consequences of SG in lower esophageal sphincter function and about the ideal procedure when a hiatus hernia is preoperatively diagnosed or discovered during the laparoscopic SG. This review systematically investigates the incidence, the pathophysiology of GERD and/or HH in morbidly obese individuals before and after SG, and the treatment options for concomitant HH repair during laparoscopic sleeve gastrectomy.

PMID: 26428250 [PubMed - indexed for MEDLINE]

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Rare presentation of orbital plasmablastic lymphoma with oral cavity involvement in an HIV-negative patient.

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Rare presentation of orbital plasmablastic lymphoma with oral cavity involvement in an HIV-negative patient.

BMJ Case Rep. 2015;2015

Authors: Podder S, Khetan P, Sivamurthy S, Mandal K

Abstract
Plasmablastic lymphoma is described as a subtype of non-Hodgkin's lymphoma under the category of diffuse large B-cell lymphoma. It is classified by WHO as HIV-associated lymphoma of the oral cavity. Several cases have been reported in non-HIV patients with extra-oral involvement. The characteristic immunohistochemical markers are generally positive for CD138, CD38 and MUM1/IRF4, and negative or weakly positive for pan B-cell markersCD20, CD79a, PAX-5 and BCL-6. We report a rare case of orbital plasmablastic lymphoma with oral and oropharyngeal involvement where the immunohistochemical markers were positive for CD138, CD43, CD45, CD79a and MUM1. A small subset of markers was weakly positive for CD20, CD30 and κ, and negative for CD10, BCL-6, CD4, CD56 and Epstein-Barr virus-encoded small RNA (EBER). Our case reinforces the fact that plasmablastic lymphoma is a different entity of non-Hodgkin's lymphoma that cannot simply be classified under diffuse large B-cell lymphoma. It demands modification of the WHO classification.

PMID: 26376702 [PubMed - indexed for MEDLINE]

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A multisensor approach to improve manometric analysis of the upper esophageal sphincter.

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A multisensor approach to improve manometric analysis of the upper esophageal sphincter.

Laryngoscope. 2016 Mar;126(3):657-64

Authors: Jones CA, Ciucci MR, Hammer MJ, McCulloch TM

Abstract
OBJECTIVES/HYPOTHESIS: High-resolution manometry (HRM) improves on previous manometric systems by including a greater number of sensors that are more densely placed. Due to deglutitive movement of the HRM catheter and upper esophageal sphincter (UES), it is unclear which HRM sensors capture pressure in the UES. To address this issue, we present two complementary studies to describe UES pressure patterns using HRM + videofluoroscopy and HRM + electromyography (EMG).
STUDY DESIGN: Case series involving a new analysis method.
METHODS: Study 1: Simultaneous HRM + videofluoroscopy were performed in 11 healthy subjects swallowing five 10-mL thin-liquid boluses. HRM catheter and UES movement were tracked to identify UES pressure patterns over multiple HRM sensors. Study 2: Simultaneous HRM + cricopharyngeal EMGs were performed in six healthy subjects swallowing five 10-mL water boluses. HRM and EMG outputs were correlated over individual and multiple HRM sensors.
RESULTS: HRM sensors move prior to UES movement (P < .001) and to a lesser extent in rostral and ventral directions (P ≤ .01) than the UES. UES closure pressure is captured with two distinct patterns: 1) a rostral UES pattern with short durations and fast rate of pressure release, depicting UES descent along the catheter as it closes; and 2) a caudal UES pattern with tonic pressures at baseline and a deglutitive nadir. The HRM + EMG multisensor correlation (r = 0.88) was significantly stronger than the single-sensor correlation (r = 0.80; P = .02).
CONCLUSIONS: During deglutition, the HRM catheter and the UES rise above baseline positions and create a distinctive, multisensor manometric trace. Accurate deglutitive UES pressure evaluation must include multiple manometric sensors.
LEVEL OF EVIDENCE: 4 Laryngoscope, 126:657-664, 2016.

PMID: 26297859 [PubMed - indexed for MEDLINE]

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A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial.

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A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial.

J Clin Gastroenterol. 2015 Sep;49(8):655-9

Authors: Person E, Rife C, Freeman J, Clark A, Castell DO

Abstract
GOAL: We hypothesized that sleeping left-side down with the head/torso elevated reduces recumbent gastroesophageal reflux (GER).
BACKGROUND: Previous studies show that sleeping with head of bed elevated or on wedge reduces GER and lying left-side down reduces GER versus right-side down and supine. No prior studies have evaluated the potential compounding effects of lying in an inclined position combined with lateral positioning on GER.
STUDY: We evaluated a sleep-positioning device (SPD) consisting of an inclined base and body pillow that maintains lateral position while elevating the head/torso. This was a single institution, randomized controlled trial involving 20 healthy volunteers receiving 4 six-hour impedance-pH tests. After placement of reflux probe, subjects returned home, ate standardized meal, and lay down in randomly assigned positions: SPD right-side down (SPD-R), SPD left-side down (SPD-L), standard wedge any position (W), or flat any position (F). A wireless accelerometer documented position during each study. Number of reflux episodes (RE) and esophageal acid exposure (EAE) were calculated over 6 hours.
RESULTS: Significantly less EAE occurred during sleeping SPD-L versus sleeping W, SPD-R, and F. The most EAE occurred during sleeping SPD-R despite use of the positioning device. RE were significantly less SPD-L than SPD-R. Patients sleeping SPD-L and SPD-R spent the majority of first 2 hours and greater than half of 6 hours in assigned position. Patients sleeping W and F averaged more time supine than right or left.
CONCLUSIONS: The sleep positioning device maintains recumbent position effectively. Lying left-side down, it reduces recumbent esophageal acid exposure.

PMID: 26053170 [PubMed - indexed for MEDLINE]

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Changes in Health-Related Quality of Life After Gastric Bypass in Patients With and Without Obesity-Related Disease.

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Changes in Health-Related Quality of Life After Gastric Bypass in Patients With and Without Obesity-Related Disease.

Obes Surg. 2015 Dec;25(12):2408-16

Authors: Risstad H, Søvik TT, Hewitt S, Kristinsson JA, Fagerland MW, Bernklev T, Mala T

Abstract
BACKGROUND: A substantial proportion of severely obese patients undergoing bariatric surgery have not developed disease as a consequence of obesity. Little is known about the effects of bariatric surgery on health-related quality of life (HRQL) in this patient group. In a prospective study at a public hospital, we compared HRQL in gastric bypass patients with and without obesity-related disease before and 2 years after surgery.
METHODS: HRQL was assessed in 232 severely obese patients before, 1 year, and 2 years after Roux-en-Y gastric bypass. We used a general HRQL questionnaire, the Short Form 36, and an obesity-specific questionnaire, the Obesity-related Problems scale. The patients were divided into two groups based on the presence of obesity-related disease (n = 146) or not (n = 86) before surgery. We defined obesity-related disease as having at least one of the following conditions: type 2 diabetes mellitus, hypertension, dyslipidemia, coronary heart disease, obstructive sleep apnea, gastroesophageal reflux disease, or osteoarthritis. Linear mixed models were used to analyze the HRQL outcomes.
RESULTS: Before surgery, patients with no obesity-related disease reported equal HRQL compared with patients with obesity-related disease. Two years after gastric bypass, substantial improvements in all subscales of Short Form 36 and in Obesity-related Problems scale were observed in both groups, and the improvements were similar in 7 out of 8 subscales of Short Form 36 as well as for the Obesity-related Problems scale.
CONCLUSIONS: Baseline HRQL was similar in patients with and without obesity-related disease prior to gastric bypass. After surgery, patients with no comorbidity had similar positive changes in HRQL as patients with one or several comorbidities. These findings indicate that other factors than obesity-related disease are at least as important for severely obese patients' impaired HRQL.

PMID: 26003550 [PubMed - indexed for MEDLINE]

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The Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery on Dietary Intake, Food Preferences, and Gastrointestinal Symptoms in Post-Surgical Morbidly Obese Lebanese Subjects: A Cross-Sectional Pilot Study.

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The Effect of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy Surgery on Dietary Intake, Food Preferences, and Gastrointestinal Symptoms in Post-Surgical Morbidly Obese Lebanese Subjects: A Cross-Sectional Pilot Study.

Obes Surg. 2015 Dec;25(12):2393-9

Authors: El Labban S, Safadi B, Olabi A

Abstract
BACKGROUND: Data on gastrointestinal (GI) and dietary changes following bariatric surgery are scarce in the Middle Eastern region. The objective of this work was to retrospectively compare dietary intake, food preferences, and GI symptoms in subjects with extreme obesity after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).
METHODS: Sixty subjects equally divided between RYGB and SG with a postoperative period of ≥6 months were recruited for a retrospective, non-randomized, and observational study. All subjects completed three questionnaires (GI symptoms, food preferences, and quantitative food frequency questionnaire (FFQ)) and three 24-h recalls.
RESULTS: At one year postoperatively, both surgical groups showed similar percentage of excess weight loss that exceeded 50%. In addition, percentage of carbohydrate, protein, and sugar intake from total energy, frequency of daily consumption from the eight food categories and daily energy intake were comparable between surgical groups. RYGB subjects consumed significantly more fruits and juices from total energy (P < 0.05) whereas SG subjects tended to consume more sweets and desserts. Heartburn (P < 0.001), regurgitation (P < 0.01), nausea (P < 0.01), vomiting (P < 0.001), and constipation (P < 0.05) were significantly more frequent among SG subjects. Flatulence (P < 0.001) and diarrhea (P < 0.05), as well as dizziness (P < 0.001), and fast heartbeat (P < 0.05) after eating were significantly more frequent after RYGB.
CONCLUSIONS: There were no major differences in dietary intake and food preferences between RYGB and SG groups. There was a trend for sweet-eating in SG subjects with less dumping symptoms to suggest different mechanisms of action for each procedure, which might impact eating behavior.

PMID: 25982803 [PubMed - indexed for MEDLINE]

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Long-termin vivodegradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50

Publication date: Available online 22 June 2016
Source:Acta Biomaterialia
Author(s): F. Amerstorfer, S.F. Fischerauer, L. Fischer, J. Eichler, J. Draxler, A. Zitek, M. Meischel, E. Martinelli, T. Kraus, S. Hann, S.E. Stanzl-Tschegg, P.J. Uggowitzer, J.F. Löffler, A.M. Weinberg, T. Prohaska
We report on the long-term effects of degrading magnesium implants on bone tissue in a growing rat skeleton using continuous in vivo micro-Computed Tomography, histological staining and Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Two different magnesium alloys—one rapidly degrading (ZX50) and one slowly degrading (WZ21)—were used to evaluate the bone response and distribution of released Mg and Y ions in the femur of male Sprague-Dawley rats.Regardless of whether the alloy degrades rapidly or slowly, we found that bone recovers restitutio ad integrum after complete degradation of themagnesium implant. The degradation of the Mg alloys generates a significant increase in Mg concentration in the cortical bone near the remaining implant parts, but the Mg accumulation disappears after the implant degrades completely. The degradation of the Y-containing alloy WZ21 leads to Y enrichment in adjacent bone tissues and in newly formed bone inside the medullary space. Locally high Y concentrations suggest migration not only of Y ions but also of Y-containing intermetallic particles. However, after the full degradation of the implant the Yenrichment disappears almost completely. Hydrogen gas formation and ion release during implant degradation did not harm bone regeneration in our samples.Statement of SignificanceMagnesium is generally considered to be one of the most attractive base materials for biodegradable implants, and many magnesium alloys have been optimized to adjust implant degradation. Delayed degradation, however, generates prolonged presence in the organism with the risk of foreign body reactions. While most studies so far have only ranged from several weeks up to 12 months, the present study provides data for complete implant degradation and bone regeneration until 24 months, for two magnesium alloys (ZX50, WZ21) with different degradation characteristics. μCT monitoring, histological staining and LA-ICPMS illustrate the distribution of the elements in the neighboring bony tissues during implant degradation, and reveal in particular high concentrations of the rare-earth element Yttrium.

Graphical abstract

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Iododerma from Contrast Material

Figure 1.

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Single Operation to Repair Multifocal Cerebrospinal Fluid Fistulae Following Gunshot Wound: A Case Report.

Single Operation to Repair Multifocal Cerebrospinal Fluid Fistulae Following Gunshot Wound: A Case Report.

J Neurol Surg Rep. 2016 Jun;77(2):e89-93

Authors: White-Dzuro GA, Entezami P, Wanna G, Russell P, Chambless LB

Abstract
Introduction Traumatic cerebrospinal fluid (CSF) fistulae can be a challenging neurosurgical disease, often requiring complicated surgical intervention. Case Presentation A 54-year-old man presented with a gunshot wound to the head with complex injury to the skull base and significant CSF leakage from multiple sites. A single surgery was performed using a combined Neurosurgery, Neurotology, and Rhinology team, which was successful in repairing the multiple skull base defects and preventing further CSF leak. Discussion Trauma to the skull base is a common inciting factor for the development of CSF fistulae. Endoscopic approaches are often preferred for repairing these defects, but craniotomy remains a viable option that may be required in more complex cases. A combined approach has not been described previously, but was successful for this severe multifocal defect. Conclusion A multidisciplinary approach allowed for a combined intervention that addressed both the anterior and middle fossae fistulae simultaneously. This limited the potential infectious complications of continued CSF leak and allowed for early rehabilitation.

PMID: 27330926 [PubMed]

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Endoscopic Removal of a Bullet in Rosenmuller Fossa: Case Report.

Endoscopic Removal of a Bullet in Rosenmuller Fossa: Case Report.

J Neurol Surg Rep. 2016 Jun;77(2):e83-5

Authors: Burks JD, Glenn CA, Conner AK, Bonney PA, Sanclement JA, Sughrue ME

Abstract
Fractures of the anterior skull base may occur in gunshot victims and can result in traumatic cerebrospinal fluid (CSF) leak. Less commonly, CSF leaks occur days or even weeks after the trauma occurred. Here, we present the case of a 21-year-old man with a delayed-onset, traumatic CSF leak secondary to a missile injury that left a bullet fragment in the Rosenmuller fossa. The patient was treated successfully with endoscopic, endonasal extraction of the bullet, and repair with a nasal septal flap. Foreign bodies lodged in Rosenmuller fossa can be successfully treated with endoscopic skull base surgery.

PMID: 27330924 [PubMed]

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Preventing and Managing Complications in Frontal Sinus Surgery.

Preventing and Managing Complications in Frontal Sinus Surgery.

Otolaryngol Clin North Am. 2016 Jun 18;

Authors: Eloy JA, Svider PF, Setzen M

Abstract
This review covers potential complications of frontal sinus surgical management and strategies for prevention of these complications. Accordingly, recent advances in frontal sinus surgical techniques are described, and the management of complications stemming both from these and traditional techniques are detailed.

PMID: 27329982 [PubMed - as supplied by publisher]

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A Prospective Study of Sudden Cardiac Death among Children and Young Adults

Sudden cardiac death among children and young adults is a devastating event for the family and wider community. Coronary artery disease is the predominant cause of sudden cardiac death in older persons, whereas among persons 1 to 35 years of age, sudden cardiac death is more often caused by…

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Crystallopathies

Deposits of crystals, misfolded proteins, or airborne particulate matter of nanoparticle or microparticle size (all of which are hereafter referred to as crystal deposits) (see the Glossary) cause diverse medical disorders (Table 1) that can manifest as either acute or chronic organ injuries…

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Body-Mass Index in 2.3 Million Adolescents and Cardiovascular Death in Adulthood

Overweight and obesity in adolescents have increased substantially in recent decades and affect a third of the adolescent population in some developed countries. Obesity early in life is considered to be a risk factor for death from cardiovascular disease and from all causes in adulthood, although…

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Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

To the Editor: Resistance to all antimicrobial agents has developed in some Neisseria gonorrhoeae strains. Dual antimicrobial therapy (ceftriaxone plus azithromycin) is a recommended first-line empirical treatment in many countries. We describe treatment failure with dual therapy in a patient with…

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Squamous-Cell Carcinoma of the Tongue

Figure 1.

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Case 19-2016: A 65-Year-Old Man with End-Stage Renal Disease and a Pruritic Rash

Presentation of Case. Dr. Daniel Y. Sugai (Dermatology): A 65-year-old man with end-stage renal disease was seen in the emergency department of this hospital because of a leg injury and a diffuse pruritic rash. The patient was in poor health, with end-stage renal disease that required hemodialysis.…

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Transient Smartphone "Blindness"

To the Editor: Transient monocular vision loss is a common clinical presentation, and the cause is not always thromboembolic. We present two cases in which careful history taking established a benign cause (for the case histories, see the Supplementary Appendix, available with the full text of this…

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Supportive peri-implant therapy following anti-infective surgical peri-implantitis treatment: 5-year survival and success

Abstract

Objectives

To evaluate clinical outcomes of supportive peri-implant therapy (SPIT) following surgical treatment of peri-implantitis.

Materials and methods

Twenty-four partially dentate patients with 36 dental implants diagnosed with peri-implantitis were treated by an anti-infective surgical protocol followed by regular supportive therapy. SPIT included removal of supra- and submucosal biofilm at the treated implants using titanium or carbon fibre curettes, or ultrasonic devices. In addition, professional prophylaxis (calculus/biofilm removal) at other implants/teeth and oral hygiene reinforcement was provided. Clinical measurements and radiographs were obtained at 1, 3 and 5 years. A successful treatment outcome was defined as implant survival with the absence of peri-implant probing depths (PD) ≥ 5 mm with concomitant bleeding/suppuration and absence of progression of peri-implant bone loss.

Results

Twelve months after treatment, there was 100% survival of the treated implants and 79% of patients (19 of 24) had a successful treatment outcome according to the defined success criteria. At 3 years, 75% of the patients (18 of 24) had a successful treatment outcome, two patients (8%) were lost to follow-up (LTF), while 8% lost an implant, and two patients had recurrence of peri-implantitis. Between 3 and 5 years, an additional two patients were LTF, and an additional two patients each lost one implant. Thus, at 5 years 63% of patients (15 of 24) had a successful treatment outcome. Complete resolution of peri-implantitis, defined as absence of bleeding at all sites, was achieved in 42% of implants (N = 15) at 5 years.

Conclusion

Five years following regular supportive therapy, the peri-implant conditions established following peri-implantitis surgery were maintained in the majority of patients and implants. Some patients had recurrence of peri-implantitis and some lost implants over the 5-year period.

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Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea

To the Editor: Resistance to all antimicrobial agents has developed in some Neisseria gonorrhoeae strains. Dual antimicrobial therapy (ceftriaxone plus azithromycin) is a recommended first-line empirical treatment in many countries. We describe treatment failure with dual therapy in a patient with…

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K13-Propeller Mutations and Malaria Resistance

Resistance has emerged to artemisinin, the backbone of combination therapy for the treatment of Plasmodium falciparum malaria. This week in the Journal, Ménard et al. present a global map of artemisinin genotypic resistance to inform strategies for the control and treatment of malaria. Artemisinin…

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Case 19-2016: A 65-Year-Old Man with End-Stage Renal Disease and a Pruritic Rash

Presentation of Case. Dr. Daniel Y. Sugai (Dermatology): A 65-year-old man with end-stage renal disease was seen in the emergency department of this hospital because of a leg injury and a diffuse pruritic rash. The patient was in poor health, with end-stage renal disease that required hemodialysis.…

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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

Increased efforts have substantially reduced the global burden of malaria caused by Plasmodium falciparum, but the recent gains are threatened by emerging resistance to artemisinins, the cornerstone of current first-line combination treatment. Artemisinins are active against a large range of…

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Bounce regime of droplet collisions: A molecular dynamics study

Zhang, YR; Jiang, XZ; Luo, KH; (2016) Bounce regime of droplet collisions: A molecular dynamics study. Journal of Computational Science 10.1016/j.jocs.2016.03.011 . (In press). Green open access

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Accurate sample assignment in a multiplexed, ultrasensitive, high-throughput sequencing assay for minimal residual disease

Bartram, J; Mountjoy, E; Brooks, T; Hancock, J; Williamson, H; Wright, G; Moppett, J; Bartram, J; Mountjoy, E; Brooks, T; Hancock, J; Williamson, H; Wright, G; Moppett, J; Goulden, N; Hubank, M; - view fewer (2016) Accurate sample assignment in a multiplexed, ultrasensitive, high-throughput sequencing assay for minimal residual disease. Journal of Molecular Diagnostics , 18 (4) pp. 494-506. 10.1016/j.jmoldx.2016.02.008 . Green open access

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The psychology of suggestion and heightened suggestibility.

Gandhi, B.; (2006) The psychology of suggestion and heightened suggestibility. Doctoral thesis, University of London. Green open access

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The preparation and characterisation of cells and their scaffolds suitable for tissue repair applications.

Pittarello, L.; (2008) The preparation and characterisation of cells and their scaffolds suitable for tissue repair applications. Doctoral thesis, University of London. Green open access

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