Prenatal diagnosis and implications of microphthalmia and anophthalmia with a review of current ultrasound guidelines: two case reports

Microphthalmia and anophthalmia are rare congenital fetal abnormalities. The combined incidence is estimated at 1 in 10,000 births. These two conditions arise from complex and incompletely understood genetic a...

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Ankylosing spondylitis, chronic fatigue and depression improved after stromal vascular fraction treatment for osteoarthritis: a case report

Osteoarthritis is a prevalent chronic disease that impacts quality of life and imposes a heavy economic burden. Despite this there is no confirmed treatment that could prevent progressive destruction of osteoa...

https://ift.tt/2ws7rGx

“We're Going to Leave You for Last, Because of How You Are”: Transgender Women's Experiences of Gender-Based Violence in Healthcare, Education, and Police Encounters in Latin America and the Caribbean

Violence and Gender, Ahead of Print.


https://ift.tt/2BVkw1a

Icariin inhibits inflammation via immunomodulation of the cutaneous hypothalamus–pituitary–adrenal axis in vitro

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2LC3yUO

Editors’ letter

https://ift.tt/2BXvZNA

Laser therapy for ocular lesions of naevus of Ota

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2MWaBws

Associated factors of widespread pattern of dermatitis among patch test population: 12‐Year retrospective study

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2NtbWrs

Severe cutaneous eruptions following the topical use of preparations containing bufexamac: Is it time to reconsider its registration in Australia?

Australasian Journal of Dermatology, EarlyView.


https://ift.tt/2ojeX2I

Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study

British Journal of Dermatology, EarlyView.


https://ift.tt/2NqIvGF

A 10‐year longitudinal follow‐up study of a U.K. paediatric transplant population to assess for skin cancer

British Journal of Dermatology, EarlyView.


https://ift.tt/2MYha1G

Dermatology on the General Practice Bookshelf

British Journal of Dermatology, EarlyView.


https://ift.tt/2NtYCmQ

Kidney Transplant Outcomes in Recipients with Cognitive Impairment: A National Registry and Prospective Cohort Study

Background Cognitive impairment is common in patients with end-stage renal disease and is associated with poor outcomes on dialysis. We hypothesized that cognitive impairment might be associated with an increased risk of all-cause graft loss (ACGL) in kidney transplant (KT) recipients. Methods Using the Modified Mini-Mental State (3MS) examination, we measured global cognitive function at KT hospital admission in a prospective, two-center cohort of 864 KT candidates (8/2009-7/2016). We estimated the association between pre-KT cognitive impairment and ACGL using Cox regression, adjusting for recipient, donor, and transplant factors. Results In living donor KT (LDKT) recipients, the prevalence was 3.3% for mild impairment (60≤3MS

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International Liver Transplantation Consensus Statement on end-stage liver disease due to nonalcoholic steatohepatitis and liver transplantation

Nonalcoholic steatohepatitis (NASH)-related cirrhosis has become one of the most common indications for liver transplantation (LT), particularly in candidates over the age of 65 years. Typically, NASH candidates have concurrent obesity, metabolic and cardiovascular risks, which directly impact patient evaluation and selection, waitlist morbidity and mortality and eventually posttransplant outcomes. The purpose of these guidelines is to highlight specific features commonly observed in NASH candidates and strategies to optimize pretransplant evaluation and waitlist survival. More specifically, the working group addressed the following clinically-relevant questions providing recommendations based on the GRADE system supported by rigorous systematic reviews and consensus: (1) Is the outcome after LT similar to that of other etiologies of liver disease? (2) Is the natural history of NASH-related cirrhosis different from other etiologies of end-stage liver disease? (3) How should cardiovascular risk be assessed in the candidate for LT? Should the assessment differ from that done in other etiologies? (4) How should comorbidities (hypertension, diabetes, dyslipidemia, obesity, renal dysfunction, etc.) be treated in the candidate for LT? Should treatment and monitoring of these comorbidities differ from that applied in other etiologies? (5) What are the therapeutic strategies recommended to improve the cardiovascular and nutritional status of a NASH patient in the waiting list for LT? (6) Is there any circumstance where obesity should contraindicate LT? (7) What is the optimal time for bariatric surgery: before, during, or after LT? and (8) Donor steatosis: how much relevant is it for LT in NASH patients Contributions: All authors drafted sections of the manuscript and revised the final manuscript for important intellectual content. In addition, MB and ET also drafted some of the sections, combined all the sections in a single manuscript, and revised the final before submission. Conflict of interest: ET: none SN: none YT: none YL: Speaker for Gilead. Grants and Speaker for Novartis. MG: none JK: none MB: Speaker for Novartis, Astellas, Gilead. Grant from Gilead. Correspondence information: Marina Berenguer – MD, La Fe University Hospital, Avenida Fernando Abril Martorell, 106 (Torre F5) – 46026 Valencia (Spain), e-mail: marina.berenguer@uv.es Ciberehd (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) is partially funded by the Instituto de Salud Carlos III. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Recipient age and mortality after liver transplantation: a population-based cohort tudy

Background The feasibility of liver transplantation (LT) in elderly recipients remains a topic of debate. Methods This cohort study evaluated the impact of recipient's age on LT outcome between January 2007 and May 2016 covered by the Korean National Health Insurance system (n = 9415). Multilevel regression models were used to determine the impact of recipient's age on in-hospital and long-term mortality after LT. Results All patients had a first LT, with 2,473 transplanted with liver from deceased donors (DD) and 6,942 from living donors (LD). The mean age was 52.2±9.0 years. The majority of LT was performed on patients in their 50s (n=4290, 45.6%) and 0.9% (n=84) of the LT was performed on patients aged over 70 years. The overall in-hospital mortality was 6.3%, and the 3-year mortality was 11.3%. The in-hospital mortality included, 13.5% associated with DDLT and 3.7% involved LDLT. When compared with that for patients aged 51 to 55 years, the risk of death among recipients aged over 70 years was about four-fold higher after adjusting for baseline liver disease (OR 4.1; 95% CI 2.21-7.58), and was nearly 3 fold higher after adjusting for baseline liver disease and perioperative complications (OR 2.92; 95% CI 1.37-6.24). And the cost of LT increased significantly with age. Conclusions The data shows that age remains an important risk factor for LT, suggesting that LT should be considered with caution in elderly recipients. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Address for Correspondence: Jinkyeong Park, M.D. Ph.D. Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, E-mail: pjk3318@gmail.com Authorship E.Gil participated in its design and drafted the manuscript. JM. Kim, K.Jeon and GY. Seo participated in its design and coordination. H.Park and D.Kang performed the statistical analysis and helped to draft the manuscript. And J.Cho directed the statistical analysis form the HIRA database. J.Park participated in its design and coordination and contributed as a corresponding author. Disclosure: none Ethics approval and consent to participate The study was reviewed by the Institutional Review Board (IRB) of Samsung Medical Center (IRB SMC 2017-01-001) and was exempted because it involved only deidentified administrative data collected previously. Availability of data and materials We cannot share our data because of administrative data of Korean government Funding: This study was supported by Samsung Medical Center grant [#SMX1151381] Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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Trends for facial injectable therapies in medical aesthetics

Shehnaz Z Arsiwala

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):45-46



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Multiple miliary osteoma cutis of face

Anup K Lahiry

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):95-97

Multiple miliary osteoma cutis is an uncommon condition presenting as multiple skin-colored papules of variable sizes on the face. A 48-year-old woman presented with multiple skin-colored hard papules on both cheeks. Examination revealed firm-to-hard dome-shaped asymptomatic papules in cluster over both cheeks. A punch biopsy was performed, which showed evidence of focal bony trabeculae with associated normal appendages. Few larger papules were incised and followed up with curettage of bony material and closed. All lesions could not be incised and removed because of large number of lesions in cluster.

https://ift.tt/2wofk0B

Dynamic relaxers of the face

Rashmi Shetty

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):47-50

Dynamics of the facial aesthetics is changing rapidly as we treat more and more faces. Our understanding of the molecule at hand and its various applications only expands as our learnings progress. Perception and expectation of the end goal to beauty itself are evolving, and therefore newer ways of analyzing, understanding, and delivering of any aesthetic drug have to evolve continuously. Botulinum toxin is one of the wonders in the aesthetic world, which led the entire focus of the medical fraternity into nonsurgical facial aesthetics. Botulinum toxin was and is still the best tool for relaxing lateral canthal lines and glabellar frown lines. However, it has evolved further to now impart changes/enhancements in skin texture and luminosity, enhancement in facial shape, and reduction in glandular activity of sebaceous, sweat, and salivary glands, therefore leading to a lot more aesthetic application while it still remains as the line eraser.

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Innovative use of abdominoplasty specimen

Saurabh Gupta, Devi P Mohapatra, Ravi K Chittoria, Elankumar Subbarayan, Sireesha K Reddy, Vinayak Chavan, Abhinav Aggarwal, Likhitha C Reddy

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):88-90

Simulator training is important for understanding nipple–areolar complex reconstruction. Human tissue is the best tissue simulator for surgical training. Abdominoplasty specimen is a useful tissue simulator, which is suitable for practicing nipple–areolar complex reconstruction. It is similar to the natural mound created in breast reconstruction. Authors have shared their experience of using abdominoplasty specimen for simulator training of nipple–areolar complex reconstruction for plastic surgery residents. Abdominoplasty specimen is cost-effective, readily available, and an efficient tool for plastic surgery training for the residents.

https://ift.tt/2MzhCUt

Simplifying injectables for volumetric rejuvenation of face

Shehnaz Zulfikar Arsiwala

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):51-59

Volumetric rejuvenation with fillers is a minimally invasive technique used for facial volume restoration. Volume restoration demands adequate knowledge of fat pads and vascularity of the face and the understanding of the depletion patterns. Volumetric restoration with injectable has witnessed a paradigm shift in the last decade with a global rejuvenation, acquiring a predominant emphasis over focal wrinkle filling to restore the depletion pattern of facial fat layers. The techniques used to achieve optimal restoration of facial volume revolve around zonal lifting and tenting, and the impact of treatment on one zone of the surrounding zones is crucial. A face mapping performed for filler technique has thus evolved, with many experts advocating varied techniques from global restoration to point lifts at key areas, to improve the outcome of filler injections, albeit safely, thus simplifying the process. A systematic approach to various techniques and the point lifts in various zones pertaining to the face structure in the Indian skin are highlighted in this article.

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Dermatological surgery in patients with cardiac implantable electronic devices: A new paradigm

Andre B S Khoo, Vishal Madan

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):100-101



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Beware what you inject: Complications of injectables—dermal fillers

Maya Vedamurthy

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):60-66

Cosmetic filler injections are most popular among the antiaging procedures. As in any other cosmetic injectable procedures, complications are likely to occur even under experienced hands. However, it is the duty of the aesthetic physician to identify and manage these potential complications. The objective of this symposia is to help the aesthetic physician to identify these complications early and manage them appropriately to improve outcomes.

https://ift.tt/2PctM2I

An innovative training model for practicing hairline designing

Jyoti Gupta, Gillian Roga, Kavish Chouhan, Amrendra Kumar

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):83-87

Hair transplantation has undergone a massive transformation in todays world. Besides advancement in technique there has also been a great increase in the demand for hair transplant. This rise in demand for hair transplant has further led to an increase in the requirement of professionally trained hair transplant surgeons. In this article we have described a new, versatile and simple technique for hair transplant surgeons to effectively practice hair line designing. This innovative technique proves vital in perfecting the art of the recipient area designing for the hairline, eyebrow, beard etc. for a surgeon who is undergoing training as well as for previously trained surgeons to rehearse an old skill to gain further confidence. Besides helping us practice the art of hairline designing this technique also teaches us the correct angle, direction, depth and density of slits which are ideal and thus helps us to be better prepared for the real life scenario.

https://ift.tt/2MEpvbc

Fat busters: Lipolysis for face and neck

Abhay Talathi, Prajakta Talathi

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):67-72

Persistence and hypertrophy of fat pads particularly of the face and neck region disturb beauty proportions, thus demand treatments. Phosphatidylcholine and deoxycholic acid are the most commonly used solutions for injection lipolysis. As we stand today, sodium deoxycholate preparation is approved by the US Food and Drug Administration for the same. This article describes the correct use of solution to achieve fat reduction and ensure safety. Complete details of patient selection, assessment, dosing, and injection techniques are described in this article. A brief note on posttreatment care and complications is also provided.

https://ift.tt/2PfCsVN

Lipoid proteinosis: Skin resurfacing with combination of fractional CO2 and non-ablative radio frequency: A rare case report

Chandraiah Madura, Arti Priya, Byalekere Shivanna Chandrashekar

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):91-94

Lipoid proteinosis (LP) is a rare autosomal-recessive genodermatosis, characterized by the deposition of amorphous hyaline-like material in different parts of the body, especially the skin and mucous membranes. Disfiguring lesions predominantly affect the facial appearance. No curative therapy and treatment options limited to symptomatic approaches are available. Facial disfigurement in this disease may have a huge negative effect on the patients' psychology and quality of life. With this regard, the patients may benefit very much from the treatments that enhance their cosmetic outlook. We present a 19-year-old female patient with LP who came to us seeking treatment for her facial lesions. She was treated with a combination regimen of fractional carbon dioxide and non-ablative radio frequency with good clinical and aesthetic outcome.

https://ift.tt/2wprJkJ

Arm contouring after massive weight loss: Liposuction-assisted brachioplasty versus standard technique

Verdiana Di Pietro, Gianfranco M Colicchia, Valerio Cervelli, Pietro Gentile

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):73-78

Massive weight loss (MWL) brachioplasty is frequently requested for the improvement of the appearance and function of arms. Despite its diffusion, this procedure can be associated with significant complications. Liposuction-assisted brachioplasty (LAB) preserves the vascular, nervous, and lymphatic network and reduces the incidence of postoperative complications. This retrospective cohort study is aimed at analyzing two different modalities of arm contouring after MWL by evaluating the outcomes and complications. Of 31 patients (all females, average age 43.5 years), 20 were managed with standard brachioplasty represented by a swallowtail scar and monobloc resection and 11 with brachioplasty combined with aggressive liposuction. Evaluated parameters included age, body mass index, method of weight loss, and complications rate. No statistical analysis was used. Major postoperative complications (reoperation, bleeding, or thromboembolism) were not reported in both groups. The incidence of minor complications (wound separation, wound infection, and seroma) was globally 42%; the incidence of complications was significantly lower in the LAB group (9% vs. 60%). The incidence of hypertrophic scarring or keloid was higher in the control group (55% vs. 18%). Most patients were satisfied after surgery: in the LAB group, 81.8% of the patients expressed a high degree of satisfaction and 18.2% a good degree of satisfaction after 4 months of follow-up. In our experience, the LAB should be preferred in MWL patients because it has a lower rate of complications and a faster recovery than the standard technique. Proper execution requires considerable technical skill and experience.

https://ift.tt/2LBl7Ez

A simple, efficient, and economical head drape technique for facial procedures: The nun’s veil drape

Guirgis A Awad

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):98-99



https://ift.tt/2MCKwDq

Anatomy and applications of the #15 scalpel blade and its variations

Somodyuti Chandra, Indrashis Podder, Manas Chatterjee, Lawrence Field

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):79-82

Scalpels have been used to make skin incisions since the advent of "modern" dermatosurgery. #15 Scalpel blade and #3 handle (Bard-Parker handle) are most frequently used by a dermatosurgeon. Besides the proper equipment, appropriate technique is mandatory to ensure a "precise" incision. In this article, we discuss about the anatomy, variations, and different uses of the #15 scalpel blade and the ideal method of making a "precise" skin incision.

https://ift.tt/2PfCmNV

29th National Dermatology Congress of the Algerian Society of Dermatology Algiers, October 18 and 19, 2017

Robert A Schwartz, Aicha Salhi

Journal of Cutaneous and Aesthetic Surgery 2018 11(2):102-103



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Giants in Allergy-Immunology Dr. Henry N. Claman

Dr. Henry Claman recruited me to move to Denver and was my primary mentor during my early years at the University of Colorado School of Medicine. I knew Henry from 1988 until his death in 2017 first as a mentee and then as a colleague and friend. When I first met Henry, I was aware of his importance to the field of immunology as the first to demonstrate that small lymphocytes from the bone marrow (B cells) were responsible for antibody production and those from the thymus (T cells) provided necessary "help".

https://ift.tt/2wohDRj

Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization

Pediatric asthma is a major contributor to emergency room utilization and hospital readmission rates.

https://ift.tt/2wsLyH2

Disease in a Nutshell Sarcoidosis

Sarcoidosis is a granulomatous disease of unknown etiology which can affect any organ system. It may cause respiratory tract, cardiac, ocular, neurologic, and cutaneous manifestations in isolation or in combination. The etiology of sarcoidosis is poorly understood but since exposure to certain environmental antigens in genetically susceptible individuals can lead to granulomatous inflammation mediated by a predominant T helper-1 (Th1) mediated response, that mechanism is possible. Several disease clusters have been reported in response to environmental events such as exposures to industrial chemicals or dust such as observed in the World Trade Center (WTC) disaster.

https://ift.tt/2wlq5AI

Surgical Management of Postparalysis Facial Palsy and Synkinesis

Modified selective neurectomy of the distal branches of the buccal, zygomatic, and cervical branches of the facial nerve in addition to platysmal myotomy is an effective surgical procedure for the treatment of postfacial paralysis synkinesis. Success of this procedure depends on identification of the peripheral facial nerve branches, preservation of zygomatic and marginal mandibular branches that innervate key smile muscles, and ablation of buccal and cervical branches that cause lateral and/or inferior excursion of the oral commissure. Results are long-lasting; objective improvements in electronic clinician-graded facial function scale score, House-Brackmann score, and decreased botulinum toxin-A requirements have been observed.

https://ift.tt/2MVznwG

Management of Long-Standing Flaccid Facial Palsy

Ineffective eyelid closure can pose a serious risk of injury to the ocular surface and eye. In cases of eyelid paresis, systematic examination of the eye and ocular adnexa will direct appropriate interventions. Specifically, 4 distinct periorbital regions should be independently assessed: eyebrow, upper eyelid, ocular surface, and lower eyelid. Corneal exposure can lead to dehydration, thinning, scarring, infection, perforation, and blindness. Long-term sequelae following facial nerve palsy may also include epiphora, gustatory lacrimation, and synkinesis.

https://ift.tt/2NseuX0

Surgical Management of Acute Facial Palsy

Bell palsy and traumatic facial nerve injury are two common causes of acute facial palsy. Most patients with Bell palsy recover favorably with medical therapy alone. However, those with complete paralysis (House-Brackmann 6/6), greater than 90% degeneration on electroneurography, and absent electromyography activity may benefit from surgical decompression via a middle cranial fossa (MCF) approach. Patients with acute facial palsy from traumatic temporal bone fracture who meet these same criteria may be candidates for decompression via an MCF or translabyrinthine approach based on hearing status.

https://ift.tt/2MUrB6k

Optical coherence tomography for observation of the olfactory epithelium in mice

Optical coherence tomography (OCT) is an imaging tool that exploits the coherence of infrared light and is clinically utilized in the field of ophthalmology and dermatology. This study aimed to examine the feasibility of using OCT for diagnosing degeneration and regeneration of the olfactory epithelium in mice.

https://ift.tt/2Nt3GaY

Cancer of the mandibular gingiva metastasizing to the small intestine

Head and neck cancer metastasizing to the small intestine is very rare. Here we report a case of cancer of the mandibular gingiva metastasizing to the small intestine. The patient was an 82-year-old man who had squamous cell carcinoma of the mandibular gingiva staged as T2N2bM0. Two months after surgery, he presented with lower abdominal pain accompanied by signs of peritoneal irritation. Urgent abdominal surgery was performed, during which a crater-shaped perforation was noted on the wall of the ileum.

https://ift.tt/2MUmnHK

Advanced head and neck surgical techniques: A survey of US otolaryngology resident perspectives

To assess the perspectives of OHNS residents with regards to their training in the following advanced head and neck surgery techniques: transoral robotic surgery (TORS), transoral laser microsurgery (TLM), sialendoscopy, and surgeon-performed ultrasound (SP-US) for possible curricula development.

https://ift.tt/2NuLLkb

BrightOcular® Cosmetic Iris Implant: A Spectrum from Tolerability to Severe Morbidity

Purpose: The BrightOcular® implants are the newest model of cosmetic iris devices that are currently advertised as safe. The previous generation known as NewColorIris® have had severe ocular side effects and were subsequently withdrawn from the market. There is little literature on the safety profile of BrightOcular® implants. Case Report: Herein we describe two cases with varying degrees of ocular tolerability. The first case had a normal ocular exam 1 year after implantation, whereas the second case had unilateral severe corneal edema requiring explantation of the iris device and Descemet membrane endothelial keratoplasty 9 months after bilateral implantation. Conclusions: These two cases attest to the unpredictability of the results of these cosmetic surgeries. Patients should be counseled about the vision-threatening complications of iris implants.
Case Rep Ophthalmol 2018;9:395–400

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A Case of Focal Choroidal Excavation Development Associated with Multiple Evanescent White Dot Syndrome

Focal choroidal excavation (FCE) is described as an excavated lesion of the choroid that can be detected by optical coherence tomography (OCT). While the exact pathogenesis of FCE remains unclear, it has been proposed in some cases that there is an association with the inflammation in the outer retina. We present a case of FCE development that was detected by spectral domain OCT (SD-OCT) and found to be associated with multiple evanescent white dot syndrome (MEWDS). A 40-year-old Japanese woman was diagnosed with MEWDS based on multiple white dots observed from the posterior pole to the midperiphery, along with yellow granularity in the fovea. SD-OCT revealed separation between the retinal pigment epithelium (RPE) and Bruch's membrane (BM) and discontinuations of the ellipsoid zone, RPE, and BM. At 4 weeks after onset, several of the white dots disappeared, the yellow granularity in the fovea became small, and we detected nonconforming choroidal excavation under the central fovea. The choroidal excavation gradually deepened and changed to a conforming pattern. These findings suggest that the degree of the impairment caused by inflammation and the plasticity of the BM and RPE complex may be associated with different types of acquired FCE.
Case Rep Ophthalmol 2018;9:388–394

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Correction for Koehler et al., Transient surface ocean oxygenation recorded in the ~2.66-Ga Jeerinah Formation, Australia [Correction]

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Correction for "Transient surface ocean oxygenation recorded in the ∼2.66-Ga Jeerinah Formation, Australia," by Matthew C. Koehler, Roger Buick, Michael A. Kipp, Eva E. Stüeken, and Jonathan Zaloumis, which was first published July 9, 2018; 10.1073/pnas.1720820115 (Proc Natl Acad Sci USA 115:7711–7716). The authors note...

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People can recognize, learn, and apply default effects in social influence [Social Sciences]

Defaults influence decisions, but Zlatev et al. (1) argue that people are unaware of those influences and unlikely to learn them. The claim is important and surprising, and it comes as a conclusion to their very thorough piece of scholarship. Nevertheless, the appearance of default neglect may instead reflect the...

https://ift.tt/2BXzl3a

Discovery of fissionogenic Cs and Ba capture five years after Oklo reactor shutdown [Earth, Atmospheric, and Planetary Sciences]

Understanding the release and sequestration of specific radioactive signatures into the environment is of extreme importance for long-term nuclear waste storage and reactor accident mitigation. Recent accidents at the Fukushima and Chernobyl nuclear reactors released radioactive 137Cs and 134Cs into the environment, the former of which is still live today....

https://ift.tt/2PPYlwe

Reply to Jung et al.: Default neglect persists over time and across contexts [Social Sciences]

We appreciate the comments and studies by Jung et al. (1). They test for default neglect in three new default games, finding that "Choice Architects" (CAs) are better than chance at correctly predicting the default effect in these new contexts. That said, we believe that Jung et al.'s claim that...

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Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1 [Biochemistry]

Mitotic inheritance of DNA methylation patterns is facilitated by UHRF1, a DNA- and histone-binding E3 ubiquitin ligase that helps recruit the maintenance DNA methyltransferase DNMT1 to replicating chromatin. The DNA methylation maintenance function of UHRF1 is dependent on its ability to bind chromatin, where it facilitates monoubiquitination of histone H3...

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Benefits of antibiotics burden in low-income countries [Biological Sciences]

Klein et al. (1) report that global antibiotic consumption increased by 65% over the 2000–2015 period, with a 114% increase in low- and middle-income countries (LMICs). The authors conclude that global antibiotic consumption must be decreased to reduce the threat of antibiotic resistance, although reduction efforts must take into account...

https://ift.tt/2BXzhjW

Probing the non-Debye low-frequency excitations in glasses through random pinning [Physics]

We investigate the properties of the low-frequency spectrum in the density of states D(ω) of a 3D model glass former. To magnify the non-Debye sector of the spectrum, we introduce a random pinning field that freezes a finite particle fraction to break the translational invariance and shifts all of the...

https://ift.tt/2PMzwRR

Reply to Abat et al.: Improved policies necessary to ensure an effective future for antibiotics [Biological Sciences]

Antibiotics, particularly penicillins, have been instrumental in lowering mortality associated with pneumococcal pneumonia since they were introduced in the 1950s (1). As we recently reported (2), since 2000, global antibiotic use has increased significantly, driven largely by increases in low- and middle-income countries (LMICs). Given this association, we read with...

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Silkworm genetic sexing through W chromosome-linked, targeted gene integration [Applied Biological Sciences]

Sex separation methods are critical for genetic sexing systems in commercial insect production and sterile insect techniques. Integration of selectable marker genes into a sex chromosome is particularly useful in insects with a heterogametic sex determination system. Here, we describe targeted gene integration of fluorescent marker expression cassettes into a...

https://ift.tt/2N4kg4l

Do the pharmacokinetic and pharmacodynamic graphs warrant additional explanation? [Biological Sciences]

We read with great interest the article by Kudalkar et al. (1), in which the authors identify and conduct substantial work for a promising novel long-acting nonnucleoside reverse transcriptase inhibitor (NNRTI) molecule. We commend the authors for addressing an urgent, unmet global need. Such studies are particularly relevant for developing...

https://ift.tt/2Npw26c

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork [Cell Biology]

Collapsed replication forks, which are a major source of DNA double-strand breaks (DSBs), are repaired by sister chromatid recombination (SCR). The Mre11–Rad50–Nbs1 (MRN) protein complex, assisted by CtIP/Sae2/Ctp1, initiates SCR by nucleolytically resecting the single-ended DSB (seDSB) at the collapsed fork. The molecular architecture of the MRN intercomplex, in which...

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Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection [Biological Sciences]

We appreciate Pandey et al.'s (1) interest in further understanding our published work (2). Our responses are given below the excerpts from the Letter.Our first and foremost concern is the data presented in their figure 6C. We fail to understand why there was a fall in the plasma viral loads...

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Electron tomography reveals details of the internal microstructure of desalination membranes [Environmental Sciences]

As water availability becomes a growing challenge in various regions throughout the world, desalination and wastewater reclamation through technologies such as reverse osmosis (RO) are becoming more important. Nevertheless, many open questions remain regarding the internal structure of thin-film composite RO membranes. In this work, fully aromatic polyamide films that...

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Sticking and stacking: Persistent ordering of fragmented DNA analogs [Applied Physical Sciences]

In a PNAS paper, Smith et al. (1) demonstrate spontaneous self-assembly of a DNA analog from a solution of mononucleotide triphosphates, exhibiting concurrently a high degree of Watson–Crick base pair selectivity with complementarity-dependent partitioning of nucleotides, a stacking order corresponding very closely to B-DNA geometry and a mesophase ordering similar...

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Recurrent computations for visual pattern completion [Psychological and Cognitive Sciences]

Making inferences from partial information constitutes a critical aspect of cognition. During visual perception, pattern completion enables recognition of poorly visible or occluded objects. We combined psychophysics, physiology, and computational models to test the hypothesis that pattern completion is implemented by recurrent computations and present three pieces of evidence that...

https://ift.tt/2BWEWqu

Dynamics of hemagglutinin-mediated membrane fusion [Biophysics and Computational Biology]

Importance of Membrane Fusion in Biology Membrane fusion is ubiquitous in biology, both in natural cellular functions such as neurotransmission and in pathological processes such as viral infection. The fusion of lipid bilayer membranes involves membrane contact, merger, and formation of an aqueous fusion pore, allowing the merging of separate...

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In This Issue [This Week in PNAS]

Genome editing improves yield of spider silk Golden orb-web spider. Image courtesy of iStock/hakoar. The high strength and elasticity of spider silk render it a desirable raw material for construction, defense, and biomedical applications. However, spiders are difficult to rear due to their territorial and cannibalistic nature. Previous efforts to...

https://ift.tt/2wlCl3W

Economic inequality drives female sexualization [Psychological and Cognitive Sciences]

Sexual selection plays a crucial role in understanding the diversity of both physiological and behavioral traits of animals and in recent years has made significant contributions to explaining the patterning of inter- and intrasexual competition in humans (1). With increasing interest in the active role of females as competitors (2),...

https://ift.tt/2NsNcje

Controlling fracture cascades through twisting and quenching [Applied Physical Sciences]

Fracture fundamentally limits the structural stability of macroscopic and microscopic matter, from beams and bones to microtubules and nanotubes. Despite substantial recent experimental and theoretical progress, fracture control continues to present profound practical and theoretical challenges. While bending-induced fracture of elongated rod-like objects has been intensely studied, the effects of...

https://ift.tt/2PPYu2K

Generating carbon schwarzites via zeolite-templating [Chemistry]

Zeolite-templated carbons (ZTCs) comprise a relatively recent material class synthesized via the chemical vapor deposition of a carbon-containing precursor on a zeolite template, followed by the removal of the template. We have developed a theoretical framework to generate a ZTC model from any given zeolite structure, which we show can...

https://ift.tt/2wlC4xW

Radiologic/histologic discrepancies in tumor identification: The case of a “basketball‐sized” mandibular tumor in a woman from 17th century West Virginia

International Journal of Osteoarchaeology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2wjINbE

Europäische PanCare-Studien zu Spätfolgen nach Krebs im Kindes- und Jugendalter

https://ift.tt/2NsgY7C

Late adverse outcomes after treatment of testicular cancer

Abstract

Background

Modern oncological treatment has rendered testicular cancer (TC) a curative malignant disease but there is a risk of decreasing survival and reduced health-related quality of life (HR-QoL) related to long-term adverse health outcomes (AHOs).

Aim

To provide an overview on AHOs after oncological treatment of TC.

Material and methods

Summary of published studies and previous reviews.

Results

Relative survival rates decrease among TC survivors 25 years after diagnosis, mainly due to treatment-related second cancer and/or cardiovascular disease, the latter mediated by components of the metabolic syndrome. With increasing age cisplatin-induced ototoxicity becomes a clinical problem in patients, whereas reported peripheral neurotoxicity only exceptionally achieves major clinical relevance. Anxiety but not depression represents the dominating psychological problem. In most patients HR-QoL is good, but working ability may be reduced by very intensive treatment.

Conclusion

Awareness of long-term AHOs among TC survivors and health professionals can contribute to reduce long-term morbidity and mortality and to improve QoL by initiating early preventive and therapeutic measures. Radiotherapy should be avoided as much as possible during risk-adapted treatment of TC. Existing data indicate premature aging among strongly treated TC survivors but larger studies and longer follow-up in longitudinal studies are required to confirm these preliminary observations.

https://ift.tt/2MZwaw2

Choosing a Pediatrician | Finding the Best Fit for Your Family

Finding the pediatrician who is the best fit for your family can be overwhelming.  As soon as you begin asking friends and family, you will find yourself wading in a sea of overlapping names and exclamations of "He's the best!", "My kids love her!" or "She is so nice!"  The truth is, most people DO love their pediatrician.  The pediatrician-family relationship is unique A pediatrician is a source of parenting knowledge and support for you as well as the healthcare provider for your children.  When you choose your pediatrician, you are saying "I trust you, I like you and I want us to work together to make the best decisions for my family." Your pediatrician is your teammate – and you get to choose who is on your team.

So, where and when do you start trying to find this elusive ideal teammate?

Researching Pediatricians

We recommend beginning your search around 28-32 weeks of pregnancy – but remember, the earlier you start, the less rushed you will feel! Your obstetrician is a good place to start; he or she can give you a few recommendations and will often refer pediatricians near where you live.  You can ask friends and families for recommendations, but keep in mind things that are important to you may not be as important to your friends or family. If someone offers a negative or positive opinion about a particular pediatrician, it may be helpful to ask why they feel that way. Consider those reviews carefully.

You can also use your health insurance website, your delivering hospital's website and social media to look for pediatrician candidates. Information about a pediatrician's education and office structure can often be found on their professional website. You should make sure a pediatrician is board certified by the American Board of Pediatrics.

Gathering this preliminary information can help you narrow down which pediatricians you wish to learn more about and eventually interview.

What's Important to You?

There are several aspects of a pediatric office that you should consider when deciding where to go. Here are some of the most important:

1. The Practice: Is it large or small? Is it near your home? Will you always see your pediatrician, or might you see a partner or a nurse practitioner? Are there separate waiting rooms or waiting spaces for sick and well children? Or separate waiting accommodations for newborns and babies? Is the waiting room crowded?
2. Practice Style: Do the pediatricians stay current with evidence-based medicine, including only prescribing antibiotics when indicated, ordering minimal labs and X-rays and giving necessary vaccinations?
3. Care for Newborns: Will your newborn be seen in the hospital by your pediatrician after delivery, or will you see one of the hospital's pediatricians?
4. Support: If you choose to breastfeed, does this pediatrician offer lactation support or education? What resources or help do they offer if you are struggling with breastfeeding?
5. Access to Care: How do you reach your pediatrician during office hours? How quickly are calls returned? And by whom? Can your child be seen the same day if you request an appointment due to illness? Who can you see after hours?
6. Access to Specialists and Ancillary Care: Is the practice located in a building that also houses pediatric specialists, a laboratory, and X-ray machines? (Note: The Children's Specialty Care Center is a great example of an all-inclusive setting with specialists, radiology, laboratory, and pediatrics all in the same building.)
7. How important is it that your pediatrician is certified by the American Board of Pediatrics? Many Pediatricians have the FAAP designation after their name which indicates they are active members of the American Academy of Pediatrics and support AAP guidelines for preventative care as well as diagnosis and management of childhood illnesses and conditions.

The 'Meet and Greet'

Call the offices you have researched and ask to meet the pediatricians.  You can ask to meet more than one pediatrician in a practice as well.  Ask for a one-on-one meeting.  When you arrive, pay attention to how the office is run and especially how you are welcomed by the front desk person.  This person is often your first contact when you call or come into an office.  No one wants to encounter a crabby or unfriendly front desk person when bringing their child to see the doctor!  Have a conversation with the doctor. Bring a list of questions if you have one and feel free to ask away!

Consider your conversation with the pediatrician and ask yourself these questions:

1. Did you like this person?
2. Did this person make you feel hurried or rushed?
3. Were you comfortable talking to this person?
4. Can you imagine yourself seeing this person frequently – talking openly, asking questions freely and feeling your concerns would be validated?

Making The Choice

Go with your gut.  Answering positively to the questions above is the most important. The choice of a pediatrician is a personal choice and hopefully a long-term relationship.

Resources for Finding Pediatricians

If you need help finding a pediatrician, you can call the St. Louis Children's Hospital answer line at 314-454-KIDS or 800-678-KIDS

The post Choosing a Pediatrician | Finding the Best Fit for Your Family appeared first on ChildrensMD.

https://ift.tt/2N2sqdu

A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus

Wolters, EE; Golla, SSV; Timmers, T; Ossenkoppele, R; van der Weijden, CWJ; Scheltens, P; Schwarte, L; ... van Berckel, BNM; + view all Wolters, EE; Golla, SSV; Timmers, T; Ossenkoppele, R; van der Weijden, CWJ; Scheltens, P; Schwarte, L; Schuit, RC; Windhorst, AD; Barkhof, F; Yaqub, M; Lammertsma, AA; Boellaard, R; van Berckel, BNM; - view fewer (2018) A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus. EJNMMI Research , 8 (1) , Article 79. 10.1186/s13550-018-0432-2 . Green open access

https://ift.tt/2BTgbeU

An experimental study on the acoustic characteristics of outdoor spaces surrounded by multi-residential buildings

Yang, H-S; Kang, J; Kim, M-J; (2017) An experimental study on the acoustic characteristics of outdoor spaces surrounded by multi-residential buildings. Applied Acoustics , 127 pp. 147-159. 10.1016/j.apacoust.2017.05.037 . Green open access

https://ift.tt/2oikkiN

Audio-visual perception of new wind parks

Yu, T; Behm, H; Bill, R; Kang, J; (2017) Audio-visual perception of new wind parks. Landscape and Urban Planning , 165 pp. 1-10. 10.1016/j.landurbplan.2017.04.012 .

https://ift.tt/2Lz3K7t

Acoustic comfort in large dining spaces

Chen, X; Kang, J; (2016) Acoustic comfort in large dining spaces. Applied Acoustics , 115 pp. 166-172. 10.1016/j.apacoust.2016.08.030 . Green open access

https://ift.tt/2PN9Zbh

Performance of PML diagnostic criteria in natalizumab-associated PML: data from the Dutch-Belgian cohort

Wijburg, MT; Warnke, C; Barkhof, F; Uitdehaag, BMJ; Killestein, J; Wattjes, MP; (2018) Performance of PML diagnostic criteria in natalizumab-associated PML: data from the Dutch-Belgian cohort. Journal of Neurology, Neurosurgery and Psychiatry 10.1136/jnnp-2018-318261 . (In press). Green open access

https://ift.tt/2BTwYOG

Effect of temporary open-air markets on the sound environment and acoustic perception based on the crowd density characteristics

Meng, Q; Sun, Y; Kang, J; (2017) Effect of temporary open-air markets on the sound environment and acoustic perception based on the crowd density characteristics. Science of The Total Environment , 601 pp. 1488-1495. 10.1016/j.scitotenv.2017.06.017 . Green open access

https://ift.tt/2oel1cW

Perceived integrated impact of visual intrusion and noise of motorways: Influential factors and impact indicators

Jiang, L; Kang, J; (2017) Perceived integrated impact of visual intrusion and noise of motorways: Influential factors and impact indicators. Transportation Research Part D: Transport and Environment , 57 pp. 217-223. 10.1016/j.trd.2017.09.027 .

https://ift.tt/2LA8hqa

Resistance of Villages to Elevated-Road Traffic Noise

Yu, WL; Kang, J; (2018) Resistance of Villages to Elevated-Road Traffic Noise. Journal of Environmental Planning and Management 10.1080/09640568.2018.1427560 . (In press).

https://ift.tt/2PMgScS

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

Slot, RER; Verfaillie, SCJ; Overbeek, JM; Timmers, T; Wesselman, LMP; Teunissen, CE; Dols, A; ... Van der Flier, WM; + view all Slot, RER; Verfaillie, SCJ; Overbeek, JM; Timmers, T; Wesselman, LMP; Teunissen, CE; Dols, A; Bouwman, FH; Prins, ND; Barkhof, F; Lammertsma, AA; Van Berckel, BNM; Scheltens, P; Sikkes, SAM; Van der Flier, WM; - view fewer (2018) Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results. Alzheimer's Research & Therapy , 10 , Article 76. 10.1186/s13195-018-0390-y . Green open access

https://ift.tt/2BUCAIr

The EMIF-AD PreclinAD study: study design and baseline cohort overview

Konijnenberg, E; Carter, SF; ten Kate, M; den Braber, A; Tomassen, J; Amadi, C; Wesselman, L; ... Visser, PJ; + view all Konijnenberg, E; Carter, SF; ten Kate, M; den Braber, A; Tomassen, J; Amadi, C; Wesselman, L; Nguyen, H-T; van de Kreeke, JA; Yaqub, M; Demuru, M; Mulder, SD; Hillebrand, A; Bouwman, FH; Teunissen, CE; Serne, EH; Moll, AC; Verbraak, FD; Hinz, R; Pendleton, N; Lammertsma, AA; van Berckel, BNM; Barkhof, F; Boomsma, D; Scheltens, P; Herholz, K; Visser, PJ; - view fewer (2018) The EMIF-AD PreclinAD study: study design and baseline cohort overview. Alzheimer's Research & Therapy , 10 , Article 75. 10.1186/s13195-018-0406-7 . Green open access

https://ift.tt/2oiFmxK

Sedimentary biogeochemical record in Lake Gonghai: implications for recent lake changes in relatively remote areas of China

Wan, D; Mao, X; Jin, Z; Song, L; Yang, J; Yang, H; (2018) Sedimentary biogeochemical record in Lake Gonghai: implications for recent lake changes in relatively remote areas of China. Science of the Total Environment (In press).

https://ift.tt/2C6NDyH

Hidden three-state survival model for bivariate longitudinal count data

Van Den Hout, ADL; Muniz-Terrera, G; (2018) Hidden three-state survival model for bivariate longitudinal count data. Lifetime Data Analysis 10.1007/s10985-018-9448-1 . (In press). Green open access

https://ift.tt/2ohdc67

Effects of the distribution density of a biomass combined heat and power plant network on heat utilisation efficiency in village town systems

Zhang, Y; Kang, J; (2017) Effects of the distribution density of a biomass combined heat and power plant network on heat utilisation efficiency in village town systems. Journal of Environmental Management , 202 pp. 21-28. 10.1016/j.jenvman.2017.07.019 . Green open access

https://ift.tt/2Lx3beg

What are the implications of building simulation algorithm choice on indoor overheating risk assessment?

Petrou, G; Mavrogianni, A; Symonds, P; Korolija, I; Mylona, A; Raslan, R; Dane, V; Petrou, G; Mavrogianni, A; Symonds, P; Korolija, I; Mylona, A; Raslan, R; Dane, V; Davies, M; - view fewer (2018) What are the implications of building simulation algorithm choice on indoor overheating risk assessment? In: (Proceedings) Building Simulation and Optimization 2018. University of Cambridge: Cambridge. (In press).

https://ift.tt/2ohcXrJ

Effects of urban street spatial parameters on sound propagation

Hupeng, W; Kang, J; Hong, J; (2017) Effects of urban street spatial parameters on sound propagation. Environment and Planning B: Urban Analytics and City Science 10.1177/2399808317714799 . (In press). Green open access

https://ift.tt/2LA85qW

Mapping Deep Gray Matter Iron in Multiple Sclerosis by Using Quantitative Magnetic Susceptibility

Barkhof, F; Thomas, DL; (2018) Mapping Deep Gray Matter Iron in Multiple Sclerosis by Using Quantitative Magnetic Susceptibility. Radiology 10.1148/radiol.2018181274 . (In press).

https://ift.tt/2ohcHJh

PolyQ Tract Toxicity in SCA1 is Length Dependent in the Absence of CAG Repeat Interruption

Nethisinghe, S; Pigazzini, ML; Pemble, S; Sweeney, MG; Labrum, R; Manso, K; Moore, D; ... Giunti, P; + view all Nethisinghe, S; Pigazzini, ML; Pemble, S; Sweeney, MG; Labrum, R; Manso, K; Moore, D; Warner, J; Davis, MB; Giunti, P; - view fewer (2018) PolyQ Tract Toxicity in SCA1 is Length Dependent in the Absence of CAG Repeat Interruption. Frontiers in Cellular Neuroscience , 12 , Article 200. 10.3389/fncel.2018.00200 . Green open access

https://ift.tt/2LuC6sg

Geographies of Violence in Jerusalem: The Spatial Logic of Urban Intergroup Conflict

Rokem, J; Weiss, CM; Miodownik, D; (2018) Geographies of Violence in Jerusalem: The Spatial Logic of Urban Intergroup Conflict. Political Geography (In press).

https://ift.tt/2PN9rCf

Relationship between traffic noise resistance and village form in China

Yu, WL; Kang, J; (2017) Relationship between traffic noise resistance and village form in China. Landscape and Urban Planning , 163 pp. 44-55. 10.1016/j.landurbplan.2017.02.016 .

https://ift.tt/2BTSGSJ

Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth cohort study

Bar-Zeev, N; King, C; Phiri, T; Beard, J; Mvula, H; Crampin, AC; Heinsbroek, E; ... Cunliffe, NA; + view all Bar-Zeev, N; King, C; Phiri, T; Beard, J; Mvula, H; Crampin, AC; Heinsbroek, E; Lewycka, S; Tate, JE; Parashar, UD; Costello, A; Mwansambo, C; Heyderman, RS; French, N; Cunliffe, NA; - view fewer (2018) Impact of monovalent rotavirus vaccine on diarrhoea-associated post-neonatal infant mortality in rural communities in Malawi: a population-based birth cohort study. The Lancet Global Health , 6 (9) e1036-e1044. 10.1016/S2214-109X(18)30314-0 . Green open access

https://ift.tt/2oi7BMS

A Study of Guselkumab in Participants With Familial Adenomatous Polyposis

Condition:   Adenomatous Polyposis Coli
Interventions:   Drug: Guselkumab;   Drug: Placebo
Sponsor:   Janssen Research & Development, LLC
Not yet recruiting

https://ift.tt/2MDY9C8

Ketamine-ketorolac Versus Fentanyl- Ketorolac I.M in Children During Bone Marrow Biopsy

Condition:   Hematological Malignancy (Leukemia- Lymphoma)
Interventions:   Drug: ketamine-ketorolac;   Drug: fentanyl- ketorolac
Sponsor:   Mansoura University
Not yet recruiting

https://ift.tt/2LzxKjI

Low-Dose Weekly vs High-Dose Cisplatin

Condition:   Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions:   Drug: High-Dose Cisplatin;   Drug: Low-Dose Cisplatin;   Radiation: Radiotherapy
Sponsor:   Lawson Health Research Institute
Not yet recruiting

https://ift.tt/2PL06e4

Endostatin Combined With Chemotherapy for Adjuvant Treatment of Esophageal Cancer

Condition:   Esophageal Cancer
Interventions:   Drug: Docetaxel;   Drug: Nedaplatin;   Drug: Endostar
Sponsor:   First Affiliated Hospital of Guangxi Medical University
Not yet recruiting

https://ift.tt/2Lzx7GS

TCR repertoire profiling of tumors, adjacent normal tissues, and peripheral blood predicts survival in nasopharyngeal carcinoma

Abstract

The T-cell immune responses in nasopharyngeal carcinoma patients have been extensively investigated recently for designing adoptive immunotherapy or immune checkpoint blockade therapy. However, the distribution characteristics of T cells associated with NPC pathogenesis are largely unknown. We performed deep sequencing for TCR repertoire profiling on matched tumor/adjacent normal tissue from 15 NPC patients and peripheral blood from 39 NPC patients, 39 patients with other nasopharyngeal diseases, and 33 healthy controls. We found that a lower diversity of TCR repertoire in tumors than paired tissues or a low similarity between the paired tissues was associated with a poor prognosis in NPC. A more diverse TCR repertoire was identified in the peripheral blood of NPC patients relative to the controls; this was related to a significant decrease in the proportion of high-frequency TCR clones in NPC. Higher diversity in peripheral blood of NPC patients was associated with a worse prognosis. Due to the peculiarity of the Vβ gene usage patterns in the peripheral blood of NPC patients, 15 Vβ genes were selected to distinguish NPC patients from controls by the least absolute shrinkage and selection operator analysis. We identified 11 clonotypes shared by tumors and peripheral blood samples from different NPC patients, defined as "NPC-associated" that might have value in adoptive immunotherapy. In conclusion, we here report the systematic and overall characteristics of the TCR repertoire in tumors, adjacent normal tissues, and peripheral blood of NPC patients. The data obtained may be relevant to future clinical studies in the setting of immunotherapy for NPC patients.

https://ift.tt/2NpVDMi

VV-ECMO during subsequent segmentectomy after right pneumonectomy

Abstract

Several reports have described subsequent pulmonary surgery after pneumonectomy. We herein report the case of an 82-year-old woman with metachronous multiple lung cancer who had undergone surgery for adenocarcinoma of the right upper lobe 17 years earlier. Completion pneumonectomy had been performed for residual lung adenocarcinoma 11 years before the presentation in question. The patient was elderly and had a poor pulmonary function, although her performance status and her cardiac function were good. Therefore, we decided to improve the safety of surgery with venovenous extracorporeal membrane oxygenation (VV-ECMO). Segmentectomy of S6 + S10a was performed under VV-ECMO support. The 30 months after surgery, the patient has had no complications but continues home oxygen therapy. Imaging has shown no evidence of recurrence.

https://ift.tt/2BPUsEx

NFkB mutations in humans: The devil is in the details

Publication date: Available online 28 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Manfred Fliegauf, Bodo Grimbacher

https://ift.tt/2wnOqWt

A New Spin on Mast Cells and Cysteinyl Leukotrienes: Leukotriene E4 Activates Mast Cells in vivo

Publication date: Available online 28 August 2018

Source: Journal of Allergy and Clinical Immunology

Author(s): Lora G. Bankova, Joshua A. Boyce

https://ift.tt/2Lzjx6m

The value of urgent care dermatology

International Journal of Dermatology, EarlyView.


https://ift.tt/2wo6YF6

Indoleamine-2,3-dioxygenase in murine and human systemic lupus erythematosus: Down-regulation by the tolerogeneic peptide hCDR1

Publication date: Available online 28 August 2018

Source: Clinical Immunology

Author(s): Zev Sthoeger, Amir Sharabi, Heidy Zinger, Ilan Asher, Edna Mozes

Abstract

וֹndoleamine-2,3-dioxygenase (IDO) plays a role in immune regulation. Increased IDO activity was reported in systemic lupus erythematosus (SLE). We investigated the effects of the tolerogenic peptide hCDR1, shown to ameliorate lupus manifestations, on IDO gene expression. mRNA was prepared from splenocytes of hCDR1- treated SLE-afflicted (NZBxNZW)F1 mice, from blood samples of lupus patients, collected before and after their in vivo treatment with hCDR1 and from peripheral blood mononuclear cells (PBMC) of patients incubated with hCDR1. IDO gene expression was determined by real-time RT-PCR. hCDR1 significantly down-regulated IDO expression in SLE-affected mice and in lupus patients (treated in vivo and in vitro). No effects were observed in healthy donors or following treatment with a control peptide. Diminished IDO gene expression was associated with hCDR1 beneficial effects. Our results suggest that the hCDR1-induced FOXP3 expressing regulatory T cells in lupus are not driven by IDO but rather by other hCDR1 regulated pathways.

https://ift.tt/2MyBxmy

Iatrogenic Neurological Injury in Children with Trisomy 21

Publication date: Available online 27 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Renata E. Husnudinov, George M. Ibrahim, Evan J. Propst, Nikolaus E. Wolter

Abstract

Purpose

Children with trisomy 21 are at a greater risk for craniocervical junction instability than the general population. These children frequently require administration of anesthesia due to surgical (including otolaryngological) interventions and are at risk for neurological injury. We reviewed the current literature describing iatrogenic neurological injury in children with trisomy 21 undergoing anesthesia in order to facilitate the development of safety recommendations.

Methods

A systematic review of the literature was performed using Medline, Embase, Scopus, and Google Scholar, following the PRISMA statement. All cases of perioperative neurological injury in children with trisomy 21, aged 18 and under were identified. Clinical and radiographic data were extracted for each report. The data were synthesized to develop recommendations regarding perioperative management.

Results

Of 348 articles screened, 16 cases of iatrogenic neurological injury (in children ages 0.7 to 18 years) were identified. Three injuries occurred during otolaryngological surgeries, nine during sedation for intubation for non-otolaryngological surgery, one during sedation for neuroimaging, one while restraining a child, and two were due to intraoperative head and neck positioning while anesthetized. Preoperative screening was reported in four cases. A diagnosis of atlantoaxial instability (AAI) or atlantooccipital instability (AOI) was made immediately following symptom presentation in three cases but was often delayed by a median (IQR) of 30(11.5-912.5) days. No cases resolved spontaneously, with 2 patients progressing to brain death and 12 requiring surgical stabilization. Of the latter, seven showed improvement, whereas one died 5 months later. No intraoperative precautions during the index procedure were reported in any of the 16 cases.

Conclusion

Iatrogenic neurological injury in children with trisomy 21 are rare but severe and likely under reported. Although the role of preoperative screening remains controversial, all children with trisomy 21 undergoing surgery should be considered at risk for neurological injury due to confirmed or undiagnosed AAI or AOI and should be transferred and positioned with appropriate caution. Children with instability should be referred for neurosurgical attention for preoperative stabilization to mitigate perioperative risk. It is imperative to consider the possibility of neurological injury secondary to medical procedures, as it is clear that neck manipulation of any sort places these children at risk.

https://ift.tt/2og5Obl

Influence of infancy care strategy on hearing in children and adolescents: a longitudinal study of children with unilateral lip and /or cleft palate

Publication date: Available online 27 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Maryna Kapitanova, Jean-François Knebel, Oumama El Ezzi, Melody Artaz, Anthony S. de Buys Roessingh, Céline Richard

Abstract

Objectives

To evaluate the relation between ventilation tube insertion, otitis media with effusion duration and otologic outcomes in unilateral cleft lip and/or cleft palate children from infancy to teenage age.

Design and Population

Retrospective longitudinal charts review of patients from the multidisciplinary cleft team of the University Hospital of Lausanne over a 30-year period. 146 charts from consecutive patients with non-syndromic unilateral cleft lip and/or cleft palate who were born between January 1986 and January 2003 were included.

Results

The earlier in life a cleft child experience his first otitis media with effusion (OME), the worse his long-term hearing will be. Along with the age of onset of OME, we disclosed an influence of the duration of OME without ventilation tube (VT) insertion on short and long-term hearing outcomes. Different patterns were observed between cleft palate (CP) and cleft lip palate children (CLP), with a higher incidence of otitis media with effusion for the CLP group than the CP group. Direct positive relationship between VT insertion and hearing were disclosed and evaluation of long-term complications did not reveal significant relation with VT insertion. Of note, OME in CLP children led to a higher rate (but not statistically significant) of chronic ear complications than in the CP group, that may indicate more persistent OME or different adverse effect on the middle ear mucosa between CP and CLP children.

Conclusions

Individualized counseling should take into account different factors such as the type of cleft, the age of onset of OME and duration of OME, keeping in mind the adverse effect of persistent middle ear fluid. In the present report, results prone an early ventilation tube insertion to prevent short and long-term injury to the middle ear homeostasis, hearing loss and related issues.

https://ift.tt/2NqW7BA

Transmastoid access in branchio-oto-renal syndrome: A reappraisal of computed tomography imaging

Publication date: Available online 27 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): William J. Parkes, Sharon L. Cushing, Susan I. Blaser, Blake C. Papsin

Abstract

Objective

To evaluate for temporal bone abnormalities that might affect transmastoid surgery such as cochlear implantation in cases of branchio-oto-renal syndrome (BOR).

Study design

Retrospective review.

Methods

Qualitative assessment of temporal bone computed tomography imaging was performed by a neuroradiologist for 30 individuals with BOR (60 ears) and 20 controls with normal hearing (20 ears). Transmastoid access was assessed categorically across 4 features: tip development, cortex pneumatization, tegmen height, and facial recess pneumatization. The appearance of 4 standard landmarks (Koerner's septum, antrum, prominence of the horizontal semicircular canal, incudal short process) was also dichotomized as normal or abnormal. Data were compared using Fisher's exact testing.

Results

Mastoid height differed between the groups with tip underdevelopment noted in 72% of BOR ears vs. 40% of controls (p = 0.02), and a low tegmen was seen in 68% of BOR ears and 25% of controls (p < 0.01). Significant differences in pneumatization were also found for the mastoid cortex (28% non-pneumatized in BOR vs. 5% in controls; p = 0.03) and the facial recess (27% non-pneumatized in BOR vs. 0% in controls; p = 0.01). Standard landmarks were easily identified in all of the control mastoids. In the BOR group, Koerner's septum was abnormally located or absent in 45%, and the antrum was severely hypoplastic or absent in 50%. Similarly, the prominence of the horizontal semicircular canal and the short process of the incus were dysplastic in 73% (44/60) and 62% (37/60), respectively.

Conclusions

Mastoid abnormalities are common in BOR syndrome. Restricted transmastoid access and abnormal or absent mastoid landmarks should be anticipated in those patients with BOR who become cochlear implant candidates.

Level of evidence

4.

https://ift.tt/2MYbmVR

Safety of Radiofrequency Ablation for Adenotonsillectomy after Cochlear Implantation

Publication date: Available online 27 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Matthew C. Gropler, Brittany A. Leader, David J. Brown, James R. Benke, Stephen P. Bowditch, Stacey L. Ishman

Abstract

Objective

While a cadaveric animal study has suggested that radiofrequency ablation can be safely used in patients with cochlear implants, no in vivo studies have been published to confirm that radiofrequency ablation does not alter the integrity of the cochlear implant device.

Methods

Cochlear implant impedance and functional performance were studied through a prospective case series in five children with seven functioning multichannel implants before and after radiofrequency ablation adenotonsillectomy.

Results

There were 4 females and 1 male patient, aged 6 to 10 years (mean 8.5 ± 1.95 years) with 7 functioning implants. Pre- and post-surgical impedance testing revealed all electrodes were within normal operating limits. There was no statistically significant difference between the mean pre and post-operative impedances in 5 of the 7 tested implants (P=0.2-0.8). The other two implants showed statistically significant improvement in impedance values which were not clinically significant (P=0.02 and P<0.001). Speech perception was unchanged as was functional performance for all 7 tested implants.

Conclusions

We found that radiofrequency ablation used in the oropharynx during adenotonsillectomy did not alter the integrity of the cochlear implant devices when assessed using electrode impedance testing, audiometry and speech perception evaluation. These results confirm those reported in previous in vitro studies and confirm the safety of radiofrequency ablation adenotonsillectomy for children who have undergone previous cochlear implant placement.

https://ift.tt/2NqVQyy

Outcomes of cochlear implantations for mumps deafness: A report of four pediatric cases

Publication date: Available online 27 August 2018

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Masako Katsushika, Akinori Kashio, Erika Ogata, Yusuke Akamatsu, Yujirou Hoshi, Shinichi Iwasaki, Tatsuya Yamasoba

Abstract

Mumps virus occasionally causes bilateral hearing loss. We report 4 cases of bilateral mumps deafness in whom cochlear implantations (CI) were performed. The age at the onset of hearing loss was 1–9 years. CI surgery was performed within 6 months from the onset of hearing loss in 3 cases and after 9 years in the other case, showing good speech perception in the early intervention cases and a poor outcome after later implantation. Early CI surgery is highly recommended in sudden onset deafness by mumps in childhood.

https://ift.tt/2MPWsB5

Laryngopharyngeal reflux disease in singers: Pathophysiology, clinical findings and perspectives of a new patient-reported outcome instrument

Publication date: Available online 27 August 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): J.R. Lechien, A. Schindler, C. Robotti, L. Lejeune, C. Finck

Abstract

Purpose of review

Laryngopharyngeal reflux (LPR) is an inflammatory disease associated with the development of voice disorder and vocal fold lesions. The occurrence of LPR in professional voice users as singers can have a dramatic impact of daily life. The aims of this paper is to review the current literature about the pathophysiological mechanisms underlying the development of voice disorder, especially in singers, and to propose a new patient-reported outcome instrument to assess complaints of these patients.

Recent findings

Many clinical and experimental studies reported that LPR leads to the development of significant macroscopic and microscopic histological changes in the mucosa of the vibratory margin of the vocal folds. Epithelial cell dehiscence, microtraumas, Reinke's space modifications, inflammatory infiltrates, mucosal drying, and epithelial thickening are associated with LPR. These histological changes may modify the biomechanical properties of the vocal fold tissue leading to hoarseness. In practice, singers with LPR may have normal or discretely pathological speaking voice but impaired singing voice (vocal fatigue, hoarseness, and loss of range). To date, the literature about the specific LPR signs and symptoms in singers is almost non-existent. However, singers are at high risk to present LPR because of necessary air support involving higher intra-abdominal pressure, increased stress due to career management and uncomfortable schedules, late meals just before sleep, bad nutrition habits like increased intake of citrus products, fats foods and spicy foods.

Perspectives

The lack of clinical singer-reported outcome instrument may decrease the management of LPR in singers. In this context, the LPR Study Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS) developed a new instrument to precisely assess symptoms related to LPR in singing voice. This instrument will be validated and could be used in clinical practice in voice centers.

https://ift.tt/2PHIXlg

Rhinological observations during a humanitarian mission in a rural sub-Saharan African setting

Publication date: Available online 27 August 2018

Source: European Annals of Otorhinolaryngology, Head and Neck Diseases

Author(s): R. Késmárszky, T. Hannington, A. Jakkel, G. Szabó

Abstract

Aims

Patients with rhinological symptoms and pathologies represent an important population. Their prevalence in developing areas without ENT care is not well documented. Due to various factors like migration, they may have an influence out of these territories. Our objective was to determine the prevalence and epidemiology of the main rhinological symptoms and pathologies during a humanitarian mission.

Material and methods

Six hundred and seventy nine patients presenting to our general medical consultations were examined. All of them had careful interrogation and a basic ENT check-up. Patient data and correlating photos were registered to be analyzed retrospectively.

Results

The ethnic origins of the patients were different. Most of them were younger than 50 years old. The rhinological problems were amongst the most frequent reasons to consult, the prevalence was higher when secondary findings and complaints were also considered, representing altogether 44 (6.48%) cases.

Conclusion

A high prevalence of rhinological pathologies showing the importance of public health issues, screening and an important need of adapted treatments was found. Due to migration, climatic changes and humanitarian missions, their presentation and incidence may vary. Health care providers and rhinologists need a thorough knowledge of community acquired and tropical pathologies.

https://ift.tt/2wsoF6t

History of Eczema is Associated with More Severe Hospital Course in Children Hospitalized for Asthma

Publication date: Available online 27 August 2018

Source: Annals of Allergy, Asthma & Immunology

Author(s): Mona Liu, Jay P. Patel, Evie Huang, Peck Y. Ong

https://ift.tt/2LzIwX0

Trichotillomania (hair pulling disorder): Clinical characteristics, psychosocial aspects, treatment approaches, and ethical considerations

Dermatologic Therapy, EarlyView.


https://ift.tt/2BUrd3v

Cyclosporine for corticosteroid‐refractory acute generalized exanthematous pustulosis due to hydroxychloroquine

Dermatologic Therapy, EarlyView.


https://ift.tt/2PP0AzU

Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis

Publication date: Available online 27 August 2018

Source: Allergology International

Author(s): Takenori Haruna, Shin Kariya, Tazuko Fujiwara, Atsushi Yuta, Takaya Higaki, Pengfei Zhao, Yukiko Ogawa, Kengo Kanai, Yuji Hirata, Aiko Oka, Kazunori Nishizaki, Mitsuhiro Okano

Abstract

Background

The development of methods to predict the clinical effectiveness of sublingual immunotherapy (SLIT) for allergic diseases is a crucial matter. We sought to determine whether whole saliva, which is the first body component that contacts allergen extracts during SLIT, is associated with the clinical effectiveness of SLIT in Japanese cedar pollinosis.

Methods

Blood monocytes or monocytic THP-1 cells were cultured in the presence or absence of either whole saliva or pure saliva with or without treatments including filtration and blockade of TLR2 and/or TLR4 signaling. IL-10 levels in the supernatants were then measured. Whole saliva-induced IL-10 production by THP-1 cells was compared between asymptomatic and disease-onset patients during peak pollen dispersal after SLIT.

Results

Both monocytes and THP-1 cells produced substantial amounts of IL-10 in response to whole saliva. IL-10 production was significantly reduced in response to pure saliva and 0.2 μm-filtered saliva. Simultaneous treatment with polymyxin B and TL2.1, a neutralizing antibody against TLR2, also reduced IL-10 production. IL-10 levels produced by THP-1 cells in response to whole saliva collected prior to SLIT were significantly higher in asymptomatic patients determined by symptom-medication scores than disease-onset patients following SLIT. Such differences were not seen in saliva collected 3 months after the initiation of SLIT or saliva collected during peak pollen dispersal.

Conclusions

Our results provide a basis for why the sublingual route is effective and preferable in allergen immunotherapy. Saliva-induced IL-10 levels produced by THP-1 cells may be a predictive marker for clinical remission after SLIT.

https://ift.tt/2MYAQlV

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Bøtker, HE; Hausenloy, D; Andreadou, I; Antonucci, S; Boengler, K; Davidson, SM; Deshwal, S; ... Heusch, G; + view all Bøtker, HE; Hausenloy, D; Andreadou, I; Antonucci, S; Boengler, K; Davidson, SM; Deshwal, S; Devaux, Y; Di Lisa, F; Di Sante, M; Efentakis, P; Femminò, S; García-Dorado, D; Giricz, Z; Ibanez, B; Iliodromitis, E; Kaludercic, N; Kleinbongard, P; Neuhäuser, M; Ovize, M; Pagliaro, P; Rahbek-Schmidt, M; Ruiz-Meana, M; Schlüter, K-D; Schulz, R; Skyschally, A; Wilder, C; Yellon, DM; Ferdinandy, P; Heusch, G; - view fewer (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Research in Cardiology , 113 (5) , Article 39. 10.1007/s00395-018-0696-8 . Green open access

https://ift.tt/2MVNxxH

A perceptual model of smellscape pleasantness

Xiao, J; Tait, M; Kang, J; (2018) A perceptual model of smellscape pleasantness. Cities , 76 pp. 105-115. 10.1016/j.cities.2018.01.013 .

https://ift.tt/2BPFG0x

Ethanol oxidation with high water content: A reactive molecular dynamics simulation study

Feng, M; Jiang, XZ; Zeng, W; Luo, KH; Hellier, P; (2018) Ethanol oxidation with high water content: A reactive molecular dynamics simulation study. Fuel , 235 pp. 515-521. 10.1016/j.fuel.2018.08.040 . Green open access

https://ift.tt/2MVObLD

Severe gangrene in a patient with anti-RNP positive limited cutaneous systemic sclerosis/rheumatoid arthritis overlap syndrome caused by vasculopathy and vasculitis

Raine, C; Canning, B; Marks, J; Donnelly, S; Ong, V; Tahir, H; (2018) Severe gangrene in a patient with anti-RNP positive limited cutaneous systemic sclerosis/rheumatoid arthritis overlap syndrome caused by vasculopathy and vasculitis. European Journal of Rheumatology 10.5152/eurjrheum.2018.17177 . (In press).

https://ift.tt/2NradDl

The clinical significance of body weight loss in idiopathic pulmonary fibrosis patients

Nakatsuka, Y; Handa, T; Kokosi, M; Tanizawa, K; Puglisi, S; Jacob, J; Sokai, A; ... Hirai, T; + view all Nakatsuka, Y; Handa, T; Kokosi, M; Tanizawa, K; Puglisi, S; Jacob, J; Sokai, A; Ikezoe, K; Kanatani, KT; Kubo, T; Tomoika, H; Taguchi, Y; Nagai, S; Chin, K; Mishima, M; Wells, AU; Hirai, T; - view fewer (2019) The clinical significance of body weight loss in idiopathic pulmonary fibrosis patients. Respiration (In press).

https://ift.tt/2og4chG

Evaluation of system mapping approaches in identifying patient safety risks

Simsekler, MCE; Ward, JR; Clarkson, PJ; (2018) Evaluation of system mapping approaches in identifying patient safety risks. International Journal for Quality in Health Care , 30 (3) pp. 227-233. 10.1093/intqhc/mzx176 .

https://ift.tt/2Nr5BNe

Design for patient safety: a systems-based risk identification framework

Simsekler, MCE; Ward, JR; Clarkson, PJ; (2018) Design for patient safety: a systems-based risk identification framework. Ergonomics , 61 (8) pp. 1046-1064. 10.1080/00140139.2018.1437224 .

https://ift.tt/2MVNi5L

Detection and reporting of RB1 promoter hypermethylation in diagnostic screening

Price, EA; Kolkiewicz, K; Patel, R; Hashim, S; Karaa, E; Scheimberg, I; Sagoo, MS; ... Onadim, Z; + view all Price, EA; Kolkiewicz, K; Patel, R; Hashim, S; Karaa, E; Scheimberg, I; Sagoo, MS; Reddy, MA; Onadim, Z; - view fewer (2018) Detection and reporting of RB1 promoter hypermethylation in diagnostic screening. Ophthalmic Genetics , 39 (4) pp. 526-531. 10.1080/13816810.2018.1479432 .

https://ift.tt/2BVWtzb

The Trauma and Life Events (TALE) checklist: Development of a tool for improving routine screening in people with psychosis

Carr, S; Hardy, A; Fornells-Ambrojo, M; (2018) The Trauma and Life Events (TALE) checklist: Development of a tool for improving routine screening in people with psychosis. European Journal of Psychotraumatology (In press).

https://ift.tt/2oe4wxg

Engaging pictograms! A methodology for graphic design in enhancing player engagement as applied to the design of a serious game for nepalese women with low literacy

Soriano, D; Mueller, S; Fordham, M; Arjyal, A; Baral, S; Hearn, GJ; Le Masson, V; ... Kostkova, P; + view all Soriano, D; Mueller, S; Fordham, M; Arjyal, A; Baral, S; Hearn, GJ; Le Masson, V; Boscor, A; Saville, NM; Kostkova, P; - view fewer (2018) Engaging pictograms! A methodology for graphic design in enhancing player engagement as applied to the design of a serious game for nepalese women with low literacy. In: Kostkova, P and Grasso, F and Castillo, C and Mejova, Y and Bosman, A and Edelstein, M, (eds.) DH '18: Proceedings of the 2018 International Conference on Digital Health. (pp. pp. 30-34). Association for Computing Machinery: New York, USA. Green open access

https://ift.tt/2Nqy1qO

The International Society of Nephrology's International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology: Report of the working group on approaches to population-level detection strategies and recommendations for a minimum dataset

Caplin, B; Yang, C-W; Anand, S; Levin, A; Madero, M; Saran, R; Jayasinghe, S; ... Wijewickrama, E; + view all Caplin, B; Yang, C-W; Anand, S; Levin, A; Madero, M; Saran, R; Jayasinghe, S; De Broe, M; Yeates, K; Tonelli, M; Jakobsson, K; Strani, L; Ruggiero, A; Glaser, J; Martin, E; Pearce, N; Wijewickrama, E; - view fewer (2018) The International Society of Nephrology's International Consortium of Collaborators on Chronic Kidney Disease of Unknown Etiology: Report of the working group on approaches to population-level detection strategies and recommendations for a minimum dataset. Kidney International (In press).

https://ift.tt/2MVN1jf

Whom Do We Trust on Social Policy Interventions?

Osman, M; Fenton, N; Pilditch, T; Lagnado, D; Neil, M; (2018) Whom Do We Trust on Social Policy Interventions? Basic and Applied Social Psychology 10.1080/01973533.2018.1469986 . (In press).

https://ift.tt/2BTGgKz

The growing ubiquity of algorithms in society: implications, impacts and innovations

Olhede, SC; Wolfe, PJ; (2018) The growing ubiquity of algorithms in society: implications, impacts and innovations. Philosophical Transactions of The Royal Society A - Mathematical, Physical and Engineering Sciences , 376 (2128) pp. 1-15. 10.1098/rsta.2017.0364 . Green open access

https://ift.tt/2MVMSMJ

Spinal cord atrophy rates Ready for prime time in multiple sclerosis clinical trials?

Prados, F; Barkhof, F; (2018) Spinal cord atrophy rates Ready for prime time in multiple sclerosis clinical trials? Neurology , 91 (4) pp. 157-158. 10.1212/WNL.0000000000005873 .

https://ift.tt/2Nt3xEu

The Outcome of Dopamine Dysregulation Syndrome in Parkinson's Disease: A Retrospective Post Mortem Study

Barbosa, PM; Djamshidian, A; Lees, AJ; Warner, TT; (2018) The Outcome of Dopamine Dysregulation Syndrome in Parkinson's Disease: A Retrospective Post Mortem Study. Movement Disorders Clinical Practice 10.1002/mdc3.12671 . (In press).

https://ift.tt/2oisBmY

A cross-sectional study of UK trials in 2015: results from a scoping project with the UK Health Research Authority

Clark, T; Wicentowski, RH; Sydes, MR; (2018) A cross-sectional study of UK trials in 2015: results from a scoping project with the UK Health Research Authority. BMJ Open (In press).

https://ift.tt/2BTbMbD

Contact hypersensitivity in adolescents

Pediatric Dermatology, EarlyView.


https://ift.tt/2PLBp12

Traumatic Epiglottitis following a Blind Insertion of the Hand during Convulsion

Traditionally, it has been recommended that first-responders should place chopsticks or their hand in a child's mouth to prevent the child from biting their tongue during convulsion. The practice persists locally in parts of Japan and can cause adverse events. We report a traumatic epiglottitis following the thrusting of a guardians' hand into a 13-month-old girl's mouth to prevent her from biting her tongue.

https://ift.tt/2BVza8A

Evaluating the effect of different voice prostheses on alaryngeal voice quality

The Laryngoscope, EarlyView.


https://ift.tt/2PL7OVE

Mobile app technology is associated with improved otolaryngology resident in‐service performance

The Laryngoscope, EarlyView.


https://ift.tt/2LwAChf

Gastrin‐Releasing Peptide Is Involved in the Establishment of Allergic Rhinitis in Mice

The Laryngoscope, EarlyView.


https://ift.tt/2PL7CFU

The Impact of Resident and Fellow Participation in Transsphenoidal Pituitary Surgery

The Laryngoscope, EarlyView.


https://ift.tt/2wrCZMQ

Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil

The Laryngoscope, EarlyView.


https://ift.tt/2PGigO9

One‐Year symptom outcomes after sialolithiasis treatment with sialendoscopy‐assisted salivary duct surgery

The Laryngoscope, EarlyView.


https://ift.tt/2Lyvlpa

Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review

The Laryngoscope, EarlyView.


https://ift.tt/2PLIXB5

Permeability and Weibel–Palade Bodies of the Blood Vessels in the Human Vocal Fold Mucosa

The Laryngoscope, EarlyView.


https://ift.tt/2wqEkmZ

Management and Follow‐up Results of Salivary Fistulas Treated With Botulinum Toxin

The Laryngoscope, EarlyView.


https://ift.tt/2PKcSt3

One‐year outcomes of sialendoscopic‐assisted salivary duct surgery for sialadenitis without sialolithiasis

The Laryngoscope, EarlyView.


https://ift.tt/2wtwLfm

In Reference to Upper Airway Stimulation Therapy and Prior Airway Surgery for Obstructive Sleep Apnea

The Laryngoscope, EarlyView.


https://ift.tt/2PKEqP1

Free Flap Transfer for Pediatric Head and Neck Reconstruction: What Factors Influence Flap Survival?

The Laryngoscope, EarlyView.


https://ift.tt/2LA1CfT

Regionalization of Head and Neck Cancer Surgery May Fragment Care and Impact Overall Survival

The Laryngoscope, EarlyView.


https://ift.tt/2PJQDU3

Outcome measures for pediatric laryngotracheal reconstruction: International consensus statement

The Laryngoscope, EarlyView.


https://ift.tt/2LAPoDs

Adjuvant Chemotherapy Is Associated With Improved Survival for Late‐Stage Salivary Squamous Cell Carcinoma

The Laryngoscope, EarlyView.


https://ift.tt/2PHJLqv

Objectively Measuring Observer Attention in Severe Thyroid‐Associated Orbitopathy: A 3D Study

The Laryngoscope, EarlyView.


https://ift.tt/2LwznP4

Compensation of Otolaryngologists in the Veterans Health Administration: Is There a Gender Gap?

The Laryngoscope, EarlyView.


https://ift.tt/2PJAGgI

The effect of inferior turbinate surgery on ciliated epithelium: A randomized, blinded study

The Laryngoscope, EarlyView.


https://ift.tt/2wuhuL1