Primary Prevention of Food Allergy

Abstract

Purpose of Review

The goal of this review is to present an updated summary of the various approaches to prevent childhood food allergies and report recent advances in potential prevention trials for food allergy.

Recent Findings

Several approaches related to maternal dietary supplementation as well as infant GI-based supplementation have been tried and are the subject of ongoing clinical investigation.

Summary

The prevalence of food allergy appears to be increasing but several, varied approaches to prevention are being actively pursued such that an effective strategy may not be too far in the future.

http://bit.ly/2Ts4Jv0

Optimization of the Surgical Field in Endoscopic Sinus Surgery: an Evidence-Based Approach

Abstract

Purpose of Review

The advent of endoscopic sinus surgery (ESS) has enabled the development of minimally invasive surgical procedures in Rhinology. However, proficiency with ESS techniques can still be hampered by poorly controlled bleeding limiting visibility of the surgical field (VSF). This can lead to increased operating time and, more importantly, increased risk of major and minor complications. To optimize the VSF and mitigate the risk of complications, many strategies have been explored.

Recent Findings

This is a narrative review of the relative risks and benefits of pre- and intra-operative interventions aimed at optimizing intraoperative conditions during ESS. The value of these interventions is determined based on their impact on intraoperative blood loss, time of surgery, and the VSF, and weighed against their adverse event profile.

Summary

This review provides a comprehensive overview of the evidence relating to the safety and efficacy of interventions used to improve intraoperative conditions during ESS.

http://bit.ly/2BipHFx

The impact of chlorophyllin on deoxynivalenol transport across jejunum mucosa explants obtained from adult pigs

Abstract

Regardless of the efforts put into preventing or reducing fungal growth, extensive mycotoxin contamination has been reported in animal feeds. In the case of pigs, one of the mycotoxins of major concern is deoxynivalenol (DON). The use of adsorbents as feed additives represents one of the strategies to control mycotoxins' contamination in feedstuff. Therefore, the aim of the study was to verify the ability of chlorophyllin (CHL) to reduce the absorption rate of DON in swine mucosa explants. Intestine was obtained from routinely slaughtered adult pigs. The mucosa explants were studied by means of Ussing chamber technique. The effect of DON (10 and 30 μg/ml) on mucosa viability and permeability and CHL (100 μg/ml) impact on DON (30 μg/ml) absorption was verified. The results revealed that mucosa explants isolated from adult animals remained unaffected for 90 min in the presence of DON in the lower concentration (10 μg/ml). Mycotoxin in the higher dose (30 μg/ml) increased mucosa permeability (decreased transepithelial electrical resistance value) and enhanced paracellular transport of lucifer yellow and mannitol but did not affect lactate dehydrogenase leakage. The introduction of CHL neither diminished the absorption rate of DON across swine mucosa explants nor prevented the toxic effects of DON on intestine. In conclusion, the results confirm the negative effect of DON on pig jejunum mucosa. However, the toxic effect of DON was observed only when it was used in relatively high doses. A promising adsorbent agent, CHL, failed to reduce the intensity of DON transport across intestine under in vitro conditions.

http://bit.ly/2GermiN

Asthma and Allergy Mobile Apps in 2018

Abstract

Purpose of Review

This paper offers a comprehensive review of interactive mobile allergy and asthma smartphone applications available within the USA in 2018, with an emphasis on interactive asthma apps.

Recent Findings

Primary care and specialty clinicians interested in introducing digital health apps into their practices will soon have more choices, for Apple® and major electronic medical record software companies are investing heavily in the mobile medical marketplace, guaranteeing personal health information and access to care will always be immediately available in one's digital hand.

Summary

Interactive mobile asthma applications are valuable assets for patients and caregivers alike, for they offer immediate communications between patients and those responsible for providing for their needs.

http://bit.ly/2GmD8r8

Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis

Thyroid, Ahead of Print.


http://bit.ly/2TrJEAJ

High incidence of MTHFR, CBS, and MTRR polymorphisms in vitiligo patients. Preliminary report in a retrospective study

OBJECTIVE: Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis. It is related to both genetic and no genetic factors. The role of genetics is currently studied with several analytical approaches, such as genetic linkage, candidate gene association studies, genome-wide association studies (GWAS), deep DNA re-sequencing and gene expression studies. To date, there are no genetic traits directly related to vitiligo pathogenesis.

PATIENTS AND METHODS: 43 cases of vitiligo patients and 30 healthy donors recruited as control, were screened by assaying the biochemical molecules involved in the self-cells cytotoxicity (haptoglobin and homocysteine) and candidate genes involved in the regulatory process of the re-methylation cycles and transsulfuration. Candidate genes and their polymorphisms screened are methylene-tetrahydrofolate-reductase (MTHFR) C677T and A1298C; cystathionine-beta-synthase enzyme (CBS) I278T and Ins68bp; and methionine-synthase-reductase (MTRR) A66G.

RESULTS: A peculiar genetic profile in vitiligo patients are defined: 11.6% of vitiligo patients shown polymorphic variant MTHFR 677TT vs. 3.3% of healthy donor MTHFR 677CC profile (p=0.0017); 14.0% of vitiligo patients shown CBS polymorphic variant 278TT vs. 3.3% of healthy donor 278II profile (p=0.0012); and 11.6% of vitiligo patients shown MTRR 66GG vs. 3.3% of healthy donor MTRR 677AA profile (p>0.0001).

CONCLUSIONS: This is the first study reporting the correlation between the polymorphic status of MTHFR C677T, CBS I278T, and MTRR A66G and vitiligo. The genetic screening of these polymorphisms could be useful for early detection of the inheritance risk factor in a subject carrying relatives with vitiligo. Although these data could suggest a kind of dysregulation, genetically based, of thiols production mechanisms. Based on these results, we have not been able to get hypothesis about the putative pathogenesis of vitiligo, and the precise cause remains unclear.

L'articolo High incidence of MTHFR, CBS, and MTRR polymorphisms in vitiligo patients. Preliminary report in a retrospective study sembra essere il primo su European Review.

http://bit.ly/2UtlxSo

Analyse und Management von postoperativen Schmerzen nach Sialendoskopie

Laryngo-Rhino-Otol
DOI: 10.1055/a-0834-6147

Hintergrund Die Sialendoskopie ist ein minimal-invasives Verfahren zur Diagnostik und Therapie von Erkrankungen des Speicheldrüsengangsystems. Sie kann in ITN und in LA durchgeführt werden. Vor diesem Hintergrund ist die postoperative Schmerzsituation interessant, über deren Ausmaß aktuell jedoch wenig bekannt ist. Daher wurden in dieser Studie die postoperativen Schmerzen nach Sialendoskopie in LA und ihr Schmerzmanagement in einer quantitativen Untersuchung erfasst und analysiert. Material und Methoden Es wurden 103 Patienten in die retrospektive Studie eingeschlossen, bei denen im Zeitraum von 2013 bis 2015 eine Sialendoskopie der Glandula parotis oder der Glandula submanibularis in Lokalanästhesie durchgeführt wurde. Analysiert wurden die postoperativen Schmerzen in Ruhe und bei Belastung am Operationstag, sowie am ersten und zweiten postoperativen Tag. Die Schmerzen wurden anhand einer numerischen Rating Skala (NRS 0–10) erfasst, welche im Rahmen des QUIPS-Projektes (Qualitätsverbesserung in der postoperativen Schmerztherapie) verwendet wird. Ergebnisse Am Operationstag betrug der Schmerz in Ruhe 0,9 ± 1,9 und bei Belastung 0,7 ± 1,4. Am ersten postoperativen Tag wurden Schmerzen von 1,2 ± 1,8 in Ruhe und 0,9 ± 1,9 bei Belastung festgestellt. Am zweiten postoperativen Tag zeigte sich eine Reduktion der Schmerzen auf 0,75 ± 1,6 in Ruhe und 0,73 ± 1,5 bei Belastung. Insgesamt wurden Metamizol (Novalgin®) und Ibuprofen als häufigste postoperative Analgetika eingesetzt. Am Operationstag erhielten 37,9 % der Patienten Schmerzmittel, am ersten postoperativen Tag 26,2 % der Patienten und am zweiten postoperativen Tag 12,6 % der Patienten. Schlussfolgerung Sialendoskopien der Glandula submandibularis und parotis sind mit moderaten postoperativen Schmerzen verbunden, welche sich gut mit Nicht-Opioiden behandeln lassen.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

http://bit.ly/2TsWA9s

EU Panel Recommends Humira Biosimilars Idacio, Kromeya

The EMA's Committee for Medicinal Products for Human Use has recommended marketing authorization for two biosimilars that are highly similar to Humira (adalimumab, AbbVie).
International Approvals

https://wb.md/2D1lYMy

REPLY to ‘Comment on “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings’

http://bit.ly/2G52kDy

Follicular mucinosis in patients with hematologic malignancies other than mycosis fungoides: A clinicopathologic study

Follicular mucinosis in association with systemic hematologic disorders other than mycosis fungoides is poorly characterized. Clinicopathological features of follicular mucinosis in the setting of hematopoietic stem cell transplantation and diverse systemic hematologic malignancies differ from mycosis fungoides-associated cases and follicular mucinosis is not necessarily a precursor to cutaneous T-cell lymphoma.

http://bit.ly/2D0QYMN

About “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings

http://bit.ly/2G67BKK

Book Review: Biodynamic Excisional Skin Tension Lines for Cutaneous Surgery

http://bit.ly/2D2bVH9

Secukinumab for moderate to severe palmoplantar pustular psoriasis: Results of the 2PRECISE study

Palmoplantar pustular psoriasis is chronic, disabling and resistant to treatment. The 2PRECISE randomized controlled trial shows potential benefits of secukinumab in the treatment of palmoplantar pustular psoriasis over 52 weeks with improved quality of life, and no unexpected adverse events.

http://bit.ly/2RxhSB9

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss

ABSTRACT

Posttranslational modification of histones alters their interaction with DNA and nuclear proteins, influencing gene expression and cell fate. In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice. The conditions of noise exposure used in this study led to losses of cochlear synapses and outer hair cells (OHCs) and permanent auditory threshold shifts. Inhibition of G9a with its specific inhibitor BIX 01294 or with siRNA significantly attenuated these pathological features. Treatment with BIX 01294 also prevented the noise-induced decrease of KCNQ4 immunolabeling in OHCs. Additionally, G9a was increased in cochlear cells, including both outer and inner sensory hair cells, some spiral ganglion neurons (SGNs), and marginal cells, 1 h after the completion of the noise exposure. Also subsequent to noise exposure, immunoreactivity for H3K9me2 appeared in some nuclei of OHCs following a high-to-low frequency gradient with more labeled OHCs in the 45-kHz than the 32-kHz region, as well as in the marginal cells and in some SGNs of the basal turn. These findings suggest that epigenetic modifications of H3K9me2 are involved in NIHL and that pharmacological targeting of G9a may offer a strategy for protection against cochlear synaptopathy and NIHL.

http://bit.ly/2WAxcRi

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss

ABSTRACT

Posttranslational modification of histones alters their interaction with DNA and nuclear proteins, influencing gene expression and cell fate. In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the human EHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice. The conditions of noise exposure used in this study led to losses of cochlear synapses and outer hair cells (OHCs) and permanent auditory threshold shifts. Inhibition of G9a with its specific inhibitor BIX 01294 or with siRNA significantly attenuated these pathological features. Treatment with BIX 01294 also prevented the noise-induced decrease of KCNQ4 immunolabeling in OHCs. Additionally, G9a was increased in cochlear cells, including both outer and inner sensory hair cells, some spiral ganglion neurons (SGNs), and marginal cells, 1 h after the completion of the noise exposure. Also subsequent to noise exposure, immunoreactivity for H3K9me2 appeared in some nuclei of OHCs following a high-to-low frequency gradient with more labeled OHCs in the 45-kHz than the 32-kHz region, as well as in the marginal cells and in some SGNs of the basal turn. These findings suggest that epigenetic modifications of H3K9me2 are involved in NIHL and that pharmacological targeting of G9a may offer a strategy for protection against cochlear synaptopathy and NIHL.

http://bit.ly/2WAxcRi

Newborn Hearing Screening in Kids

At birth, most children hear and listen, and will start to respond to sounds. However, 1-3 of every 1000 children born in the United States have some level of hearing loss. Early screening and diagnosis help us identify children as early as possible. Every state and nearly all US territories have a universal newborn hearing screening. We screen more than 95% of babies by their first month.

We screen babies' hearing in the hospital or birthing center. There are two different screening methods. Both are quick (5-10 minutes). Also, they can be done while your baby is sleeping or resting. Both help rule out significant hearing loss.

1) Automated Auditory Brainstem Response (AABR or ABR)

This measures how the hearing nerve and brain respond to sound. We place electrodes (much like stickers) on the forehead and behind the ear. Then, we place soft earbuds and play clicks or tones into the baby's ears.

2) Otoacoustic Emissions (OAE)

We place soft earbuds and play a soft sound. If the inner ear is working correctly, and there is no fluid, we can get a good response ("echo back") that we can measure.

What happens if my baby "refers" on a newborn hearing screening?

"Refer" means that we could not reliably obtain conclusive hearing information. However, it does not mean that the baby is deaf/hard of hearing. Many times, it may be due to external factors, such as excess noise in the room, or fluid in the external or middle ear space, or too much movement during the screening. If the child again refers on the second screening, then we will recommend a full hearing test with a pediatric audiologist.

The next step will be to try to do a "sleep ABR", where the baby does the test during natural sleep (before 3 months of age). We place an earbud in the ear, with electrodes behind the ear and on the forehead. Then, we play differently pitched sounds at different volumes. We record responses from the hearing nerve and brain stem to find the softest level to which the baby will respond.

If we confirm hearing changes on the follow-up ABR, then a team of providers including pediatric audiologists and pediatric otolaryngologists (ENTs) will come together to discuss treatment and possible early intervention. Remember, our overall goal is to identify hearing loss as soon as possible and to offer amplification/tools for hearing success as needed.

Follow-Up Screenings

If there are no risk factors at birth, (and the baby passes the screening), then a follow-up hearing screening by 3 years of age is often recommended, unless parents have any hearing concerns before then.
Many kids will have a hearing screening through their pediatrician (i.e., well visits), and will have periodic screening around speech and language acquisition. Most children will have a repeat hearing screening by the time they are in Pre-K or kindergarten. The AAP (American Academy of Pediatrics) recommends children get screened again at ages 4, 5, 6, 8, and 10. They recommend additional screenings sometime between ages 11-14, 15-17, or any time there is a concern.

The post Newborn Hearing Screening in Kids appeared first on ChildrensMD.

http://bit.ly/2G4YpGH

How to Perform CPR on a Child | Parent Resources

CPR is an essential life skill that everyone should know and you as parents can help teach your family the importance of knowing the procedure. In this episode, we'll show you how to perform both CPR and the Heimlich maneuver on a child.

The post How to Perform CPR on a Child | Parent Resources appeared first on ChildrensMD.

http://bit.ly/2Gff2yO

An Urban Ecology of Seoul's Nanjido Landfill Park

Kim, Jeong Hye; (2018) An Urban Ecology of Seoul's Nanjido Landfill Park. Doctoral thesis (Ph.D), UCL (University College London).

http://bit.ly/2WCCUlt

Structural and functional studies of the budding yeast kinetochore complex CBF3

Leber, Vera; (2018) Structural and functional studies of the budding yeast kinetochore complex CBF3. Doctoral thesis (Ph.D), UCL (University College London). Green open access

http://bit.ly/2RxcRbB

From the Saints to the State. Modes of Intimate Devotion to Saintly Images in Oaxaca, Mexico

Lamrani Maria, Myriam; (2018) From the Saints to the State. Modes of Intimate Devotion to Saintly Images in Oaxaca, Mexico. Doctoral thesis (Ph.D), UCL (University College London). Green open access

http://bit.ly/2WztmIc

III-V Nanostructures for Photovoltaics Applications

Kim, Dongyoung; (2018) III-V Nanostructures for Photovoltaics Applications. Doctoral thesis (Ph.D), UCL (University College London). Green open access

http://bit.ly/2RuEnqs

Assessing the environmental conditions in the zone adjoining the façade: a monitoring study in office buildings

Kikira, Maria; (2018) Assessing the environmental conditions in the zone adjoining the façade: a monitoring study in office buildings. Doctoral thesis (Ph.D), UCL (University College London).

http://bit.ly/2WztdEE

A New Spinal Orthosis for Adolescent Idiopathic Scoliosis

Condition:   Scoliosis; Adolescence
Interventions:   Device: Spinal Orthosis with an Integrated System of Electric Surface Stimulation and Heat Sensing;   Device: spinal orthosis
Sponsor:   Changhua Christian Hospital
Recruiting

http://bit.ly/2t1qndL

A Phase I/II Clinical Trial of PepCan in Head and Neck Cancer Patients

Condition:   Head and Neck Cancer
Intervention:   Biological: PepCan
Sponsor:   University of Arkansas
Not yet recruiting

http://bit.ly/2t1D0pc

Safety and Efficacy of SCT200 in Patients With Advanced Esophageal Squamous Cell Carcinoma

Condition:   Esophageal Squamous Cell Carcinoma
Intervention:   Drug: recombinant anti-EGFR monoclonal antibody
Sponsors:   Sinocelltech Ltd.;   Tianjin Medical University Cancer Institute and Hospital
Recruiting

http://bit.ly/2HJLHi5

The endoscopic endonasal approach for pediatric craniopharyngiomas

Publication date: Available online 1 February 2019

Source: Operative Techniques in Otolaryngology-Head and Neck Surgery

Author(s): Ian J. Koszewski, Hermes G. Garcia, William Parkes, Chandala Chitguppi, Mindy R. Rabinowitz, Gurston G. Nyquist, James J. Evans, Marc R. Rosen

Craniopharyngiomas are rare but challenging tumors of the ventral skull base affecting primarily pediatric patients. In select cases, the endoscopic endonasal approach represents an appropriate surgical option when tumor resection is favored. However, nuances of the pediatric nasal corridor must be carefully considered to optimize both tumor resection and skull base reconstruction. Here we review pertinent developmental details, options for creation of an optimal endonasal corridor, principles of tumor resection, and techniques for reconstruction. Considerations for intraoperative and postoperative patient care are also reviewed.

http://bit.ly/2HXuq5t

Modified Cormack Lehane Scores Evaluated by Laryngoscopy During Awake Versus Under General Anesthesia

Conditions:   Thyroid Cancer;   Thyroid Nodule;   Thyroid Adenoma
Interventions:   Procedure: Flexible fiberoptic laryngoscopy;   Procedure: Direct laryngoscopy
Sponsor:   Istanbul University
Not yet recruiting

http://bit.ly/2HJkhZV

Ultrasound-Guided Aspiration of PTA vs Conventional Landmark Technique - a RCT

Condition:   Peritonsillar Abscess
Interventions:   Diagnostic Test: Intraoral ultrasound;   Procedure: The landmark technique
Sponsors:   Tobias Todsen;   Odense University Hospital
Recruiting

http://bit.ly/2HJkjkv

Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Subjects With Locally Advanced or Metastatic Solid Tumors

Condition:   Advanced Solid Tumors Cancer
Interventions:   Drug: ABBV-151;   Drug: ABBV-181
Sponsor:   AbbVie
Not yet recruiting

http://bit.ly/2t0RhCI

Tavokinogene Telseplasmid With Electroporation, Pembrolizumab, and Epacadostat in Treating Patients With Unresectable Squamous Cell Carcinoma of the Head and Neck

Conditions:   Metastatic Head and Neck Squamous Cell Carcinoma;   Recurrent Head and Neck Squamous Cell Carcinoma;   Unresectable Head and Neck Squamous Cell Carcinoma
Interventions:   Device: Electroporation;   Drug: Epacadostat;   Drug: Pembrolizumab
Sponsors:   University of California, San Francisco;   National Cancer Institute (NCI)
Not yet recruiting

http://bit.ly/2HM4Y2q

Intra-parotid Facial Nerve Imaging in Parotidectomy

Conditions:   Parotid Tumors;   Facial Nerve Paresis
Intervention:   Diagnostic Test: 3D-DESS MRI (3 dimensional double echo steady state MRI)
Sponsor:   Samsung Medical Center
Recruiting

http://bit.ly/2t44Oct

De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma

Condition:   Oropharyngeal Cancer
Interventions:   Radiation: Radiation;   Drug: Cisplatin
Sponsor:   Canadian Cancer Trials Group
Not yet recruiting

http://bit.ly/2HHDjzP

Does Vestibular Rehabilitation Significantly Improve the Level of Vestibular Function Following Vestibular Neuritis?

Condition:   Vestibular Neuritis
Interventions:   Other: Vestibular rehabilitation;   Drug: Corticosteroid
Sponsor:   Aalborg Universitetshospital
Recruiting

http://bit.ly/2HKNjby

Efficacy of Navigation for Disparities and Untimely Radiation ThErapy: The ENDURE Study

Condition:   Cancer of Head and Neck
Intervention:   Other: Patient Navigation
Sponsor:   Medical University of South Carolina
Not yet recruiting

http://bit.ly/2t8LFGJ

Combination of Targeted and Immunotherapy for Advanced Biliary Tract and Esophagogastric Gastric Cancer

Conditions:   Esophageal Cancer;   Biliary Tract Cancer;   GastroEsophageal Cancer;   Hepatobiliary Neoplasm
Interventions:   Drug: DKN-01;   Drug: Atezolizumab;   Drug: Paclitaxel
Sponsors:   European Organisation for Research and Treatment of Cancer - EORTC;   Hoffmann-La Roche;   Leap Therapeutics, Inc.
Not yet recruiting

http://bit.ly/2HLy7uO

Atezolizumab and Bevacizumab in Patients With Recurrent or Metastatic Squamous-cell Carcinoma of the Head and Neck

Condition:   Head and Neck Neoplasms
Interventions:   Drug: Atezolizumab;   Drug: Bevacizumab
Sponsor:   Centre Leon Berard
Not yet recruiting

http://bit.ly/2t0yxU0

A Study to Assess the Effects of Multiple Study Drug Regimens in Subjects With Newly Diagnosed Locally Advanced Head and Neck Squamous Cell Carcinoma

Condition:   Head and Neck Cancer
Interventions:   Drug: ABBV-181;   Drug: ABBV-368;   Drug: ABBV-927
Sponsor:   AbbVie
Not yet recruiting

http://bit.ly/2HLQIGX

Effects on Quality of Life With Zinc Supplementation in Patients With Gastrointestinal Cancer

Conditions:   Gastric Carcinoma;   Liver and Intrahepatic Bile Duct Carcinoma;   Unresectable Esophageal Carcinoma;   Unresectable Pancreatic Carcinoma
Intervention:   Dietary Supplement: Zinc
Sponsor:   Emory University
Not yet recruiting

http://bit.ly/2t8LFqd

Validation of USPIO-enhanced MRI for Detection of Lymph Node Metastases in Head and Neck Carcinoma

Condition:   Head and Neck Squamous Cell Carcinoma
Intervention:   Diagnostic Test: USPIO-enhanced MRI
Sponsor:   Radboud University
Not yet recruiting

http://bit.ly/2t2wjDv

The Efficacy of Postoperative Application of High Flow Nasal Cannula at Acute Phase for Minimally Invasive Esophagectomy Surgery Patients

Condition:   Esophageal Cancer
Intervention:   Device: High flow nasal cannula, HFNC
Sponsor:   National Taiwan University Hospital
Not yet recruiting

http://bit.ly/2HLxQrM

A Phase II Study of SHR-1210 vs Placebo as Consolidation Chemotherapy After Radical Concurrent Chemoradiotherapy in Locally Advanced ESCC

Condition:   Esophageal Squamous Cell Carcinoma
Interventions:   Drug: SHR-1210;   Drug: Placebo
Sponsors:   The First Affiliated Hospital of Zhengzhou University;   Jiangsu HengRui Medicine Co., Ltd.
Not yet recruiting

http://bit.ly/2sYUCC3

Induction Chemotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma

Condition:   Locally Advanced Malignant Neoplasm
Interventions:   Drug: Induction chemotherapy;   Combination Product: Chemoradiotherapy
Sponsor:   Barretos Cancer Hospital
Recruiting

http://bit.ly/2HLxKAq

😴😴😴Sleep Medicine🕵🕵️‍♀️

16:51

  Characterizing Pediatric Inpatient Sleep Duration and Disruptions

via Sleep Medicine

Publication date: Available online 31 January 2019

Source: Sleep Medicine

Author(s): Amarachi I. Erondu, Nicola M. Orlov, Leah B. Peirce, Samantha L. Anderson, Michael Chamberlain, Kelsey Hopkins, Christopher Lyttle, David Gozal, Vineet M. Arora

Abstract

Objective

To contextualize inpatient sleep duration and disruptions in a general pediatric hospital ward by comparing in-hospital and at-home sleep durations to recommended guidelines and objectively measure nighttime room entries.

Methods

Caregivers of patients 4 weeks - 18 years of age reported patient sleep duration and disruptions in anonymous surveys. Average at-home and in-hospital sleep durations were compared to National Sleep Foundation recommendations. Objective nighttime traffic was evaluated as the average number of room entries between 11:00pm and 7:00am using GOJO hand-hygiene room entry data.

Results

Among 246 patients, patients slept less in the hospital than at home with newborn and infant cohorts experiencing 7- and 4-hour sleep deficits respectively (Newborn: 787 ± 318 min at home vs. 354 ± 211 min in hospital, p<0.001; Infants: 530 ± 115 min at home vs. 412 ± 152 min in hospital, p<0.01). Newborn children also experienced >2 hour sleep deficits at home when compared to NSF recommendations (Newborns: 787 ± 318 min at home vs. 930 min recommended, p< 0.05). Objective nighttime traffic measures revealed that hospitalized children experienced 10 room entries/night (10 ± 5.9 entries). Nighttime traffic was significantly correlated with caregiver-reported nighttime awakenings (Spearman Rank Correlation Coefficient: 0.58, p=.04).

Conclusion

Hospitalization is a missed opportunity to improve sleep both in the hospital and at home.

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16:51

  Insomnia Treatment Response as a Function of Objectively Measured Sleep Duration

via Sleep Medicine

Publication date: Available online 31 January 2019

Source: Sleep Medicine

Author(s): Amélie Rochefort, Denise C. Jarrin, Lynda Bélanger, Hans Ivers, Charles M. Morin

Abstract

Objectives

To examine the potential moderating effect of objectively measured sleep duration at baseline on the response to cognitive behavioral therapy for insomnia (CBT-I), administered singly or combined with medication (CBT-I+Med).

Methods

Based on the average PSG-derived sleep duration across two baseline nights and the type of treatment received, 159 adults with insomnia (50.3 ± 10.1 years; 61.0% women) were classified into one of four groups: participants with short sleep duration (i.e., ≤ 6h) treated with CBT-I (n = 26) or CBT-I+Med (n = 25), and participants with normal sleep duration (i.e., > 6h) treated with CBT-I (n = 54) or CBT-I+Med (n = 54). Primary outcome measures were sleep/wake parameters derived from a sleep diary and insomnia severity and secondary outcomes were beliefs about sleep, fatigue, depression and anxiety.

Results

Patients with both short and normal sleep durations at baseline improved significantly on most sleep continuity parameters with CBT-I administered singly or combined with medication. Irrespective of treatment received, participants with short sleep duration also showed significantly greater improvements in subjective sleep (i.e., reduced wake after sleep onset, increased sleep efficiency) relative to those with normal sleep duration. Conversely, participants with normal sleep duration showed greater improvements on some measures of daytime functioning and sleep satisfaction.

Conclusions

There was no moderating effect of baseline sleep duration on treatment response to cognitive behavioral therapy. Despite some marginal differential treatment response on selected daytime functioning outcomes, the benefits from CBT-I were not significantly different as a function of short or normal sleep duration at baseline. Further prospective investigation of insomnia phenotypes taking into account other variables than sleep duration is warranted in order to develop more targeted insomnia therapies.

Trial registration

www.clinicaltrials.gov (#NCT 00042146)

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Thu Jan 31, 2019 12:40

  Association of change in physical activity and sleep complaints: Results from a 6-year longitudinal study with Swedish health care workers

via Sleep Medicine

Publication date: Available online 31 January 2019

Source: Sleep Medicine

Author(s): Markus Gerber, Mats Börjesson, Ingibjörg H. Jonsdottir, Magnus Lindwall

Abstract

Objective

To increase our understanding of patterns of change in physical activity and sleep complaints and to test whether intra-individual changes in physical activity are correlated with intra-individual changes in sleep complaints across four measurement time-points over six years, adopting both a between-person and within-person perspective.

Methods

Data from a longitudinal cohort study were used in this research. At baseline, 3187 participants took part in the study (86% women, Mage=46.9 years). The response rate was 84% (n=3136) after two years, 60% (n=2232) after four years, and 40% (n=1498) after six years. Physical activity was assessed with the [51] widely used 4-level physical activity scale (SGPALS), and sleep complaints, with three items from the Karolinska Sleep Questionnaire (KSQ). Patterns and correlations of change between physical activity and sleep complaints were examined with latent growth curve modeling.

Results

Changes in physical activity were associated with changes in sleep complaints across the six years. More specifically, significant associations occurred between baseline levels, correlated (between-person) change, and coupled (within-person change). These associations indicate that higher physical activity levels are not only cross-sectionally linked with fewer sleep complaints, but that increases in physical activity over time (either in comparison to others or to oneself) are paralleled by decreases in sleep complaints.

Conclusions

Given that changes in physical activity and sleep are correlated, our findings indicate that it is both worthwhile to initiate more physically active lifestyles in physically inactive individuals and to ensure that those who are already physically active maintain their physical activity levels over longer periods.

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  Continuous positive airway pressure alters brain microstructure and perfusion patterns in patients with obstructive sleep apnea

via Sleep Medicine

Publication date: Available online 31 January 2019

Source: Sleep Medicine

Author(s): Hillel S. Maresky, Isaac Shpirer, Miriam M. Klar, Max Levitt, Efrat Sasson, Sigal Tal

Abstract

Objectives

To assess the effects of continuous positive airway pressure (CPAP) treatment on brain structure and function in patients with obstructive sleep apnea (OSA).

Methods

A prospective study of seven OSA patients recruited from the sleep center at our institution was carried out. Patients were treated with 6 weeks of CPAP treatment. Pre-treatment and post-treatment magnetic resonance imaging (MRI) perfusion scans were obtained and compared to assess for treatment-induced changes. Microstructural changes were quantified using functional anistrophy (FA) and mean diffusivity (MD), and brain perfusion was quantified using cerebral blood flow (CBF) and cerebral blood volume (CBV).

Results

Of the seven patients included the in study, six (85.7%) were male, and the mean age of the study population was 51 years (standard deviation = 13.14). Increased FA and decreased MD were found in the hippocampus, temporal lobes, fusiform gyrus, and occipital lobes. Decreased FA and increased MD were found in frontal regions for all patients (p<0.05). Increased CBF and CBV were also observed following treatment (p<0.05).

Conclusion

In addition to symptom resolution, CPAP treatment may allow for healing of OSA-induced brain damage as seen by restoration of brain structure and perfusion.

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Thu Jan 31, 2019 12:40

  Postpartum fatigue, daytime sleepiness, and psychomotor vigilance are modifiable through a brief residential early parenting program

via Sleep Medicine

Publication date: Available online 31 January 2019

Source: Sleep Medicine

Author(s): Nathan Wilson, Karen Wynter, Clare Anderson, Shantha.M.W. Rajaratnam, Jane Fisher, Bei Bei

Abstract

Objective

/Background: In the months after childbirth, women are vulnerable to sleep disturbances and sleep-related deficits in functioning, such as fatigue, daytime sleepiness, and attentional lapses. Currently there is limited evidence that these deficits are modifiable. Using both self-report and objective measures, this study examined changes in sleep-related daytime functioning among women attending a residential early parenting program for assistance with unsettled infant behavior and mild to moderate postpartum distress.

Methods

Participants were 78 women (age M=34.16, SD=4.16 years) attending a 5-day program with their infants (age M=8.67, SD=4.82 months). Sleep was assessed via self-report. Sleep-related daytime functioning was operationalized as fatigue, sleepiness, and sustained attention, and measured using validated questionnaires (all women) and the 10-min visual Psychomotor Vigilance Test (PVT; subgroup of 47 women). All measures were administered on both admission (baseline) and discharge.

Results

On admission, participants reported elevated sleep disturbance (94%), fatigue (91%), as well as trait (54%) and state (67%) sleepiness. From admission to discharge, there were medium effect size reductions in fatigue and sleepiness, and large effect size improvements in sleep quality related domains such as increased sleep efficiency and reduced nighttime awakenings (all p<.001); changes in total sleep time were nonsignificant (p=.22). PVT reciprocal mean reaction times were also significantly faster (p=.001; medium effect size).

Conclusions

This study demonstrated that among women attending a brief residential early parenting program, fatigue, daytime sleepiness, and objectively measured psychomotor vigilance can be improved. Implications for further research and potential treatments are discussed.

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Thu Jan 31, 2019 12:40

  Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study)

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Publication date: Available online 30 January 2019

Source: Sleep Medicine

Author(s): Glaucylara Reis Geovanini, Geraldo Lorenzi-Filho, Lilian K. de Paula, Camila Maciel Oliveira, Rafael de Oliveira Alvim, Felipe Beijamini, André Brooking Negrão, Malcolm von Schantz, Kristen L. Knutson, José Eduardo Krieger, Alexandre Costa Pereira

Abstract

Aim

To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration.

Methods

A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration).

Results

The sample mean age was 43±16 years, 66% were female, and mean body mass index (BMI) was 26±5 kg/m2. Only 20% were classified as obese (BMI ≥30). Fifty per cent of participants reported poor sleep quality as defined by a PSQI score ≥5. A high PSQI score was significantly associated with higher very-low-density lipoprotein (VLDL) cholesterol levels (beta=0.392, p=0.012) and higher triglyceride levels (beta=0.017, p=0.006), even after adjustments, including the apnea–hypopnea index. Further adjustments accounting for marital status, alcohol intake, and medication use did not change these findings. No significant association was observed between PSQI scores and glucose or blood pressure. According to PSQI components, sleep disturbances (beta=1.976, p=0.027), sleep medication use (beta=1.121, p=0.019), and daytime dysfunction (beta=1.290, p=0.024) were significantly associated with higher VLDL serum levels. Only the daytime dysfunction domain of the PSQI components was significantly associated with higher triglyceride levels (beta=0.066, p=0.004).

Conclusion

Poorer lipid profile was independently associated with poor sleep quality, assessed by the PSQI questionnaire, regardless of a normal sleep duration and accounting for OSA and socio-economic status.

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Thu Jan 31, 2019 12:40

  The journal on a new trajectory

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Publication date: January 2019

Source: Sleep Medicine, Volume 53

Author(s): Sudhansu Chokroverty

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🤓🧘 Dangerous non-food products🧛‍♂️🤦🤦‍♀️

Serious risk 

1 of 3 photos PreviousNext Share on             Alert number: A12/0189/19        Category:  Hobby/sports equipment   Product:  Self-balancing scooter (hoverboard)   Brand: GOCLEVER   Name: City Board SUV - Hoverboard   Type / number of model:  CBLSSBEU Black with LG battery   Batch number / Barcode:  5906736072463   Risk type:  Burns, Fire   The hoverboard's charging circuit has no cut-off switch. The battery can consequently overcharge and overheat which could lead to a fire. In addition, the plastic housing of the hoverboard can easily catch fire. The product does not comply with the requirements of the Machinery Directive and the relevant European Standards EN 60335-1 and EN 62133-2.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

1 of 2 photos PreviousNext Share on             Alert number: A12/0190/19        Category:  Hobby/sports equipment   Product:  Self-balancing scooter/Hoverboard   Brand: Denver   Name: Balance scooter   Type / number of model:  Scooter: DBO-6501 WHITE MK2 Power charger: JY-420150   Batch number / Barcode:  5706751035494   Risk type:  Burns, Fire   The charging circuit of the product has no cut-off switch. The battery can consequently overcharge and overheat which may lead to a fire. Furthermore, the plastic housing of the hoverboard can easily catch fire.  The product does not comply with the requirements of the Machinery Directive and the relevant European Standard EN 60335-1.   Measures ordered by public authorities (to: Other): Warning consumers of the risks, Withdrawal of the product from the market

1 of 1 photo Share on             Alert number: A12/0172/19        Category:  Chemical products   Product:  Tattoo ink   Brand: Eternal Ink   Name: ROSA - HOT PINK   Type / number of model:  Unknown   Batch number / Barcode:  Batch number 02/09/16   Risk type:  Chemical   The product contains the aromatic amine o-anisidine (measured value: 26 mg/kg). This aromatic amine can cause cancer, cell mutations and affect reproduction.  The Council of Europe Resolution ResAP (2008)1 on requirements and criteria for the safety of tattoos and permanent make-up, recommends that aromatic amines with carcinogenic mutagenic, reprotoxic or sensitising properties should neither be present in tattoos and permanent make-up products nor released from azo-colourants.   Measures ordered by public authorities (to: Distributor): Ban on the marketing of the product and any accompanying measures

1 of 2 photos PreviousNext Share on             Alert number: A12/0174/19        Category:  Chemical products   Product:  Tattoo ink   Brand: Eternal Ink   Name: CARAMEL   Type / number of model:  Unknown   Batch number / Barcode:  batch R-136, expiry date 06/2020   Risk type:  Chemical   The product contains the aromatic amines o-anisidine (measured value 74 mg/kg) and o-toluidine (measured value 67 mg/kg). Aromatic amines can cause cancer, cell mutations and affect reproduction.  The Council of Europe Resolution ResAP (2008)1 on requirements and criteria for the safety of tattoos and permanent make-up, recommends that aromatic amines with carcinogenic, mutagenic, reprotoxic or sensitising properties should neither be present in tattoos and permanent make-up products nor released from azo-colourants.   Measures ordered by public authorities (to: Distributor): Ban on the marketing of the product and any accompanying measures

1 of 1 photo Share on             Alert number: A12/0179/19        Category:  Lighters   Product:  Novelty lighter   Brand: Unknown   Name: Butane gas lighters - coke bottle   Type / number of model:  Unknown   Batch number / Barcode: Unknown THE PRODUCT IS COUNTERFEIT   Risk type:  Burns, Fire   The lighter is appealing to children due to its shape and colour. Children may play with it and suffer burns or cause a fire.  The product does not comply with the relevant European standard EN 13869.   Measures taken by economic operators: Recall of the product from end users, Warning consumers of the risks, Withdrawal of the product from the market (By: Other)

1 of 1 photo Share on             Alert number: A12/0180/19        Category:  Lighters   Product:  Novelty lighter   Brand: Unknown   Name: Refillable butane gas lighter in the form of a lip   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Burns, Fire   The lighter is appealing to children. due to its shape and colour. Children may play with it and suffer burns or cause a fire.  The product does not comply with the relevant European standard EN 13869.   Measures taken by economic operators: Recall of the product from end users, Warning consumers of the risks, Withdrawal of the product from the market (By: Other)

1 of 1 photo Share on             Alert number: A12/0181/19        Category:  Lighters   Product:  Novelty lighter   Brand: Unknown   Name: Accessories - butane gas lighter-fire-extinguisher   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Burns, Fire   The lighter is appealing to children due to its shape and colour. Children may play with it and suffer burns or cause a fire.  The product does not comply with the relevant European standard EN 13869.   Measures taken by economic operators: Recall of the product from end users, Warning consumers of the risks, Withdrawal of the product from the market (By: Other)

Share on             Alert number: A12/0158/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Cadillac   Name: Escalade   Type / number of model:  Type-approval number: e13*2007/46*1479*00 Type: K2XX   Batch number / Barcode:  The vehicles concerned were manufactured in 2015.   Risk type:  Injuries   The software is faulty which may lead to sporadic failure of the electric power steering. The driver might consequently lose control of the vehicle.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0159/19        Category:  Motor vehicles   Product:  Motorcycle   Brand: Yamaha   Name: Tricity, MWS125, MWS125A, MWS150A   Type / number of model:  Type-approval number: e13*168/2013*00049 Type: SEC 2   Batch number / Barcode:  The vehicles concerned were produced between 2017 and 2018.   Risk type:  Injuries   Poor material resistance of the hoses in the area of the cooling water expansion tank can lead to the loss of cooling water. The cooling liquid could leak onto the road and the rider could consequently lose control of the motorcycle.    Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0160/19        Category:  Motor vehicles   Product:  Passenger car   Brand: VW   Name: Touareg   Type / number of model:  Type-approval number: e1*2007/46*1827*; Type: CR   Batch number / Barcode:  The vehicles in question were produced between 8/8/2018 and 5/10/2018.   Risk type:  Injuries   A seat-belt latch may not have been sufficiently secured to the rear, right-hand seat. In the event of an accident, the rear seat-belt latch may therefore break, increasing the risk of injuries to passengers.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0161/19        Category:  Motor vehicles   Product:  Passenger Car   Brand: Bentley   Name: Mulsanne   Type / number of model:  Type approval numbers: e11*KS07/46*0116*00, e11*KS07/46*0116*01, e11*KS07/46*0116*02, e11*KS07/46*0116*03, e11*KS07/46*0116*04, e11*KS07/46*0116*05   Batch number / Barcode:  The affected vehicles were manufactured between 08/03/2012 and 21/07/2018   Risk type:  Injuries   The body mounting panels of the rear seatbelt buckle anchorages have been made using an incorrect grade of material. In the event of an impact accident, if the rear centre seat is occupied at the same time as an outer rear seat, the rear seatbelt buckle may become detached from the bodywork, leading to injuries.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0162/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Mercedes-Benz   Name: A-class   Type / number of model:  Type-approval number: e1*2007/46*1829*03; Type: F2A   Batch number / Barcode:  The vehicles in question were manufactured between 13/11/2017 and 22/08/2018.   Risk type:  Injuries   No perforation has been made in the outer covering of the instrument panel to enable the deployment of the passenger airbag. In the event of an accident involving deployment of the airbag at low temperatures, sharp edges could be created on the instrument panel in the airbag's deployment area, damaging the airbag. Moreover, parts of the instrument panel may become detached, increasing the risk of injury to the occupants.    Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0163/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Mercedes-Benz   Name: C-class, GLC   Type / number of model:  EC type approvals: e1*2001/116*0480*23-30, e1*2007/46*1884*00, e1*2001/116*0431*48-50, e1*2001/116*0457*35-41, e1*2001/116*0463*20, e1*2001/116*0464*22 Types: 204, -X, -X AMG, -K, -K AMG, -AMG   Batch number / Barcode:  The vehicles in question were manufactured between 1 August 2017 and 11 October 2018.   Risk type:  Injuries   In vehicles with automatic child-seat detection, the status shown in the centre console of the passenger airbags may not be correctly indicated. In this case, the vehicle users would not be correctly informed of the actual activation status of the passenger airbag and may not react appropriately to a potentially false passenger classification, thereby increasing the risk of injury for passengers in the event of an accident.    Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0164/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Mercedes-Benz   Name: C-class, E-class, CLS   Type / number of model:  EC type-approvals: e1*2001/116*0431, e1*2001/116*0457, e1*2001/116*0501, e1*2007/46*1560, e1*2007/46*1818, e1*2001/116*0464, e1*2001/116*0463, e1*2007/46*1666*08 , Types: 204, 204 K, 212, R1ES, R1ECLS, 204 AMG, 204 K AMG, R1EC   Batch number / Barcode:  The vehicles in question were produced between 14 February 2014 and 16 December 2018.   Risk type:  Injuries   There may be cracks in a securing nut in the steering gear of rear-wheel-drive vehicles. The nut could consequently break if the steering system is subject to a very high lateral force, which could result in rotating parts in the steering gear affecting the casing and thereby blocking the steering system.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0170/19        Category:  Motor vehicles   Product:  Tyres   Brand: Continental   Name: Winter Contact TS860   Type / number of model:  ECE type approvals: R30: E4 0289778; R117: E4 027400 S2WR2   Batch number / Barcode:  This concerns one week of the manufacturing year 2018 identified by the following code: DOT 6GAED29W4118.   Risk type:  Injuries   Loosening of the tread could occur. This could have an adverse effect on the handling and stability of the vehicle.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0171/19        Category:  Motor vehicles   Product:  Tyres   Brand: Uniroyal   Name: MS Plus 77   Type / number of model:  ECE type approvals: R30: E4 0268280; R117: E4 025045 S2WR2   Batch number / Barcode:  This concerns one week of the manufacturing year 2018 identified by the following code: DOT 6GXWDDBR4118.   Risk type:  Injuries   Loosening of the tread could occur. This could have an adverse effect on the handling and stability of the vehicle.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0175/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Jeep   Name: Cherokee, Compass   Type / number of model:  EC type-approvals: e4*2007/46*0783*11, e11*2007/46*4037*02; Types: KL, MX   Batch number / Barcode:  The vehicles concerned were produced between 17 March 2018 and 21 June 2018.   Risk type:  Injuries   Incorrect coating of the brake pistons can result in the formation of gas in the hydraulic system. This may adversely affect the functioning of the brakes on the rear-axle wheels.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0176/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Alfa Romeo   Name: Stelvio   Type / number of model:  EC type-approval: e3*2007/46*0435*02; Type: 949; sales description: Stelvio   Batch number / Barcode:  The vehicles concerned were produced between 18 January 2017 and 18 September 2018.   Risk type:  Fire   A non-compliant generator cable may be damaged as a result of contact with the exhaust gas recirculation line. This could cause a short-circuit and in the worst case fire in the engine compartment.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0178/19        Category:  Motor vehicles   Product:  Vehicle component   Brand: JOST   Name: KLK HE 1200-22; KLK HE 1300-22   Type / number of model:  Unknown   Batch number / Barcode:  Period of manufacture: December 2016 to 16.11.2018.   Risk type:  Injuries   Owing to a defect in the continuous steel casting process, the ball-bearing turntables may break. Consequently, the connection to the lower turntable of a trailer may be lost, which could lead to an accident.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer) Company recall page:  https://www.jost-klk.com/en/

Share on             Alert number: A12/0183/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Opel   Name: Zafira   Type / number of model:  Type-approval numbers: e1*2001/116*0325*00-11, e1*2007/46*0497*00-05 Type: A-H/monocab   Batch number / Barcode:  The vehicles concerned were manufactured between 2 November 2004 and 24 October 2014.   Risk type:  Fire   There is a defective regulator on the blower motor. This can cause a fire in the cable set.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0185/19        Category:  Motor vehicles   Product:  Passenger Car   Brand: Land Rover   Name: Range Rover, Sport, Velar, Discovery   Type / number of model:  Range Rover E11*2007/46*0649 Range Rover Sport E11*2007/46*0909 Range Rover Velar E11*2007/46*3954 Discovery E11*2007/46*3784   Batch number / Barcode:  Specific vehicles built between 10/10/2018 and 19/12/2018   Risk type:  Injuries   The crankshaft pulley retaining bolt may fracture. As a consequence, the crankshaft nose could break leading to engine power loss and the potential for engine failure. Furthermore, the loose pulley could damage under bonnet components or puncture the bonnet and become a hazard to pedestrians or other road users.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0188/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Porsche   Name: 991 Carrera, Cayenne, Macan, Panamera   Type / number of model:  Type-approval numbers: se13*2007/46*1187 e13*2007/46*1085* e13*2007/46*1106* e13*2007/46*1107* e13*2007/46*1108* e13*2007/46*1164* e13*2007/46*0970* e13*2007/46*1143* e13*2007/46*1160* , e13*2007/46*1161*; types: 991, 92A, 95B, 970;   Batch number / Barcode:  The vehicles concerned were produced in 2014 and 2015   Risk type:  Injuries   It is possible that the vehicles do not meet the series standards applicable at the time of delivery as regards certain safety systems and assemblies (e.g. seating, front axle control arm bolts, brake components). As a consequence, the cars might be unsafe.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0192/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Jaguar   Name: F-Pace, F-Type, XJ   Type / number of model:  F-PACE E11*2007/46*3324 F-TYPE E11*2001/116*0272 XJ E11*2007/46*0089   Batch number / Barcode:  Specific vehicles built between 12/10/2018 and 11/12/2018   Risk type:  Injuries   The crankshaft pulley retaining bolt may fracture. As a consequence, the crankshaft nose could break leading to engine power loss and the potential for engine failure. Furthermore, the loose pulley could damage under bonnet components or puncture the bonnet and become a hazard to pedestrians or other road users.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0193/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Land Rover   Name: Range Rover, Range Rover Sport   Type / number of model:  Type Approval Number : Range Rover E11*2007/46*0649 Range Rover Sport E11*2007/46*0909   Batch number / Barcode:  Specific vehicles built between 10/11/2017 and 18/12/2018 and fitted with the 4.4L SDV8 diesel engines   Risk type:  Injuries   Due to a faulty software, the directional indicators may fail to operate when the steering column mounted control stalks are used and the driver does not receive visual or audible warnings if this occurs. As a consequence, there is an increased risk of a crash.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0194/19        Category:  Motor vehicles   Product:  Passenger car   Brand: Bentley   Name: Continental GT   Type / number of model:  Type approval numbers: e13*2007/46*0634*01 e13*2007/46*0634*02   Batch number / Barcode:  Specific vehicles built between 22/01/2018 and 17/12/2018   Risk type:  Injuries   Due to a software fault a temporary loss of power assistance could occur, requiring the driver to apply additional steering force. This could lead to an accident.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

1 of 6 photos PreviousNext Share on             Alert number: A12/0157/19        Category:  Other   Product:  Smart watch for children   Brand: ENOX   Name: Safe-KID-One   Type / number of model:  Unknown   Batch number / Barcode:  4260088660947   Risk type:  Other   The mobile application accompanying the watch has unencrypted communications with its backend server and the server enables unauthenticated access to data. As a consequence, the data such as location history, phone numbers, serial number can easily be retrieved and changed. A malicious user can send commands to any watch making it call another number of his choosing, can communicate with the child wearing the device or locate the child through GPS.  The product does not comply with the Radio Equipment Directive.   Measures ordered by public authorities (to: Distributor): Recall of the product from end users

1 of 3 photos PreviousNext Share on             Alert number: A12/0152/19        Category:  Toys   Product:  Toy scooter   Brand: illumination   Name: Despicable Me DM3   Type / number of model:  808580   Batch number / Barcode: Unknown   Risk type:  Injuries   The scooter is not sufficiently stable. Children can fall to the ground and hurt themselves.  The product does not comply with the requirements of the Toy Safety Directive and with the relevant European Standard EN 71-1.   Measures taken by economic operators: Destruction of the product (By: Importer) Measures ordered by public authorities (to: Importer): Import rejected at border

1 of 1 photo Share on             Alert number: A12/0168/19        Category:  Toys   Product:  Children's fancy-dress costume   Brand: Unknown   Name: ABYED - Anime Animal Costume Cosplay   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Choking   The slider of the zip can be easily detached. A child could put it in the mouth and choke on it.  The product does not comply with the requirements of the Toy Safety Directive and the relevant European Standard EN 71-1.   Measures taken by economic operators: This product listing was removed by AMAZON, Withdrawal of the product from the market (By: Other)

1 of 4 photos PreviousNext Share on             Alert number: A12/0182/19        Category:  Toys   Product:  Pull-along toy   Brand: ECOTOYS   Name: Drewniany piesek na sznurku   Type / number of model:  Item N0. 2205   Batch number / Barcode:  4 894063 031592 Seria 07/2016   Risk type:  Strangulation   The cord attached to the toy is too long. The cord could wrap itself around the child's neck without the child being able to remove it, causing strangulation. The product does not comply with the requirements of the Toy Safety Directive and the relevant European standard EN 71-1.   Measures ordered by public authorities (to: Importer): Making the marketing of the product subject to prior conditions

1 of 1 photo Share on             Alert number: A12/0184/19        Category:  Toys   Product:  Educational toy   Brand: Makeblock   Name: mBot   Type / number of model:  FRA mBot V1.1-Blue (bluethooth version)   Batch number / Barcode: Unknown   Risk type:  Burns, Chemical   Due to a short-circuit, the batteries can overheat and the plastic of the battery compartment can melt. Moreover, the battery compartment of the remote-control can easily be opened without use of any tools, giving access to the button cell batteries. A child may sustain burns from the overheating parts or put the batteries in the mouth and swallow them, which can cause damage to the child's gastrointestinal tract.  The product does not comply with the requirements of the Toy Safety Directive and the relevant European standards EN 62115 and EN 71-1.   Measures ordered by public authorities (to: Importer): Import rejected at border

1 of 2 photos PreviousNext Share on             Alert number: A12/0191/19        Category:  Toys   Product:  Squeezable toy   Brand: Unknown   Name: Children's toy   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Chemical   The plastic material of the product contains di-(2-ethylhexyl) phthalate (DEHP) (measured value: 12% by weight) and diisobutyl phthalate (DIBP) (26% by weight). These phthalates may harm the health of children causing possible damage to the reproductive system. The product does not comply with the REACH Regulation.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

1 of 1 photo Share on             Alert number: A12/0195/19        Category:  Toys   Product:  Soft toy   Brand: Unknown   Name: Soft toy turtle, 18 cm   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Chemical, Choking   The eyes and the suction cup can easily be detached and the paint on the eyes contains lead (measured value: 63 mg/kg) The fibrous stuffing material of the toy is easily accessible due to the weakness of certain seams. A small child may put the small parts, the suction cup or the stuffing material in the mouth and choke. Exposure to lead is harmful for human health and can cause developmental neurotoxicity. The product does not comply with the requirements of the Toy Safety Directive and with the relevant European standards EN 71-1 and EN 71-3.   Measures taken by economic operators: Withdrawal of the product from the market (By: Other)

1 of 2 photos PreviousNext Share on             Alert number: A12/0196/19        Category:  Toys   Product:  Electric toy   Brand: Unknown   Name: Funny microphone   Type / number of model:  NO. 729   Batch number / Barcode: Unknown   Risk type:  Environment   Four solders in the toy contain lead (measured value up to 44.8% by weight) and two of the four solders contain cadmium (measured value up to 0.66% by weight) in concentrations above limit values. Lead and cadmium pose a risk to the environment. The product does not comply with the Commission Directive on the restriction of the use of certain hazardous substances in electrical and electronic equipment (RoHS 2 Directive).    Measures taken by economic operators: Withdrawal of the product from the market (By: Importer)

1 of 2 photos PreviousNext Share on             Alert number: A12/0200/19        Category:  Toys   Product:  Science kit   Brand: Alga   Name: Electro Alarm   Type / number of model:  21928505   Batch number / Barcode:  4893669285057   Risk type:  Environment   Solder in one place in the toy contains lead in concentration above limit value (measured value up to 11.7% by weight). Lead poses a risk to the environment.  The product does not comply with the Commission Directive on the restriction of the use of certain hazardous substances in electrical and electronic equipment (RoHS 2 Directive).   Measures taken by economic operators: Withdrawal of the product from the market (By: Manufacturer)

1 of 5 photos PreviousNext Share on             Alert number: A12/0165/19        Category:  Clothing, textiles and fashion items   Product:  Children's dress   Brand: Lamond   Name: Lány ruha   Type / number of model:  999-0521-3   Batch number / Barcode: Unknown   Risk type:  Choking, Injuries   The small decorative rhinestones can easily be detached from the dress.  A small child may put them in the mouth and choke. The sharp safety pin of the decorative flower is easily accessible. A small child may put the small parts in the mouth and choke, while the safety pin can cause eye or skin injuries.   Measures ordered by public authorities (to: Distributor): Recall of the product from end users, Withdrawal of the product from the market

1 of 4 photos PreviousNext Share on             Alert number: A12/0166/19        Category:  Clothing, textiles and fashion items   Product:  Babies' clothing set   Brand: Petite Ponpon Baby   Name: Unknown   Type / number of model:  Unknown   Batch number / Barcode: Unknown   Risk type:  Choking   The small decorative elements of the product may be easily detached. A small child may put them in the mouth and choke.   Measures ordered by public authorities (to: Distributor): Recall of the product from end users, Withdrawal of the product from the market

1 of 4 photos PreviousNext Share on             Alert number: A12/0169/19        Category:  Clothing, textiles and fashion items   Product:  Ladies' sandals   Brand: ElleNor   Name: Damen Pantolette   Type / number of model:  Unknown   Batch number / Barcode:  4039653754509   Risk type:  Chemical   The amount of chromium (VI) in the leather of the insoles is too high (measured value 12.4 mg/kg). Chromium (VI) is sensitising and may trigger allergic reactions. The product does not comply with the REACH Regulation.   Measures taken by economic operators: Recall of the product from end users (By: Importer)

1 of 5 photos PreviousNext Share on             Alert number: A12/0186/19        Category:  Clothing, textiles and fashion items   Product:  Children's sweatshirt   Brand: RITCHIE JEANS CO   Name: Deška jopa   Type / number of model:  RT7394X, Reference: WIPACK J   Batch number / Barcode:  3660283413408   Risk type:  Strangulation   There are drawstrings with free ends in the hood. The drawstrings may become trapped during various activities of the child, leading to strangulation. The product does not comply with the relevant European standard EN 14682.   Measures taken by economic operators: Making the marketing of the product subject to prior conditions (By: Distributor)

1 of 4 photos PreviousNext Share on             Alert number: A12/0187/19        Category:  Clothing, textiles and fashion items   Product:  Children's sweatshirt   Brand: LONGBOARD   Name: Deška jopa   Type / number of model:  JUST MUVE, Reference 46974000   Batch number / Barcode:  3253538179817   Risk type:  Strangulation   There are drawstrings with free ends in the hood. The drawstrings may become trapped during various activities of the child, leading to strangulation. The product does not comply with the relevant European standard EN 14682.   Measures taken by economic operators: Making the marketing of the product subject to prior conditions (By: Distributor)

1 of 4 photos PreviousNext Share on             Alert number: A12/0173/19        Category:  Cosmetics   Product:  Hair dye   Brand: Color Mate   Name: Hair Color   Type / number of model:  Light Brown 9.7   Batch number / Barcode:  8 906016 050843 Batch Number: 07   Risk type:  Chemical   The product contains barium (measured value: 13.6 % by weight) as peroxide. Barium peroxide is corrosive and irritant. Barium can be absorbed from the dye and have toxic effects on kidney and heart. The product contains too much p-aminophenol (measured value: 13.6% by weight, final calculated concentration: 3.8%) and insufficient coupling agent. Uncoupled p-aminopohenol is a strong skin sensitiser and may trigger allergic skin reactions. The product does not comply with the Cosmetic Products Regulation.   Measures ordered by public authorities (to: Retailer): Destruction of the product

1 of 2 photos PreviousNext Share on             Alert number: A12/0153/19        Category:  Electrical appliances and equipment   Product:  USB-Charger   Brand: Samsung (Counterfeit)   Name: Samsung EP-TA20EWE (Counterfeit)   Type / number of model:  EP-TA20EWE   Batch number / Barcode: Unknown THE PRODUCT IS COUNTERFEIT   Risk type:  Electric shock   The electrical insulation and the clearance/creepage distances between the primary and accessible secondary circuit are not sufficient. The user could touch accessible live parts and receive an electric shock. The product does not comply with the requirements of the Low Voltage Directive and the relevant European standard EN 60950.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

1 of 2 photos PreviousNext Share on             Alert number: A12/0154/19        Category:  Electrical appliances and equipment   Product:  USB-Charger   Brand: Unknown   Name: EP-TA20EWE   Type / number of model:  EP-TA20EWE   Batch number / Barcode:  86696806738   Risk type:  Electric shock   The electrical insulation and the clearance /creepage distances between the primary and accessible secondary circuit are not sufficient. The user could touch accessible live parts and receive an electric shock. The product does not comply with the requirements of the Low Voltage Directive and the relevant European standard EN 60950.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

1 of 3 photos PreviousNext Share on             Alert number: A12/0155/19        Category:  Electrical appliances and equipment   Product:  USB-Charger   Brand: Unknown   Name: Unknown   Type / number of model:  keke-f5   Batch number / Barcode: Unknown   Risk type:  Electric shock   The electrical insulation and the clearance/creepage distances between the primary and accessible secondary circuit are not sufficient. The user could touch accessible live parts and receive an electric shock. The product does not comply with the requirements of the Low Voltage Directive and the relevant European standard EN 60950.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

1 of 2 photos PreviousNext Share on             Alert number: A12/0156/19        Category:  Electrical appliances and equipment   Product:  USB-Charger   Brand: Unknown   Name: Unknown   Type / number of model:  EP-TA20JWE   Batch number / Barcode:  S/N R37G15Z7JP1RT3   Risk type:  Electric shock   The electrical insulation and the clearance/creepage distances between the primary and accessible secondary circuit are not sufficient. The user could touch accessible live parts and receive an electric shock. The product does not comply with the requirements of the Low Voltage Directive and the relevant European standard EN 60950.   Measures ordered by public authorities (to: Other): Withdrawal of the product from the market

Weekly overview report on professional products

Serious risk 

Share on             Alert number: A12/0167/19        Category:  Motor vehicles   Product:  Lorry   Brand: Mitsubishi Fuso   Name: eCanter   Type / number of model:  Type-approval number: E4*2007/46*0785*; Type: FE4P10TF1N2   Batch number / Barcode:  The vehicles concerned were produced between September 2017 and December 2017.   Risk type:  Burns, Fire, Injuries   Owing to a defective power distribution unit (PDU), short circuits in the vehicle electronics may occur. Increased resistance or a power interruption may occur and/or, where currents are high, a thermal event may ensue. This could lead to the vehicle breaking down or catching fire.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0177/19        Category:  Motor vehicles   Product:  Lorry   Brand: Mercedes-Benz   Name: Econic   Type / number of model:  Type-approval number: e1*2007/46*1221* Type: NGE-L64   Batch number / Barcode:  The vehicles in question were manufactured between 1 October 2013 and 26 July 2018.   Risk type:  Injuries   Pneumatic brake lines on the parking brake may, under certain conditions, be damaged by chafing on the drive shafts when the vehicle is lowered to the lowest position. As a result, it could, over time, cause the wheels to jam when applying the brakes.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0197/19        Category:  Motor vehicles   Product:  Lorry   Brand: Mercedes-Benz   Name: Unimog   Type / number of model:  Type-approval numbers: e1*2007/46*1214, *1215, *1216 Types: UGE-452, UGE-232, UGE-453   Batch number / Barcode:  The vehicles affected were produced between August 2013 and January 2018.   Risk type:  Injuries   There is a possible damage to the electrical wiring harness. This may affect the functioning of the rear lighting unit (including trailer), the electrical supply to the cab, the motor control module (MCM) and the anti-lock braking system (ABS) of the rear axle.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0198/19        Category:  Motor vehicles   Product:  Lorry   Brand: Scania   Name: 4-, G-, P-, R-series and possibly others   Type / number of model:  EC type-approvals: e4*2007/46*0030, *0031, *0032, *0038, *0039, *0040, *0045, *0046, *0605 and possibly other types: N320, N321, N322, N330, N331, N332, N340, N341, N351.   Batch number / Barcode:  The vehicles affected were produced between 2007 and June 2017.   Risk type:  Injuries   Defective alignment of the steering geometry, or inadequate alignment of the steering stops, may result in chafing of the wheels on the steering column. As a result, the steering column might break, leading to a loss of steering control.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)

Share on             Alert number: A12/0199/19        Category:  Motor vehicles   Product:  Bus   Brand: EvoBus   Name: Sprinter Transfer, Sprinter Mobility   Type / number of model:  EC type-approvals: e13*2007/46*1295, e13*2007/46*1294 Types: KA-UM/UL/UXL-M2, KA-UM/UL/UXL-M3   Batch number / Barcode:  The vehicles concerned were manufactured between June 2010 and July 2018.   Risk type:  Injuries   The inbuilt microphone for tour guide announcements is located in the passenger airbag's inflation zone. If the airbag were activated, it could be damaged.   Measures taken by economic operators: Recall of the product from end users (By: Manufacturer)