Use of Raman optical tweezers for cell cycle analysis

Analyst, 2015, Accepted Manuscript
DOI: 10.1039/C5AN00971E, Paper

Sunita Ahlawat, Aniket Chowdhury, Abha Uppal, Nitin Kumar, Pradeep Kumar Gupta
We report the results of our investigations on the use of Raman optical tweezers for label free analysis of cells in different phases of their cell cycle. The studies performed...
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Interferon gamma effect on immune mediator production in human nerve cells infected by two strains of Toxoplasma gondii

Authors: Nour Mammari, Philippe Vignoles, Mohamad Adnan Halabi, Marie-Laure Dardé and Bertrand Courtioux.<br />Parasite Vol. 22 , page 39<br />Published online: 21/12/2015<br /> Keywords: Toxoplasma gondii ; Human nerve cells ; IFN-γ ; Immunity.<img src="http://ift.tt/1IjGgkp" height="1" width="1" alt=""/>

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Protective Effects of Streblus asper Leaf Extract on H2O2-Induced ROS in SK-N-SH Cells and MPTP-Induced Parkinson’s Disease-Like Symptoms in C57BL/6 Mouse

This study investigated the effects of Streblus asper leaf extract (SA) on reactive oxygen species (ROS) in SK-N-SH cell culture and on motor functions and behaviors in MPTP-treated C57BL/6 mice. SK-N-SH cell viability after incubation with SA for 24 h was measured by MTT assay. Intracellular ROS levels of SK-N-SH cells were quantified after pretreatment with SA (0, 200, 600, and 1000 µg/mL) in the presence of H2O2 (300 µM). Male C57BL/6 mice were force-fed with water or 200 mg/kg/day SA for 32 days. Intraperitoneal injection of MPTP was used to induce Parkinson's disease-like symptoms. Catalepsy, beam balance ability, olfactory discrimination, social recognition, and spontaneous locomotor activity were assessed on days 19, 21, 23, 26, and 32, respectively. In cell culture, SA at 200, 600, and 1000 µg/mL significantly decreased ROS levels in H2O2-treated SK-N-SH cells. MPTP-treated C57BL/6 mice showed a significant change in all parameters tested when compared to the control group. Pretreatment and concurrent treatment with 200 mg/kg/day SA could antagonize the motor and cognitive function deficits induced by MPTP. The results show that SA possesses anti-Parkinson effects in MPTP-treated C57BL/6 mice and that reduction in ROS levels might be one of the mechanisms.

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Larval trematode infections in Lymnaea glabra populations living in the Brenne Regional Natural Park, central France

Authors: Daniel Rondelaud, Philippe Vignoles and Gilles Dreyfuss.<br />Parasite Vol. 22 , page 38<br />Published online: 21/12/2015<br /> Keywords: Brenne Regional Natural Park ; Cercaria ; Digenean ; Lymnaea glabra ; Lymnaeidae ; Snail.<img src="http://ift.tt/1IjGg44" height="1" width="1" alt=""/>

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Specific self-monitoring of metal-associated amyloid-[small beta] peptide disaggregation by a fluorescent chelator

Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5CC08898D, Communication

Tao Yang, Xiaohui Wang, Changli Zhang, Xiang Ma, Kun Wang, Yanqing Wang, Jian Luo, Liu Yang, Cheng Yao, Xiaoyong Wang
A dual-functional fluorescent chelator can specifically target and disassemble metal-associated A[small beta] aggregates and simultaneously self-monitor the disaggregation by fluorescence in brain homogenates of mice with Alzheimer's disease.
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From DNA to catalysis: a thymine-acetate ligated non-heme iron(III) catalyst for oxidative activation of aliphatic C-H bonds

Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5CC07597A, Communication

Afnan Al-hunaiti, Minna Raisanen, Timo Repo
A non-heme, iron(III)/THA(thymine-1-acetate) catalyst together with H₂O₂ as an oxidant is efficient in oxidative C-H activation of alkanes.
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Carbon dots with aggregation induced emission enhancement for visual permittivity detection

Chem. Commun., 2016, Advance Article
DOI: 10.1039/C5CC08635C, Communication

Ze Xi Liu, Zhu Lian Wu, Ming Xuan Gao, Hui Liu, Cheng Zhi Huang
A simple and rapid bottom-up synthesis route to synthesize TA-CDs by using tannic acid (TA) as the carbon source was developed, which show visual permittivity dependent aggregation induced emission enhancement (AIEE) properties owing to the hampered rotations of the surface groups on CDs and reduced non-radiative decay during CD aggregation.
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