Too little is understood about head and neck cancer by those who make decisions about it

Publication date: June 2016
Source:British Journal of Oral and Maxillofacial Surgery, Volume 54, Issue 5
Author(s): David A. Mitchell




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Stability and complications of miniplates for mandibular reconstruction with a fibular graft: outcomes for 544 patients

Publication date: June 2016
Source:British Journal of Oral and Maxillofacial Surgery, Volume 54, Issue 5
Author(s): Shang-Ping Liu, Zhi-Gang Cai, Jie Zhang, Jian-Guo Zhang, Yi Zhang
Fibular flaps are usually used for the reconstruction of the mandible, but the use of plate systems, including miniplates and reconstruction plates, has recently been debated. We have made a retrospective study of 544 consecutive patients who had fibular grafts with miniplates used for fixation, and also made retrospective measurements of orthopantomographs from 37 patients to assess the stability of the miniplates used in the fibular flaps. When miniplates were used with fibular flaps there were 10.3% (56/544) complications, of which 4.8% (26/544) were loosening of the screws, 2.6% (14/544) fracture of the plate, 1.5% (8/544) exposure of the plate, and 6.4% (35/544) infection. The median (IQR) time at which the complications occurred was 24 (7–48) months. We conclude that loosening of screws is common at the binding interface near the condyle and in the molar region; plates are more likely to fracture near the binding interface in proximity to the molar region; and plates at the chin are the most likely to be exposed. Diabetes and the use of radiotherapy were associated with complications. Our data suggest that miniplates used for mandibular reconstruction are relatively reliable.



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Editorial Board

Publication date: June 2016
Source:British Journal of Oral and Maxillofacial Surgery, Volume 54, Issue 5





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Training Groups

Publication date: June 2016
Source:British Journal of Oral and Maxillofacial Surgery, Volume 54, Issue 5





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Plant-growth regulators alter phytochemical constituents and pharmaceutical quality in Sweet potato (Ipomoea batatas L.)

Sweet potato (Ipomoea batatas L.) is one of the most important consumed crops in many parts of the world because of its economic importance and content of health-promoting phytochemicals.

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A Fucus vesiculosus extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines

We previously reported the anti-estrogenic activity of the brown seaweed, Fucus vesiculosus. The present study aimed to further investigate its anti-estrogenic modes of action and to assess other potentially biol...

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Hypoxia-Inducible Factor-1α and Autoimmune Lupus, Arthritis

Abstract

Hypoxia elicits an orchestrated response in cells, tissues, and entire organisms to survive a hypoxic challenge. On a molecular level, this response can be controlled by oxygen-dependent stabilization of the transcription factor hypoxia-inducible factor (HIF)-1α. Recently, studies have shown that HIF-1α plays an important role in the development and function of T helper (Th) cells, regulatory T (Treg) cells, and dendritic cells (DCs). Because these cells are critical in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, the roles of HIF-1α in these autoimmune disorders cannot be neglected. In this review, we discuss recent findings on the important roles of HIF-1α in immune cells and the possible pathologic roles of HIF-1α in autoimmune diseases. The obtained information may lead to deeper insights into the roles of HIF-1α in these disorders.

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