Αρχειοθήκη ιστολογίου

Δευτέρα 6 Ιουνίου 2016

Ellipsys Vascular Percutaneous System for AV Fistulas Gets EU Green Light

eLLIPSYSAvenu Medical, a firm based in San Juan Capistrano, California, won European CE Mark approval to introduce its minimally invasive and cost effective Ellipsys Vascular Access System for creating arteriovenous (AV) fistulas in dialysis patients.

Ellipsys-tipSome details about the device according to the company,

The system enables physicians to percutaneously access the proximal radial artery in the forearm to create an AV fistula. Under high frequency ultrasound guidance, the Ellipsys System uses a novel outer access cannula, guidewire and vessel capture construct that creates a connection of the vein to the artery using an intravascular approach.

A select amount of low power thermal energy is used to cut the walls of the vessels and fuse the tissue, creating an in-vivo anastomosis without leaving any foreign material (including sutures) in the resulting AV fistula. The use of thermal energy has been successfully used in other vessel sealing applications with results equal to or better than traditional suturing methods.

The technology is currently under an Investigational Device Exemption by the FDA in the U.S.

Here's Avenu Medical's animation demonstrating how the device is used:

Product page: Ellipsys Vascular Access System…

Via: Avenu Medical…

The post Ellipsys Vascular Percutaneous System for AV Fistulas Gets EU Green Light appeared first on Medgadget.

Medgadget?d=yIl2AUoC8zA Medgadget?d=qj6IDK7rITs Medgadget?i=CLiv7Egd5Jc:ewx-VKt1yxc:gIN9


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Current status of the implantable LVAD

Abstract

With the ongoing shortage of available organs for heart transplantation, mechanical circulatory support devices have been increasingly utilized for managing acute and chronic heart failure that is refractory to medical therapy. In particular, the introduction of the left ventricular assist devices (LVAD) has revolutionized the field. In this review, we will discuss a brief history of the LVAD, available devices, current indications, patient selection, complications, and outcomes. In addition, we will discuss recent outcomes and advancements in the field of noncardiac surgery in the LVAD patient. Finally, we will discuss several topics for surgical consideration during LVAD implantation.



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Observation of the efficacy of radiofrequency catheter ablation on patients with different forms of atrial fibrillation

OBJECTIVE: To study the efficacy and safety of radiofrequency catheter ablation (RFCA) in patients with different forms of atrial fibrillation.

PATIENTS AND METHODS: By retrospective analysis, we summarize 720 cases, where patients diagnosed with atrial fibrillation in our hospital were treated with RFCA from February 2010 to October 2014. Among the cases, 425 were diagnosed with paroxysmal atrial fibrillation and 295 with non-paroxysmal atrial fibrillation (including persistent atrial fibrillation and permanent atrial fibrillation). All patients were followed up until June 2015 to compare and analyze the differences in operation success rates, complications and recurrence rates.

RESULTS: 395 cases (92.9%) of paroxysmal atrial fibrillation and 253 cases (85.8%) with non-paroxysmal atrial fibrillation were subject to surgery and followed up. The age of onset, disease course, underlying diseases, left atrial diameter and combined anti-arrhythmics of patients with paroxysmal atrial fibrillation were lower than those of patients with non-paroxysmal atrial fibrillation, and the differences were statistically significant (p<0.05). The success rate of the first ablation was higher than that of non-paroxysmal atrial fibrillation. Procedure time, procedure method, complications and recurrence rate of patients with paroxysmal atrial fibrillation were lower than those of non-paroxysmal atrial fibrillation group, and the differences were statistically significant (p<0.05). When we compared apoplexy and heart failure caused by atrial fibrillation in the two groups, the difference was not statistically significant (Apoplexy: p=0.186; Heart failure: p=0.170).

CONCLUSIONS: The individual ablation success rate was higher for paroxysmal atrial fibrillation, and long-term follow-up showed that the occurrence of apoplexy and heart failure was not different from the non-paroxysmal atrial fibrillation group.

L'articolo Observation of the efficacy of radiofrequency catheter ablation on patients with different forms of atrial fibrillation sembra essere il primo su European Review.



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ARID1A alteration in aggressive urothelial carcinoma and variants of urothelial carcinoma

Publication date: September 2016
Source:Human Pathology, Volume 55
Author(s): Jianhong Li, Shaolei Lu, Kara Lombardo, Rene Monahan, Ali Amin
ARID1A mutation leads to loss of the products of this tumor-suppressor gene. Studies demonstrated ARID1A mutation in 20% of stage IV urothelial carcinomas (UCs) with worse prognosis. The expression of ARID1A in aggressive variants of UC is not studied properly. From 2000 to 2015, 81 variants of UC (29 micropapillary, 33 sarcomatoid, 31 small cell, 2 nested, and 3 plasmacytoid variants) were identified in the archives of Rhode Island Hospital. Immunohistochemistry for anti-ARID1A antibody (Sigma-Aldrich, St Louis, MO) was performed. The staining pattern was semiquantitatively scored, and results were analyzed by Fisher exact test (2 tailed) on contingency tables, survival curve, and log-rank test. Patients were predominantly male (78%) with mean age of 67.9 years. The plasmacytoid variant group occurred in younger ages (mean: 54 years). Half of the specimens contained concurrent conventional UCs. Normal urothelium invariably exhibited strong ARID1A nuclear staining. There was no difference in expression between upper and lower tracts. ARID1A expression was lower in the variants compared with conventional UCs (P<.0001). In micropapillary UCs, an inverse correlation between stage and ARID1A expression was noted, with significant correlation between ARID1A expression and overall survival (P=.0221). Sarcomatoid UCs and small cell CCs showed lower ARID1A expression compared with UCs that was not statistically significant, and neither showed any significant correlation with stage or overall survival. ARID1A expression is significantly decreased in higher stages of UC and its aggressive variants; therefore, ARID1A mutation appears to play an important role in the prognosis of UC and its aggressive variants. This finding may have therapeutic implications.



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Microbial complexes levels in conventional and self-ligating brackets

Abstract

Objectives

The aims were to evaluate the levels of bacterial species in saliva and in situ and to assess whether the design of brackets influences the risk of developing periodontal disease.

Materials and methods

Twenty patients (13.3 mean age) were bonded with self-ligating brackets and a conventional bracket. Saliva was collected before bonding and 30 and 60 days after bonding. One sample of each bracket was removed 30 and 60 days after bonding. The analysis was determined by checkerboard DNA–DNA hybridization. The data was evaluated by the non-parametric test.

Results

A significant increase in the levels of bacterial species in the saliva occurred in 15 of the 22 analyzed species. The self-ligating brackets presented the highest incidence percentages for the orange and red complexes 60 days after bonding. In situ analyses showed different patterns according to the bracket design. The levels of Campylobacter rectus showed significant differences (p = 0.011) 60 days after bonding among the three brackets; the highest values were observed in the In-Ovation®R bracket.

Conclusions

The bracket design seems to influence the levels of bacterial species involved in periodontal disease. Considering the wide variety of bacterial species, additional studies are needed to aid in the establishment of effective protocols to prevent the development of periodontal disease during orthodontic treatment.

Clinical relevance

A dynamic alteration in the oral microbiota may lead to inflammatory reactions in the supporting soft and hard tissues. The different types of brackets interfere with bacterial adherence. Bracket design should be considered in orthodontic treatment.



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My love-hate relationship with EMS

A recent encounter with a salty EMR-firefighter who had learned all the wrong lessons from EMS, made me wonder why is it that some of us can find rejuvenation after burnout, and others can't" Is it simply a matter of perspective and all it takes to improve your outlook is someone pointing out to you all the good things you've ignored"

Or is it that so many of us come into EMS already broken in some way, hoping that by healing others we can heal ourselves"

For some, that seems to work. For many others, though, it seems to build a callous over the broken edges, so that they may never knit together again.

For my part, I pray that it's simply a matter of perspective. Otherwise, the years I've spent advocating for EMS seem pretty pointless.

I suppose that it's simply a personal decision about what matters more to you — the things you hate about EMS, or the things you love about EMS. As another EMS Week — my 23rd — fades in my rearview mirror, I find that what I hate and what I love about EMS are inextricably linked, and my perspective about which one is more important is changing.

I hate that people call an ambulance for trivial reasons, but I love that I am expected to go.
Anyone who has worked in EMS for more than five minutes has encountered a patient that called an ambulance for something that wasn't strictly defined as an emergency. Whether it is ignorance or blatant abuse, it happens far more often than it should.

Much of it stems from two generations of citizens being constantly told — often by EMS itself — that the slightest twinge or sniffle might herald something serious and to call 911. And while blatant abuse and gaming the system for free medical care, a meal or a ride across town is still somewhat rare, most of us have encountered those patients.

Dealing with them gnaws at my job satisfaction like a rat gnaws at your electrical wiring, building a cozy little nest with the remnants of my idealism, a nest that threatens to one day burst into flame and destroy everything I hold dear.

But I also love the honor in the implicit compact between the people who call 911 and the people who respond; you call, we come. There is a beauty in the simplicity of it.

You call. We come.

Young, old, wealthy, poor, trivial or life-threatening, wealthy philanthropist or felonious meth dealer, in America it's a pretty safe bet that when you call an ambulance, an ambulance will come.

The system isn't perfect. It's riddled with cracks and flaws, and often takes longer than it should. But the people within it make an earnest attempt to respond to your call for help, each and every time.

We don't look at your neighborhood on a map and decide if your socioeconomic status or ethnicity is worthy of our care. When the car crash victim turns out to be the drunk driver who killed a family of three, we render the same care had the roles been reversed.

And many of us pay a tremendous emotional price for it. There's an emotional burden in always being the good guys.

While many of us may try to ease that burden with bitching and complaining to our peers, or engaging in black humor that horrifies the occasional outsider who happens to overhear, when the tones drop, we put all that away and we respond.

You call. We come.

I take great pride in that. I condemn systems abuse as much as the next guy, but I honestly wonder if screening calls for appropriate utilization of 911 doesn't chip away at the honor of my part in the compact.

You call, we come.

It doesn't even occur to me not to respond. I'm not wired that way.

I hate that EMS has changed me, yet the man I was sorely needed to change.
Death holds no fear or fascination for me anymore. Car accidents, shootings, stabbings, blood and gore — they're just meat. Because I'm good at compartmentalizing, people who don't know me think I can be cold and uncaring.

And I suppose I can be. I worry about that myself sometimes. On a call a few years back, a horse in the roadway caused a multi-vehicle crash. As I lifted the shattered head of the first victim I triaged and her uninjured husband begged me to help her, I thought to myself, "Dead meat. Find the next patient."

And that's exactly what I did.

I flash back to that call sometimes, and fear grips my heart in its leaden fist, as I wonder, "How much have I had to carve off of my soul to make that decision so automatically" And will I have any left to give to my daughter, my girlfriend and my friends""

But when I think back on it, there wasn't much to like about the person I used to be before EMS. He was cocky and arrogant. He was superficial. He was the quintessential class clown, hiding his pain behind a mask of humor.

He had been hurt so much as a child, that he held everyone at arm's length. He loved no one, and dared let no one come close enough to love him.

The young paramedic I was used to avoid funerals. Funerals were events where people expressed uncomfortable emotions like grief and sorrow, things I'd rather avoid.

Now, I've learned that pain and sorrow are nothing to fear. I have borne witness to more pain and suffering, more grief, sorrow and death than most non-EMS people can ever fathom.

Each passing year teaches me to hold my loved ones close, and to treasure every moment. I'm a better man, a better father and a better boyfriend because of what EMS has taught me.

If I seem more weary and scarred these days, it's only because my aches have been earned. A full life weighs more than an empty one.

I hate that EMS has taken so many of my friends, but they all died doing what they loved.
I've lost friends to helicopter and ambulance crashes. A few died by suicide.

Others left EMS after back injuries, patient assaults or burnout. They are still alive, but EMS changed them so drastically that they're not the same people I once knew.

I advocate tirelessly for better ambulance design, more appropriate use of helicopter EMS and more stringent safety standards and practices. I do this because I don't want to lose any more brothers and sisters in EMS — not even the ones I've yet to meet.

When I think about the friends I've lost, not a one of them would have chosen to die of old age in a nursing home. Old age, yes, but not in a nursing home.

To go into cardiac arrest right after they got ROSC on somebody else, that's the way they'd have wanted to go. Or maybe they'd pick a massive stroke right during a night of passion with the supermodel you met when you saved her life … yep, in the ambulance.

I hate dealing with drunks, but drunks are endlessly entertaining.
Be it angry and belligerent, weepy and maudlin or rambling and incoherent, I've never been able to master any of the dialects of drunkese. I have been sexually propositioned, threatened with an ass kicking, and proposed marriage by more drunks than I can count — and often all three by the same drunk.

Dealing with drunk patients taxes every bit of professionalism, customer service skills and civility I can muster. I am ashamed to say that I have sometimes failed at it.

On the other hand, I have laughed uproariously with and at some of my drunk patients. Many of the most entertaining people in the back of my ambulance were there because they imbibed "tee many martoonis."

And for a writer, drunks are a gold mine of entertaining material. A wise man once said that no entertaining story ever begins with, "So there I was, eating a salad …"

Looking back on my career, it's the perspective earned from 23 years in EMS that has taught me that for every gripe and complaint about what my job entails, there's a "yeah, but" in my memories. So far, all those "buts" make everything else worth it.

Here's hoping your collection of "yeah, buts" make everything else worth it as well.



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One-Dimensional Finite Element Method Solution of a Class of Integro-Differential Equations: Application to Non-Fickian Transport in Disordered Media

Abstract

We study an integro-differential equation that has important applications to problems of anomalous transport in highly disordered media. In one application, the equation is the continuum limit of a continuous time random walk used to quantify non-Fickian (anomalous) contaminant transport. The finite element method is used for the spatial discretization of this equation, with an implicit scheme for its time discretization. To avoid storage of the entire history, an efficient sum-of-exponential approximation of the kernel function is constructed that allows a simple recurrence relation. A 1D formulation with a linear element is implemented to demonstrate this approach, by comparison with available experiments and with an exact solution in the Laplace domain, transformed numerically to the time domain. The proposed scheme convergence assessment is briefly addressed. Future extensions of this implementation are then outlined.



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