Efficacy of photodynamic therapy combined with a guide sheath method concomitant with chemotherapy in a small-cell lung cancer patient with central endobronchial stenosis

Publication date: Available online 28 August 2016
Source:Photodiagnosis and Photodynamic Therapy
Author(s): Fumi Suzuki, Masafumi Misawa, Hiroshi Sugimura, Satoshi Yamawaki, Masahiro Aoshima




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Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Publication date: Available online 28 August 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Mübeccel Akdis, Alar Aab, Can Altunbulakli, Kursat Azkur, Rita A. Costa, Reto Crameri, Su Duan, Thomas Eiwegger, Andrzej Eljaszewicz, Ruth Ferstl, Remo Frei, Mattia Garbani, Anna Globinska, Lena Hess, Carly Huitema, Terufumi Kubo, Zsolt Komlosi, Patricia Konieczna, Nora Kovacs, Umut C. Kucuksezer, Norbert Meyer, Hideaki Morita, Judith Olzhausen, Liam O'Mahony, Marija Pezer, Moira Prati, Ana Rebane, Claudio Rhyner, Arturo Rinaldi, Milena Sokolowska, Barbara Stanic, Kazunari Sugita, Angela Treis, Willem van de Veen, Kerstin Wanke, Marcin Wawrzyniak, Paulina Wawrzyniak, Oliver F. Wirz, Josefina Sierra Zakzuk, Cezmi A. Akdis
There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.



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Efficacy of buprenorphine added to 2% lignocaine plus adrenaline 1:80,000 in providing postoperative analgesia after lower third molar surgery

A number of trials have examined the peripheral analgesic effect of opioids, known to have an anti-nociceptive effect at the central and/or spinal cord level. This study aimed to evaluate the efficacy of buprenorphine added to 2% lignocaine with adrenaline 1:80,000 in providing postoperative analgesia after lower third molar surgery. Sixty patients were randomized to three groups: group A received lignocaine 2% with adrenaline 1:80,000 for inferior alveolar nerve block (IANB), along with intramuscular (IM) injection of 1ml saline; group B received buprenorphine mixed with lignocaine 2% with adrenaline 1:80,000 for IANB (0.01mg buprenorphine/ml lignocaine with adrenaline), along with 1ml saline IM; group C received lignocaine 2% with adrenaline 1:80,000 for IANB, along with 0.03mg buprenorphine IM.

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Schneider membrane thickness classification evaluated by cone-beam computed tomography and its importance in the predictability of perforation. Retrospective analysis of 200 patients

Publication date: Available online 28 August 2016
Source:British Journal of Oral and Maxillofacial Surgery
Author(s): M. Rapani, C. Rapani, L. Ricci
Perforation of the Schneiderian membrane is a common complication of sinus augmentation. The aim of this retrospective study was to assess the associations between the lateral wall technique and the ridge approach and the risk of perforation, together with the relations between the thickness of the membrane and the risk of perforation. We studied 200 patients (103 men and 97 women) who had cone-beam computed tomography (CT) before a sinus lift with either a lateral wall technique (n=100) or the rigid approach (n=100) for insertion of prosthetic implants. Two-hundred cone-beam CT images were studied, and the mucosal thickness was evaluated. Perforations of the membrane were recorded during operation. The thickness of the Schneiderian membrane on cone-beam CT images was classified as Type I (not recordable), Type II (0-2mm), Type III (3-4mm), or Type IV(>4mm). Type I was recorded in 52 (26%), Type II in 35 (18%), type III in 67 (34%), and type IV in 46 (23%). There were 16 perforations: 12 Type I and four Type II, seven of 100 with the lateral wall technique, and nine of 100 who had the rigid approach. Based on these results we suggest that a membrane 0-2mm thick may be an important determinant of perforation, regardless of the procedure used.



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Bacterial Messages From Beyond?

H.P. Lovecraft fan and composer Reber Clark (http://ift.tt/1QAYlux) collaborated with my undergraduate student Ruth Isenberg and myself on a science+music+HPL video. When a log phase culture of Photobacterium leignothi is poured into a Petri dish, and 10 second exposures are taken ev...

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Six year adalimumab efficacy in steroid-dependent Crohn's disease patients: A prospective real life study

Adalimumab is effective in the treatment of Crohn's disease. We have already reported data on the efficacy of adalimumab in 110 steroid-dependent patients. At the end of the study 90 patients (64.5%) maintained clinical remission.

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Schneider membrane thickness classification evaluated by cone-beam computed tomography and its importance in the predictability of perforation. Retrospective analysis of 200 patients

Perforation of the Schneiderian membrane is a common complication of sinus augmentation. The aim of this retrospective study was to assess the associations between the lateral wall technique and the ridge approach and the risk of perforation, together with the relations between the thickness of the membrane and the risk of perforation. We studied 200 patients (103 men and 97 women) who had cone-beam computed tomography (CT) before a sinus lift with either a lateral wall technique (n=100) or the rigid approach (n=100) for insertion of prosthetic implants.

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