PrEP: why we are waiting.

Jansen, MP; Tromp, N; Baltussen, R; (2016) PrEP: why we are waiting. Lancet HIV , 3 (1) e11-e12. 10.1016/S2352-3018(15)00250-7 .

http://discovery.ucl.ac.uk/1528584/

Interdependence and dynamics of essential services in an extensive risk context: a case study in Montserrat, West Indies

Sword-Daniels, VL; Rossetto, T; Wilson, TM; Sargeant, S; (2015) Interdependence and dynamics of essential services in an extensive risk context: a case study in Montserrat, West Indies. Natural Hazards and Earth System Sciences Discussions , 3 (2) pp. 1025-1059. 10.5194/nhessd-3-1025-2015 .

http://discovery.ucl.ac.uk/1528583/

Radio-controlled Movement of a Robot Endoscope in the Human Gastrointestinal Tract

Swain, C; Mills, TN; Kelleher, B; Mosse, CA; Burke, MPD; Fritcher-Ravens, A; (2005) Radio-controlled Movement of a Robot Endoscope in the Human Gastrointestinal Tract. In: (Proceedings) American Society for Gastrointestinal Endoscopy's 'Digestive Disease Week. (pp. AB101-AB101). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528582/

Development and Testing of an Electrically Propelled Capsule Endoscope in Man

Fritscher-Ravens, A; Burke, MPD; Mills, T; Mosse, CA; Mylonaki, M; Swain, CP; (2003) Development and Testing of an Electrically Propelled Capsule Endoscope in Man. In: (Proceedings) American Society for Gastrointestinal Endoscopy's 'Digestive Disease Week. (pp. AB84-AB84). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528581/

Remote Propulsion of Wireless Capsule Endoscopes

Swain, PC; Mosse, A; Burke, MPD; Fritscher-Ravens, A; Lewkovicz, S; Kraizer, Y; Mills, T; (2002) Remote Propulsion of Wireless Capsule Endoscopes. In: (Proceedings) Digestive Disease Week 2002, May 19 - 22, 2002; San Francisco, Californi. (pp. AB88-AB88). Gastrointestinal Endoscopy: US.

http://discovery.ucl.ac.uk/1528580/

What is the evidence for genetics in chronic rhinosinusitis?.

Purpose of review: To perform analysis of evidence in current literature on the topic of genetics and chronic rhinosinusitis (CRS), with a particular focus on recent findings in the cystic fibrosis transmembrane regulator (CFTR), genes associated with primary ciliary dyskinesia, and taste receptor T2R38. Other genes that have been found to have association with CRS are also presented and discussed. Recent findings: Recent studies in CFTR and CRS research have investigated possible CFTR-potentiators for treatment of refractory CRS. The T2R38 gene has been shown to be applicable in the clinical setting with a testable phenotype and may have a role in the prognosis and influencing management strategies of CRS patients. Many genes of the immune system have been studied, with genome-wide association studies and candidate-gene approaches identifying new associations that will need replication and further elucidation. Summary: CRS is a multifactorial disease, with strong evidence of a genetic component in its pathophysiology for some cases. Currently, there are over 70 genes that have been genetically associated with CRS in the past 15 years. Future investigations into genetic causes and predispositions of CRS may allow for improved prognostication and development of disease-prevention strategies as well as novel therapeutic targets. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

http://ift.tt/2ft4oEx

Sinonasal methicillin-resistant Staphylococcus aureus: updates on treatment.

Purpose of review: Over the past two decades, the management of methicillin-resistant Staphylococcus aureus (MRSA) in chronic rhinosinusitis has posed significant challenges. This document reviews current management techniques and novel treatment modalities for sinonasal MRSA infections. Recent findings: Topical antibiotic therapy, that is, drops (ofloxacin) and ointments (mupirocin) as off-label use for the management of MRSA chronic sinusitis, has shown beneficial results. Other more recently trialed nonantibiotic modalities such as antimicrobial photodynamic therapy and colloidal silver irrigation are also showing promise. Summary: Sinonasal MRSA is considered to be associated with recalcitrant chronic sinusitis. Advancements in systemic and local antibiotics in its management have been slow and unsatisfactory. Attention is shifting to the use of nonantibiotic antibacterial treatments. Knowledge of these options is critical to improve the overall management of these chronic patients. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

http://ift.tt/2ft3PL5