Relational responding: testing, training and sequencing effects among children with autism and typically-developing children

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Relational responding: testing, training and sequencing effects among children with autism and typically-developing children

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Visualizing Visual Adaptation

This article describes a novel method for simulating and studying adaptation in the visual system.

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EMT and Paramedic full time positions - A-1 Ambulance Inc.

EMT and Paramedics will be responsible for caring for and transporting both ALS and BLS patients along with out of town transfers. The EMT and Paramedic will work together with the medical director to provide top notch care that is in his/her scope of practice and adhere to the protocols already in place.

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Spatiotemporal reorganization of the reading network in adult dyslexia

Publication date: Available online 24 April 2017
Source:Cortex
Author(s): Eddy Cavalli, Pascale Colé, Chotiga Pattamadilok, Jean-Michel Badier, Christelle Zielinski, Valérie Chanoine, Johannes C. Ziegler
Developmental dyslexia is characterized by impairments in reading fluency and spelling that persist into adulthood. Here, we hypothesized that high-achieving adult dyslexics (i.e., university students with a history of dyslexia) manage to cope with these deficits by relying to a greater extent on morphological information than do non-impaired adult readers. We used magnetoencephalography (MEG) in a primed lexical decision task, in which we contrasted orthographic, morphological and semantic processing. Behavioral results confirmed that adult dyslexics did indeed rely to a greater extent on the semantic properties of morphemes than controls. In line with this, MEG results showed early morphological effects (100-200ms) in a frontal network, which reflected the contribution of semantic processing. The same effects occurred much later in controls (∼400ms). In contrast, controls showed early orthographic priming effects in posterior left inferior temporal gyrus at around 130ms, which were not seen in dyslexics. In the left inferior temporal gyrus, dyslexics showed only late activation of semantic and orthographic information. The present results suggest a spatiotemporal reorganization of the reading network, in which morphological information located in frontal regions is activated earlier in high-achieving adults dyslexics than controls.



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The Dynamic Invertible Intramolecular Charge-transfer Fluorescence Probe: Real-time Monitoring of Mitochondrial ATPase Activity

Chem. Commun., 2017, Accepted Manuscript
DOI: 10.1039/C7CC02450A, Communication

Hua Zhang, Yafu Wang, Xiaopeng Xuan, Ge Wang, Haiming Guo, Jiangli Fan
The dynamic invertible intramolecular charge-transfer (ICT) process could provide abundant response signals for the real-time monitoring in living organism. Herein, based on the dynamic invertible ICT, we reported a cancer...
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Psychiatric associations of adult-onset focal dystonia phenotypes

Background

Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown.

Objectives

The aim of this study was to determine whether depression, anxiety and social anxiety vary by dystonia onset site and evaluate whether pain and dystonia severity account for any differences.

Methods

Patients with isolated focal dystonia evaluated within 5 years from symptom onset, enrolled in the Natural History Project of the Dystonia Coalition, were included in the analysis. Individual onset sites were grouped into five body regions: cervical, laryngeal, limb, lower cranial and upper cranial. Neuropsychiatric symptoms were rated using the Beck Depression Inventory, Hospital Anxiety and Depression Scale and Liebowitz Social Anxiety Scale. Pain was estimated using the 36-Item Short Form Survey.

Results

Four hundred and seventy-eight subjects met our inclusion criteria. High levels of depression, anxiety and social anxiety occurred in all groups; however, the severity of anxiety and social anxiety symptoms varied by onset site group. The most pronounced differences were higher anxiety in cervical and laryngeal, lower anxiety in upper cranial and higher social anxiety in laryngeal. Increases in pain were associated with worse neuropsychiatric symptom scores within all groups. Higher anxiety and social anxiety in laryngeal and lower anxiety in upper cranial persisted after correcting for pain and dystonia severity.

Conclusion

Anxiety and social anxiety severity vary by onset site of focal dystonia, and this variation is not explained by differences in pain and dystonia severity.

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