Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: A meta-analysis

Abstract

Background

Neutrophils play substantial roles in cancer progression. Previous reports demonstrated the prognostic impact of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in various types of solid cancers. The purpose of this study was to quantify the prognostic impact of NLR on head and neck squamous cell carcinoma (HNSCC).

Methods

We systematically searched electronic databases, identified articles regarding NLR and HNSCC mortality, and extracted hazard ratios (HRs) and 95% confidence intervals (CIs). Pooled HRs for overall survival (OS) and disease-specific survival (DSS) were estimated using random effect models.

Results

Nineteen studies enrolling 3770 patients were included in the analyses. Overall, NLR greater than the cutoff value was associated with poorer OS and DSS (HR 1.69; 95% CI 1.47-1.93; P < .001 and HR 1.88; 95% CI 1.20-2.95; P = .006, respectively).

Conclusion

Elevated NLR predicts worse outcomes in patients with HNSCC.

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Heterotopic thyroid autotransplantation: A preliminary clinical study

Abstract

Background

Thyroid autotransplantation offers an attractive alternative to subtotal thyroidectomy and replacement therapy. However, it has not been sufficiently clinically investigated.

Methods

Total thyroidectomy was performed for 20 patients with benign thyroid disorders, and at least 10 g of thyroid tissue were implanted intramuscularly. Graft monitoring was achieved through ^99mTc scan at 2 months, free triiodothyronine (FT3), FT4, and thyroid-stimulating hormone (TSH) measurements at 1, 2, 4, 6, 8, 10, and 12 months postoperatively, and clinical examination.

Results

Grafts survived and gradually functioned in all patients to a variable extent after a latent period (mean ^99mTc uptake = 1.28 ± 0.37%). Mean values for FT3, FT4, TSH at 12 months were 1.75 ± 0.48 pg/mL, 1.06 ± 0.26 ng/dL, and 28.08 ± 34.01 μIU/mL respectively.

Conclusion

Thyroid autotransplantation restored euthyroid status in 33.3% of patients after 12 months. A role of age, operative time, and ^99mTc-uptake in determining the final graft outcome is possible.

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AHNS Series: Do you know your guidelines? Review of current knowledge on laryngeal cancer

Abstract

The following article is part of a series in an initiative by the American Head and Neck Society's Education Committee and will review clinical practice guidelines for head and neck oncology. The primary goal is to increase awareness of current best practices pertaining to head and neck surgery and oncology. This manuscript is a review of current knowledge in laryngeal cancer with a focus on anatomy, epidemiology, diagnosis, evaluation, and treatment.

http://ift.tt/2zThWn9

Abscess with osteomyelitis of the clivus after adenoidectomy: An uncommon complication of a common procedure

Publication date: Available online 26 October 2017
Source:European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): E. Moreddu, C. Le Treut, J.-M. Triglia, R. Nicollas




http://ift.tt/2y8Rj09

P275 Refractory hypereosinophilia manifesting as nodular sclerosis classical hodgkin lymphoma—a case presentation

The differential of hypereosinophilia is broad and includes atopy, infection, malignancy, and in rare cases of exclusion, hypereosinophilic syndrome (HES). Thorough evaluation is necessary to elucidate the cause and prevent sequelae of hypereosinophilia.

http://ift.tt/2iDiB7S

P283 Pneumococcal osteomyelitis: a rare diagnosis suggestive of immune deficiency

Despite routine immunization with pneumococcal conjugate vaccines, Streptococcus pneumoniae is still a significant cause of bacteremia, pneumonia and meningitis. Osteoarticular pneumococcal infections are very rare, accounting for less than 5% of all invasive pneumococcal diseases (IPD).

http://ift.tt/2zaosJ3

P282 Recurrent candidal esophagitis in an otherwise healthy host

Candida Albicans is a yeast that naturally colonizes the skin and mucosa. Chronic Mucocutaneous Candidiasis Syndrome (CMCS) presents with recurrent superficial candida infection, and is associated with other clinical manifestations such as autoimmunity or bacterial infections. Chronic Mucocutaneous Candidaisis Disease (CMCD) is a new entity in which patients present solely with superficial candidiasis. Here we present an interesting case of CMCD.

http://ift.tt/2iDkQIs